-
1
-
-
34247172535
-
Myelodysplastic syndromes: incidence and survival in the United States
-
Ma X, Does M, Raza A, Mayne ST. Myelodysplastic syndromes: incidence and survival in the United States. Cancer 2007;109: 1536-42.
-
(2007)
Cancer
, vol.109
, pp. 1536-1542
-
-
Ma, X.1
Does, M.2
Raza, A.3
Mayne, S.T.4
-
2
-
-
78951473511
-
Epidemiology, natural history, and practice patterns of patients with myelodysplastic syndromes in 2010
-
Sekeres MA. Epidemiology, natural history, and practice patterns of patients with myelodysplastic syndromes in 2010. J Natl Compr Canc Netw 2011;9:57-63.
-
(2011)
J Natl Compr Canc Netw
, vol.9
, pp. 57-63
-
-
Sekeres, M.A.1
-
3
-
-
0034054939
-
Incidence, characterization and prognostic significance of chromosomal abnormalities in 640 patients with primary myelodysplastic syndromes Grupo Cooperativo Español de Citogenética Hematológica.
-
Sole F, Espinet B, Sanz GF, et al. Incidence, characterization and prognostic significance of chromosomal abnormalities in 640 patients with primary myelodysplastic syndromes. Grupo Cooperativo Español de Citogenética Hematológica. Br J Haematol 2000;108:346-56.
-
(2000)
Br J Haematol
, vol.108
, pp. 346-356
-
-
Sole, F.1
Espinet, B.2
Sanz, G.F.3
-
4
-
-
0022617302
-
Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes
-
Le Beau MM, Albain KS, Larson RA, et al. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 1986;4:325-45.
-
(1986)
no. 5 and 7. J Clin Oncol
, vol.4
, pp. 325-345
-
-
Le Beau, M.M.1
Albain, K.S.2
Larson, R.A.3
-
5
-
-
84866621729
-
Revised international prognostic scoring system for myelodysplastic syndromes
-
Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 2012;120:2454-65.
-
(2012)
Blood
, vol.120
, pp. 2454-2465
-
-
Greenberg, P.L.1
Tuechler, H.2
Schanz, J.3
-
6
-
-
84888219405
-
Clinical and biological implications of driver mutations in myelodysplastic syndromes
-
Papaemmanuil E, Gerstung M, Malcovati L, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 2013;122:3616-27.
-
(2013)
Blood
, vol.122
, pp. 3616-3627
-
-
Papaemmanuil, E.1
Gerstung, M.2
Malcovati, L.3
-
7
-
-
79959794787
-
Clinical effect of point mutations in myelodysplastic syndromes
-
Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med 2011;364:2496-506.
-
(2011)
N Engl J Med
, vol.364
, pp. 2496-2506
-
-
Bejar, R.1
Stevenson, K.2
Abdel-Wahab, O.3
-
8
-
-
84866749552
-
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
-
Bejar R, Stevenson KE, Caughey BA, et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol 2012;30: 3376-82.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3376-3382
-
-
Bejar, R.1
Stevenson, K.E.2
Caughey, B.A.3
-
9
-
-
79956291339
-
TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
-
Jadersten M, Saft L, Smith A, et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol 2011;29:1971-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1971-1979
-
-
Jadersten, M.1
Saft, L.2
Smith, A.3
-
10
-
-
84891876933
-
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
-
Traina F, Visconte V, Elson P, et al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Leukemia 2014;28:78-87.
-
(2014)
Leukemia
, vol.28
, pp. 78-87
-
-
Traina, F.1
Visconte, V.2
Elson, P.3
-
11
-
-
84920989180
-
Screening for SF3B1 mutations is a useful tool to differentiate between acquired clonal and non-clonal sideroblastic anemia
-
Visconte V, Tabarroki A, Gerace CJ, et al. Screening for SF3B1 mutations is a useful tool to differentiate between acquired clonal and non-clonal sideroblastic anemia. Leuk Lymphoma 2014:1-3.
-
(2014)
Leuk Lymphoma
, pp. 1-3
-
-
Visconte, V.1
Tabarroki, A.2
Gerace, C.J.3
-
12
-
-
84904520914
-
Prognostic models in myelodysplastic syndromes
-
Bejar R. Prognostic models in myelodysplastic syndromes. Hematology Am Soc Hematol Educ Program 2013;2013:504-10.
-
(2013)
Hematology Am Soc Hematol Educ Program
, vol.2013
, pp. 504-510
-
-
Bejar, R.1
-
13
-
-
84991688432
-
Current and novel therapeutic approaches in myelodysplastic syndromes
-
Estephan F, Tiu RV. Current and novel therapeutic approaches in myelodysplastic syndromes. J Community Support Oncol 2014;12:236-49.
-
(2014)
J Community Support Oncol
, vol.12
, pp. 236-249
-
-
Estephan, F.1
Tiu, R.V.2
-
14
-
-
79957503201
-
Updates in cytogenetics and molecular markers in MDS
-
Tiu RV, Visconte V, Traina F, Schwandt A, Maciejewski JP. Updates in cytogenetics and molecular markers in MDS. Curr Hematol Malig Rep 2011;6:126-35.
-
(2011)
Curr Hematol Malig Rep
, vol.6
, pp. 126-135
-
-
Tiu, R.V.1
Visconte, V.2
Traina, F.3
Schwandt, A.4
Maciejewski, J.P.5
-
15
-
-
0028216548
-
Fluorescence in situ hybridization improves the detection of monosomy 7 in myelodysplastic syndromes
-
Flactif M, Lai JL, Preudhomme C, Fenaux P. Fluorescence in situ hybridization improves the detection of monosomy 7 in myelodysplastic syndromes. Leukemia 1994;8:1012-8.
-
(1994)
Leukemia
, vol.8
, pp. 1012-1018
-
-
Flactif, M.1
Lai, J.L.2
Preudhomme, C.3
Fenaux, P.4
-
16
-
-
10744227653
-
Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics
-
Bernasconi P, Cavigliano PM, Boni M, et al. Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics? A study on 57 patients. Leukemia 2003;17:2107-12.
-
(2003)
A study on 57 patients. Leukemia
, vol.17
, pp. 2107-2112
-
-
Bernasconi, P.1
Cavigliano, P.M.2
Boni, M.3
-
17
-
-
84883741044
-
Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis
-
Broseus J, Alpermann T, Wulfert M, et al. Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis. Leukemia 2013;27:1826-31.
-
(2013)
Leukemia
, vol.27
, pp. 1826-1831
-
-
Broseus, J.1
Alpermann, T.2
Wulfert, M.3
-
18
-
-
84855603339
-
Chromosome analysis using spectral karyotyping (SKY)
-
Imataka G, Arisaka O. Chromosome analysis using spectral karyotyping (SKY). Cell Biochem Biophys 2012;62:13-7.
-
(2012)
Cell Biochem Biophys
, vol.62
, pp. 13-17
-
-
Imataka, G.1
Arisaka, O.2
-
19
-
-
79955945973
-
Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies
-
Tiu RV, Gondek LP, O'Keefe CL, et al. Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies. Blood 2011;117:4552-60.
-
(2011)
Blood
, vol.117
, pp. 4552-4560
-
-
Tiu, R.V.1
Gondek, L.P.2
O'Keefe, C.L.3
-
20
-
-
38949123096
-
Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
-
Gondek LP, Tiu R, O'Keefe CL, Sekeres MA, Theil KS, Maciejewski JP. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood 2008;111:1534-42.
-
(2008)
Blood
, vol.111
, pp. 1534-1542
-
-
Gondek, L.P.1
Tiu, R.2
O'Keefe, C.L.3
Sekeres, M.A.4
Theil, K.S.5
Maciejewski, J.P.6
-
21
-
-
84862248169
-
Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited
-
Jerez A, Gondek LP, Jankowska AM, et al. Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited. J Clin Oncol 2012;30:1343-9.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1343-1349
-
-
Jerez, A.1
Gondek, L.P.2
Jankowska, A.M.3
-
22
-
-
34548125332
-
Single nucleotide polymorphism arrays complement metaphase cytogenetics in detection of new chromosomal lesions in MDS
-
Gondek LP, Tiu R, Haddad AS, et al. Single nucleotide polymorphism arrays complement metaphase cytogenetics in detection of new chromosomal lesions in MDS. Leukemia 2007;21:2058-61.
-
(2007)
Leukemia
, vol.21
, pp. 2058-2061
-
-
Gondek, L.P.1
Tiu, R.2
Haddad, A.S.3
-
23
-
-
36148993604
-
Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes
-
Mohamedali A, Gaken J, Twine NA, et al. Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007;110:3365-73.
-
(2007)
Blood
, vol.110
, pp. 3365-3373
-
-
Mohamedali, A.1
Gaken, J.2
Twine, N.A.3
-
24
-
-
84880393400
-
Next-generation sequencing: methodology and application
-
Grada A, Weinbrecht K. Next-generation sequencing: methodology and application. J Invest Dermatol 2013;133:e11.
-
(2013)
J Invest Dermatol
, vol.133
-
-
Grada, A.1
Weinbrecht, K.2
-
25
-
-
72849144434
-
Sequencing technologies-the next generation
-
Metzker ML. Sequencing technologies-the next generation. Nat Rev Genet 2010;11:31-46.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 31-46
-
-
Metzker, M.L.1
-
26
-
-
84895810208
-
Epigenetics of myelodysplastic syndromes
-
Itzykson R, Fenaux P. Epigenetics of myelodysplastic syndromes. Leukemia 2014;28:497-506.
-
(2014)
Leukemia
, vol.28
, pp. 497-506
-
-
Itzykson, R.1
Fenaux, P.2
-
27
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010;363:2424-33.
-
(2010)
N Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
28
-
-
77954089584
-
Array-based genomic resequencing of human leukemia
-
Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene 2010;29:3723-31.
-
(2010)
Oncogene
, vol.29
, pp. 3723-3731
-
-
Yamashita, Y.1
Yuan, J.2
Suetake, I.3
-
29
-
-
84886804684
-
DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients
-
Shivarov V, Gueorguieva R, Stoimenov A, Tiu R. DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients. Leuk Res 2013;37:1445-50.
-
(2013)
Leuk Res
, vol.37
, pp. 1445-1450
-
-
Shivarov, V.1
Gueorguieva, R.2
Stoimenov, A.3
Tiu, R.4
-
30
-
-
82855177869
-
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes
-
Thol F, Winschel C, Ludeking A, et al. Rare occurrence of DNMT3A mutations in myelodysplastic syndromes. Haematologica 2011;96:1870-3.
-
(2011)
Haematologica
, vol.96
, pp. 1870-1873
-
-
Thol, F.1
Winschel, C.2
Ludeking, A.3
-
31
-
-
80053135096
-
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
-
Jankowska AM, Makishima H, Tiu RV, et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011;118:3932-41.
-
(2011)
Blood
, vol.118
, pp. 3932-3941
-
-
Jankowska, A.M.1
Makishima, H.2
Tiu, R.V.3
-
32
-
-
84856477048
-
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapyrelated and secondary acute myeloid leukemia
-
Fried I, Bodner C, Pichler MM, et al. Frequency, onset and clinical impact of somatic DNMT3A mutations in therapyrelated and secondary acute myeloid leukemia. Haematologica 2012;97:246-50.
-
(2012)
Haematologica
, vol.97
, pp. 246-250
-
-
Fried, I.1
Bodner, C.2
Pichler, M.M.3
-
33
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011;44:23-31.
-
(2011)
Nat Genet
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
-
34
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
Walter MJ, Ding L, Shen D, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011; 25:1153-8.
-
(2011)
Leukemia
, vol.25
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
-
35
-
-
79960229916
-
Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
-
Itzykson R, Kosmider O, Cluzeau T, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia 2011;25:1147-52.
-
(2011)
Leukemia
, vol.25
, pp. 1147-1152
-
-
Itzykson, R.1
Kosmider, O.2
Cluzeau, T.3
-
36
-
-
67650588639
-
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/ myeloproliferative neoplasms
-
Jankowska AM, Szpurka H, Tiu RV, et al. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/ myeloproliferative neoplasms. Blood 2009;113:6403-10.
-
(2009)
Blood
, vol.113
, pp. 6403-6410
-
-
Jankowska, A.M.1
Szpurka, H.2
Tiu, R.V.3
-
37
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009;41:838-42.
-
(2009)
Nat Genet
, vol.41
, pp. 838-842
-
-
Langemeijer, S.M.1
Kuiper, R.P.2
Berends, M.3
-
38
-
-
84877582944
-
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
-
Ko M, An J, Bandukwala HS, et al. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature 2013;497:122-6.
-
(2013)
Nature
, vol.497
, pp. 122-126
-
-
Ko, M.1
An, J.2
Bandukwala, H.S.3
-
40
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010;468:839-43.
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
-
41
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011;20:11-24.
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
-
42
-
-
84887021053
-
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis
-
Cheng J, Guo S, Chen S, et al. An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep 2013;5:471-81.
-
(2013)
Cell Rep
, vol.5
, pp. 471-481
-
-
Cheng, J.1
Guo, S.2
Chen, S.3
-
43
-
-
78149454504
-
Nextgeneration sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
-
Smith AE, Mohamedali AM, Kulasekararaj A, et al. Nextgeneration sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Blood 2010;116:3923-32.
-
(2010)
Blood
, vol.116
, pp. 3923-3932
-
-
Smith, A.E.1
Mohamedali, A.M.2
Kulasekararaj, A.3
-
44
-
-
84905686309
-
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients
-
Kihara R, Nagata Y, Kiyoi H, et al. Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Leukemia 2014;28:1586-95.
-
(2014)
Leukemia
, vol.28
, pp. 1586-1595
-
-
Kihara, R.1
Nagata, Y.2
Kiyoi, H.3
-
45
-
-
84856725273
-
Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients
-
Patnaik MM, Hanson CA, Hodnefield JM, et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia 2012;26:101-5.
-
(2012)
Leukemia
, vol.26
, pp. 101-105
-
-
Patnaik, M.M.1
Hanson, C.A.2
Hodnefield, J.M.3
-
46
-
-
77957771067
-
IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
-
Schnittger S, Haferlach C, Ulke M, Alpermann T, Kern W, Haferlach T. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 2010;116:5486-96.
-
(2010)
Blood
, vol.116
, pp. 5486-5496
-
-
Schnittger, S.1
Haferlach, C.2
Ulke, M.3
Alpermann, T.4
Kern, W.5
Haferlach, T.6
-
47
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18:553-67.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
48
-
-
84879374380
-
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
-
DiNardo CD, Propert KJ, Loren AW, et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood 2013;121: 4917-24.
-
(2013)
Blood
, vol.121
, pp. 4917-4924
-
-
DiNardo, C.D.1
Propert, K.J.2
Loren, A.W.3
-
49
-
-
84926657869
-
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro
-
Sarkaria SM, Christopher MJ, Klco JM, Ley TJ. Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro. Leukemia 2014;28:2403-6.
-
(2014)
Leukemia
, vol.28
, pp. 2403-2406
-
-
Sarkaria, S.M.1
Christopher, M.J.2
Klco, J.M.3
Ley, T.J.4
-
50
-
-
66849124925
-
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
-
Gelsi-Boyer V, Trouplin V, Adelaide J, et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009;145:788-800.
-
(2009)
Br J Haematol
, vol.145
, pp. 788-800
-
-
Gelsi-Boyer, V.1
Trouplin, V.2
Adelaide, J.3
-
51
-
-
84920976136
-
Impact of cytogenetics and molecular genetics in the clinical outcomes of patients with deletion (20)q diagnosed with MDS and other myeloid malignancies.
-
4th International Bone Marrow Failure Disease Scientific Symposium 2014
-
Tabarroki A, Zhang L, Visconte V, et al. Impact of cytogenetics and molecular genetics in the clinical outcomes of patients with deletion (20)q diagnosed with MDS and other myeloid malignancies. 4th International Bone Marrow Failure Disease Scientific Symposium 2014. (http://www.aamds.org/node/2472)
-
-
-
Tabarroki, A.1
Zhang, L.2
Visconte, V.3
-
52
-
-
84920947962
-
ASXL1 mutations define a subgroup of AML patients with distinct gene expression profile and poor prognosis: a meta-analysis of 3311 adult AML patients
-
Shivarov V, Gueorguieva R, Ivanova M, Tiu RV. ASXL1 mutations define a subgroup of AML patients with distinct gene expression profile and poor prognosis: a meta-analysis of 3311 adult AML patients. Leuk Lymphoma 2014:1-11.
-
(2014)
Leuk Lymphoma
, pp. 1-11
-
-
Shivarov, V.1
Gueorguieva, R.2
Ivanova, M.3
Tiu, R.V.4
-
53
-
-
84896730335
-
Myelodysplastic syndromes (MDS) with 20q deletion show a high frequency of associated cytogenetic and molecular lesions with an association to U2AF1, SRSF2, and prognostically adverse ASXL1 mutations
-
ASH Annual Meeting: abst
-
Bacher U, Haferlach T, Schnittger S, et al. Myelodysplastic syndromes (MDS) with 20q deletion show a high frequency of associated cytogenetic and molecular lesions with an association to U2AF1, SRSF2, and prognostically adverse ASXL1 mutations. Blood 2013;122(ASH Annual Meeting):abst 657.
-
(2013)
Blood
, vol.122
, pp. 657
-
-
Bacher, U.1
Haferlach, T.2
Schnittger, S.3
-
54
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
Shih AH, Abdel-Wahab O, Patel JP, Levine RL. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer 2012;12:599-612.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
Levine, R.L.4
-
55
-
-
84888116023
-
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
-
Abdel-Wahab O, Gao J, Adli M, et al. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 2013;210:2641-59.
-
(2013)
J Exp Med
, vol.210
, pp. 2641-2659
-
-
Abdel-Wahab, O.1
Gao, J.2
Adli, M.3
-
56
-
-
74949143986
-
Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
-
Fisher CL, Pineault N, Brookes C, et al. Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood 2010;115: 38-46.
-
(2010)
Blood
, vol.115
, pp. 38-46
-
-
Fisher, C.L.1
Pineault, N.2
Brookes, C.3
-
57
-
-
77957987676
-
Novel homo-and hemizygous mutations in EZH2 in myeloid malignancies
-
Makishima H, Jankowska AM, Tiu RV, et al. Novel homo-and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia 2010;24:1799-804.
-
(2010)
Leukemia
, vol.24
, pp. 1799-1804
-
-
Makishima, H.1
Jankowska, A.M.2
Tiu, R.V.3
-
58
-
-
84864696330
-
A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF)
-
Bejanyan N, Tiu RV, Raza A, et al. A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF). Cancer 2012;118:3968-76.
-
(2012)
Cancer
, vol.118
, pp. 3968-3976
-
-
Bejanyan, N.1
Tiu, R.V.2
Raza, A.3
-
60
-
-
83455234787
-
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
-
Malcovati L, Papaemmanuil E, Bowen DT, et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood 2011; 118:6239-46.
-
(2011)
Blood
, vol.118
, pp. 6239-6246
-
-
Malcovati, L.1
Papaemmanuil, E.2
Bowen, D.T.3
-
62
-
-
80054010617
-
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
-
Papaemmanuil E, Cazzola M, Boultwood J, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011;365:1384-95.
-
(2011)
N Engl J Med
, vol.365
, pp. 1384-1395
-
-
Papaemmanuil, E.1
Cazzola, M.2
Boultwood, J.3
-
63
-
-
84862731816
-
Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis
-
Jerez A, Sugimoto Y, Makishima H, et al. Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis. Blood 2012;119:6109-17.
-
(2012)
Blood
, vol.119
, pp. 6109-6117
-
-
Jerez, A.1
Sugimoto, Y.2
Makishima, H.3
-
64
-
-
84883637783
-
SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype
-
Visconte V, Tabarroki A, Rogers HJ, et al. SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype. Haematologica 2013;98: e105-7.
-
(2013)
Haematologica
, vol.98
, pp. e105-e107
-
-
Visconte, V.1
Tabarroki, A.2
Rogers, H.J.3
-
65
-
-
84862497037
-
Prognostic irrelevance of ring sideroblast percentage in World Health Organizationdefined myelodysplastic syndromes without excess blasts
-
Patnaik MM, Hanson CA, Sulai NH, et al. Prognostic irrelevance of ring sideroblast percentage in World Health Organizationdefined myelodysplastic syndromes without excess blasts. Blood 2012;119:5674-7.
-
(2012)
Blood
, vol.119
, pp. 5674-5677
-
-
Patnaik, M.M.1
Hanson, C.A.2
Sulai, N.H.3
-
66
-
-
84920663583
-
Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron.
-
Visconte V, Avishai N, Mahfouz R, et al. Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron. Leukemia 2014. doi: 10.1038/leu.2014.170.
-
(2014)
Leukemia
-
-
Visconte, V.1
Avishai, N.2
Mahfouz, R.3
-
67
-
-
84876107840
-
The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts
-
Nikpour M, Scharenberg C, Liu A, et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia 2013;27:889-96.
-
(2013)
Leukemia
, vol.27
, pp. 889-896
-
-
Nikpour, M.1
Scharenberg, C.2
Liu, A.3
-
68
-
-
84906064773
-
Splicing factor 3b subunit 1 (SF3B1) heterozygous mice manifest a hematologic phenotype similar to low risk myelodysplastic syndromes with ring sideroblasts
-
ASH Annual Meeting: abst
-
Visconte V, Rogers HJ, Tabarroki A, et al. Splicing factor 3b subunit 1 (SF3B1) heterozygous mice manifest a hematologic phenotype similar to low risk myelodysplastic syndromes with ring sideroblasts. Blood 2013;122(ASH Annual Meeting):abst 259.
-
(2013)
Blood
, vol.122
, pp. 259
-
-
Visconte, V.1
Rogers, H.J.2
Tabarroki, A.3
-
69
-
-
84929324650
-
Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts
-
Visconte V, Tabarroki A, Zhang L, et al. Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts. J Hematol Oncol 2014;7:89.
-
(2014)
J Hematol Oncol
, vol.7
, pp. 89
-
-
Visconte, V.1
Tabarroki, A.2
Zhang, L.3
-
70
-
-
84908299112
-
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia
-
Matsunawa M, Yamamoto R, Sanada M, et al. Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia. Leukemia 2014;28:1844-50.
-
(2014)
Leukemia
, vol.28
, pp. 1844-1850
-
-
Matsunawa, M.1
Yamamoto, R.2
Sanada, M.3
-
71
-
-
84903169674
-
Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia
-
Wang C, Sashida G, Saraya A, et al. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia. Blood 2014;123:3336-43.
-
(2014)
Blood
, vol.123
, pp. 3336-3343
-
-
Wang, C.1
Sashida, G.2
Saraya, A.3
-
72
-
-
84859856420
-
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
-
Thol F, Kade S, Schlarmann C, et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood 2012;119:3578-84.
-
(2012)
Blood
, vol.119
, pp. 3578-3584
-
-
Thol, F.1
Kade, S.2
Schlarmann, C.3
-
74
-
-
84555192302
-
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
-
Graubert TA, Shen D, Ding L, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet 2011;44:53-7.
-
(2011)
Nat Genet
, vol.44
, pp. 53-57
-
-
Graubert, T.A.1
Shen, D.2
Ding, L.3
-
75
-
-
84859597590
-
Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
-
Makishima H, Visconte V, Sakaguchi H, et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 2012;119:3203-10.
-
(2012)
Blood
, vol.119
, pp. 3203-3210
-
-
Makishima, H.1
Visconte, V.2
Sakaguchi, H.3
-
76
-
-
84886905271
-
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
-
Przychodzen B, Jerez A, Guinta K, et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood 2013;122:999-1006.
-
(2013)
Blood
, vol.122
, pp. 999-1006
-
-
Przychodzen, B.1
Jerez, A.2
Guinta, K.3
-
77
-
-
84920943791
-
Sudemycin selectively inhibits growth of primary murine hematopoietic cells expressing mutant U2AF1
-
ASH Annual Meeting: abst
-
Tripathi M, Lunn CL, Okeyo-Owuor T, Walter MJ, Webb TR, Graubert T. Sudemycin selectively inhibits growth of primary murine hematopoietic cells expressing mutant U2AF1. Blood 2012;120(ASH Annual Meeting):abst 554.
-
(2012)
Blood
, vol.120
, pp. 554
-
-
Tripathi, M.1
Lunn, C.L.2
Okeyo-Owuor, T.3
Walter, M.J.4
Webb, T.R.5
Graubert, T.6
-
78
-
-
84867801670
-
The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution
-
Wu SJ, Kuo YY, Hou HA, et al. The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution. Blood 2012;120:3106-11.
-
(2012)
Blood
, vol.120
, pp. 3106-3111
-
-
Wu, S.J.1
Kuo, Y.Y.2
Hou, H.A.3
-
79
-
-
84906060707
-
SRSF2 is essential for hematopoiesis and its mutations dysregulate alternative RNA splicing in MDS
-
ASH Annual Meeting: abst
-
Komeno Y, Qiu J, Lin L, et al. SRSF2 is essential for hematopoiesis and its mutations dysregulate alternative RNA splicing in MDS. Blood 2013;122(ASH Annual Meeting):abst 261.
-
(2013)
Blood
, vol.122
, pp. 261
-
-
Komeno, Y.1
Qiu, J.2
Lin, L.3
-
80
-
-
84920976134
-
Impact of allogeneic hematopoietic stem cell transplant (HSCT) on patients harboring the spliceosome mutation SRSF2
-
Hamilton BK, Tabarroki A, Elson P, et al. Impact of allogeneic hematopoietic stem cell transplant (HSCT) on patients harboring the spliceosome mutation SRSF2. J Clin Oncol 2013; 31(Suppl):abst 7008.
-
(2013)
J Clin Oncol
, vol.31
, pp. 7008
-
-
Hamilton, B.K.1
Tabarroki, A.2
Elson, P.3
-
81
-
-
84920976133
-
PRPF8 defects cause missplicing in myeloid malignancies
-
ASH Annual Meeting: abst
-
Kurtovic Kozaric A, Makishima H, Przychodzen BP, et al. PRPF8 defects cause missplicing in myeloid malignancies. Blood 2013;122(ASH Annual Meeting):abst 2838.
-
(2013)
Blood
, vol.122
, pp. 2838
-
-
Kurtovic Kozaric, A.1
Makishima, H.2
Przychodzen, B.P.3
-
82
-
-
84883744431
-
Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies
-
Gomez-Segui I, Makishima H, Jerez A, et al. Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies. Leukemia 2013;27:1943-6.
-
(2013)
Leukemia
, vol.27
, pp. 1943-1946
-
-
Gomez-Segui, I.1
Makishima, H.2
Jerez, A.3
-
83
-
-
84920675692
-
PRPF8 defects cause missplicing in myeloid malignancies
-
Kurtovic-Kozaric A, Przychodzen B, Singh J, et al. PRPF8 defects cause missplicing in myeloid malignancies. Leukemia 2014. doi: 10.1038/leu.2014.144.
-
(2014)
Leukemia
-
-
Kurtovic-Kozaric, A.1
Przychodzen, B.2
Singh, J.3
-
84
-
-
84879692782
-
In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation
-
Keightley MC, Crowhurst MO, Layton JE, et al. In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. FEBS Lett 2013;587:2150-7.
-
(2013)
FEBS Lett
, vol.587
, pp. 2150-2157
-
-
Keightley, M.C.1
Crowhurst, M.O.2
Layton, J.E.3
-
85
-
-
79751486147
-
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation
-
Liu F, Zhao X, Perna F, et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 2011;19: 283-94.
-
(2011)
Cancer Cell
, vol.19
, pp. 283-294
-
-
Liu, F.1
Zhao, X.2
Perna, F.3
-
86
-
-
33745213401
-
The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow
-
Ingram W, Lea NC, Cervera J, et al. The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow. Leukemia 2006;20:1319-21.
-
(2006)
Leukemia
, vol.20
, pp. 1319-1321
-
-
Ingram, W.1
Lea, N.C.2
Cervera, J.3
-
87
-
-
84862257537
-
JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia
-
Jekarl DW, Han SB, Kim M, et al. JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia. Korean J Hematol 2010;45:46-50.
-
(2010)
Korean J Hematol
, vol.45
, pp. 46-50
-
-
Jekarl, D.W.1
Han, S.B.2
Kim, M.3
-
88
-
-
33749325187
-
Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
-
Szpurka H, Tiu R, Murugesan G, et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood 2006;108:2173-81.
-
(2006)
Blood
, vol.108
, pp. 2173-2181
-
-
Szpurka, H.1
Tiu, R.2
Murugesan, G.3
-
90
-
-
28544431813
-
The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients
-
Ohyashiki K, Aota Y, Akahane D, et al. The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients. Leukemia 2005;19:2359-60.
-
(2005)
Leukemia
, vol.19
, pp. 2359-2360
-
-
Ohyashiki, K.1
Aota, Y.2
Akahane, D.3
-
91
-
-
79957593717
-
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
-
Makishima H, Jankowska AM, McDevitt MA, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood 2011;117:e198-206.
-
(2011)
Blood
, vol.117
, pp. e198-e206
-
-
Makishima, H.1
Jankowska, A.M.2
McDevitt, M.A.3
-
92
-
-
34848824979
-
RUNX1 gene mutation in primary myelodysplastic syndrome-the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome
-
Chen CY, Lin LI, Tang JL, et al. RUNX1 gene mutation in primary myelodysplastic syndrome-the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome. Br J Haematol 2007;139:405-14.
-
(2007)
Br J Haematol
, vol.139
, pp. 405-414
-
-
Chen, C.Y.1
Lin, L.I.2
Tang, J.L.3
-
93
-
-
12444314088
-
Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia
-
Steensma DP, Gibbons RJ, Mesa RA, Tefferi A, Higgs DR. Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia. Eur J Haematol 2005;74:47-53.
-
(2005)
Eur J Haematol
, vol.74
, pp. 47-53
-
-
Steensma, D.P.1
Gibbons, R.J.2
Mesa, R.A.3
Tefferi, A.4
Higgs, D.R.5
-
94
-
-
1542373639
-
High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
-
Harada H, Harada Y, Niimi H, Kyo T, Kimura A, Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 2004;103:2316-24.
-
(2004)
Blood
, vol.103
, pp. 2316-2324
-
-
Harada, H.1
Harada, Y.2
Niimi, H.3
Kyo, T.4
Kimura, A.5
Inaba, T.6
-
95
-
-
84878446656
-
Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia
-
Shih AH, Chung SS, Dolezal EK, et al. Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia. Haematologica 2013;98:908-12.
-
(2013)
Haematologica
, vol.98
, pp. 908-912
-
-
Shih, A.H.1
Chung, S.S.2
Dolezal, E.K.3
-
96
-
-
84873995626
-
TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis
-
Kulasekararaj AG, Smith AE, Mian SA, et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis. Br J Haematol 2013;160:660-72.
-
(2013)
Br J Haematol
, vol.160
, pp. 660-672
-
-
Kulasekararaj, A.G.1
Smith, A.E.2
Mian, S.A.3
-
97
-
-
84885068819
-
TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients
-
Caceres G, McGraw K, Yip BH, et al. TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. Proc Natl Acad Sci U S A 2013;110:16127-32.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16127-16132
-
-
Caceres, G.1
McGraw, K.2
Yip, B.H.3
-
98
-
-
84855225601
-
The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia
-
Tiacci E, Grossmann V, Martelli MP, Kohlmann A, Haferlach T, Falini B. The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia. Haematologica 2012;97:3-5.
-
(2012)
Haematologica
, vol.97
, pp. 3-5
-
-
Tiacci, E.1
Grossmann, V.2
Martelli, M.P.3
Kohlmann, A.4
Haferlach, T.5
Falini, B.6
-
99
-
-
84888246901
-
BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders
-
Damm F, Chesnais V, Nagata Y, et al. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood 2013;122:3169-77.
-
(2013)
Blood
, vol.122
, pp. 3169-3177
-
-
Damm, F.1
Chesnais, V.2
Nagata, Y.3
-
100
-
-
26944438049
-
Mutation in RAP1 is a rare event in myelodysplastic syndromes
-
Gyan E, Frew M, Bowen D, et al. Mutation in RAP1 is a rare event in myelodysplastic syndromes. Leukemia 2005;19:1678-80.
-
(2005)
Leukemia
, vol.19
, pp. 1678-1680
-
-
Gyan, E.1
Frew, M.2
Bowen, D.3
-
101
-
-
19344366459
-
Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae
-
Glynn EF, Megee PC, Yu HG, et al. Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae. PLoS Biol 2004;2:E259.
-
(2004)
PLoS Biol
, vol.2
-
-
Glynn, E.F.1
Megee, P.C.2
Yu, H.G.3
-
102
-
-
84908611207
-
Genetic alterations of the cohesin complex genes in myeloid malignancies
-
Thota S, Viny AD, Makishima H, et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood 2014; 124:1790-8.
-
(2014)
Blood
, vol.124
, pp. 1790-1798
-
-
Thota, S.1
Viny, A.D.2
Makishima, H.3
-
103
-
-
84871988651
-
Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
-
Piazza R, Valletta S, Winkelmann N, et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet 2013;45:18-24.
-
(2013)
Nat Genet
, vol.45
, pp. 18-24
-
-
Piazza, R.1
Valletta, S.2
Winkelmann, N.3
-
104
-
-
84880976662
-
Somatic SETBP1 mutations in myeloid malignancies
-
Makishima H, Yoshida K, Nguyen N, et al. Somatic SETBP1 mutations in myeloid malignancies. Nat Genet 2013;45:942-6.
-
(2013)
Nat Genet
, vol.45
, pp. 942-946
-
-
Makishima, H.1
Yoshida, K.2
Nguyen, N.3
-
105
-
-
84878947680
-
SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias
-
Damm F, Itzykson R, Kosmider O, et al. SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. Leukemia 2013;27:1401-3.
-
(2013)
Leukemia
, vol.27
, pp. 1401-1403
-
-
Damm, F.1
Itzykson, R.2
Kosmider, O.3
-
106
-
-
84885571172
-
SETBP1 mutation analysis in 944 patients with MDS and AML
-
Thol F, Suchanek KJ, Koenecke C, et al. SETBP1 mutation analysis in 944 patients with MDS and AML. Leukemia 2013; 27:2072-5.
-
(2013)
Leukemia
, vol.27
, pp. 2072-2075
-
-
Thol, F.1
Suchanek, K.J.2
Koenecke, C.3
-
107
-
-
84904391912
-
Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10)
-
Visconte V, Tabarroki A, Zhang L, et al. Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10). Am J Hematol 2014;89:862.
-
(2014)
Am J Hematol
, vol.89
, pp. 862
-
-
Visconte, V.1
Tabarroki, A.2
Zhang, L.3
-
108
-
-
84883742761
-
SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations
-
Meggendorfer M, Bacher U, Alpermann T, et al. SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations. Leukemia 2013;27:1852-60.
-
(2013)
Leukemia
, vol.27
, pp. 1852-1860
-
-
Meggendorfer, M.1
Bacher, U.2
Alpermann, T.3
-
109
-
-
35448934364
-
Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome
-
Kerbauy DB, Deeg HJ. Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Exp Hematol 2007;35:1739-46.
-
(2007)
Exp Hematol
, vol.35
, pp. 1739-1746
-
-
Kerbauy, D.B.1
Deeg, H.J.2
-
110
-
-
79551518231
-
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase
-
Zhou L, McMahon C, Bhagat T, et al. Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res 2011;71:955-63.
-
(2011)
Cancer Res
, vol.71
, pp. 955-963
-
-
Zhou, L.1
McMahon, C.2
Bhagat, T.3
-
111
-
-
78549250108
-
Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia
-
Kornblau SM, McCue D, Singh N, Chen W, Estrov Z, Coombes KR. Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia. Blood 2010;116: 4251-61.
-
(2010)
Blood
, vol.116
, pp. 4251-4261
-
-
Kornblau, S.M.1
McCue, D.2
Singh, N.3
Chen, W.4
Estrov, Z.5
Coombes, K.R.6
-
112
-
-
79953891819
-
Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes
-
Feng X, Scheinberg P, Wu CO, et al. Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes. Haematologica 2011;96:602-6.
-
(2011)
Haematologica
, vol.96
, pp. 602-606
-
-
Feng, X.1
Scheinberg, P.2
Wu, C.O.3
-
113
-
-
79953100658
-
T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy
-
Sloand EM, Melenhorst JJ, Tucker ZC, et al. T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy. Blood 2011;117: 2691-9.
-
(2011)
Blood
, vol.117
, pp. 2691-2699
-
-
Sloand, E.M.1
Melenhorst, J.J.2
Tucker, Z.C.3
-
114
-
-
0031451827
-
Telomere length in myelodysplastic syndromes
-
Boultwood J, Fidler C, Kusec R, et al. Telomere length in myelodysplastic syndromes. Am J Hematol 1997;56:266-71.
-
(1997)
Am J Hematol
, vol.56
, pp. 266-271
-
-
Boultwood, J.1
Fidler, C.2
Kusec, R.3
-
115
-
-
84920976132
-
Telomere length in MDS patients bone marrow is highly correlated with complex cytogenetics, IPSS risk groups and transfusion dependency
-
ASH Annual Meeting: abst
-
Jiang J, Kulasekararaj AG, Krishnamurthy P, et al. Telomere length in MDS patients bone marrow is highly correlated with complex cytogenetics, IPSS risk groups and transfusion dependency. Blood 2011;118(ASH Annual Meeting):abst 3826.
-
(2011)
Blood
, vol.118
, pp. 3826
-
-
Jiang, J.1
Kulasekararaj, A.G.2
Krishnamurthy, P.3
-
116
-
-
3843080730
-
Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis
-
Sieglova Z, Zilovcova S, Cermak J, et al. Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis? Leuk Res 2004;28:1013-21.
-
(2004)
Leuk Res
, vol.28
, pp. 1013-1021
-
-
Sieglova, Z.1
Zilovcova, S.2
Cermak, J.3
-
117
-
-
0041592752
-
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome
-
Yamaguchi H, Baerlocher GM, Lansdorp PM, et al. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 2003;102:916-8.
-
(2003)
Blood
, vol.102
, pp. 916-918
-
-
Yamaguchi, H.1
Baerlocher, G.M.2
Lansdorp, P.M.3
-
118
-
-
70350721794
-
Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia
-
Kirwan M, Vulliamy T, Marrone A, et al. Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia. Hum Mutat 2009;30:1567-73.
-
(2009)
Hum Mutat
, vol.30
, pp. 1567-1573
-
-
Kirwan, M.1
Vulliamy, T.2
Marrone, A.3
-
119
-
-
84902708860
-
A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome
-
Ueda Y, Calado RT, Norberg A, et al. A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome. BMC Med Genet 2014;15:68.
-
(2014)
BMC Med Genet
, vol.15
, pp. 68
-
-
Ueda, Y.1
Calado, R.T.2
Norberg, A.3
-
120
-
-
77449149371
-
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
-
Shen L, Kantarjian H, Guo Y, et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010;28:605-13.
-
(2010)
J Clin Oncol
, vol.28
, pp. 605-613
-
-
Shen, L.1
Kantarjian, H.2
Guo, Y.3
-
121
-
-
0038305924
-
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series
-
Smith SM, Le Beau MM, Huo D, et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 2003;102:43-52.
-
(2003)
Blood
, vol.102
, pp. 43-52
-
-
Smith, S.M.1
Le Beau, M.M.2
Huo, D.3
-
122
-
-
78049422805
-
Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8
-
Koh Y, Kim I, Bae JY, et al. Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8. Jpn J Clin Oncol 2010;40:1037-45.
-
(2010)
Jpn J Clin Oncol
, vol.40
, pp. 1037-1045
-
-
Koh, Y.1
Kim, I.2
Bae, J.Y.3
-
123
-
-
0036934475
-
Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001
-
Mauritzson N, Albin M, Rylander L, et al. Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001. Leukemia 2002;16:2366-78.
-
(2002)
Leukemia
, vol.16
, pp. 2366-2378
-
-
Mauritzson, N.1
Albin, M.2
Rylander, L.3
-
124
-
-
0023888449
-
Recommendations for a morphologic, immunologic, and cytogenetic (MIC) working classification of the primary and therapy-related myelodysplastic disorders. Report of the workshop held in Scottsdale
-
Recommendations for a morphologic, immunologic, and cytogenetic (MIC) working classification of the primary and therapy-related myelodysplastic disorders. Report of the workshop held in Scottsdale, Arizona, USA, on February 23-25, 1987. Third MIC Cooperative Study Group. Cancer Genet Cytogenet 1988;32:1-10.
-
(1988)
Cancer Genet Cytogenet
, vol.32
, pp. 1-10
-
-
|