Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10)

American Journal of Hematology

Volumn 89, Issue 8, 2014, Pages 862-

  Visconte, Valeria ^a   Tabarroki, Ali ^a   Zhang, Li ^b   Hasrouni, Edy ^a   Gerace, Chris ^a   Frum, Robyn ^a   Ai, Jing ^a   Advani, Anjali S ^a   Duong, Hien K ^a   Kalaycio, Matt ^a   Saunthararajah, Yogen ^a   Sekeres, Mikkael A ^a   His, Eric D ^c   Shetty, Shashirekha ^c   Rogers, Heesun J ^c   Tiu, Ramon V ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ANEMIA; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CHRONIC MYELOID LEUKEMIA; CHRONIC MYELOMONOCYTIC LEUKEMIA; CHRONIC NEUTROPHILIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MUTATION; GENE SEQUENCE; GRANULOPOIESIS; HUMAN; ISOCHROMOSOME; LEUKEMOGENESIS; LEUKOCYTE DISORDER; LEUKOCYTOSIS; MALE; MOLECULAR PATHOLOGY; MONOCYTOSIS; MUTATIONAL ANALYSIS; MYELOID LEUKEMIA; MYELOPROLIFERATIVE NEOPLASM; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS;

AGED; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GRANULOCYTES; HEMATOLOGIC NEOPLASMS; HUMANS; ISOCHROMOSOMES; MALE; MIDDLE AGED; MUTATION; MYELOPROLIFERATIVE DISORDERS; NUCLEAR PROTEINS; RIBONUCLEOPROTEINS;

EID: 84904391912     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23755     Document Type: Article

References (6)

1. Fioretos T, Strombeck B, Sandberg T, et al. Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations. Blood 1999;94:225-232.
2. Kanagal-Shamanna R, Bueso-Ramos CE, Barkoh B, et al. Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53. Cancer 2012;118:2879-2888.
3. Visconte V, Tabarroki A, Zhang L, et al. Molecular Characterization Of Myeloid Neoplasms Harboring Isochromosome 17q Abnormality. Blood 2013;122:2596.
4. Rogers HJ, Visconte V, Tabarroki A, et al. Myeloid neoplasms with isochromosome 17q [i(17q)] share myelodysplastic/myeloproliferative features, poor prognosis and high risk of leukemic transformation related to mutational overlap of SETBP1, SRSF1, CSF3R and TP53 genes. Mod Pathol 2014;27(Suppl 2):374A.
5. McClure RF, Dewald GW, Hoyer JD, et al. Isolated isochromosome 17q: A distinct type of mixed myeloproliferative disorder/myelodysplastic syndrome with an aggressive clinical course. Br J Haematol 1999;106:445-454.
6. Pinheiro RF, Chauffaille Mde L, Silva MR. Isochromosome 17q in MDS: A marker of a distinct entity. Cancer Genet Cytogenet 2006;166:189-190.