Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- And effector domain-dependent manner and influences its cellular localization and carbamoylphosphate synthetase (CPSase) activity

Journal of Biological Chemistry

Volumn 290, Issue 2, 2015, Pages 1096-1105

  Sato, Tatsuhiro ^a   Akasu, Hitomi ^a   Shimono, Wataru ^a   Matsu, Chisa ^a   Fujiwara, Yuki ^a   Shibagaki, Yoshio ^a   Heard, Jeffrey J ^b   Tamanoi, Fuyuhiko ^b   Hattori, Seisuke ^a  

^a KITASATO UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; MAMMALS; NUCLEOTIDES; PROTEINS;

C-TERMINAL REGIONS; CARBAMOYL PHOSPHATES; CELLULAR LOCALIZATION; DE NOVO SYNTHESIS; FARNESYLTRANSFERASE; MEMBRANE ASSOCIATION; NUCLEOTIDE SYNTHESIS; PROTEIN SYNTHESIS;

BIOSYNTHESIS;

ASPARTATE CARBAMOYLTRANSFERASE; CARBAMOYL PHOSPHATE SYNTHASE; CASPASE ACTIVATED DEOXYRIBONUCLEASE; DIHYDROOROTASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PYRIMIDINE NUCLEOTIDE; RHEB PROTEIN; RHEB1 PROTEIN; RHEB2 PROTEIN; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; CAD TRIFUNCTIONAL ENZYME; CARBAMOYL PHOSPHATE SYNTHASE (GLUTAMINE HYDROLYSING); MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; NEUROPEPTIDE; PROTEIN BINDING; PYRIMIDINE NUCLEOSIDE; RAS PROTEIN; RHEB PROTEIN, HUMAN; RHEBL1 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GROWTH REGULATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; GENETICS; HUMAN; LYSOSOME; METABOLISM; PATHOLOGY;

MAMMALIA;

ANIMALS; ASPARTATE CARBAMOYLTRANSFERASE; CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA); CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CELL PROLIFERATION; DIHYDROOROTASE; HUMANS; LYSOSOMES; MICE; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NEUROPEPTIDES; PROTEIN BINDING; PYRIMIDINE NUCLEOSIDES; RAS PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84920903544     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.592402     Document Type: Article

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