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Volumn 113, Issue 1, 2015, Pages 380-389

Chronic intermittent hypoxia alters neurotransmission from lateral paragigantocellular nucleus to parasympathetic cardiac neurons in the brain stem

Author keywords

Apnea; Brain stem; Cardiac vagal neurons; Hypercapnia; Hypoxia; REM sleep

Indexed keywords

OREXIN A; 4 AMINOBUTYRIC ACID; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

EID: 84920901781     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00302.2014     Document Type: Article
Times cited : (16)

References (67)
  • 2
    • 4143082645 scopus 로고    scopus 로고
    • Pathophysiology of upper airway obstruction: A developmental perspective
    • Arens R, Marcus CL. Pathophysiology of upper airway obstruction: a developmental perspective. Sleep 27: 997-1019, 2004.
    • (2004) Sleep , vol.27 , pp. 997-1019
    • Arens, R.1    Marcus, C.L.2
  • 3
    • 34547647774 scopus 로고    scopus 로고
    • Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea
    • Bazzano LA, Khan Z, Reynolds K, He J. Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea. Hypertension 50: 417-423, 2007.
    • (2007) Hypertension , vol.50 , pp. 417-423
    • Bazzano, L.A.1    Khan, Z.2    Reynolds, K.3    He, J.4
  • 4
    • 0027178462 scopus 로고
    • Power spectrum analysis and heart rate variability in Stage 4 and REM sleep: Evidence for state-specific changes in autonomic dominance
    • Berlad II, Shlitner A, Ben-Haim S, Lavie P. Power spectrum analysis and heart rate variability in Stage 4 and REM sleep: evidence for state-specific changes in autonomic dominance. J Sleep Res 2: 88-90, 1993.
    • (1993) J Sleep Res , vol.2 , pp. 88-90
    • Berlad, I.I.1    Shlitner, A.2    Ben-Haim, S.3    Lavie, P.4
  • 5
    • 0036836273 scopus 로고    scopus 로고
    • The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: A combined microinjection and functional neuroanatomical study
    • Boissard R, Gervasoni D, Schmidt MH, Barbagli B, Fort P, Luppi PH. The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. Eur J Neurosci 16: 1959-1973, 2002.
    • (2002) Eur J Neurosci , vol.16 , pp. 1959-1973
    • Boissard, R.1    Gervasoni, D.2    Schmidt, M.H.3    Barbagli, B.4    Fort, P.5    Luppi, P.H.6
  • 10
    • 0142122405 scopus 로고    scopus 로고
    • Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla
    • Ciriello J, Li Z, de Oliveira CV. Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla. Brain Res 991: 84-95, 2003.
    • (2003) Brain Res , vol.991 , pp. 84-95
    • Ciriello, J.1    Li, Z.2    De Oliveira, C.V.3
  • 11
    • 84859265158 scopus 로고    scopus 로고
    • Orexinergic modulation of GABAergic neurotransmission to cardiac vagal neurons in the brain stem nucleus ambiguus changes during development
    • Dergacheva O, Bateman R, Byrne P, Mendelowitz D. Orexinergic modulation of GABAergic neurotransmission to cardiac vagal neurons in the brain stem nucleus ambiguus changes during development. Neuroscience 209: 12-20, 2012.
    • (2012) Neuroscience , vol.209 , pp. 12-20
    • Dergacheva, O.1    Bateman, R.2    Byrne, P.3    Mendelowitz, D.4
  • 12
    • 84880998751 scopus 로고    scopus 로고
    • Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem
    • Dergacheva O, Boychuk CR, Mendelowitz D. Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem. J Neurophysiol 110: 672-679, 2013.
    • (2013) J Neurophysiol , vol.110 , pp. 672-679
    • Dergacheva, O.1    Boychuk, C.R.2    Mendelowitz, D.3
  • 13
    • 78951477559 scopus 로고    scopus 로고
    • Hypocretin-1 (Orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus
    • Dergacheva O, Philbin K, Bateman R, Mendelowitz D. Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus. Neuroscience 175: 18-23, 2011.
    • (2011) Neuroscience , vol.175 , pp. 18-23
    • Dergacheva, O.1    Philbin, K.2    Bateman, R.3    Mendelowitz, D.4
  • 14
    • 23944479532 scopus 로고    scopus 로고
    • Hypocretin-1 (Orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus
    • Dergacheva O, Wang X, Huang ZG, Bouairi E, Stephens C, Gorini C, Mendelowitz D. Hypocretin-1 (orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus. J Pharmacol Exp Ther 314: 1322-1327, 2005.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1322-1327
    • Dergacheva, O.1    Wang, X.2    Huang, Z.G.3    Bouairi, E.4    Stephens, C.5    Gorini, C.6    Mendelowitz, D.7
  • 15
    • 77955973923 scopus 로고    scopus 로고
    • The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: A mechanism for rapid eye movement sleep-dependent changes in heart rate
    • Dergacheva O, Wang X, Lovett-Barr MR, Jameson H, Mendelowitz D. The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate. J Neurophysiol 104: 685-694, 2010.
    • (2010) J Neurophysiol , vol.104 , pp. 685-694
    • Dergacheva, O.1    Wang, X.2    Lovett-Barr, M.R.3    Jameson, H.4    Mendelowitz, D.5
  • 16
    • 84903554330 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons
    • Dyavanapalli J, Jameson H, Dergacheva O, Jain V, Alhusayyen M, Mendelowitz D. Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons. J Physiol 592: 2799-2811, 2014.
    • (2014) J Physiol , vol.592 , pp. 2799-2811
    • Dyavanapalli, J.1    Jameson, H.2    Dergacheva, O.3    Jain, V.4    Alhusayyen, M.5    Mendelowitz, D.6
  • 17
    • 20444480200 scopus 로고    scopus 로고
    • Hypoxia recruits a respiratoryrelated excitatory pathway to brainstem premotor cardiac vagal neurons in animals exposed to prenatal nicotine
    • Evans C, Wang J, Neff R, Mendelowitz D. Hypoxia recruits a respiratoryrelated excitatory pathway to brainstem premotor cardiac vagal neurons in animals exposed to prenatal nicotine. Neuroscience 133: 1073-1079, 2005.
    • (2005) Neuroscience , vol.133 , pp. 1073-1079
    • Evans, C.1    Wang, J.2    Neff, R.3    Mendelowitz, D.4
  • 18
    • 0021871231 scopus 로고
    • Apnea duration and hypoxemia during REM sleep in patients with obstructive sleep apnea
    • Findley LJ, Wilhoit SC, Suratt PM. Apnea duration and hypoxemia during REM sleep in patients with obstructive sleep apnea. Chest 87: 432-436, 1985.
    • (1985) Chest , vol.87 , pp. 432-436
    • Findley, L.J.1    Wilhoit, S.C.2    Suratt, P.M.3
  • 19
    • 84875263398 scopus 로고    scopus 로고
    • Baroreflex and chemoreflex controls of sympathetic activity following intermittent hypoxia
    • Freet CS, Stoner JF, Tang X. Baroreflex and chemoreflex controls of sympathetic activity following intermittent hypoxia. Auton Neurosci 174: 8-14, 2013.
    • (2013) Auton Neurosci , vol.174 , pp. 8-14
    • Freet, C.S.1    Stoner, J.F.2    Tang, X.3
  • 20
    • 0033841252 scopus 로고    scopus 로고
    • Sleep architecture and respiratory disturbances in children with obstructive sleep apnea
    • Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med 162: 682-686, 2000.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 682-686
    • Goh, D.Y.1    Galster, P.2    Marcus, C.L.3
  • 21
    • 36148956735 scopus 로고    scopus 로고
    • Selective impairment of central mediation of baroreflex in anesthetized young adult Fischer 344 rats after chronic intermittent hypoxia
    • Gu H, Lin M, Liu J, Gozal D, Scrogin KE, Wurster R, Chapleau MW, Ma X, Cheng ZJ. Selective impairment of central mediation of baroreflex in anesthetized young adult Fischer 344 rats after chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol 293: H2809-H2818, 2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H2809-H2818
    • Gu, H.1    Lin, M.2    Liu, J.3    Gozal, D.4    Scrogin, K.E.5    Wurster, R.6    Chapleau, M.W.7    Ma, X.8    Cheng, Z.J.9
  • 22
    • 0035378588 scopus 로고
    • Selected Contribution: Regulation of sleep-wake states in response to intermittent hypoxic stimuli applied only in sleep
    • 2001
    • Hamrahi H, Stephenson R, Mahamed S, Liao KS, Horner RL. Selected Contribution: Regulation of sleep-wake states in response to intermittent hypoxic stimuli applied only in sleep. J Appl Physiol (1985) 90: 2490-2501, 2001.
    • (1985) J Appl Physiol , vol.90 , pp. 2490-2501
    • Hamrahi, H.1    Stephenson, R.2    Mahamed, S.3    Liao, K.S.4    Horner, R.L.5
  • 23
    • 0028171923 scopus 로고
    • Jones BE. Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleepwake states studied by cytotoxic lesions in the cat
    • Holmes CJ, Jones BE. Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleepwake states studied by cytotoxic lesions in the cat. Neuroscience 62: 1179-1200, 1994.
    • (1994) Neuroscience , vol.62 , pp. 1179-1200
    • Holmes, C.J.1
  • 25
    • 0034912638 scopus 로고    scopus 로고
    • Preproorexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats
    • Johren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P. Preproorexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology 142: 3324-3331, 2001.
    • (2001) Endocrinology , vol.142 , pp. 3324-3331
    • Johren, O.1    Neidert, S.J.2    Kummer, M.3    Dendorfer, A.4    Dominiak, P.5
  • 26
    • 64749092090 scopus 로고    scopus 로고
    • Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure
    • Kamendi HW, Cheng Q, Dergacheva O, Gorini C, Jameson HS, Wang X, McIntosh JM, Mendelowitz D. Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure. J Neurophysiol 101: 1141-1150, 2009.
    • (2009) J Neurophysiol , vol.101 , pp. 1141-1150
    • Kamendi, H.W.1    Cheng, Q.2    Dergacheva, O.3    Gorini, C.4    Jameson, H.S.5    Wang, X.6    McIntosh, J.M.7    Mendelowitz, D.8
  • 27
    • 69149089848 scopus 로고    scopus 로고
    • Obstructive sleep apnea and cardiovascular disease
    • Kato M, Adachi T, Koshino Y, Somers VK. Obstructive sleep apnea and cardiovascular disease. Circ J 73: 1363-1370, 2009.
    • (2009) Circ J , vol.73 , pp. 1363-1370
    • Kato, M.1    Adachi, T.2    Koshino, Y.3    Somers, V.K.4
  • 29
    • 77649315319 scopus 로고    scopus 로고
    • Obstructive sleep apnoea: Definitions, epidemiology and natural history
    • Lam JC, Sharma SK, Lam B. Obstructive sleep apnoea: definitions, epidemiology and natural history. Indian J Med Res 131: 165-170, 2010.
    • (2010) Indian J Med Res , vol.131 , pp. 165-170
    • Lam, J.C.1    Sharma, S.K.2    Lam, B.3
  • 30
    • 33751235283 scopus 로고    scopus 로고
    • [The changes and implications of plasma orexin-A levels in patients with obstructive sleep apnea-hypopnea syndrome.]
    • Liao XM, Yu Q. [The changes and implications of plasma orexin-A levels in patients with obstructive sleep apnea-hypopnea syndrome.] Zhonghua Jie He He Hu Xi Za Zhi 28: 368-371, 2005.
    • (2005) Zhonghua Jie He He Hu Xi Za Zhi , vol.28 , pp. 368-371
    • Liao, X.M.1    Yu, Q.2
  • 31
    • 34547872784 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia impairs baroreflex control of heart rate but enhances heart rate responses to vagal efferent stimulation in anesthetized mice
    • Lin M, Liu R, Gozal D, Wead WB, Chapleau MW, Wurster R, Cheng ZJ. Chronic intermittent hypoxia impairs baroreflex control of heart rate but enhances heart rate responses to vagal efferent stimulation in anesthetized mice. Am J Physiol Heart Circ Physiol 293: H997-H1006, 2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H997-H1006
    • Lin, M.1    Liu, R.2    Gozal, D.3    Wead, W.B.4    Chapleau, M.W.5    Wurster, R.6    Cheng, Z.J.7
  • 34
    • 7044269205 scopus 로고    scopus 로고
    • Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: Implications for sudden infant death syndrome
    • Neff RA, Simmens SJ, Evans C, Mendelowitz D. Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. J Neurosci 24: 9261-9268, 2004.
    • (2004) J Neurosci , vol.24 , pp. 9261-9268
    • Neff, R.A.1    Simmens, S.J.2    Evans, C.3    Mendelowitz, D.4
  • 36
    • 0038066433 scopus 로고    scopus 로고
    • Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome
    • Nishijima T, Sakurai S, Arihara Z, Takahashi K. Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome. Peptides 24: 407-411, 2003.
    • (2003) Peptides , vol.24 , pp. 407-411
    • Nishijima, T.1    Sakurai, S.2    Arihara, Z.3    Takahashi, K.4
  • 37
    • 0034027806 scopus 로고    scopus 로고
    • Gender differences in the polysomnographic features of obstructive sleep apnea
    • O’Connor C, Thornley KS, Hanly PJ. Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med 161: 1465-1472, 2000.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1465-1472
    • O’Connor, C.1    Thornley, K.S.2    Hanly, P.J.3
  • 39
    • 3442878929 scopus 로고    scopus 로고
    • Obstructive sleep apnea and cardiovascular disease
    • Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 79: 1036-1046, 2004.
    • (2004) Mayo Clin Proc , vol.79 , pp. 1036-1046
    • Parish, J.M.1    Somers, V.K.2
  • 41
    • 39049126446 scopus 로고    scopus 로고
    • The epidemiology of adult obstructive sleep apnea
    • Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5: 136-143, 2008.
    • (2008) Proc am Thorac Soc , vol.5 , pp. 136-143
    • Punjabi, N.M.1
  • 42
    • 0035714529 scopus 로고    scopus 로고
    • Gender differences in the regulation of blood pressure
    • Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension 37: 1199-1208, 2001.
    • (2001) Hypertension , vol.37 , pp. 1199-1208
    • Reckelhoff, J.F.1
  • 43
    • 33947581014 scopus 로고    scopus 로고
    • Autonomic function in sleep apnea patients: Increased heart rate variability except during REM sleep in obese patients
    • Reynolds EB, Seda G, Ware JC, Vinik AI, Risk MR, Fishback NF. Autonomic function in sleep apnea patients: increased heart rate variability except during REM sleep in obese patients. Sleep Breath 11: 53-60, 2007.
    • (2007) Sleep Breath , vol.11 , pp. 53-60
    • Reynolds, E.B.1    Seda, G.2    Ware, J.C.3    Vinik, A.I.4    Risk, M.R.5    Fishback, N.F.6
  • 44
    • 0023753951 scopus 로고
    • Executive mechanisms of paradoxical sleep
    • Sakai K. Executive mechanisms of paradoxical sleep. Arch Ital Biol 126: 239-257, 1988.
    • (1988) Arch Ital Biol , vol.126 , pp. 239-257
    • Sakai, K.1
  • 45
    • 4444330566 scopus 로고    scopus 로고
    • Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypopnea syndrome
    • Sakurai S, Nishijima T, Takahashi S, Yamauchi K, Arihara Z, Takahashi K. Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypopnea syndrome. Respiration 71: 380-384, 2004.
    • (2004) Respiration , vol.71 , pp. 380-384
    • Sakurai, S.1    Nishijima, T.2    Takahashi, S.3    Yamauchi, K.4    Arihara, Z.5    Takahashi, K.6
  • 46
    • 15844418649 scopus 로고    scopus 로고
    • Low plasma orexin-A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apneahypopnea syndrome
    • Sakurai S, Nishijima T, Takahashi S, Yamauchi K, Arihara Z, Takahashi K. Low plasma orexin-A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apneahypopnea syndrome. Chest 127: 731-737, 2005.
    • (2005) Chest , vol.127 , pp. 731-737
    • Sakurai, S.1    Nishijima, T.2    Takahashi, S.3    Yamauchi, K.4    Arihara, Z.5    Takahashi, K.6
  • 48
    • 84855302021 scopus 로고    scopus 로고
    • Role of the lateral paragigantocellular nucleus in the network of paradoxical (REM) sleep: An electrophysiological and anatomical study in the rat
    • Sirieix C, Gervasoni D, Luppi PH, Leger L. Role of the lateral paragigantocellular nucleus in the network of paradoxical (REM) sleep: an electrophysiological and anatomical study in the rat. PloS One 7: e28724, 2012.
    • (2012) Plos One , vol.7
    • Sirieix, C.1    Gervasoni, D.2    Luppi, P.H.3    Leger, L.4
  • 50
    • 7044247495 scopus 로고    scopus 로고
    • GABAergic and glycinergic presympathetic neurons of rat medulla oblongata identified by retrograde transport of pseudorabies virus and in situ hybridization
    • Stornetta RL, McQuiston TJ, Guyenet PG. GABAergic and glycinergic presympathetic neurons of rat medulla oblongata identified by retrograde transport of pseudorabies virus and in situ hybridization. J Comp Neurol 479: 257-270, 2004.
    • (2004) J Comp Neurol , vol.479 , pp. 257-270
    • Stornetta, R.L.1    McQuiston, T.J.2    Guyenet, P.G.3
  • 51
    • 0032782975 scopus 로고    scopus 로고
    • Distribution and quantification of immunoreactive orexin A in rat tissues
    • Taheri S, Mahmoodi M, Opacka-Juffry J, Ghatei MA, Bloom SR. Distribution and quantification of immunoreactive orexin A in rat tissues. FEBS Lett 457: 157-161, 1999.
    • (1999) FEBS Lett , vol.457 , pp. 157-161
    • Taheri, S.1    Mahmoodi, M.2    Opacka-Juffry, J.3    Ghatei, M.A.4    Bloom, S.R.5
  • 52
    • 40749112381 scopus 로고    scopus 로고
    • Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleep
    • Valladares EM, Eljammal SM, Motivala S, Ehlers CL, Irwin MR. Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleep. Sleep Med 9: 310-316, 2008.
    • (2008) Sleep Med , vol.9 , pp. 310-316
    • Valladares, E.M.1    Eljammal, S.M.2    Motivala, S.3    Ehlers, C.L.4    Irwin, M.R.5
  • 53
    • 33644938379 scopus 로고    scopus 로고
    • Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat
    • Verret L, Fort P, Gervasoni D, Leger L, Luppi PH. Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat. J Comp Neurol 495: 573-586, 2006.
    • (2006) J Comp Neurol , vol.495 , pp. 573-586
    • Verret, L.1    Fort, P.2    Gervasoni, D.3    Leger, L.4    Luppi, P.H.5
  • 54
    • 20444488422 scopus 로고    scopus 로고
    • Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery
    • Verret L, Leger L, Fort P, Luppi PH. Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery. Eur J Neurosci 21: 2488-2504, 2005.
    • (2005) Eur J Neurosci , vol.21 , pp. 2488-2504
    • Verret, L.1    Leger, L.2    Fort, P.3    Luppi, P.H.4
  • 56
    • 0029971289 scopus 로고    scopus 로고
    • Sleep, dreams, and sudden death: The case for sleep as an autonomic stress test for the heart
    • Verrier RL, Muller JE, Hobson JA. Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart. Cardiovasc Res 31: 181-211, 1996.
    • (1996) Cardiovasc Res , vol.31 , pp. 181-211
    • Verrier, R.L.1    Muller, J.E.2    Hobson, J.A.3
  • 57
    • 0037044704 scopus 로고    scopus 로고
    • Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats
    • Wang J, Irnaten M, Venkatesan P, Evans C, Baxi S, Mendelowitz D. Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats. Neurosci Lett 332: 195-199, 2002.
    • (2002) Neurosci Lett , vol.332 , pp. 195-199
    • Wang, J.1    Irnaten, M.2    Venkatesan, P.3    Evans, C.4    Baxi, S.5    Mendelowitz, D.6
  • 58
    • 84871827863 scopus 로고    scopus 로고
    • Influence of hypercapnia on the synthesis of neuropeptides and their receptors in murine brain
    • Wang W, Li Q, Pan Y, Zhu D, Wang L. Influence of hypercapnia on the synthesis of neuropeptides and their receptors in murine brain. Respirology 18: 102-107, 2013a.
    • (2013) Respirology , vol.18 , pp. 102-107
    • Wang, W.1    Li, Q.2    Pan, Y.3    Zhu, D.4    Wang, L.5
  • 59
    • 84877277751 scopus 로고    scopus 로고
    • Orexin: A potential role in the process of obstructive sleep apnea
    • Wang W, Pan Y, Li Q, Wang L. Orexin: a potential role in the process of obstructive sleep apnea. Peptides 42: 48-54, 2013b.
    • (2013) Peptides , vol.42 , pp. 48-54
    • Wang, W.1    Pan, Y.2    Li, Q.3    Wang, L.4
  • 60
    • 0034065207 scopus 로고    scopus 로고
    • Autonomic cardiovascular regulation in patients with obstructive sleep apnoea: A study based on spectral analysis of heart rate variability
    • Wiklund U, Olofsson BO, Franklin K, Blom H, Bjerle P, Niklasson U. Autonomic cardiovascular regulation in patients with obstructive sleep apnoea: a study based on spectral analysis of heart rate variability. Clin Physiol 20: 234-241, 2000.
    • (2000) Clin Physiol , vol.20 , pp. 234-241
    • Wiklund, U.1    Olofsson, B.O.2    Franklin, K.3    Blom, H.4    Bjerle, P.5    Niklasson, U.6
  • 64
    • 43049170354 scopus 로고    scopus 로고
    • Attenuation of heart rate control and neural degeneration in nucleus ambiguus following chronic intermittent hypoxia in young adult Fischer 344 rats
    • Yan B, Soukhova-O’Hare GK, Li L, Lin Y, Gozal D, Wead WB, Wurster RD, Cheng ZJ. Attenuation of heart rate control and neural degeneration in nucleus ambiguus following chronic intermittent hypoxia in young adult Fischer 344 rats. Neuroscience 153: 709-720, 2008.
    • (2008) Neuroscience , vol.153 , pp. 709-720
    • Yan, B.1    Soukhova-O’hare, G.K.2    Li, L.3    Lin, Y.4    Gozal, D.5    Wead, W.B.6    Wurster, R.D.7    Cheng, Z.J.8
  • 65
    • 33750952457 scopus 로고    scopus 로고
    • Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: Glycerol replacement of NaCl protects CNS neurons
    • Ye JH, Zhang J, Xiao C, Kong JQ. Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons. J Neurosci Methods 158: 251-259, 2006.
    • (2006) J Neurosci Methods , vol.158 , pp. 251-259
    • Ye, J.H.1    Zhang, J.2    Xiao, C.3    Kong, J.Q.4
  • 66
    • 0027462562 scopus 로고
    • The occurrence of sleep-disordered breathing among middle-aged adults
    • Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235, 1993.
    • (1993) N Engl J Med , vol.328 , pp. 1230-1235
    • Young, T.1    Palta, M.2    Dempsey, J.3    Skatrud, J.4    Weber, S.5    Badr, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.