Autonomic function in sleep apnea patients: Increased heart rate variability except during REM sleep in obese patients

Sleep and Breathing

Volumn 11, Issue 1, 2007, Pages 53-60

  Reynolds, Erica B ^a   Seda, Gilbert ^b   Ware, J C ^c,e   Vinik, Aaron I ^c   Risk, Marcelo R ^d   Fishback, Nancy F ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NAVAL MEDICAL CENTER PORTSMOUTH   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e SENTARA NORFOLK GENERAL HOSPITAL   (United States)

Author keywords

Autonomic dysfunction; Body mass index; Heart rate variability; Obstructive sleep apnea

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; AGING; APNEA; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; BODY MASS; BREATHING RATE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROCARDIOGRAM; FEMALE; HEART RATE VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REM SLEEP; RETROSPECTIVE STUDY; SLEEP APNEA SYNDROME; WAKEFULNESS;

ADULT; AGE FACTORS; AGED; AUTONOMIC NERVOUS SYSTEM; BODY MASS INDEX; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; POLYSOMNOGRAPHY; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SLEEP APNEA, OBSTRUCTIVE; SLEEP STAGES; SLEEP, REM;

EID: 33947581014     PISSN: 15209512     EISSN: 15221709     Source Type: Journal    
DOI: 10.1007/s11325-006-0083-9     Document Type: Article

References (42)

1. Risk MR, Bril V, Broadbridge C et al (2001) Heart rate variability measurement in diabetic neuropathy: Review of methods. Diabetes Technol Ther 3:63-76
2. Klieger RE, Bigger JT, Bosner MS et al (1991) Stability over time of variables measuring heart rate variability in normal subjects. Am J Cardiol 68:626-630
3. Bootsma M, Swenne CA, Van Bolhuis HH et al (1994) Heart rate and heart rate variability as indexes of sympathovagal balance. Am J Physiol 266:H1565-H1571
4. Pomeranz B, Macaulay RJ, Caudill MA et al (1985) Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 248:H151-H153
5. Malliani A, Pagani M, Lombardi F (1994) Physiology and clinical implications of variability of cardiovascular parameters with focus on heart rate and blood pressure. Am J Cardiol 73:3C-9C
6. Vinik AI, Maser RE, Mitchell B et al (2003) Diabetic autonomic neuropathy. Diabetes Care 26:1553-1579
7. Makikallio TH, Huikuri HV, Makikallio A et al (2001) Prediction of sudden cardiac death by fractal analysis of heart rate variability in elderly subjects. J Am Coll Cardiol 37:1395-1402
8. Algra A, Tijssen JG, Roelandt JR et al (1993) Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death. Circulation 88:180-185
9. Molgaard H, Sorensen KE, Bjerregaard P (2001) Attenuated 24-h heart rate variability in apparently healthy subjects, subsequently suffering sudden cardiac death. J Am Coll Cardiol 37:1395-1402
10. Boveda S, Galinier M, Pathak A et al (2001) Prognostic value of heart rate variability in time domain analysis in congestive heart failure. J Interv Card Electrophysiol 5:181-187
11. Vanoli E, Adamson PB, Ba-Lin Pinna et al (1995) Heart rate variability during specific sleep stages: A comparison of healthy subjects with patients after myocardial infarction. Circulation 91:1918-1922
12. Bonnet MH, Arand DL (1997) Heart rate variability: Sleep stage, time of night, and arousal influences. Electroencephalogr Clin Neurophysiol 102:390-396
13. Cajochen C, Pischke J, Aeschbach D et al (1994) Heart rate dynamics during human sleep. Physiol Behav 55:769-774
14. Trinder J, Kleiman J, Carrington M et al (2001) Autonomic activity during human sleep as a function of time and sleep stage. J Sleep Res 10:253-264
15. Crasset V, Mezzetti S, Antoine M et al (2001) Effects of aging and cardiac denervation on heart rate variability during sleep. Circulation 103:84-88
16. Okada H, Iwase S, Mano T et al (1991) Changes in muscle sympathetic nerve activity during sleep in humans. Neurology 41:1961-1966
17. Narkiewicz K, Montano N, Cogliati C et al (1998) Altered cardiovascular variability in obstructive sleep apnea. Circulation 98:1071-1077
18. Garcia-Rio F, Racionero MA, Pino JM et al (2000) Sleep apnea and hypertension: The role of peripheral chemoreceptors and the sympathetic nervous system. Chest 117:1417-1425
19. Sanner BM, Doberauer C, Konermann M et al (1997) Pulmonary hypertension in patients with obstructive sleep apnea syndrome. Arch Intern Med 157:2483-2487
20. Siverberg DS, Oksenberg A (1997) Essential hypertension and abnormal upper airway resistance during sleep. Sleep 20:794-806
21. Bixler EO, Vgontzas AN, Lin HM et al (2000) Association of hypertension and sleep-disordered breathing. Arch Intern Med 160:2289-2295
22. Nieto FJ, Young TB, Lind BK et al (2000) Association of sleep disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA 283:1829-1836
23. Peppard, PE, Young T, Paltra M et al (2000) Prospective study of the association between sleep-disordered breathing and hypertension. New Engl J Med 342:1378-1384
24. Noda A, Yasuma F, Okada T et al (1998) Circadian rhythm of autonomic activity in patients with obstructive sleep apnea syndrome. Clin Cardiol 21:271-276
25. Baharav A, Kotagal S, Rubin BK et al (1999) Autonomic cardiovascular control in children with obstructive sleep apnea. Clin Auton Res 9:345-351
26. Salo TM, Jula AM, Piha JS et al (2000) Comparison of autonomic withdrawal in men with obstructive sleep apnea syndrome, systemic hypertension, and neither condition. Am J Cardiol 85:232-238
27. Wiklund U, Olofsson BO, Franklin K et al (2000) Autonomic cardiovascular regulation in patients with obstructive sleep apnoea: A study based on spectral analysis of heart rate variability. Clin Physiol 20:234-241
28. Bauer T, Ewig S, Schafer H et al (1996) Heart rate variability in patients with sleep-related breathing disorders. Cardiology 87:492-496
29. Khoo, MC, Kim TS, Berry, RB (1999) Spectral indices of cardiac autonomic function in obstructive sleep apnea. Sleep 22:443-450
30. Penzel T, Kantelhardt JW, Grote et al (2003) Comparison of detrended fluctuation analysis and spectral analysis for heart rate variability in sleep and sleep apnea. IEEE Trans Biomed Eng 50:1143-1151
31. Roche F, Gaspoz JM, Court-Fortune I et al (1999) Screening of obstructive sleep apnea syndrome by heart rate variability analysis. Circulation 100:1411-1415
32. Keyl C, Lemberger P, Dambacher M et al (1996) Heart rate variability in patients with obstructive sleep apnea. Clin Sci 91:56-57
33. Bigger JTJr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE, Rottman JN (1992) Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 85(1):164-171 (Jan)
34. Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE, Rottman JN (1992) Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction. Am J Cardiol 69(9):891-898 (Apr 1)
35. Blackman RB, Tukey JW (1959) Measurement of power spectra from the point of view of communications engineering. Dover, New York
36. Berger RD, Saul JP, Cohen R (1989) Transfer function analysis of autonomic regulation. I Canine atrial rate response. Am J Physiol 256:H142-H152
37. Saul JP, Berger RD, Chen MH et al (1989) Transfer function analysis of autonomic regulation. II Respiratory sinus arrhythmia. Am J Physiol 256:H153-H161
38. Saul JP, Berger RD, Albretch P et al (1991) Transfer function analysis of the circulation: Unique insights into cardiovascular regulation. Am J Physiol 261:H1231-H1245
39. Dworschak M, Maurer JT, Haschemian T, Rapp H-J, Waschke KF (2001) The use of spectral measures of heart rate variability to differentiate between male snorers and patients with sleep apnoea syndrome. Anaesthesia 56:424-428
40. Elsenbruch S, Harnish MJ, Orr WC (1999) Heart rate variability during waking and sleep in healthy males and females. Sleep 22:1067-1071
41. Berlad II, Shlitner A, Ben-Haim S et al (1993) Power spectrum analysis and heart rate variability in Stage 4 and REM sleep: Evidence for state-specific changes in autonomic dominance. J Sleep Res 2:88-90
42. Khoo MC, Belozeroff V, Berry RB, Sassoon CS (2001) Cardiac autonomic control in obstructive sleep apnea: Effects of long-term CPAP therapy. Am J Respir Crit Care Med 164:807-812