Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients

Circulation Research

Volumn 116, Issue 1, 2015, Pages 87-98

  Hoffmann, Jedrzej ^a   Shmeleva, Evgeniya V ^a   Boag, Stephen E ^a   Fiser, Karel ^f,g   Bagnall, Alan ^a,c   Murali, Santosh ^a,i   Dimmick, Ian ^d   Pircher, Hanspeter ^e   Martin Ruiz, Carmen ^b   Egred, Mohaned ^a,c   Keavney, Bernard ^a,h   Von Zglinicki, Thomas ^b   Das, Rajiv ^a,c   Todryk, Stephen ^a,i   Spyridopoulos, Ioakim ^a,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c FREEMAN HOSPITAL   (United Kingdom)

^d Flow Cytometry Core Facility International Center for Life   (United Kingdom)

^e UNIVERSITY OF FREIBURG   (Germany)

^f CHARLES UNIVERSITY   (Czech Republic)

^g UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ NORTHUMBRIA UNIVERSITY   (United Kingdom)

Author keywords

aging; cytotoxic T lymphocytes; human cytomegalovirus; myocardial infarction; programmed cell death 1; reperfusion; telomere

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; INTERLEUKIN 15; INTERLEUKIN 7; PROGRAMMED DEATH 1 LIGAND 1;

ACUTE HEART INFARCTION; ADULT; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEART MUSCLE REPERFUSION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOSENESCENCE; LONGITUDINAL STUDY; MALE; MEMORY T LYMPHOCYTE; PERCUTANEOUS CORONARY INTERVENTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SENESCENCE; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; T CELL DEPLETION; TELOMERE; TELOMERE SHORTENING; TH1 CELL; TH17 CELL; TH2 CELL; TIME; AGED; BLOOD; CELL AGING; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PHYSIOLOGY; PROCEDURES; VIROLOGY;

AGED; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CROSS-SECTIONAL STUDIES; CYTOMEGALOVIRUS; FEMALE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION;

EID: 84920879761     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304393     Document Type: Article

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