Continuous cytomegalovirus seroconversion in a large group of healthy blood donors

Vox Sanguinis

Volumn 86, Issue 1, 2004, Pages 41-44

  Hecker, M ^a   Qiu, D ^a   Marquardt, K ^a   Bein, G ^a   Hackstein, Holger ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

CMV; Epidemiology; Infection; Seroconversion

Indexed keywords

ADULT; AGE; AGED; ALGORITHM; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; GENDER; HUMAN; IMMUNE DEFICIENCY; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEROCONVERSION; SEROPREVALENCE; VIRUS TRANSMISSION;

ADOLESCENT; ADULT; AGE FACTORS; ALGORITHMS; BLOOD DONORS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROBABILITY; RISK; SEROEPIDEMIOLOGIC STUDIES; SEX FACTORS;

EID: 1042300031     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0042-9007.2004.00388.x     Document Type: Article

References (23)

1. Hillyer CD, Snydman DR, Berkman EM: The risk of cytomegalovirus infection in solid organ and bone marrow recipients: transfusion of blood products. Transfusion 1990; 30:659-666
2. Reusser P, Fisher LD, Buckner CD, Thomas ED, Meyers JD: Cytomegalovirus infection after autologous bone marrow transplantation: occurrence of cytomegalovirus disease and effect on engraftment. Blood 1990; 75:1888-1894
3. Manez R, Kusne S, Martin M, Linden P, Irish W, Torre-Cisneros J, Kramer D, Ho M, Starzel TE: The impact of blood transfusion on the occurrence of pneumonitis in primary cytomegalovirus infections after liver transplantation. Transfusion 1993; 30:594-597
4. Rubin RH: Impact of cytomegalovirus infections on organ transplant recipients. Rev Infect Dis 1990; 12:S754-S766
5. Södenberg-Naucler C, Fish KN, Nelson JA: Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 1997; 91:119-126
6. Hirata M, Terasaki PI, Cho YW: Cytomegalovirus antibody status and renal transplantation: 1987-94. Transplantation 1996; 62: 34-37
7. Nichols WG, Corey L, Gooley T, Davis C, Boeckh M: High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection. J Infect Dis 2002; 185:273-282
8. De Medeiros CR, Moreira VA, Pasquini R: Cytomegalovirus as a cause of very late interstitial pneumonia after bone marrow transplantation. Bone Marrow Transplant 2000; 26:443-444
9. Roback JD: CMV and blood transfusions. Rev Med Virol 2002; 12:211-219
10. Bowden RA, Sayers M, Flournoy N, Newton B, Banaji M, Thomas ED, Meyers JD: Cytomegalovirus immune globulin and seronegative blood products to prevent primary cytomegalovirus infection after marrow transplantation. N Engl J Med 1986; 314:1006-1010
11. Nichols WG, Price TH, Gooley T, Corey L, Boeckh M: Transfusion-transmitted cytomegalovirus infection after receipt of leukoreduced blood products. Blood 2003; 101:4195-4200
12. Preiksaitis JK: The cytomegalovirus - 'safe' blood product: is leukoreduction equivalent to antibody screening? Transfus Med Rev 2000; 14:112-136
13. Preiksaitis JK: Prevention of transfusion-acquired CMV infection: is there a role for NAT? Transfusion 2003; 43:302-305
14. Galea G, Urbaniak SJ: Cytomegalovirus studies on blood donors in north-east Scotland and a review of UK data. Vox Sang 1993; 64:24-30
15. Dworsky ME, Welch K, Cassady G, Stagno S: Occupational risk for primary cytomegalovirus infection among pediatric health-care workers. N Engl J Med 1983; 309:950-953
16. Roback JD, Bray RA, Hillyer CD: Longitudinal monitoring of WBC subsets in packed RBC units after filtration: implications for transfusion transmission of infections. Transfusion 2000; 40:500-506
17. Laupacis A, Brown J, Costello B, Delage G, Freedman J, Hume H, King S, Kleinman S, Mazzulli T, Wells G: Prevention of post-transfusion CMV in the era of universal WBC reduction: a consensus statement. Transfusion 2001; 41:560-569
18. Bowden RA, Slichter SJ, Sayers M: A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995; 86:3598-3603
19. Drew WL, Tegtmeier G, Harvey JA, Laycock ME, Miner RC, Busch MP: Frequency and duration of plasma viremia in seroconverting blood donors and recipients. Transfusion 2003; 43:309-313
20. Zanghelli F, Boppana SB, Emery VC, Grffiths PD, Pass RF: Asymptomatic primary cytomegalovirus infection: virologic and immunologic features. J Infect Dis 1999; 180:702-707
21. Revello MG, Zavattoni M, Sarasini A, Percivalle E, Simoncini L, Gerna G: Human cytomegalovirus in blood of immunocompetent persons during primary infection: prognostic implications for pregnancy. J Infect Dis 1998; 177:1170-1175
22. Roback JD, Drew WL, Lacock ME, Todd D, Hillyer CD, Busch MP: CMV DNA is rarely detected in healthy blood donors using validated PCR assays. Transfusion 2003; 43:314-321
23. Bitsch A, Kirchner H, Dupke R, Bein G: Failure to detect human cytomegalovirus DNA in peripheral blood leukocytes of healthy blood donors by polymerase chain reaction. Transfusion 1992; 32:612-617