Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations

Pediatric Allergy and Immunology

Volumn 25, Issue 6, 2014, Pages 552-557

  Kljaic Bukvic, Blazenka ^a   Blekic, Mario ^a   Aberle, Neda ^a   Curtin, John A ^b   Hankinson, Jenny ^b   Semic Jusufagic, Aida ^b   Belgrave, Danielle ^b   Simpson, Angela ^b   Custovic, Adnan ^b  

^a JOSIP JURAJ STROSSMAYER UNIVERSITY OF OSIJEK   (Croatia)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Asthma; CD14; Children; Endotoxin; Gene environment interactions; LY96; TLR4

Indexed keywords

CD14 ANTIGEN; ENDOTOXIN; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; DUST;

ADOLESCENT; ADULT; ALLELE; ARTICLE; ASTHMA; ATOPY; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBURBAN AREA; URBAN AREA; ADVERSE EFFECTS; DISEASE COURSE; DUST; GENETICS; IMMUNOLOGY; METABOLISM; PRESCHOOL CHILD;

ADOLESCENT; ALLELES; ANTIGENS, CD14; ASTHMA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; DUST; ENDOTOXINS; ENVIRONMENTAL EXPOSURE; FEMALE; HOSPITALIZATION; HUMANS; LYMPHOCYTE ANTIGEN 96; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION;

EID: 84920876310     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12258     Document Type: Article

References (29)

1. Custovic A, Marinho S, Simpson A. Gene-environment interactions in the development of asthma and atopy. Expert Rev Respir Med 2012: 6: 301-8.
2. Wu J, Hankinson J, Kopec-Harding K, Custovic A, Simpson A. Interaction between glutathione S-transferase variants, maternal smoking and childhood wheezing changes with age. Pediatr Allergy Immunol 2013: 24: 501-8.
3. Custovic A, Rothers J, Stern D, et al. Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol 2011: 127: 390-7, e1-9.
4. Okada H, Kuhn C, Feillet H, Bach JF. The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Clin Exp Immunol 2010: 160: 1-9.
5. Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002: 347: 869-77.
6. Gehring U, Strikwold M, Schram-Bijkerk D, et al. Asthma and allergic symptoms in relation to house dust endotoxin: phase two of the International Study on Asthma and Allergies in Childhood (ISAAC II). Clin Exp Allergy 2008: 38: 1911-20.
7. Michel O, Duchateau J, Sergysels R. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J Appl Physiol (1985) 1989: 66: 1059-64.
8. Triantafilou M, Triantafilou K. Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol 2002: 23: 301-4.
9. Simpson A, Martinez FD. The role of lipopolysaccharide in the development of atopy in humans. Clin Exp Allergy 2010: 40: 209-23.
10. Sabroe I, Read RC, Whyte MKB, Dockrell DH, Vogel SN, Dower SK. Toll-like receptors in health and disease: complex questions remain. J Immunol 2003: 171: 1630.
11. Daley D, Lemire M, Akhabir L, et al. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet 2009: 125: 445-59.
12. Fagerås Böttcher M, Hmani-Aifa M, Lindström A, et al. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12 (p70) responses in Swedish children. J Allergy Clin Immunol 2004: 114: 561-7.
13. Pacheco K, Maier L, Silveira L, et al. Association of Toll-like receptor 4 alleles with symptoms and sensitization to laboratory animals. J Allergy Clin Immunol 2008: 122: 896-902.
14. Reijmerink NE, Bottema RWB, Kerkhof M, et al. TLR related pathway analysis: novel gene-gene interactions in the development of asthma and atopy. Allergy 2010: 65: 199-207.
15. Sackesen C, Karaaslan C, Keskin O, et al. The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. Allergy 2005: 60: 1485-92.
16. Senthilselvan A, Rennie D, Chenard L, et al. Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy. Ann Allergy Asthma Immunol 2008: 100: 463-8.
17. Smit LAM, Bongers SIM, Ruven HJT, et al. Atopy and new onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case control study. Clin Exp Allergy 2007: 37: 1602-8.
18. Smit LAM, Siroux V, Bouzigon E, et al. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 2009: 179: 363-8.
19. Werner M, Topp R, Wimmer K, et al. TLR4 gene variants modify endotoxin effects on asthma. J Allergy Clin Immunol 2003: 112: 323-30.
20. Smit LA, Heederik D, Doekes G, et al. Endotoxin exposure, CD14 and wheeze among farmers: a gene-environment interaction. Occup Environ Med 2011: 68: 826-31.
21. Blekic M, Kljaic Bukvic B, Aberle N, et al. 17q12-21 and asthma: interactions with early-life environmental exposures. Ann Allergy Asthma Immunol 2013: 110: 347-53, e2.
22. Bukvic BK, Blekic M, Simpson A, et al. Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure. Pediatr Allergy Immunol 2013: 24: 10-8.
23. Simpson A, John SL, Jury F, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 2006: 174: 386-92.
24. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 1995: 57: 289-300.
25. Topp R, Wimmer K, Fahlbusch B, et al. Repeated measurements of allergens and endotoxin in settled house dust over a time period of 6 years. Clin Exp Allergy 2003: 33: 1659-66.
26. Gray P, Michelsen KS, Sirois CM, et al. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol 2010: 184: 6359-66.
27. Schromm AB, Lien E, Henneke P, et al. Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line. J Exp Med 2001: 194: 79.
28. Visintin A, Mazzoni A, Spitzer JA, Segal DM. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc Natl Acad Sci USA 2001: 98: 12156.
29. Simpson JC, Niven RM, Pickering CA, Oldham LA, Fletcher AM, Francis HC. Comparative personal exposures to organic dusts and endotoxin. Ann Occup Hyg 1999: 43: 107-15.