Endotoxin exposure, CD14 and wheeze among farmers: A gene - environment interaction

Occupational and Environmental Medicine

Volumn 68, Issue 11, 2011, Pages 826-831

  Smit, Lidwien A M ^a   Heederik, Dick ^a   Doekes, Gert ^a   Koppelman, Gerard H ^b   Bottema, Renske W B ^b   Postma, Dirkje S ^c   Wouters, Inge M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; ENDOTOXIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MD 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADULT; ALLELE; ARTICLE; ASTHMA; FEMALE; FORCED EXPIRATORY VOLUME; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SPIROMETRY; WHEEZING;

ADULT; AGRICULTURE; ANTIGENS, CD14; ENDOTOXINS; FEMALE; HUMANS; LYMPHOCYTE ANTIGEN 96; MALE; MIDDLE AGED; MYELOID DIFFERENTIATION FACTOR 88; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY SOUNDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 80053910211     PISSN: 13510711     EISSN: 14707926     Source Type: Journal    
DOI: 10.1136/oem.2010.060038     Document Type: Article

References (33)

1. Schenker MB, Christiani D, Cormier Y, et al. Respiratory health hazards in agriculture. Am J Respir Crit Care Med 1998;158:S1-76.
2. Sigsgaard T, Bonefeld-Jorgensen EC, Hoffmann HJ, et al. Microbial cell wall agents as an occupational hazard. Toxicol Appl Pharmacol 2005;207(Suppl 2):310-19.
3. Wang Z, Larsson K, Palmberg L, et al. Inhalation of swine dust induces cytokine release in the upper and lower airways. Eur Respir J 1997;10:381-7. (Pubitemid 27063855)
4. Eduard W, Douwes J, Omenaas E, et al. Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers. Thorax 2004;59:381-6. (Pubitemid 38624743)
5. Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest 2009;136:716-25.
6. Vogelzang PF, van der Gulden JW, Folgering H, et al. Endotoxin exposure as a major determinant of lung function decline in pig farmers. Am J Respir Crit Care Med 1998;157:15-18. (Pubitemid 28071255)
7. Smit LA, Heederik D, Doekes G, et al. Ex vivo cytokine release reflects sensitivity to occupational endotoxin exposure. Eur Respir J 2009;34:795-802.
8. Castellan RM, Olenchock SA, Kinsley KB, et al. Inhaled endotoxin and decreased spirometric values. An exposure - response relation for cotton dust. N Engl J Med 1987;317:605-10. (Pubitemid 17118987)
9. Senthilselvan A, Dosman JA, Chenard L, et al. Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility. J Allergy Clin Immunol 2009;123:1034-40, 1040.e1-2.
10. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187-91. (Pubitemid 30394990)
11. Levan TD, Michel O, Dentener M, et al. Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation. J Allergy Clin Immunol 2008;121:434-40.e1.
12. Smit LA, Bongers SI, Ruven HJ, et al. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested caseecontrol study. Clin Exp Allergy 2007;37:1602-8. (Pubitemid 47609856)
13. Pacheco K, Maier L, Silveira L, et al. Association of Toll-like receptor 4 alleles with symptoms and sensitization to laboratory animals. J Allergy Clin Immunol 2008;122:896-902.e4.
14. LeVan TD, Von Essen S, Romberger DJ, et al. Polymorphisms in the CD14 gene associated with pulmonary function in farmers. Am J Respir Crit Care Med 2005;171:773-9. (Pubitemid 40471149)
15. Eder W, Klimecki W, Yu L, et al. Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol 2005;116:601-7. (Pubitemid 41267134)
16. Simpson A, John SL, Jury F, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 2006;174:386-92. (Pubitemid 44223118)
17. Williams LK, McPhee RA, Ownby DR, et al. Gene - environment interactions with CD14 C-260T and their relationship to total serum IgE levels in adults. J Allergy Clin Immunol 2006;118:851-7. (Pubitemid 44498756)
18. Zambelli-Weiner A, Ehrlich E, Stockton ML, et al. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. J Allergy Clin Immunol 2005;115:1203-9. (Pubitemid 40824590)
19. Noss I, Wouters IM, Visser M, et al. Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment. Appl Environ Microbiol 2008;74:5621-7.
20. Smit LA, Heederik D, Doekes G, et al. Exposure - response analysis of allergy and respiratory symptoms in endotoxin-exposed adults. Eur Respir J 2008;31:1241-8.
21. Smit LA, Heederik D, Doekes G, et al. Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness. Int Arch Allergy Immunol 2010;152:151-8.
22. Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993;16:5-40.
23. Doekes G, Douwes J, Wouters I, et al. Enzyme immunoassays for total and allergen specific IgE in population studies. Occup Environ Med 1996;53:63-70. (Pubitemid 26019522)
24. Armstrong BG. Effect of measurement error on epidemiological studies of environmental and occupational exposures. Occup Environ Med 1998;55:651-6. (Pubitemid 28428961)
25. International HapMap Consortium. A haplotype map of the human genome. Nature 2005;437:1299-320.
26. Lazarus R, Vercelli D, Palmer LJ, et al. Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev 2002;190:9-25. (Pubitemid 36071923)
27. Bottema RW, Reijmerink NE, Kerkhof M, et al. Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. Eur Respir J 2008;32:593-602.
28. de Jager W, te Velthuis H, Prakken BJ, et al. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003;10:133-9. (Pubitemid 36133841)
29. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 1995;57:289-300.
30. Simpson A, Martinez FD. The role of lipopolysaccharide in the development of atopy in humans. Clin Exp Allergy 2010;40:209-23.
31. Reijmerink NE, Bottema RW, Kerkhof M, et al. TLR-related pathway analysis: novel gene - gene interactions in the development of asthma and atopy. Allergy 2010;65:199-207.
32. Smit LA, Siroux V, Bouzigon E, et al. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 2009;179:363-8.
33. Eder W, Klimecki W, Yu L, et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004;113:482-8. (Pubitemid 38338954)