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Volumn 30, Issue 1, 2015, Pages 37-44

Levodopa: Effect on cell death and the natural history of Parkinson's disease

Author keywords

Levodopa; Oxidative stress; Parkinson's disease

Indexed keywords

LEVODOPA; REACTIVE OXYGEN METABOLITE; ANTIPARKINSON AGENT;

EID: 84920870768     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26119     Document Type: Review
Times cited : (82)

References (65)
  • 1
    • 4644314827 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson's disease: current controversies
    • Olanow CW, Agid Y, Mizuno Y, et al. Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord 2004;19:997-1005.
    • (2004) Mov Disord , vol.19 , pp. 997-1005
    • Olanow, C.W.1    Agid, Y.2    Mizuno, Y.3
  • 2
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow CW. Oxidation reactions in Parkinson's disease. Neurology 1990;40:32-37.
    • (1990) Neurology , vol.40 , pp. 32-37
    • Olanow, C.W.1
  • 3
    • 0018095085 scopus 로고
    • Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
    • Graham DG. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 1978;14:633-643.
    • (1978) Mol Pharmacol , vol.14 , pp. 633-643
    • Graham, D.G.1
  • 4
    • 0024828170 scopus 로고
    • The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra
    • Fornstedt B, Brun A, Rosengren E, Carlsson A. The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra. J Neural Transm Park Dis Dement Sect 1989;1:279-295.
    • (1989) J Neural Transm Park Dis Dement Sect , vol.1 , pp. 279-295
    • Fornstedt, B.1    Brun, A.2    Rosengren, E.3    Carlsson, A.4
  • 6
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, et al. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 1994;36:348-355.
    • (1994) Ann Neurol , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3
  • 7
    • 0031722906 scopus 로고    scopus 로고
    • Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species
    • Spencer JP, Jenner P, Daniel SE, et al. Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species. J Neurochem 1998; 71:2112-2122.
    • (1998) J Neurochem , vol.71 , pp. 2112-2122
    • Spencer, J.P.1    Jenner, P.2    Daniel, S.E.3
  • 8
    • 0027952849 scopus 로고
    • Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study
    • Dexter DT, Holley AE, Flitter WD, et al. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disord 1994;9:92-97.
    • (1994) Mov Disord , vol.9 , pp. 92-97
    • Dexter, D.T.1    Holley, A.E.2    Flitter, W.D.3
  • 9
    • 0029917194 scopus 로고    scopus 로고
    • Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
    • Yoritaka A, Hatton N, Uchida K, et al. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A 1996;93:2696-2701.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2696-2701
    • Yoritaka, A.1    Hatton, N.2    Uchida, K.3
  • 10
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • Alam ZI, Jenner A, Daniel SE, et al. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 1997;69:1196-1203.
    • (1997) J Neurochem , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3
  • 11
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996;47(Suppl 3):161-170.
    • (1996) Neurology , vol.47 , pp. 161-170
    • Jenner, P.1    Olanow, C.W.2
  • 12
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway KA, Rochet JC, Bieganski RM, Lansbury PT, Jr. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 2001;294:1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury Jr, P.T.4
  • 13
    • 4344641972 scopus 로고    scopus 로고
    • Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease
    • Rochet JC, Outeiro TF, Conway KA, et al. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. J Mol Neurosci 2004;23:23-34.
    • (2004) J Mol Neurosci , vol.23 , pp. 23-34
    • Rochet, J.C.1    Outeiro, T.F.2    Conway, K.A.3
  • 14
    • 38849174979 scopus 로고    scopus 로고
    • Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    • Martinez-Vicente M, Talloczy Z, Kaushik S, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008;118:777-788.
    • (2008) J Clin Invest , vol.118 , pp. 777-788
    • Martinez-Vicente, M.1    Talloczy, Z.2    Kaushik, S.3
  • 15
    • 0028834192 scopus 로고
    • L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation
    • Basma AN, Morris EJ, Nicklas WJ, Geller HM. L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation. J Neurochem 1995;64:825-832.
    • (1995) J Neurochem , vol.64 , pp. 825-832
    • Basma, A.N.1    Morris, E.J.2    Nicklas, W.J.3    Geller, H.M.4
  • 16
    • 0031023430 scopus 로고    scopus 로고
    • Levodopa induces apoptosis in cultured neuronal cells-a possible accelerator of nigrostriatal degeneration in Parkinson's disease?
    • Ziv I, Zilkha-Falb R, Offen D, et al. Levodopa induces apoptosis in cultured neuronal cells-a possible accelerator of nigrostriatal degeneration in Parkinson's disease? Mov Disord 1997;12:17-23.
    • (1997) Mov Disord , vol.12 , pp. 17-23
    • Ziv, I.1    Zilkha-Falb, R.2    Offen, D.3
  • 17
    • 0029051317 scopus 로고
    • Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA: implications for the treatment of Parkinson's disease
    • Walkinshaw G, Waters CM. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA: implications for the treatment of Parkinson's disease. J Clin Invest 1995;95:2458-2464.
    • (1995) J Clin Invest , vol.95 , pp. 2458-2464
    • Walkinshaw, G.1    Waters, C.M.2
  • 18
    • 0027362832 scopus 로고
    • Toxic and protective effects of L-DOPA on mesencephalic cell cultures
    • Mytilineou C, Han SK, Cohen G. Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J Neurochem 1993;61:1470-1478.
    • (1993) J Neurochem , vol.61 , pp. 1470-1478
    • Mytilineou, C.1    Han, S.K.2    Cohen, G.3
  • 19
    • 0030059868 scopus 로고    scopus 로고
    • L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress
    • Han SK, Mytilineou C, Cohen G. L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J Neurochem 1996; 66:501-510.
    • (1996) J Neurochem , vol.66 , pp. 501-510
    • Han, S.K.1    Mytilineou, C.2    Cohen, G.3
  • 20
    • 0027268723 scopus 로고
    • Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line
    • Pardo B, Mena MA, Fahn S, García de Yébenes J. Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line. Mov Disord 1993;8:278-284.
    • (1993) Mov Disord , vol.8 , pp. 278-284
    • Pardo, B.1    Mena, M.A.2    Fahn, S.3    García de Yébenes, J.4
  • 21
    • 0025770366 scopus 로고
    • Ascorbic acid in mesencephalic cultures: effects on dopaminergic neuron development
    • Kalir HH, Mytilineou C. Ascorbic acid in mesencephalic cultures: effects on dopaminergic neuron development. J Neurochem 1991;57:458-464.
    • (1991) J Neurochem , vol.57 , pp. 458-464
    • Kalir, H.H.1    Mytilineou, C.2
  • 22
    • 0029990439 scopus 로고    scopus 로고
    • Astrocytes protect neurons from hydrogen peroxide toxicity
    • Desagher S, Glowinski J, Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci 1996;16:2553-2562.
    • (1996) J Neurosci , vol.16 , pp. 2553-2562
    • Desagher, S.1    Glowinski, J.2    Premont, J.3
  • 23
    • 0030880246 scopus 로고    scopus 로고
    • Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
    • Mena MA, Casarejos MJ, Carazo A, Paino CL, García de Yébenes J. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm 1997;104:317-328.
    • (1997) J Neural Transm , vol.104 , pp. 317-328
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3    Paino, C.L.4    García de Yébenes, J.5
  • 24
    • 0026786548 scopus 로고
    • Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals
    • Tallaksen CM, Bohmer T, Bell H. Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals. Am J Clin Nutr 1992;56:559-564.
    • (1992) Am J Clin Nutr , vol.56 , pp. 559-564
    • Tallaksen, C.M.1    Bohmer, T.2    Bell, H.3
  • 26
    • 0021129038 scopus 로고
    • Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically
    • Perry TL, Yong VW, Ito M, Foulks JG, Wall RA, Godin DV, Clavier RM. Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically. J Neurochem 1984;43:990-993.
    • (1984) J Neurochem , vol.43 , pp. 990-993
    • Perry, T.L.1    Yong, V.W.2    Ito, M.3    Foulks, J.G.4    Wall, R.A.5    Godin, D.V.6    Clavier, R.M.7
  • 27
    • 0019447228 scopus 로고
    • Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse
    • Hefti F, Melamed E, Bhawan J, Wurtman RJ. Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse. Neurology 1981;31:1194-1195.
    • (1981) Neurology , vol.31 , pp. 1194-1195
    • Hefti, F.1    Melamed, E.2    Bhawan, J.3    Wurtman, R.J.4
  • 28
    • 0036166979 scopus 로고    scopus 로고
    • Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys
    • Lyras L, Zeng BY, McKenzie G, et al. Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys. J Neural Transm 2002;109:53-67.
    • (2002) J Neural Transm , vol.109 , pp. 53-67
    • Lyras, L.1    Zeng, B.Y.2    McKenzie, G.3
  • 29
    • 0031968959 scopus 로고    scopus 로고
    • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
    • Murer MG, Dziewczapolski G, Menalled LB, et al. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol 1998;43:561-575.
    • (1998) Ann Neurol , vol.43 , pp. 561-575
    • Murer, M.G.1    Dziewczapolski, G.2    Menalled, L.B.3
  • 30
    • 0035353737 scopus 로고    scopus 로고
    • Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions
    • Datla KP, Blunt SB, Dexter DT. Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions. Mov Disord 2001;16:424-434.
    • (2001) Mov Disord , vol.16 , pp. 424-434
    • Datla, K.P.1    Blunt, S.B.2    Dexter, D.T.3
  • 31
    • 0034862982 scopus 로고    scopus 로고
    • Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study
    • Zeng BY, Pearce RK, MacKenzie GM, Jenner P. Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study. J Neural Transm 2001;108:925-941.
    • (2001) J Neural Transm , vol.108 , pp. 925-941
    • Zeng, B.Y.1    Pearce, R.K.2    MacKenzie, G.M.3    Jenner, P.4
  • 32
    • 0037309436 scopus 로고    scopus 로고
    • Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress
    • Mytilineou C, Walker RH, JnoBaptiste R, Olanow CW. Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress. J Pharm Exp Ther 2003;304:792-800.
    • (2003) J Pharm Exp Ther , vol.304 , pp. 792-800
    • Mytilineou, C.1    Walker, R.H.2    JnoBaptiste, R.3    Olanow, C.W.4
  • 33
    • 0037668195 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines
    • Nair VD, Olanow CW, Sealfon SC. Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J 2003;373:25-32.
    • (2003) Biochem J , vol.373 , pp. 25-32
    • Nair, V.D.1    Olanow, C.W.2    Sealfon, S.C.3
  • 34
    • 47249083512 scopus 로고    scopus 로고
    • Differential modulation of Akt/GSK-3β pathway regulates apoptotic and cytoprotective signaling responses
    • Nair VD, Olanow CW. Differential modulation of Akt/GSK-3β pathway regulates apoptotic and cytoprotective signaling responses. J Biol Chem 2008;283:15469-15478.
    • (2008) J Biol Chem , vol.283 , pp. 15469-15478
    • Nair, V.D.1    Olanow, C.W.2
  • 35
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996;47:S161-S170.
    • (1996) Neurology , vol.47 , pp. S161-S170
    • Jenner, P.1    Olanow, C.W.2
  • 36
    • 0022946382 scopus 로고
    • Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period
    • Quinn N, Parkes D, Janota I, Marsden CD. Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period. Mov Disord 1986;1:65-68.
    • (1986) Mov Disord , vol.1 , pp. 65-68
    • Quinn, N.1    Parkes, D.2    Janota, I.3    Marsden, C.D.4
  • 37
    • 82955167998 scopus 로고    scopus 로고
    • Does levodopa accelerate the pathologic process in Parkinson disease brain?
    • Parkkinen L, O'Sullivan SS, Kuoppamäki M, et al. Does levodopa accelerate the pathologic process in Parkinson disease brain? Neurology 2011;77:1420-1426.
    • (2011) Neurology , vol.77 , pp. 1420-1426
    • Parkkinen, L.1    O'Sullivan, S.S.2    Kuoppamäki, M.3
  • 38
    • 82955235717 scopus 로고    scopus 로고
    • Levodopa toxicity and Parkinson disease. Still a need for equipoise
    • Olanow CW, Obeso JA. Levodopa toxicity and Parkinson disease. Still a need for equipoise. Neurology 2011;77:1416-1417.
    • (2011) Neurology , vol.77 , pp. 1416-1417
    • Olanow, C.W.1    Obeso, J.A.2
  • 39
    • 0025117838 scopus 로고
    • Longitudinal study of effects of early levodopa treatment on disability and mortality in Parkinson's disease
    • Diamond SG, Markham CH. Longitudinal study of effects of early levodopa treatment on disability and mortality in Parkinson's disease. Adv Neurol 1990;53:399-403.
    • (1990) Adv Neurol , vol.53 , pp. 399-403
    • Diamond, S.G.1    Markham, C.H.2
  • 40
    • 84908345308 scopus 로고    scopus 로고
    • Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial
    • Gray R, Ives N, Rick C, et al. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet 2014;384:1196-1205.
    • (2014) Lancet , vol.384 , pp. 1196-1205
    • Gray, R.1    Ives, N.2    Rick, C.3
  • 41
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression
    • Parkinson Study Group.
    • Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA 2002;287:1653-1661.
    • (2002) JAMA , vol.287 , pp. 1653-1661
  • 42
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET Study
    • Whone A, Watts R, Stoessl J, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET Study: Ann Neurol 2003;54:93-101.
    • (2003) Ann Neurol , vol.54 , pp. 93-101
    • Whone, A.1    Watts, R.2    Stoessl, J.3
  • 43
    • 0037432067 scopus 로고    scopus 로고
    • Slowing Parkinson's disease progression: recent dopamine agonist trials
    • Ahlskog JE. Slowing Parkinson's disease progression: recent dopamine agonist trials. Neurology 2003;60:381-389.
    • (2003) Neurology , vol.60 , pp. 381-389
    • Ahlskog, J.E.1
  • 44
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson's disease
    • Parkinson Study Group.
    • Fahn S, Oakes D, Shoulson I, et al.; Parkinson Study Group. Levodopa and the progression of Parkinson's disease. N Eng J Med 2004;351:2498-2508.
    • (2004) N Eng J Med , vol.351 , pp. 2498-2508
    • Fahn, S.1    Oakes, D.2    Shoulson, I.3
  • 45
    • 0034106361 scopus 로고    scopus 로고
    • Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson's disease
    • Hauser RA, Koller WC, Hubble JP, Malapira T, Busenbark K, Olanow CW. Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson's disease. Mov Disord 2000;15:485-489.
    • (2000) Mov Disord , vol.15 , pp. 485-489
    • Hauser, R.A.1    Koller, W.C.2    Hubble, J.P.3    Malapira, T.4    Busenbark, K.5    Olanow, C.W.6
  • 46
    • 0036764810 scopus 로고    scopus 로고
    • Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson's disease
    • Hauser RA, Holford NH. Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson's disease. Mov Disord 2002;17:961-968.
    • (2002) Mov Disord , vol.17 , pp. 961-968
    • Hauser, R.A.1    Holford, N.H.2
  • 47
    • 0033768218 scopus 로고    scopus 로고
    • Dyskinesias and motor fluctuations in Parkinson's disease
    • Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain 2000;123:2297-2305.
    • (2000) A community-based study. Brain , vol.123 , pp. 2297-2305
    • Schrag, A.1    Quinn, N.2
  • 48
    • 84881558752 scopus 로고    scopus 로고
    • Factors predictive of the development of levodopa-induced dyskinesia and wearing-off in Parkinson's disease
    • for the STRIDE-PD investigators.
    • Olanow CW, Kieburtz K, Rascol O, et al.; for the STRIDE-PD investigators. Factors predictive of the development of levodopa-induced dyskinesia and wearing-off in Parkinson's disease. Mov Disord 2013;28:1064-1071.
    • (2013) Mov Disord , vol.28 , pp. 1064-1071
    • Olanow, C.W.1    Kieburtz, K.2    Rascol, O.3
  • 49
    • 33746105694 scopus 로고    scopus 로고
    • Continuous dopamine receptor stimulation in the treatment of Parkinson's disease: scientific rationale and clinical implications
    • Olanow CW, Obeso JA, Stocchi F. Continuous dopamine receptor stimulation in the treatment of Parkinson's disease: scientific rationale and clinical implications. Lancet Neurol 2006;5:677-687.
    • (2006) Lancet Neurol , vol.5 , pp. 677-687
    • Olanow, C.W.1    Obeso, J.A.2    Stocchi, F.3
  • 50
    • 0022474704 scopus 로고
    • Duodenal delivery of levodopa for on-off fluctuations in parkinsonism: preliminary observations
    • Kurlan R, Rubin AJ, Miller C, Rivera-Calimlim L, Clarke A, Shoulson I. Duodenal delivery of levodopa for on-off fluctuations in parkinsonism: preliminary observations. Ann Neurol 1986;20:262-265.
    • (1986) Ann Neurol , vol.20 , pp. 262-265
    • Kurlan, R.1    Rubin, A.J.2    Miller, C.3    Rivera-Calimlim, L.4    Clarke, A.5    Shoulson, I.6
  • 51
    • 20844454214 scopus 로고    scopus 로고
    • Infusion of levodopa methyl ester in patients with advanced PD: a clinical and pharmacokinetic study
    • Stocchi F, Vacca L, Ruggieri S, Olanow CW. Infusion of levodopa methyl ester in patients with advanced PD: a clinical and pharmacokinetic study. Arch Neurol 2005;62:905-910.
    • (2005) Arch Neurol , vol.62 , pp. 905-910
    • Stocchi, F.1    Vacca, L.2    Ruggieri, S.3    Olanow, C.W.4
  • 52
    • 84892516916 scopus 로고    scopus 로고
    • Double-blind, double-dummy study of continuous intrajejunal delivery of levodopa/carbidopa intestinal gel in advanced Parkinson's disease
    • Olanow CW, Kieburtz K, Odin P, et al. Double-blind, double-dummy study of continuous intrajejunal delivery of levodopa/carbidopa intestinal gel in advanced Parkinson's disease. Lancet Neurol 2014;13:141-149.
    • (2014) Lancet Neurol , vol.13 , pp. 141-149
    • Olanow, C.W.1    Kieburtz, K.2    Odin, P.3
  • 53
    • 77749330753 scopus 로고    scopus 로고
    • Increased melanoma risk in Parkinson disease: a prospective clinicopathological study
    • North American Parkinson's and Melanoma Survey Investigators.
    • Bertoni JM, Arlette JP, Fernandez HH, et al.; North American Parkinson's and Melanoma Survey Investigators. Increased melanoma risk in Parkinson disease: a prospective clinicopathological study. Arch Neurol 2010;67:347-352.
    • (2010) Arch Neurol , vol.67 , pp. 347-352
    • Bertoni, J.M.1    Arlette, J.P.2    Fernandez, H.H.3
  • 55
    • 84884717728 scopus 로고    scopus 로고
    • Neuropathy and levodopa in Parkinson's disease: evidence from a multicenter study
    • Ceravolo R, Cossu G, Bandettini di Poggio M, et al. Neuropathy and levodopa in Parkinson's disease: evidence from a multicenter study. Mov Disord 2013;28:1391-1397.
    • (2013) Mov Disord , vol.28 , pp. 1391-1397
    • Ceravolo, R.1    Cossu, G.2    Bandettini di Poggio, M.3
  • 56
    • 0014082977 scopus 로고
    • Parkinsonism: onset, progression and mortality
    • Hoehn M, Yahr M. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-442.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.1    Yahr, M.2
  • 57
    • 0001912710 scopus 로고
    • Comments on the epidemiology of parkinsonism including prevalence and incidence statistics for Rochester, Minnesota, 1935-1966
    • In: Barbeau A, Brunette JR, eds. . Amsterdam: Excerpta Medica
    • Nobrega F, Glattre E, Kurland LT, et al. Comments on the epidemiology of parkinsonism including prevalence and incidence statistics for Rochester, Minnesota, 1935-1966. In: Barbeau A, Brunette JR, eds. Progress in Neurogenetics. Amsterdam: Excerpta Medica; 1967:474-485.
    • (1967) Progress in Neurogenetics , pp. 474-485
    • Nobrega, F.1    Glattre, E.2    Kurland, L.T.3
  • 59
    • 0029937494 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • Tanner CM, Goldman SM. Epidemiology of Parkinson's disease. Neurol Clinics 1996;14:317-335.
    • (1996) Neurol Clinics , vol.14 , pp. 317-335
    • Tanner, C.M.1    Goldman, S.M.2
  • 60
    • 0026326709 scopus 로고
    • Progression and survival in Parkinson's disease
    • Marttila RJ, Rinne KU. Progression and survival in Parkinson's disease. Acta Neurol Scand 1991;84:24-28.
    • (1991) Acta Neurol Scand , vol.84 , pp. 24-28
    • Marttila, R.J.1    Rinne, K.U.2
  • 62
    • 84911087192 scopus 로고    scopus 로고
    • Mortality in Parkinson's disease: a systematic review and meta-analysis
    • Macleod AD, Taylor KSM, Counsell CE. Mortality in Parkinson's disease: a systematic review and meta-analysis. Mov Disord 2014;29:1615-1622.
    • (2014) Mov Disord , vol.29 , pp. 1615-1622
    • Macleod, A.D.1    Taylor, K.S.M.2    Counsell, C.E.3
  • 63
    • 0032730204 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson's disease: a consensus meeting
    • Agid Y, Ahlskog E, Albanese A, et al. Levodopa in the treatment of Parkinson's disease: a consensus meeting. Mov Disord 1999;14:911-913.
    • (1999) Mov Disord , vol.14 , pp. 911-913
    • Agid, Y.1    Ahlskog, E.2    Albanese, A.3
  • 64
    • 0037125594 scopus 로고    scopus 로고
    • Levodopa: why the controversy?
    • Agid Y, Olanow CW, Mizuno Y. Levodopa: why the controversy? Lancet 2002;360:575.
    • (2002) Lancet , vol.360 , pp. 575
    • Agid, Y.1    Olanow, C.W.2    Mizuno, Y.3
  • 65
    • 4644314827 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson's disease: current controversies
    • Olanow CW, Agid Y, Mizuno Y, et al. Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord 2004;19:997-1005.
    • (2004) Mov Disord , vol.19 , pp. 997-1005
    • Olanow, C.W.1    Agid, Y.2    Mizuno, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.