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Volumn 12, Issue 1, 1997, Pages 17-23

Levodopa induces apoptosis in cultured neuronal cells - A possible accelerator of nigrostriatal degeneration in Parkinson's disease?

Author keywords

Apoptosis; Levodopa; Oxidative stress; Parkinson's disease; Toxicity

Indexed keywords

ACETYLCYSTEINE; DITHIOTHREITOL; LEVODOPA;

EID: 0031023430     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870120105     Document Type: Article
Times cited : (89)

References (12)
  • 1
    • 0018095085 scopus 로고
    • Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
    • Graham DG. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 1978;14:633-643.
    • (1978) Mol Pharmacol , vol.14 , pp. 633-643
    • Graham, D.G.1
  • 2
    • 0018148688 scopus 로고
    • Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward c1300 neuroblastoma cells in vitro
    • Graham DJ, Tiffany SM, Bell WR, Gutknecht WF. Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward c1300 neuroblastoma cells in vitro. Mol Pharmacol 1978;14:644-653.
    • (1978) Mol Pharmacol , vol.14 , pp. 644-653
    • Graham, D.J.1    Tiffany, S.M.2    Bell, W.R.3    Gutknecht, W.F.4
  • 3
    • 0023814368 scopus 로고
    • Catecholamine toxicity in cerebral cortex in dissociated cell culture
    • Rosenberg PA. Catecholamine toxicity in cerebral cortex in dissociated cell culture. J Neurol Sci 1988;8:2887-2894.
    • (1988) J Neurol Sci , vol.8 , pp. 2887-2894
    • Rosenberg, P.A.1
  • 4
    • 0025371344 scopus 로고
    • Excitotoxicity of L-DOPA and 6-OH-DOPA: Implications for Parkinson's and Huntington's diseases
    • Olney JW, Zorumski CF, Stewart GR, Price MT, Wang G, Labruyere J. Excitotoxicity of L-DOPA and 6-OH-DOPA: implications for Parkinson's and Huntington's diseases. Exp Neural 1990;108:269-272.
    • (1990) Exp Neural , vol.108 , pp. 269-272
    • Olney, J.W.1    Zorumski, C.F.2    Stewart, G.R.3    Price, M.T.4    Wang, G.5    Labruyere, J.6
  • 5
    • 0027362832 scopus 로고
    • Toxic and protective effects of L-DOPA on mesencephalic cell cultures
    • Mytilineou C, Han SK, Cohen G. Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J Neurochem 1993;61:1470-1478.
    • (1993) J Neurochem , vol.61 , pp. 1470-1478
    • Mytilineou, C.1    Han, S.K.2    Cohen, G.3
  • 7
    • 0017785767 scopus 로고
    • L-Dopa: Selective toxicity for melanoma cells in vitro
    • Wick MM, Byers L, Frei E. L-Dopa: selective toxicity for melanoma cells in vitro. Science 1977;197:468-469.
    • (1977) Science , vol.197 , pp. 468-469
    • Wick, M.M.1    Byers, L.2    Frei, E.3
  • 8
    • 0018665830 scopus 로고
    • Levodopa and dopamine analogs: Melanin precursors as antitumor agents in experimental human and murine leukemia
    • Wick MM. Levodopa and dopamine analogs: melanin precursors as antitumor agents in experimental human and murine leukemia. Cancer Treat Rep 1979;63:991-997.
    • (1979) Cancer Treat Rep , vol.63 , pp. 991-997
    • Wick, M.M.1
  • 9
    • 0017383558 scopus 로고
    • Long term levodopa therapy for Parkinson's disease
    • Yahr MD. Long term levodopa therapy for Parkinson's disease. Lancet 1977:1:706-707.
    • (1977) Lancet , vol.1 , pp. 706-707
    • Yahr, M.D.1
  • 10
    • 0019447228 scopus 로고
    • Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse
    • Hefti F, Melamed E, Bhawan J, Wurtman RJ. Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse. Neurology 1981;31:1194-1195.
    • (1981) Neurology , vol.31 , pp. 1194-1195
    • Hefti, F.1    Melamed, E.2    Bhawan, J.3    Wurtman, R.J.4
  • 11
    • 0021129038 scopus 로고
    • Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically
    • Perry TL, Yong VW, Ito M, et al. Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically. J Neurochem 1984;43:990-993.
    • (1984) J Neurochem , vol.43 , pp. 990-993
    • Perry, T.L.1    Yong, V.W.2    Ito, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.