Parkinson's disease, levodopa-use and the risk of melanoma

Parkinsonism and Related Disorders

Volumn 15, Issue 8, 2009, Pages 551-553

  Vermeij, J D ^a   Winogrodzka, A ^a   Trip, J ^a   Weber, W E J ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Levodopa; Melanoma; Parkinson's Disease

Indexed keywords

CARBIDOPA; LEVODOPA; SELEGILINE; TOCOPHEROL;

CANCER INCIDENCE; CANCER RISK; CLINICAL TRIAL; DISEASE ASSOCIATION; DRUG CHOICE; DRUG EFFICACY; DRUG RESPONSE; DRUG USE; HIGH RISK PATIENT; HUMAN; LONG TERM CARE; MELANOMA; PARKINSON DISEASE; PRESCRIPTION; PRIORITY JOURNAL; REVIEW; RISK REDUCTION;

ANIMALS; HUMANS; LEVODOPA; MELANOMA; PARKINSON DISEASE; RISK FACTORS; SKIN NEOPLASMS;

EID: 68349128669     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2009.05.002     Document Type: Review

References (24)

1. Pahwa R. Understanding Parkinson's disease: an update on current diagnostic and treatment strategies. J Am Med Dir Assoc 7 7 Suppl. 2 (2006 Sep) 4-10
2. Agid Y. Levodopa: is toxicity a myth?. Neurology 50 4 (1998 Apr) 858-863
3. Tse W. Optimizing pharmacotherapy: strategies to manage the wearing-off phenomenon. J Am Med Dir Assoc 7 7 Suppl. 2 (2006 Sep) 12-17
4. Constantinescu R., Romer M., and Kieburtz K. Malignant melanoma in early Parkinson's disease: the DATATOP trial. Mov Disord 22 5 (2007 Apr 15) 720-722
5. Driver J.A., Logroscino G., Buring J.E., Gaziano J.M., and Kurth T. A prospective cohort study of cancer incidence following the diagnosis of Parkinson's disease. Cancer Epidemiol Biomarkers Prev 16 6 (2007 Jun) 1260-1265
6. Olsen J.H., Friis S., and Frederiksen K. Malignant melanoma and other types of cancer preceding Parkinson disease. Epidemiology 17 5 (2006 Sep) 582-587
7. Olsen J.H., Friis S., Frederiksen K., McLaughlin J.K., Mellemkjaer L., and Moller H. Atypical cancer pattern in patients with Parkinson's disease. Br J Cancer 92 1 (2005 Jan 17) 201-205
8. Olsen J.H., Tangerud K., Wermuth L., Frederiksen K., and Friis S. Treatment with levodopa and risk for malignant melanoma. Mov Disord 22 9 (2007 Jul 15) 1252-1257
9. Sinemet. [cited 18-10-08]. Available from: (2008). http://www.drugs.com/cdi/sinemet.html
10. Sinemet. [cited 18-10-08]. Available from: (2008). http://emc.medicines.org.uk/emc/assets/c/html/
11. Sinemet. Farmacotherapeutic Kompass. Available from: (2008). http://www.fk.cvz.nl/
12. Sinemet. [cited 18-10-08]. Available from: (2008). http://www.msnewzealand.com/content/downloads/SINEMETCR%200720004%20(%20Code%20No%20only)%20CMI.pdf
13. Nebenwirkungen S. [cited 18-10-08]. Available from: (2008). http://www.onlineberatung-therapie.de/psychopharmaka/psychopharmakon/sinemet.html
14. European Parkinson's Disease Association (EPDA) - Sinemet. [cited 18-10-08]. Available from:. http://www.parkinsonsdecisionaid.eu.com/medInfo/sinemet/
15. Skibba J.L., Pinckley J., Gilbert E.F., and Johnson R.O. Multiple primary melanoma following administration of levodopa. Arch Pathol 93 6 (1972 Jun) 556-561
16. Zanetti R., Loria D., and Rosso S. Melanoma, Parkinson's disease and levodopa: causal or spurious link? A review of the literature. Melanoma Res 16 3 (2006 Jun) 201-206
17. Lieberman A.N., and Shupack J.L. Levodopa and melanoma. Neurology 24 4 (1974 Apr) 340-343
18. Sober A.J., and Wick M.M. Levodopa therapy and malignant melanoma. Jama 240 6 (1978 Aug 11) 554-555
19. Pfutzner W., and Przybilla B. Malignant melanoma and levodopa: is there a relationship? Two new cases and a review of the literature. J Am Acad Dermatol 37 2 Pt 2 (1997 Aug) 332-336
20. Fiala K.H., Whetteckey J., and Manyam B.V. Malignant melanoma and levodopa in Parkinson's disease: causality or coincidence?. Parkinsonism Relat Disord 9 6 (2003 Aug) 321-327
21. Zanetti R., and Rosso S. Levodopa and the risk of melanoma. Lancet 369 9558 (2007 Jan 27) 257-258
22. Grant W.B. Smoking, Parkinson's disease, and melanoma. Cancer Epidemiol Biomarkers Prev 16 11 (2007 Nov) 2517-2518 author reply 8
23. Markovic S.N., Erickson L.A., Rao R.D., Weenig R.H., Pockaj B.A., Bardia A., et al. Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc 82 3 (2007 Mar) 364-380
24. Driver J.A., Logroscino G., Buring J.E., Gaziano J.M., and Kurth T. Smoking, Parkinson's disease, and melanoma. Cancer Epidemiol Biomarkers Prev 16 11 (2007 Nov) 2518