Peripheral whole blood FOXP3 TSDR methylation: A potential marker in severity assessment of autoimmune diseases and chronic infections

Immunological Investigations

Volumn 44, Issue 2, 2015, Pages 126-136

  Ngalamika, Owen ^a,b   Liang, Gongping ^a   Zhao, Ming ^a   Yu, Xinhai ^a   Yang, Yang ^a   Yin, Heng ^a   Liu, Yu ^a   Yung, Susan ^c   Chan, Tak Mao ^c   Lu, Qianjin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY TEACHING HOSPITAL   (Zambia)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Autoimmune diseases; Chronic microbial infections; FOXP3 TSDR; HRM PCR; Psoriasis; Regulatory T cells; Systemic lupus erythematosus

Indexed keywords

GENOMIC DNA; PROTEIN; REGULATORY T LYMPHOCYTE SPECIFIC DEMETHYLATED REGION PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ACNE; ADULT; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DISEASE ACTIVITY; DISEASE SEVERITY; FEMALE; FINGERNAIL ONYCHOMYCOSIS; GENITAL HERPES; HERPES SIMPLEX; HIGH RESOLUTION MELT POLYMERASE CHAIN REACTION; HUMAN; MAJOR CLINICAL STUDY; MELTING POINT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN METHYLATION; PSORIASIS; REGULATORY T LYMPHOCYTE; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; TOENAIL ONYCHOMYCOSIS; AUTOIMMUNE DISEASES; CHRONIC DISEASE; CPG ISLAND; DNA METHYLATION; GENETICS; INFECTION; LUPUS ERYTHEMATOSUS, SYSTEMIC; METABOLISM; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; CHRONIC DISEASE; CPG ISLANDS; DNA METHYLATION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFECTION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84920869772     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2014.938165     Document Type: Article

References (31)

1. Allan SE, Crome SQ, Crellin NK, et al. (2007). Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Inter Immunol, 19, 345-54.
2. Alvarado-Sanchez B, Hernandez-Castro B, Portales-Perez D, et al. (2006). Regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun, 27, 110-18.
3. Ballestar E. (2010). Epigenetics lessons from twins: prospects for autoimmune disease. Clin Rev Allergy Immunol, 39, 30-41.
4. Baron U, Floess S, Wieczorek G, et al. (2007). DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Euro J Immunol, 37, 2378-89.
5. Belkaid Y, Piccirillo CA, Mendez S, et al. (2002). CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature, 420, 502-7.
6. Bennett CL, Christie J, Ramsdell F, et al. (2001). The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet, 27, 20-1.
7. Biller BJ, Elmslie RE, Burnett RC, et al. (2007). Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Veterin immunol Immunopathol, 116, 69-78.
8. Bombardier C, Gladman DD, Urowitz MB, et al. (1992). Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheumat, 35, 630-40.
9. Cinek T, Sadra A, Imboden JB. (2000). Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol (Baltimore, MD: 1950), 164, 5-8.
10. Coleman MM, Keane J, Mills KH. (2010). Editorial: Tregs and BCG-dangerous liaisons in TB. J Leukoc Biol, 88, 1067-9.
11. Floess S, Freyer J, Siewert C, et al. (2007). Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol, 5, e38.
12. Fontenot JD, Rudensky AY. (2005). Awell adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol, 6, 331-7.
13. Gudjonsson JE, Krueger G. (2012). A role for epigenetics in psoriasis: Methylated cytosine-guanine sites differentiate lesional from nonlesional skin and from normal skin. J Invest Dermatol, 132, 506-8.
14. Horwitz DA. (2008). Regulatory T cells in systemic lupus erythematosus: Past, present and future. Arthrit Res Ther, 10, 227-35.
15. Kole AK, Ghosh A. (2009). Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center. Ind J Dermatol, 54, 132-6.
16. Liu J, Lluis A, Illi S, et al. (2010). T regulatory cells in cord blood-FOXP3 demethylation as reliable quantitative marker. PLoS One, 5, e13267.
17. Meghari S, Bechah Y, Capo C, et al. (2008). Persistent Coxiella burnetii infection in mice overexpressing IL-10: An efficient model for chronic Q fever pathogenesis. PLoS Pathog, 4, e23.
18. Najafi S, Firooze Moqadam I, Mohammadzadeh M, et al. (2014). Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis. Immunol investig, 43, 405-9.
19. Ngalamika O, Zhang Y, Yin H, et al. (2012). Epigenetics, autoimmunity and hematologic malignancies: A comprehensive review. J Autoimmun, 39, 451-65.
20. O'Shea JJ, Ma A, Lipsky P. (2002). Cytokines and autoimmunity. Nature reviews. Immunology, 2, 37-45.
21. Polansky JK, Kretschmer K, Freyer J, et al. (2008). DNA methylation controls Foxp3 gene expression. Euro J Immunol, 38, 1654-63.
22. Strickland FM, Richardson BC. (2008). Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond. Autoimmunity, 41, 278-86.
23. Su DL, Lu ZM, Shen MN, et al. (2012). Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J Biomed Biotechnol, 2012, 347141.
24. Suarez A, Lopez P, Gomez J, Gutierrez C. (2006). Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheumat Dis, 65, 1512-17.
25. Suri-Payer E, Fritzsching B. (2006). Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol, 28, 3-16.
26. Tiwananthagorn S, Iwabuchi K, Ato M, et al. (2012). Involvement of CD4(+) Foxp3(+) regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice. PLoS Neglected Tropical Diseases, 6, e1798.
27. Wang J, Ioan-Facsinay A, van der Voort EI, et al. (2007). Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Euro J Immunol, 37, 129-38.
28. Wieczorek G, Asemissen A, Model F, et al. (2009). Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res, 69, 599-608.
29. Yee CS, Farewell VT, Isenberg DA, et al. (2011). The use of Systemic Lupus Erythematosus Disease Activity Index-2000 to define active disease and minimal clinically meaningful change based on data from a large cohort of systemic lupus erythematosus patients. Rheumatology (Oxford, England), 50, 982-8.
30. Young D, Hussell T, Dougan G. (2002). Chronic bacterial infections: Living with unwanted guests. Nat Immunol, 3, 1026-32.
31. Zhao M, Liang GP, Tang MN, et al. (2012). Total glucosides of paeony induces regulatory CD4(+)CD25(+) T cells by increasing Foxp3 demethylation in lupus CD4(+) T cells. Clin Immunol (Orlando, FL), 143, 180-7.