Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV

mAbs

Volumn 6, Issue 6, 2014, Pages 1585-1597

  Paul, Matthew ^a   Reljic, Rajko ^a   Klein, Katja ^b   Drake, Pascal M W ^a   Van Dolleweerd, Craig ^a   Pabst, Martin ^c   Windwarder, Markus ^c   Arcalis, Elsa ^c   Stoger, Eva ^c   Altmann, Friedrich ^c   Cosgrove, Catherine ^d   Bartolf, Angela ^d   Baden, Susan ^d   Ma, Julian K C ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Antibody stability; Glycosylation; HIV microbicide; Molecular farming; Secretory IgA

Indexed keywords

GLYCOPROTEIN GP 140; MANNOSE; SECRETORY IMMUNOGLOBULIN; NEUTRALIZING ANTIBODY; POLYSACCHARIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN;

ANTIGEN BINDING; ANTIVIRAL ACTIVITY; APOPLAST; ARTICLE; CARBOHYDRATE ANALYSIS; CELL COMPARTMENTALIZATION; CELL VACUOLE; CONTROLLED STUDY; DRUG PURIFICATION; ENZYME STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; LEAF TISSUE; NICOTIANA BENTHAMIANA; NICOTIANA TABACUM; NONHUMAN; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; TRANSIENT EXPRESSION; VIRION; VIRUS NEUTRALIZATION; BINDING SITE; BODY FLUID; DRUG EFFECTS; ELECTRON MICROSCOPY; FEMALE; FLUORESCENCE MICROSCOPY; GENETICS; GLYCOSYLATION; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; PLANT LEAF; TOBACCO; TRANSGENIC PLANT; ULTRASTRUCTURE; VAGINA;

ANTIBODIES, NEUTRALIZING; BINDING SITES; BODY FLUIDS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; FEMALE; GLYCOSYLATION; HIV; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN A, SECRETORY; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; POLYSACCHARIDES; PROTEIN BINDING; RECOMBINANT PROTEINS; TOBACCO; VAGINA; VIRION;

EID: 84920866675     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.36336     Document Type: Article

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