Combinatorial analysis of secretory immunoglobulin A (sIgA) expression in plants

International Journal of Molecular Sciences

Volumn 14, Issue 3, 2013, Pages 6205-6222

  Juarez, Paloma ^a   Huet Trujillo, Estefania ^a   Sarrion Perdigones, Alejandro ^a   Falconi, Erica Elvira ^a   Granell, Antonio ^a   Orzaez, Diego ^a  

^a Ciudad Politécnica de la Innovación   (Spain)

Author keywords

Antibody; GoldenBraid; Plant synthetic biology; Rotavirus; Secretory IgA

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN JOINING CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN SECRETORY COMPONENT; KDEL PEPTIDE; PEPTIDE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANTIBODY PRODUCTION; ARTICLE; BIOTECHNOLOGICAL PRODUCTION; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DNA SEQUENCE; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; FRESH WEIGHT; GENETIC TRANSFORMATION; IMMUNOGLOBULIN PRODUCTION; NICOTIANA BENTHAMIANA; NONHUMAN; PLANT LEAF; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; ROTAVIRUS; SYNTHETIC BIOLOGY; TRANSIENT EXPRESSION; WESTERN BLOTTING;

NICOTIANA BENTHAMIANA; ROTAVIRUS;

EID: 84875540341     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14036205     Document Type: Article

References (48)

1. Reichert, J.M.; Valge-Archer, V.E. Development trends for monoclonal antibody cancer therapeutics. Nat. Rev. Drug Discov. 2007, 6, 349-356.
2. Corthesy, B. Role of secretory immunoglobulin a and secretory component in the protection of mucosal surfaces. Future Microbiol. 2010, 5, 817-829.
3. Corthesy, B. Recombinant secretory immunoglobulin a in passive immunotherapy: Linking immunology and biotechnology. Curr. Pharm. Biotechnol. 2003, 4, 51-67.
4. Corthesy, B. Secretory immunoglobulin a: Well beyond immune exclusion at mucosal surfaces. Immunopharmacol. Immunotoxicol. 2009, 31, 174-179.
5. Sarrion-Perdigones, A.; Juarez, P.; Granell, A.; Orzaez, D. Production of antibodies in plants. In Cell Engineering; Al-Rubeai, M., Ed.; Springer Science Business Media: Dublin, Ireland, 2011; Volume 7, pp. 143-164.
6. Paul, M.; van Dolleweerd, C.; Drake, P.M.; Reljic, R.; Thangaraj, H.; Barbi, T.; Stylianou, E.; Pepponi, I.; Both, L.; Hehle, V.; et al. Molecular pharming: Future targets and aspirations. Hum. Vaccin. 2011, 7, 375-382.
7. Fischer, R.; Stoger, E.; Schillberg, S.; Christou, P.; Twyman, R.M. Plant-Based production of biopharmaceuticals. Curr. Opin. Plant Biol. 2004, 7, 152-158.
8. Twyman, R.M.; Stoger, E.; Schillberg, S.; Christou, P.; Fischer, R. Molecular farming in plants: Host systems and expression technology. Trends Biotechnol. 2003, 21, 570-578.
9. Saint-Jore-Dupas, C.; Faye, L.; Gomord, V. From planta to pharma with glycosylation in the toolbox. Trends Biotechnol. 2007, 25, 317-323.
10. Ma, J.K.; Hiatt, A.; Hein, M.; Vine, N.D.; Wang, F.; Stabila, P.; van Dolleweerd, C.; Mostov, K.; Lehner, T. Generation and assembly of secretory antibodies in plants. Science 1995, 268, 716-719.
11. Ma, J.K.; Hikmat, B.Y.; Wycoff, K.; Vine, N.D.; Chargelegue, D.; Yu, L.; Hein, M.B.; Lehner, T. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat. Med. 1998, 4, 601-606.
12. Weintraub, J.A.; Hilton, J.F.; White, J.M.; Hoover, C.I.; Wycoff, K.L.; Yu, L.; Larrick, J.W.; Featherstone, J.D. Clinical trial of a plant-derived antibody on recolonization of mutans streptococci. Caries Res. 2005, 39, 241-250.
13. Wycoff, K.L. Secretory IgA antibodies from plants. Curr. Pharm. Des. 2004, 11, 2429-2437.
14. Nicholson, L.; Gonzalez-Melendi, P.; van Dolleweerd, C.; Tuck, H.; Perrin, Y.; Ma, J.K.; Fischer, R.; Christou, P.; Stoger, E. A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol. J. 2005, 3, 115-127.
15. Wieland, W.H.; Lammers, A.; Schots, A.; Orzaez, D.V. Plant expression of chicken secretory antibodies derived from combinatorial libraries. J. Biotechnol. 2006, 122, 382-391.
16. Larrick, J.W.; Yu, L.; Naftzger, C.; Jaiswal, S.; Wycoff, K. Production of secretory IgA antibodies in plants. Biomol. Eng. 2001, 18, 87-94.
17. Foley, R.C.; Raison, R.L.; Beh, K.J. Monoclonal antibody against sheep kappa light chain. Hybridoma 1991, 10, 507-515.
18. Furtado, P.B.; Whitty, P.W.; Robertson, A.; Eaton, J.T.; Almogren, A.; Kerr, M.A.; Woof, J.M.; Perkins, S.J. Solution structure determination of monomeric human IgA2 by X-ray and neutron scattering, analytical ultracentrifugation and constrained modelling: A comparison with monomeric human IgA1. J. Mol. Biol. 2004, 338, 921-941.
19. De Muynck, B.; Navarre, C.; Boutry, M. Production of antibodies in plants: Status after twenty years. Plant Biotechnol. J. 2010, 8, 529-563.
20. Ma, J.K.C.; Drake, P.M.W.; Christou, P. The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet. 2003, 4, 794-805.
21. Petruccelli, S.; Otegui, M.S.; Lareu, F.; Tran Dinh, O.; Fitchette, A.C.; Circosta, A.; Rumbo, M.; Bardor, M.; Carcamo, R.; Gomord, V.; et al. A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seeds. Plant Biotechnol. J. 2006, 4, 511-527.
22. De Muynck, B.; Navarre, C.; Nizet, Y.; Stadlmann, J.; Boutry, M. Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells. Transgenic Res. 2009, 18, 467-482.
23. Düring, K.; Hippe, S.; Kreuzaler, F.; Schell, J. Synthesis and self-assembly of a functional monoclonal antibody in transgenic nicotiana tabacum. Plant Mol. Biol. 1990, 15, 281-293.
24. De Wilde, C.; de Rycke, R.; Beeckman, T.; de Neve, M.; Van Montagu, M.; Engler, G.; Depicker, A. Accumulation pattern of IgG antibodies and Fab fragments in transgenic Arabidopsis thaliana plants. Plant Cell Physiol. 1998, 39, 639-646.
25. Schouten, A.; Roosien, J.; van Engelen, F.A.; de Jong, G.A.; Borst-Vrenssen, A.W.; Zilverentant, J.F.; Bosch, D.; Stiekema, W.J.; Gommers, F.J.; Schots, A.; et al. The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant Mol. Biol. 1996, 30, 781-793.
26. Bencurova, M.; Hemmer, W.; Focke-Tejkl, M.; Wilson, I.B.; Altmann, F. Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin. Glycobiology 2004, 14, 457-466.
27. Gomord, V.; Fitchette, A.C.; Menu-Bouaouiche, L.; Saint-Jore-Dupas, C.; Plasson, C.; Michaud, D.; Faye, L. Plant-specific glycosylation patterns in the context of therapeutic protein production. Plant Biotechnol. J. 2010, 8, 564-587.
28. Sarrion-Perdigones, A.; Falconi, E.E.; Zandalinas, S.I.; Juarez, P.; Fernandez-del-Carmen, A.; Granell, A.; Orzaez, D. Goldenbraid: An iterative cloning system for standardized assembly of reusable genetic modules. PLoS One 2011, 6, e21622.
29. Weber, E.; Engler, C.; Gruetzner, R.; Werner, S.; Marillonnet, S. A modular cloning system for standardized assembly of multigene constructs. PLoS One 2011, 6, e16765.
30. Monedero, V.; Rodriguez-Diaz, J.; Viana, R.; Buesa, J.; Perez-Martinez, G. Selection of single-chain antibodies against the VP8* subunit of rotavirus VP4 outer capsid protein and their expression in lactobacillus casei. Appl. Environ. Microbiol. 2004, 70, 6936-6939.
31. Juarez, P.; Presa, S.; Espi, J.; Pineda, B.; Anton, M.T.; Moreno, V.; Buesa, J.; Granell, A.; Orzaez, D. Neutralizing antibodies against rotavirus produced in transgenically labelled purple tomatoes. Plant Biotechnol. J. 2012, 10, 341-352.
32. Langley, R.; Wines, B.; Willoughby, N.; Basu, I.; Proft, T.; Fraser, J.D. The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha Ri binding and serum killing of bacteria. J. Immunol. 2005, 174, 2926-2933.
33. Sack, M.; Paetz, A.; Kunert, R.; Bomble, M.; Hesse, F.; Stiegler, G.; Fischer, R.; Katinger, H.; Stoeger, E.; Rademacher, T. Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. FASEB J. 2007, 21, 1655-1664.
34. Ramessar, K.; Rademacher, T.; Sack, M.; Stadlmann, J.; Platis, D.; Stiegler, G.; Labrou, N.; Altmann, F.; Ma, J.; Stoger, E.; et al. Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc. Natl. Acad. Sci. USA 2008, 105, 3727-3732.
35. Brandtzaeg, P.; Prydz, H. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 1984, 311, 71-73.
36. Johansen, F.E.; Braathen, R.; Brandtzaeg, P. Role of J chain in secretory immunoglobulin formation. Scand. J. Immunol. 2000, 52, 240-248.
37. Braathen, R.; Hohman, V.S.; Brandtzaeg, P.; Johansen, F.E. Secretory antibody formation: Conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians. J. Immunol. 2007, 178, 1589-1597.
38. Murthy, A.K.; Chaganty, B.K.; Troutman, T.; Guentzel, M.N.; Yu, J.J.; Ali, S.K.; Lauriano, C.M.; Chambers, J.P.; Klose, K.E.; Arulanandam, B.P. Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin a mediate inhibition of Vibrio cholerae biofilm formation. PLoS One 2011, 6, e16847.
39. Mathias, A.; Corthesy, B. N-Glycans on secretory component: Mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis. Gut Microbes 2011, 2, 287-293.
40. Hu, L.; Crawford, S.E.; Czako, R.; Cortes-Penfield, N.W.; Smith, D.F.; le Pendu, J.; Estes, M.K.; Prasad, B.V. Cell attachment protein VP8* of a human rotavirus specifically interacts with a-type histo-blood group antigen. Nature 2012, 485, 256-259.
41. Yu, X.; Dang, V.T.; Fleming, F.E.; von Itzstein, M.; Coulson, B.S.; Blanchard, H. Structural basis of rotavirus strain preference towards N-acetyl-or N-glycolylneuraminic acid-containing receptors. J. Virol. 2012, 86, 13456-13466.
42. Haselhorst, T.; Fleming, F.E.; Dyason, J.C.; Hartnell, R.D.; Yu, X.; Holloway, G.; Santegoets, K.; Kiefel, M.J.; Blanchard, H.; Coulson, B.S.; et al. Sialic acid dependence in rotavirus host cell invasion. Nat. Chem. Biol. 2009, 5, 91-93.
43. Bonner, A.; Almogren, A.; Furtado, P.B.; Kerr, M.A.; Perkins, S.J. The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses. J. Biol. Chem. 2009, 284, 5077-5087.
44. Yoo, E.M.; Morrison, S.L. IgA: An immune glycoprotein. Clin. Immunol. 2005, 116, 3-10.
45. Karnoup, A.S.; Turkelson, V.; Anderson, W.H.K. O-linked glycosylation in maize-expressed human IgA1. Glycobiology 2005, 15, 965-981.
46. Ramsland, P.A.; Willoughby, N.; Trist, H.M.; Farrugia, W.; Hogarth, P.M.; Fraser, J.D.; Wines, B.D. Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1. Proc. Natl. Acad. Sci. 2007, 104, 15051-15056.
47. Almogren, A.; Senior, B.W.; Kerr, M.A. A comparison of the binding of secretory component to immunoglobulin A (IgA) in human colostral S-IgA1 and S-IgA2. Immunology 2007, 120, 273-280.
48. Orzaez, D.; Mirabel, S.; Wieland, W.H.; Granell, A. Agroinjection of tomato fruits. A tool for rapid functional analysis of transgenes directly in fruit. Plant. Physiol. 2006, 140, 3-11.