-
1
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7:45-56.
-
(2008)
Cell Metab.
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
Slentz, D.4
Mosedale, M.5
Ilkayeva, O.6
-
2
-
-
0142164965
-
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
-
Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys. 2003;419:101-109.
-
(2003)
Arch Biochem Biophys.
, vol.419
, pp. 101-109
-
-
Chavez, J.A.1
Summers, S.A.2
-
3
-
-
0038532298
-
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
-
Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, et al. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem. 2003;278:10297-10303.
-
(2003)
J Biol Chem.
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
Knotts, T.A.2
Wang, L.P.3
Li, G.4
Dobrowsky, R.T.5
Florant, G.L.6
-
4
-
-
31644443192
-
Ceramides in insulin resistance and lipotoxicity
-
Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res. 2006;45:42-72.
-
(2006)
Prog Lipid Res.
, vol.45
, pp. 42-72
-
-
Summers, S.A.1
-
5
-
-
33847036385
-
Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells
-
Ghosh N, Patel N, Jiang K, Watson JE, Cheng J, Chalfant CE, et al. Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells. Endocrinology. 2007;148:1359-1366.
-
(2007)
Endocrinology
, vol.148
, pp. 1359-1366
-
-
Ghosh, N.1
Patel, N.2
Jiang, K.3
Watson, J.E.4
Cheng, J.5
Chalfant, C.E.6
-
6
-
-
56249108080
-
Ceramide starves cells to death by downregulating nutrient transporter proteins
-
Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci U S A. 2008;105:17402-17407.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17402-17407
-
-
Guenther, G.G.1
Peralta, E.R.2
Rosales, K.R.3
Wong, S.Y.4
Siskind, L.J.5
Edinger, A.L.6
-
7
-
-
1542358155
-
Ceramide synthesis and metabolism as a target for cancer therapy
-
Reynolds CP, Maurer BJ, Kolesnick RN. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett. 2004;206:169-180.
-
(2004)
Cancer Lett.
, vol.206
, pp. 169-180
-
-
Reynolds, C.P.1
Maurer, B.J.2
Kolesnick, R.N.3
-
8
-
-
0033575310
-
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereo-specific and regulated by phosphatidic acid
-
Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereo-specific and regulated by phosphatidic acid. J Biol Chem. 1999;274:20313-20317.
-
(1999)
J Biol Chem.
, vol.274
, pp. 20313-20317
-
-
Chalfant, C.E.1
Kishikawa, K.2
Mumby, M.C.3
Kamibayashi, C.4
Bielawska, A.5
Hannun, Y.A.6
-
9
-
-
0028122397
-
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
-
Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994;269:19605-19609.
-
(1994)
J Biol Chem.
, vol.269
, pp. 19605-19609
-
-
Wolff, R.A.1
Dobrowsky, R.T.2
Bielawska, A.3
Obeid, L.M.4
Hannun, Y.A.5
-
10
-
-
84863155142
-
Bioactives of Artemisia dracunculus L mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells
-
Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, et al. Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells. Diabetes. 2012;61:597-605.
-
(2012)
Diabetes
, vol.61
, pp. 597-605
-
-
Obanda, D.N.1
Hernandez, A.2
Ribnicky, D.3
Yu, Y.4
Zhang, X.H.5
Wang, Z.Q.6
-
11
-
-
33750572410
-
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
-
Dimopoulos N, Watson M, Sakamoto K, Hundal HS. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J. 2006;399:473-481.
-
(2006)
Biochem J.
, vol.399
, pp. 473-481
-
-
Dimopoulos, N.1
Watson, M.2
Sakamoto, K.3
Hundal, H.S.4
-
12
-
-
33847628837
-
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intra-myocellular lipid
-
Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, et al. Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intra-myocellular lipid. J Cell Physiol. 2007;211:244-252.
-
(2007)
J Cell Physiol.
, vol.211
, pp. 244-252
-
-
Sabin, M.A.1
Stewart, C.E.2
Crowne, E.C.3
Turner, S.J.4
Hunt, L.P.5
Welsh, G.I.6
-
13
-
-
0026002683
-
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
-
Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest. 1991;88:960-966.
-
(1991)
J Clin Invest.
, vol.88
, pp. 960-966
-
-
Boden, G.1
Jadali, F.2
White, J.3
Liang, Y.4
Mozzoli, M.5
Chen, X.6
-
14
-
-
73949160860
-
Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
-
Hirabara SM, Curi R, Maechler P. Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol. 2010;222:187-194.
-
(2010)
J Cell Physiol.
, vol.222
, pp. 187-194
-
-
Hirabara, S.M.1
Curi, R.2
Maechler, P.3
-
15
-
-
4544242908
-
Intra-cellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
-
Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS. Intra-cellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J. 2004;382:619-629.
-
(2004)
Biochem J.
, vol.382
, pp. 619-629
-
-
Powell, D.J.1
Turban, S.2
Gray, A.3
Hajduch, E.4
Hundal, H.S.5
-
16
-
-
33845401821
-
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
-
Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab. 2006;291:E1341-E1350.
-
(2006)
Am J Physiol Endocrinol Metab.
, vol.291
, pp. E1341-E1350
-
-
Turpin, S.M.1
Lancaster, G.I.2
Darby, I.3
Febbraio, M.A.4
Watt, M.J.5
-
18
-
-
0035081372
-
Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study
-
Vessby B, Unsitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia. 2001;44:312-319.
-
(2001)
Diabetologia
, vol.44
, pp. 312-319
-
-
Vessby, B.1
Unsitupa, M.2
Hermansen, K.3
Riccardi, G.4
Rivellese, A.A.5
Tapsell, L.C.6
-
19
-
-
0028260497
-
Lipid mediators and protein kinase C activation for the intracellular signaling network
-
Nakamura S, Nishizuka Y. Lipid mediators and protein kinase C activation for the intracellular signaling network. J Biochem. 1994;115:1029-1034.
-
(1994)
J Biochem.
, vol.115
, pp. 1029-1034
-
-
Nakamura, S.1
Nishizuka, Y.2
-
20
-
-
0029060391
-
Protein kinase C and lipid signaling for sustained cellular responses
-
Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 1995;9:484-496.
-
(1995)
FASEB J.
, vol.9
, pp. 484-496
-
-
Nishizuka, Y.1
-
21
-
-
33750877988
-
Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-γ coactivator 1α in skeletal muscle cells involves MEK1/2 and nuclear factor-κB activation
-
Coll T, Jové M, Rodríguez-Calvo R, Eyre E, Palomer X, Sánchez RM, et al. Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-γ coactivator 1α in skeletal muscle cells involves MEK1/2 and nuclear factor-κB activation. Diabetes. 2006;55:2779-2787.
-
(2006)
Diabetes
, vol.55
, pp. 2779-2787
-
-
Coll, T.1
Jové, M.2
Rodríguez-Calvo, R.3
Eyre, E.4
Palomer, X.5
Sánchez, R.M.6
-
22
-
-
73749085101
-
Oleate protects against palmitate-induced insulin resistance in L6 myotubes
-
Gao D, Griffiths HR, Bailey CJ. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Br J Nutr. 2009;102: 1557-1563.
-
(2009)
Br J Nutr.
, vol.102
, pp. 1557-1563
-
-
Gao, D.1
Griffiths, H.R.2
Bailey, C.J.3
-
23
-
-
0033974996
-
Diabetes and the mediterranean diet: A beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity
-
Ryan M, McInerney D, Owens D, Collins P, Johnson A, Tomkin GH. Diabetes and the mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM. 2000;93:85-91.
-
(2000)
QJM
, vol.93
, pp. 85-91
-
-
Ryan, M.1
McInerney, D.2
Owens, D.3
Collins, P.4
Johnson, A.5
Tomkin, G.H.6
-
24
-
-
2542593338
-
Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
-
Schrauwen P, Hesselink MK. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes. 2004; 53:1412-1417.
-
(2004)
Diabetes
, vol.53
, pp. 1412-1417
-
-
Schrauwen, P.1
Hesselink, M.K.2
-
25
-
-
78649660058
-
Different effects of oleate vs palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: Role of oxidative stress
-
Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab. 2010;299:E1096-E1105.
-
(2010)
Am J Physiol Endocrinol Metab.
, vol.299
, pp. E1096-E1105
-
-
Yuzefovych, L.1
Wilson, G.2
Rachek, L.3
-
26
-
-
84885046089
-
Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt
-
Shibata E, Kanno T, Tsuchiya A, Kuribayashi K, Tabata C, Nakano T, et al. Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. Cell Physiol Biochem 2013;32: 871-879.
-
(2013)
Cell Physiol Biochem
, vol.32
, pp. 871-879
-
-
Shibata, E.1
Kanno, T.2
Tsuchiya, A.3
Kuribayashi, K.4
Tabata, C.5
Nakano, T.6
-
27
-
-
84870313599
-
Indomethacin serves as a potential inhibitor of protein phosphatases
-
Kanno T, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T. Indomethacin serves as a potential inhibitor of protein phosphatases. Cell Physiol Biochem. 2012;30:1014-1022.
-
(2012)
Cell Physiol Biochem.
, vol.30
, pp. 1014-1022
-
-
Kanno, T.1
Tsuchiya, A.2
Shimizu, T.3
Tanaka, A.4
Nishizaki, T.5
-
28
-
-
84890634561
-
Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B
-
Tsuchiya A, Kanno T, Nishizaki T. Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B. Cell Physiol Biochem. 2013;32:1451-1459.
-
(2013)
Cell Physiol Biochem.
, vol.32
, pp. 1451-1459
-
-
Tsuchiya, A.1
Kanno, T.2
Nishizaki, T.3
-
29
-
-
84890284142
-
PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway
-
Tsuchiya A, Kanno T, Nishizaki T. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway. J Endocrinol. 2013;220:49-59.
-
(2013)
J Endocrinol.
, vol.220
, pp. 49-59
-
-
Tsuchiya, A.1
Kanno, T.2
Nishizaki, T.3
-
30
-
-
84879487865
-
Crosstalk between PI3 kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK pathways downstream PDGF receptor
-
Niba ET, Nagaya H, Kanno T, Tsuchiya A, Gotoh A, Tabata C, et al. Crosstalk between PI3 kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK pathways downstream PDGF receptor. Cell Physiol Biochem. 2013;31:905-913.
-
(2013)
Cell Physiol Biochem.
, vol.31
, pp. 905-913
-
-
Niba, E.T.1
Nagaya, H.2
Kanno, T.3
Tsuchiya, A.4
Gotoh, A.5
Tabata, C.6
-
32
-
-
0031941815
-
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
-
Byon JC, Kusari AB, Kusari J. Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol Cell Biochem. 1998;182:101-108.
-
(1998)
Mol Cell Biochem.
, vol.182
, pp. 101-108
-
-
Byon, J.C.1
Kusari, A.B.2
Kusari, J.3
-
33
-
-
0039619868
-
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants
-
Wälchli S, Curchod ML, Gobert RP, Arkinstall S, Hooft van Huijsduijnen R. Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants. J Biol Chem. 2000; 275:9792-9796.
-
(2000)
J Biol Chem.
, vol.275
, pp. 9792-9796
-
-
Wälchli, S.1
Curchod, M.L.2
Gobert, R.P.3
Arkinstall, S.4
Hooft Van Huijsduijnen, R.5
-
34
-
-
0034507958
-
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
-
Salmeen A, Andersen JN, Myers MP, Tonks NK, Barford D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell. 2000;6:1401-1412.
-
(2000)
Mol Cell.
, vol.6
, pp. 1401-1412
-
-
Salmeen, A.1
Andersen, J.N.2
Myers, M.P.3
Tonks, N.K.4
Barford, D.5
-
35
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ. J Clin Invest. 2003;112:197-208.
-
(2003)
J Clin Invest.
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
-
36
-
-
84902590042
-
Rho GTPases in insulin-stimulated glucose uptake
-
Satoh T. Rho GTPases in insulin-stimulated glucose uptake. Small GTPases. 2014;5:e28102.
-
(2014)
Small GTPases.
, vol.5
-
-
Satoh, T.1
|