Free fatty acids inhibit protein tyrosine phosphatase 1b and activate AKT

Cellular Physiology and Biochemistry

Volumn 32, Issue 4, 2013, Pages 871-879

  Shibata, Eisuke ^a   Kanno, Takeshi ^a   Tsuchiya, Ayako ^a   Kuribayashi, Kohzo ^b   Tabata, Chiharu ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b ASAHI UNIVERSITY   (Japan)

Author keywords

Akt; Free fatty acid; Protein phosphatase 2A; Protein tyrosine phosphatase 1B

Indexed keywords

BEHENIC ACID; FATTY ACID; LINOLEIC ACID; LINOLENIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE 1B; STEARIC ACID; WORTMANNIN; SMALL INTERFERING RNA; THREONINE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; CHEMOLUMINESCENCE; DEPHOSPHORYLATION; GENETIC TRANSFECTION; PH; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ALPHA-LINOLENIC ACID; BLOTTING, WESTERN; CELL LINE; ENZYME ACTIVATION; FATTY ACIDS, NONESTERIFIED; HUMANS; PALMITIC ACID; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA, SMALL INTERFERING; STEARIC ACIDS;

EID: 84885046089     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354489     Document Type: Article

References (24)

1. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995;9:484-496.
2. Nishizaki T, Ikeuchi Y, Matsuoka T, Sumikawa K: Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II. Neuroreport 1997;8:597-601. (Pubitemid 27128200)
3. Kanno T, Yaguchi T, Nagata T, Tanaka A, Nishizaki T: DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol 2009;221:183-188.
4. Kanno T, Shimizu T, Tanaka A, Nishimoto T, Nishizaki T: Free fatty acid derivative HUHS2002 potentiates a7 ACh receptor responses through indirect activation of CaMKII. Lipids 2012;47:865-871.
5. Ohta K, Miyamoto H, Yaguchi T, Nagai K, Yamamoto S, Nomura T, Tanaka A, Nishizaki T: Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway. Mol Brain Res 2003;119:83-89. (Pubitemid 37324800)
6. Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ, Minkin S: Dietary fat and breast cancer risk revisited: a meta-Analysis of the published literature. Br J Cancer 2003;89:1672-1685. (Pubitemid 37464139)
7. Hanf V, Gonder U: Nutrition and primary prevention of breast cancer: foods, nutrients and breast cancer risk. Eur J Obstet Gynecol Reprod Biol 2005;123:139-149. (Pubitemid 41728356)
8. Lof M, Weiderpass E: Impact of diet on breast cancer risk. Curr Opin Obstet Gynecol 2009;21:80-85
9. Freedman LS, Kipnis V, Schatzkin A, Potischman N: Methods of epidemiology: evaluating the fat-breast cancer hypothesis-comparing dietary instruments and other developments. Cancer J 2008;14:69-74
10. Habermann N, Ulrich CM, Lundgreen A, Makar KW, Poole EM, Caan B, Kulmacz R, Whitton J, Galbraith R, Potter JD, Slattery ML: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. Genes Nutr 2013;8:115-126
11. Huncharek M, Kupelnick B: Dietary fat intake and risk of epithelial ovarian cancer: a meta-Analysis of 6,689 subjects from 8 observational studies. Nutr Cancer 2001;40:87-91 (Pubitemid 34274912)
12. Mnnist S, Pietinen P, Virtanen MJ, Salminen I, Albanes D, Giovannucci E, Virtamo J: Fatty acids and risk of prostate cancer in a nested case-control study in male smokers. Cancer Epidemiol Biomarkers Prev 2003;12:1422-1428 (Pubitemid 38031744)
13. Song G, Ouyang G, Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005;9:59-71
14. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 2001;9:1227-1240
15. Kanno T, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T: Indomethacin serves as a potential inhibitor of protein phosphatases. Cell Physiol Biochem 2012;30:1014-1022
16. Agarwal E, Brattain MG, Chowdhury S: Cell survival and metastasis regulation by Akt signaling in colorectal cancer. Cell Signal 2013;25:1711-1719
17. Cheung M, Testa JR: Diverse mechanisms of AKT pathway activation in human malignancy. Curr Cancer Drug Targets 2013;13:234-244
18. Hers I, Vincent EE, Tavar JM: Akt signalling in health and disease. Cell Signal 2011;23:1515-1527
19. Burris HA 3rd: Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway. Cancer Chemother Pharmacol 2013;71:829-842
20. Gadgeel SM, Wozniak A: Preclinical rationale for PI3K/Akt/mTOR pathway inhibitors as therapy for epidermal growth factor receptor inhibitor-resistant non-small-cell lung cancer. Clin Lung Cancer 2013;14:322-332
21. Bitting RL, Armstrong AJ: Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer. Endocr Relat Cancer 2013;20:R83-99
22. Ko JK, Auyeung KK: Target-oriented mechanisms of novel herbal therapeutics in the chemotherapy of gastrointestinal cancer and inflammation. Curr Pharm Des 2013;19:48-66
23. Kuramitsu Y, Tominaga W, Baron B, Tokuda K, Wang Y, Kitagawa T, Nakamura K: Up-regulation of DDX39 in human malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. Anticancer Res 2013;33:2557-2560
24. Sekido Y: Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells. Cancer Sci 2010;101:1-6.