Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells

Diabetes

Volumn 61, Issue 3, 2012, Pages 597-605

  Obanda, Diana N ^a   Hernandez, Amy ^b   Ribnicky, David ^a,c   Yu, Yongmei ^a   Zhang, Xian H ^a   Wang, Zhong Q ^a   Cefalu, William T ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b Louisiana State University System   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FATTY ACID; GLYCOGEN; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL EXPERIMENT; ARTEMISIA DRACUNCULUS; ARTICLE; CONTROLLED STUDY; HUMAN; LIPID METABOLISM; MUSCLE CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ANIMALS; CELLS, CULTURED; CERAMIDES; FATTY ACIDS, NONESTERIFIED; GLYCOGEN; INSULIN; MUSCLE, SKELETAL; PLANT EXTRACTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; SIGNAL TRANSDUCTION;

EID: 84863155142     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0396     Document Type: Article

References (22)

1. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008;7:45-56
2. Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3- L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys 2003;419:101-109 (Pubitemid 37329976)
3. Chavez JA, Knotts TA, Wang LP, et al. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 2003;278:10297-10303 (Pubitemid 36800291)
4. Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 2006;45:42-72 (Pubitemid 43170804)
5. Ghosh N, Patel N, Jiang K, et al. Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells. Endocrinology 2007;148:1359-1366
6. Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci USA 2008;105:17402-17407
7. Reynolds CP, Maurer BJ, Kolesnick RN. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett 2004;206:169-180 (Pubitemid 38317287)
8. Dobrzyń A, Górski J. Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition. Effect of prolonged exercise. Am J Physiol Endocrinol Metab 2002;282:E277-E285 (Pubitemid 34654797)
9. Helge JW, Dobrzyn A, Saltin B, Gorski J. Exercise and training effects on ceramide metabolism in human skeletal muscle. Exp Physiol 2004;89: 119-127 (Pubitemid 38128860)
10. Planavila A, Alegret M, Sánchez RM, Rodríguez-Calvo R, Laguna JC, Vázquez-Carrera M. Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice. Biochem Pharmacol 2005;69:1195-1204 (Pubitemid 40417491)
11. Ribnicky DM, Poulev A, Watford M, Cefalu WT, Raskin I. Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine 2006;13:550-557 (Pubitemid 44224045)
12. Ribnicky DM, Kuhn P, Poulev A, et al. Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. Int J Pharm 2009;370:87-92
13. Wang ZQ, Ribnicky D, Zhang XH, Raskin I, Yu Y, Cefalu WT. Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture. Metabolism 2008;57(Suppl. 1): S58-S64 (Pubitemid 351814703)
14. y mice. J Nutr Biochem. In press
15. Gómez-Lechón MJ, Ponsoda X, Castell JV. A microassay for measuring glycogen in 96-well-cultured cells. Anal Biochem 1996;236:296-301 (Pubitemid 26136109)
16. Haynes TA, Duerksen-Hughes PJ, Filippova M, Filippov V, Zhang K. C18 ceramide analysis in mammalian cells employing reversed-phase highperformance liquid chromatography tandem mass spectrometry. Anal Biochem 2008;378:80-86
17. Merrill AH Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem 2002;277:25843-25846
18. Dobrzyn A, Dobrzyn P, Lee SH, et al. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 2005;288:E599-E607 (Pubitemid 40250556)
19. Schmitz-Peiffer C, Craig DL, Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999;274: 24202-24210
20. Bourbon NA, Sandirasegarane L, Kester M. Ceramide-induced inhibition of Akt is mediated through protein kinase Cz: implications for growth arrest. J Biol Chem 2001;277:3286-3292 (Pubitemid 34953194)
21. Taghvaei NM, Meshkani R, Taghikhani M, Larijani B, Adeli K. Palmitate enhances protein tyrosine phosphatase 1B (PTP1B) gene expression at transcriptional level in C2C12 skeletal muscle cells. Inflammation 2011;34:43-48
22. Ravichandran LV, Chen H, Li Y, Quon MJ. Phosphorylation of PTP1B at Ser (50) by Akt impairs its ability to dephosphorylate the insulin receptor. Mol Endocrinol 2001;15:1768-1780 (Pubitemid 32939307)