Evidence for the existence of pyrimidinergic transmission in rat brain

Neuropharmacology

Volumn 91, Issue , 2015, Pages 77-86

  Cansev, Mehmet ^a   Orhan, Fulya ^a   Yaylagul, Esra O ^a   Isik, Esra ^a   Turkyilmaz, Mesut ^a   Aydin, Sami ^a   Gumus, Abdullah ^a   Sevinc, Cansu ^a   Coskun, Necdet ^a   Ulus, Ismail H ^b   Wurtman, Richard J ^c  

^a ULUDAG UNIVERSITY   (Turkey)

^b ACIBADEM UNIVERSITY   (Turkey)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Neurotransmission; P2Y receptors; Pyrimidinergic; UDP; Uridine; UTP

Indexed keywords

DIACYLGLYCEROL; INOSITOL TRISPHOSPHATE; MRS 2578; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG; URIDINE; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; ACETYLCHOLINE; CHOLINE; PURINERGIC P2Y RECEPTOR;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CEREBROSPINAL FLUID; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ANALYSIS; EXTRACELLULAR FLUID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VIVO STUDY; LIMIT OF DETECTION; MALE; MEMBRANE DEPOLARIZATION; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PYRIMIDINERGIC TRANSMISSION; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BRAIN CHEMISTRY; CHEMISTRY; DRUG EFFECTS; METABOLISM; SPRAGUE DAWLEY RAT;

ACETYLCHOLINE; ANIMALS; BRAIN CHEMISTRY; CHOLINE; CORPUS STRIATUM; EXTRACELLULAR FLUID; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y; URIDINE; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

EID: 84920747605     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.12.019     Document Type: Article

References (50)

1. M.P. Abbracchio, and G. Burnstock Purinergic signalling: pathophysiological roles Jpn. J. Pharmacol. 78 1998 113 145
2. M.P. Abbracchio, G. Burnstock, J.M. Boeynaems, E.A. Barnard, J.L. Boyer, C. Kennedy, G.E. Knight, M. Fumagalli, C. Gachet, K.A. Jacobson, and G.A. Weisman International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Pharmacol. Rev. 58 2006 281 341
3. 2 nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease Mol. Neurobiol. 49 2014 1031 1042
4. J.L. Albert, J.P. Boyle, J.A. Roberts, R.A. Challiss, S.E. Gubby, and M.R. Boarder Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase Br. J. Pharmacol. 122 1997 935 941
5. G. Arslan, C.M. Filipeanu, E. Irenius, B. Kull, E. Clementi, C. Allgaier, D. Erlinge, and B.B. Fredholm P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells Neuropharmacology 39 2000 482 496
6. Y. Baqi, S. Weyler, J. Iqbal, H. Zimmermann, and C.E. Müller Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) Purinergic Signal. 5 2009 91 106
7. G. Burnstock, and A. Verkhratsky Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death Cell Death Dis. 1 2010 e9
8. G. Burnstock, U. Krügel, M.P. Abbracchio, and P. Illes Purinergic signalling: from normal behaviour to pathological brain function Prog. Neurobiol. 95 2011 229 274
9. J.M. Camden, A.M. Schrader, R.E. Camden, F.A. Gonzalez, L. Erb, C.I. Seye, and G.A. Weisman P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing J. Biol. Chem. 280 2005 18696 18702
10. M. Cansev, C.J. Watkins, E.M. van der Beek, and R.J. Wurtman Oral uridine-5′-monophosphate (UMP) increases brain CDP-choline levels in gerbils Brain Res. 1058 2005 101 108
11. M. Cansev Uridine and cytidine in the brain: their transport and utilization Brain Res. Rev. 52 2006 389 397
12. M. Cansev Involvement of uridine-nucleotide-stimulated P2Y receptors in neuronal growth and function Cent. Nerv. Syst. Agents Med. Chem. 7 2007 223 229
13. M. Cansev, and R.J. Wurtman Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils Neuroscience 148 2007 421 431
14. R.L. Carter, I.P. Fricks, M.O. Barrett, L.E. Burianek, Y. Zhou, H. Ko, A. Das, K.A. Jacobson, E.R. Lazarowski, and T.K. Harden Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor Mol. Pharmacol. 76 2009 1341 1348
15. J.K. Chambers, L.E. Macdonald, H.M. Sarau, R.S. Ames, K. Freeman, J.J. Foley, Y. Zhu, M.M. McLaughlin, P. Murdock, L. McMillan, J. Trill, A. Swift, N. Aiyar, P. Taylor, L. Vawter, S. Naheed, P. Szekeres, G. Hervieu, C. Scott, J.M. Watson, A.J. Murphy, E. Duzic, C. Klein, D.J. Bergsma, S. Wilson, and G.P. Livi A G protein-coupled receptor for UDP-glucose J. Biol. Chem. 275 2000 10767 10771
16. D. Communi, S. Pirotton, M. Parmentier, and J.M. Boeynaems Cloning and functional expression of a human uridine nucleotide receptor J. Biol. Chem. 270 1995 30849 30852
17. D. Communi, M. Parmentier, and J.M. Boeynaems Cloning, functional expression and tissue distribution of the human P2Y6 receptor Biochem. Biophys. Res. Commun. 222 1996 303 308
18. B.E. Crack, C.E. Pollard, M.W. Beukers, S.M. Roberts, S.F. Hunt, A.H. Ingall, K.C. McKechnie, A.P. IJzerman, and P. Leff Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase Br. J. Pharmacol. 114 1995 475 481
19. C. Czech, P. Berndt, K. Busch, O. Schmitz, J. Wiemer, V. Most, H. Hampel, J. Kastler, and H. Senn Metabolite profiling of Alzheimer's disease cerebrospinal fluid PLoS One 7 2012 e31501
20. D. Davalos, J. Grutzendler, G. Yang, J.V. Kim, Y. Zuo, S. Jung, D.R. Littman, M.L. Dustin, and W.B. Gan ATP mediates rapid microglial response to local brain injury in vivo Nat. Neurosci. 8 2005 752 758
21. A. Dobolyi, A. Reichart, T. Szikra, N. Szilágyi, A.K. Kékesi, T. Karancsi, P. Slégel, M. Palkovits, and G. Juhász Analysis of purine and pyrimidine bases, nucleosides and deoxynucleosides in brain microsamples (microdialysates and micropunches) and cerebrospinal fluid Neurochem. Int. 32 1998 247 256
22. A. Dobolyi, A. Reichart, T. Szikra, G. Nyitrai, K.A. Kékesi, and G. Juhász Sustained depolarisation induces changes in the extracellular concentrations of purine and pyrimidine nucleosides in the rat thalamus Neurochem. Int. 37 2000 71 79
23. E. van Duuren, G. van der Plasse, R. van der Blom, R.N. Joosten, A.B. Mulder, C.M. Pennartz, and M.G. Feenstra Pharmacological manipulation of neuronal ensemble activity by reverse microdialysis in freely moving rats: a comparative study of the effects of tetrodotoxin, lidocaine, and muscimol J. Pharmacol. Exp. Ther. 323 2007 61 69
24. T. Gasser, J.D. Moyer, and R.E. Handschumacher Novel single-pass exchange of circulating uridine in rat liver Science 213 1981 777 778
25. E.P. Kennedy, and S.B. Weiss The function of cytidine coenzymes in the biosynthesis of phospholipides J. Biol. Chem. 222 1956 193 214
26. M. Kinoshita, K. Nasu-Tada, K. Fujishita, K. Sato, and S. Koizumi Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s) Cell Mol. Neurobiol. 33 2013 47 58
27. M.K. Lai, M.G. Tan, S. Kirvell, C. Hobbs, J. Lee, M.M. Esiri, C.P. Chen, and P.T. Francis Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology J. Neural Transm. 115 2008 1165 1172
28. U. Lalo, O. Palygin, S. Rasooli-Nejad, J. Andrew, P.G. Haydon, and Y. Pankratov Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex PLoS Biol. 12 2014 e1001747
29. E.R. Lazarowski, L. Homolya, R.C. Boucher, and T.K. Harden Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation J. Biol. Chem. 272 1997 24348 24354
30. E.R. Lazarowski, and T.K. Harden Quantitation of extracellular UTP using a sensitive enzymatic assay Br. J. Pharmacol. 127 1999 1272 1278
31. D. Lecca, and S. Ceruti Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation Biochem. Pharmacol. 75 2008 1869 1881
32. C.H. Lee, and P.C. Ruben Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin Channels (Austin) 2 2008 407 412
33. S.A. Lévesque, E.G. Lavoie, J. Lecka, F. Bigonnesse, and J. Sévigny Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases Br. J. Pharmacol. 152 2007 141 150
34. S. Lorenzl, D.S. Albers, N. Relkin, T. Ngyuen, S.L. Hilgenberg, J. Chirichigno, M.E. Cudkowicz, and M.F. Beal Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease Neurochem. Int. 43 2003 191 196
35. K.D. Lustig, A.K. Shiau, A.J. Brake, and D. Julius Expression cloning of an ATP receptor from mouse neuroblastoma cells Proc. Natl. Acad. Sci. U. S. A. 90 1993 5113 5117
36. S.K. Mishra, N. Braun, V. Shukla, M. Füllgrabe, C. Schomerus, H.W. Korf, C. Gachet, Y. Ikehara, J. Sévigny, S.C. Robson, and H. Zimmermann Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation Development 133 2006 675 684
37. R.A. Nicholas, W.C. Watt, E.R. Lazarowski, Q. Li, and K. Harden Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor Mol. Pharmacol. 50 1996 224 229
38. Y. Pankratov, U. Lalo, A. Verkhratsky, and R.A. North Quantal release of ATP in mouse cortex J. Gen. Physiol. 129 2007 257 265
39. A.M. Pooler, D.H. Guez, R. Benedictus, and R.J. Wurtman Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected] Neuroscience 134 2005 207 214
40. G.D. Price, S.J. Robertson, and F.A. Edwards Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus Eur. J. Neurosci. 17 2003 844 850
41. T. Sakamoto, M. Cansev, and R.J. Wurtman Oral supplementation with docosahexaenoic acid and uridine-5′-monophosphate increases dendritic spine density in adult gerbil hippocampus Brain Res. 1182 2007 50 59
42. I.H. Ulus, C.J. Watkins, M. Cansev, and R.J. Wurtman Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release Cell Mol. Neurobiol. 26 2006 563 577
43. M. Wang, Q. Kong, F.A. Gonzalez, G. Sun, L. Erb, C. Seye, and G.A. Weisman P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration J. Neurochem. 95 2005 630 640
44. G.A. Weisman, D. Ajit, R. Garrad, T.S. Peterson, L.T. Woods, C. Thebeau, J.M. Camden, and L. Erb Neuroprotective roles of the P2Y(2) receptor Purinergic Signal. 8 2012 559 578
45. B.H. Westerink Analysis of biogenic amines in microdialysates of the brain J. Chromatogr. B Biomed. Sci. Appl. 747 2000 21 32
46. F. Wiegand, W. Liao, C. Busch, S. Castell, F. Knapp, U. Lindauer, D. Megow, A. Meisel, A. Redetzky, K. Ruscher, G. Trendelenburg, I. Victorov, M. Riepe, H.C. Diener, and U. Dirnagl Respiratory chain inhibition induces tolerance to focal cerebral ischemia J. Cereb. Blood Flow Metab. 19 1999 1229 1237
47. R.J. Wurtman, M. Regan, I. Ulus, and L. Yu Effect of oral CDP-choline on plasma choline and uridine levels in humans Biochem. Pharmacol. 60 2000 989 992
48. R.J. Wurtman, I.H. Ulus, M. Cansev, C.J. Watkins, L. Wang, and G. Marzloff Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally Brain Res. 1088 2006 83 92
49. H. Zimmermann Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system Prog. Neurobiol. 49 1996 589 618
50. H. Zimmermann Nucleotide signaling in nervous system development Pflugers Arch. 452 2006 573 588