In vivo delivery of siRNA to the brain by carbosilane dendrimer

Journal of Controlled Release

Volumn 200, Issue , 2015, Pages 60-70

  Serramía, Ma Jesús ^a,b,c   Álvarez, Susana ^a,b,c   Fuentes Paniagua, Elena ^c,d   Clemente, Maria Isabel ^a,c   Sánchez Nieves, Javier ^c,d   Gómez, Rafael ^c,d   De La Mata, Javier ^c,d   Muñoz Fernández, Ma Ángeles ^a,c  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Blood brain barrier; Brain; Carbosilane dendrimer; Central nervous system; HIV infection; siRNA delivery

Indexed keywords

BLOOD; BRAIN; CYTOTOXICITY; DENDRIMERS; MAMMALS; NEUROPHYSIOLOGY;

BLOOD-BRAIN BARRIER; CARBOSILANE DENDRIMER; CENTRAL NERVOUS SYSTEMS; HIV INFECTION; SIRNA DELIVERY;

DISEASES;

DENDRIMER; FLUORESCEIN ISOTHIOCYANATE; NEF PROTEIN; RIBONUCLEASE; SILANE DERIVATIVE; SMALL INTERFERING RNA; CARBOSILANE; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG DELIVERY SYSTEM; ELECTROPHORETIC MOBILITY; ENZYME DEGRADATION; EX VIVO STUDY; FLOW CYTOMETRY; FLUORESCENCE IMAGING SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; ULTRAVIOLET IRRADIATION; VALIDATION STUDY; VIRUS INFECTIVITY; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL LINE; CHEMISTRY; GENETICS; METABOLISM;

ANIMALS; ASTROCYTES; CELL LINE; CELLS, CULTURED; DENDRIMERS; HUMANS; MICE, INBRED BALB C; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RNA, SMALL INTERFERING; SILANES;

EID: 84920742523     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.12.042     Document Type: Article

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