Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors

Journal of Neuro-Oncology

Volumn 95, Issue 3, 2009, Pages 355-365

  Yang, Weilian ^a   Barth, Rolf F ^a   Wu, Gong ^a   Huo, Tianyao ^a   Tjarks, Werner ^a   Ciesielski, Michael ^b   Fenstermaker, Robert A ^b   Ross, Brain D ^c   Wikstrand, Carol J ^d,f   Riley, Kent J ^e,h   Binns, Peter J ^e,g  

^a OHIO STATE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d Saba University   (Netherlands Antilles)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g MOUNT AUBURN HOSPITAL   (United States)

^h RADIATION MONITORING DEVICES INC   (United States)

Author keywords

Boron neutron capture therapy; Boronated EGF; Convection enhanced delivery; F98 rat glioma

Indexed keywords

4 BORONOPHENYLALANINE; BORON; BORONATED DENDRIMER EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IODINE 125; POLYAMIDOAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER TRANSPLANTATION; CLINICAL STUDY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOSIMETRY; DRUG EFFICACY; GENETIC TRANSFECTION; GLIOMA; GLIOMA CELL; HEMISPHERE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NEUTRON CAPTURE THERAPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; TUMOR GROWTH;

ANIMALS; BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; BRAIN NEOPLASMS; CELL LINE, TUMOR; CONVECTION; DRUG DELIVERY SYSTEMS; EPIDERMAL GROWTH FACTOR; GLIOMA; IODINE RADIOISOTOPES; KAPLAN-MEIERS ESTIMATE; MAGNETIC RESONANCE IMAGING; NEOPLASM TRANSPLANTATION; POLYAMINES; PROPORTIONAL HAZARDS MODELS; RADIOMETRY; RATS; RATS, INBRED F344; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFECTION;

EID: 70450235185     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-9945-x     Document Type: Article

References (57)

1. AW Burgess 2008 EGFR family: structure physiology signalling and therapeutic targets Growth Factors 26 263 274 10.1080/08977190802312844 18800267
2. G Sauter T Maeda FM Waldman RL Davis BG Feuerstein 1996 Patterns of epidermal growth factor receptor amplification in malignant gliomas Am J Pathol 148 1047 1053 8644846
3. RF Barth W Yang DM Adams JH Rotaru S Shukla M Sekido W Tjarks RA Fenstermaker M Ciesielski MM Nawrocky JA Coderre 2002 Molecular targeting of the epidermal growth factor receptor for neutron capture therapy of gliomas Cancer Res 62 3159 3166 12036929 (Pubitemid 34602409)
4. W Yang RF Barth DM Adams MJ Ciesielski RA Fenstermaker S Shukla W Tjarks MA Caligiuri 2002 Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas Cancer Res 62 6552 6558 12438250 (Pubitemid 35364121)
5. W Yang RF Barth G Wu AK Bandyopadhyaya BT Thirumamagal W Tjarks PJ Binns K Riley H Patel JA Coderre MJ Ciesielski RA Fenstermaker 2004 Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas Appl Radiat Isot 61 981 985 10.1016/j.apradiso.2004. 05.071 15308179 (Pubitemid 39092651)
6. RF Barth G Wu W Yang PJ Binns KJ Riley H Patel JA Coderre W Tjarks AK Bandyopadhyaya BT Thirumamagal MJ Ciesielski RA Fenstermaker 2004 Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent Appl Radiat Isot 61 899 903 10.1016/j.apradiso. 2004.05.004 15308165 (Pubitemid 39092637)
7. G Wu W Yang RF Barth S Kawabata M Swindall AK Bandyopadhyaya W Tjarks B Khorsandi TE Blue AK Ferketich M Yang GA Christoforidis TJ Sferra PJ Binns KJ Riley MJ Ciesielski RA Fenstermaker 2007 Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated cetuximab Clin Cancer Res 13 1260 1268 10.1158/1078-0432.CCR-06-2399 17317838 (Pubitemid 46437053)
8. W Yang RF Barth G Wu S Kawabata TJ Sferra AK Bandyopadhyaya W Tjarks AK Ferketich ML Moeschberger PJ Binns KJ Riley JA Coderre MJ Ciesielski RA Fenstermaker CJ Wikstrand 2006 Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4 Clin Cancer Res 12 3792 3802 10.1158/1078-0432.CCR-06-0141 16778107 (Pubitemid 44000261)
9. W Yang G Wu RF Barth MR Swindall AK Bandyopadhyaya W Tjarks K Tordoff M Moeschberger TJ Sferra PJ Binns KJ Riley MJ Ciesielski RA Fenstermaker CJ Wikstrand 2008 Molecular targeting and treatment of composite EGFR and EGFRvIII-positive gliomas using boronated monoclonal antibodies Clin Cancer Res 14 883 891 10.1158/1078-0432.CCR-07-1968 18245552 (Pubitemid 351231173)
10. RF Barth JA Coderre MG Vicente TE Blue 2005 Boron neutron capture therapy of cancer: current status and future prospects Clin Cancer Res 11 3987 4002 10.1158/1078-0432.CCR-05-0035 15930333 (Pubitemid 40791562)
11. RF Barth 2009 Boron neutron capture therapy at the crossroads: challenges and opportunities Appl Radiat Isot 67 S3 S6 10.1016/j.apradiso.2009.03.102 10.1016/j.apradiso.2009.03.102 19467879
12. Vicente MGH (ed) (2006) Boron in medicinal chemistry. Anti-Cancer Agents in Med Chem 6: 73-181
13. S Altieri RF Barth S Bortolussi A Zonta 2009 Thirteenth International Congress on Neutron Capture Therapy Appl Radiat Isot 67 S1 S2 10.1016/j.apradiso.2009.03.009 19395267
14. PF Morrison MY Chen RS Chadwick RR Lonser EH Oldfield 1999 Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics Am J Physiol 277 R1218 1229 10516265
15. DR Groothuis 2000 The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery Neuro Oncol 2 45 59 10.1215/15228517-2- 1-45 11302254
16. Y Mardor O Rahav Y Zauberman Z Lidar A Ocherashvilli D Daniels Y Roth SE Maier A Orenstein Z Ram 2005 Convection-enhanced drug delivery: increased efficacy and magnetic resonance image monitoring Cancer Res 65 6858 6863 10.1158/0008-5472.CAN-05-0161 16061669 (Pubitemid 41065083)
17. UW Thomale B Tyler V Renard B Dorfman VP Chacko BS Carson EJ Haberl GI Jallo 2009 Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model Childs Nerv Syst 25 433 441 10.1007/s00381-008-0767-5 19082613
18. S Ferguson MS Lesniak 2007 Convection enhanced drug delivery of novel therapeutic agents to malignant brain tumors Curr Drug Deliv 4 169 180 10.2174/156720107780362302 17456036 (Pubitemid 46557493)
19. KA Lopez AE Waziri PD Canoll JN Bruce 2006 Convection-enhanced delivery in the treatment of malignant glioma Neurol Res 28 542 548 10.1179/ 016164106X116836 16808887 (Pubitemid 44141325)
20. JH Sampson G Akabani GE Archer MS Berger RE Coleman AH Friedman HS Friedman K Greer JE Herndon II S Kunwar RE McLendon A Paolino NA Petry JM Provenzale DA Reardon TZ Wong MR Zalutsky I Pastan DD Bigner 2008 Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors Neuro Oncol 10 320 329 10.1215/15228517-2008-012 18403491
21. Barth RF, Kaur B (2009) Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas. J Neurooncol
22. CJ Wikstrand RE McLendon AH Friedman DD Bigner 1997 Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII Cancer Res 57 4130 4140 9307304
23. CJ Wikstrand LP Hale SK Batra ML Hill PA Humphrey SN Kurpad RE McLendon D Moscatello CN Pegram CJ Reist, et al. 1995 Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas Cancer Res 55 3140 3148 7606735
24. W Yang RF Barth DE Carpenter ML Moeschberger JH Goodman 1996 Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption Neurosurgery 38 985 992 10.1097/00006123-199605000-00027 8727825 (Pubitemid 26127584)
25. BD Ross YJ Zhao ER Neal LD Stegman M Ercolani O Ben-Yoseph TL Chenevert 1998 Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: an MRI study Proc Natl Acad Sci U S A 95 7012 7017 10.1073/pnas.95.12.7012 9618530 (Pubitemid 28278098)
26. W Yang RF Barth G Wu MJ Ciesielski RA Fenstermaker BA Moffat BD Ross CJ Wikstrand 2005 Development of a syngeneic rat brain tumor model expressing EGFRvIII and its use for molecular targeting studies with monoclonal antibody L8A4 Clin Cancer Res 11 341 350 15671565
27. RF Barth W Yang JH Rotaru ML Moeschberger DD Joel MM Nawrocky JH Goodman AH Soloway 1997 Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption Cancer Res 57 1129 1136 9067283 (Pubitemid 27138613)
28. G Wu RF Barth W Yang M Chatterjee W Tjarks MJ Ciesielski RA Fenstermaker 2004 Site-specific conjugation of boron-containing dendrimers to anti-EGF receptor monoclonal antibody cetuximab (IMC-C225) and its evaluation as a potential delivery agent for neutron capture therapy Bioconjug Chem 15 185 194 10.1021/bc0341674 14733599 (Pubitemid 38165994)
29. RF Barth DM Adams AH Soloway EB Mechetner F Alam AKM Anisuzzaman 1991 Determination of boron in tissues and cells using direct-current plasma atomic emission spectroscopy Anal Chem 63 890 893 10.1021/ac00009a010 1858981
30. RD Rogus OK Harling JC Yanch 1994 Mixed field dosimetry of epithermal neutron beams for boron neutron capture therapy at the MITR-II research reactor Med Phys 21 1611 1625 10.1118/1.597267 7869994 (Pubitemid 24328891)
31. Madsen RW, Moeschberger ML (1986) Statistical concepts. Prentice-Hall, Englewood Cliffs, New Jersey
32. Klein JP, Moeschberger ML (2003) Survival analysis techniques for censored and truncated data, 2nd edn. Springer, New York
33. NR Clendenon RF Barth WA Gordon JH Goodman F Alam AE Staubus CP Boesel AJ Yates ML Moeschberger RG Fairchild, et al. 1990 Boron neutron capture therapy of a rat glioma Neurosurgery 26 47 55 10.1097/00006123-199001000-00007 2294479
34. RF Barth W Yang JA Coderre 2003 Rat brain tumor models to assess the efficacy of boron neutron capture therapy: a critical evaluation J Neurooncol 62 61 74 12749703
35. J Capala RF Barth M Bendayan M Lauzon DM Adams AH Soloway RA Fenstermaker J Carlsson 1996 Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors Bioconjug Chem 7 7 15 10.1021/bc950077q 8741985 (Pubitemid 2617056)
36. M Kawakami K Kawakami RK Puri 2003 Interleukin-4-Pseudomonas exotoxin chimeric fusion protein for malignant glioma therapy J Neurooncol 65 15 25 10.1023/A:1026294416718 14649882 (Pubitemid 37441311)
37. R Raghavan ML Brady MI Rodriguez-Ponce A Hartlep C Pedain JH Sampson 2006 Convection-enhanced delivery of therapeutics for brain disease, and its optimization Neurosurg Focus 20 12 10.3171/foc.2006.20.4.7
38. JH Sampson R Raghavan ML Brady JM Provenzale JE Herndon II D Croteau AH Friedman DA Reardon RE Coleman T Wong DD Bigner I Pastan MI Rodriguez-Ponce P Tanner R Puri C Pedain 2007 Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions Neuro Oncol 9 343 353 10.1215/15228517-2007-007 17435179 (Pubitemid 47179574)
39. RK Jain 2001 Delivery of molecular and cellular medicine to solid tumors Adv Drug Deliv Rev 46 149 168 10.1016/S0169-409X(00)00131-9 11259838
40. Y Boucher H Salehi B Witwer Harsh GRt RK Jain 1997 Interstitial fluid pressure in intracranial tumours in patients and in rodents Br J Cancer 75 829 836 9062403
41. M Stohrer Y Boucher M Stangassinger RK Jain 2000 Oncotic pressure in solid tumors is elevated Cancer Res 60 4251 4255 10945638
42. PF Morrison DW Laske H Bobo EH Oldfield RL Dedrick 1994 High-flow microinfusion: tissue penetration and pharmacodynamics Am J Physiol 266 R292 305 8304553
43. RA Kroll MA Pagel LL Muldoon S Roman-Goldstein EA Neuwelt 1996 Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor Neurosurgery 38 746 752 10.1097/00006123-199604000-00024 8692395 discussion 752-744
44. T Faillot H Magdelenat E Mady P Stasiecki D Fohanno P Gropp M Poisson JY Delattre 1996 A phase I study of an anti-epidermal growth factor receptor monoclonal antibody for the treatment of malignant gliomas Neurosurgery 39 478 483 10.1097/00006123-199609000-00009 8875477 (Pubitemid 26292020)
45. W Yang RF Barth R Leveille DM Adams M Ciesielski RA Fenstermaker J Capala 2001 Evaluation of systemically administered radiolabeled epidermal growth factor as a brain tumor targeting agent J Neurooncol 55 19 28 10.1023/A:1013017821166 11804279 (Pubitemid 34023622)
46. L Gedda P Olsson J Ponten J Carlsson 1996 Development and in vitro studies of epidermal growth factor-dextran conjugates for boron neutron capture therapy Bioconjug Chem 7 584 591 10.1021/bc9600473 8889021 (Pubitemid 26369623)
47. LW Brady C Miyamoto DV Woo M Rackover J Emrich H Bender S Dadparvar Z Steplewski H Koprowski P Black, et al. 1992 Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: a phase II trial Int J Radiat Oncol Biol Phys 22 225 230 1309204
48. HP Kalofonos TR Pawlikowska A Hemingway N Courtenay-Luck B Dhokia D Snook GB Sivolapenko GR Hooker CG McKenzie PJ Lavender, et al. 1989 Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase J Nucl Med 30 1636 1645 2795204
49. SH Bigner PA Humphrey AJ Wong B Vogelstein J Mark HS Friedman DD Bigner 1990 Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts Cancer Res 50 8017 8022 2253244
50. W Yang RF Barth G Wu W Tjarks P Binns K Riley 2009 Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents Appl Radiat Isot 67 S328 S331 10.1016/j.apradiso.2009.03.030 19467880
51. M Baumann M Krause 2004 Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results Radiother Oncol 72 257 266 10.1016/j.radonc.2004.07.007 15450723 (Pubitemid 39265378)
52. Kato I, Fujita Y, Maruhashi A et al. (2009) Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies. Appl Radiat Isot (in press)
53. M Mrhalova J Plzak J Betka R Kodet 2005 Epidermal growth factor receptor - its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas Neoplasma 52 338 343 16059652
54. JA Bonner PM Harari J Giralt N Azarnia DM Shin RB Cohen CU Jones R Sur D Raben J Jassem R Ove MS Kies J Baselga H Youssoufian N Amellal EK Rowinsky KK Ang 2006 Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 567 578 10.1056/NEJMoa053422 16467544 (Pubitemid 43209104)
55. AF Sobrero J Maurel L Fehrenbacher W Scheithauer YA Abubakr MP Lutz ME Vega-Villegas C Eng EU Steinhauer J Prausova HJ Lenz C Borg G Middleton H Kroning G Luppi O Kisker A Zubel C Langer J Kopit HA Burris III 2008 EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer J Clin Oncol 26 2311 2319 10.1200/JCO.2007.13.1193 18390971
56. D Cunningham Y Humblet S Siena D Khayat H Bleiberg A Santoro D Bets M Mueser A Harstrick C Verslype I Chau E Van Cutsem 2004 Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer N Engl J Med 351 337 345 10.1056/NEJMoa033025 15269313 (Pubitemid 38944402)
57. Y Kimura Y Ariyoshi M Shimahara S Miyatake S Kawabata K Ono M Suzuki A Maruhashi 2009 Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node Appl Radiat Isot 67 S47 S49 10.1016/j.apradiso.2009.03.019 19395269