Synergistic effects of carboxymethyl-hexanoyl chitosan, cationic polyurethane-short branch PEI in miR122 gene delivery: Accelerated differentiation of iPSCs into mature hepatocyte-like cells and improved stem cell therapy in a hepatic failure model

Acta Biomaterialia

Volumn 13, Issue , 2015, Pages 228-244

  Chien, Yueh ^a,d   Chang, Yuh Lih ^a,d   Li, Hsin Yang ^a,d   Larsson, Mikael ^b   Wu, Wai Wah ^a,c   Chien, Chian Shiu ^a,d   Wang, Chien Ying ^a,d   Chu, Pen Yuan ^a,d   Chen, Kuan Hsuan ^a,d   Lo, Wen Liang ^a,d   Chiou, Shih Hwa ^a,d   Lan, Yuan Tzu ^a,d   Huo, Teh Ia ^a,d   Lee, Shou Dong ^c   Huang, Pin I ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Acute hepatic failure; Induced pluripotent stem cells; miR122; Nano structured chitosan

Indexed keywords

CHITOSAN; GENE THERAPY; GENE TRANSFER; POLYURETHANES; RNA; STEM CELLS;

ACUTE HEPATIC FAILURE; CARBOXYMETHYL; DENTAL PULP; HEPATOCYTES; HEXANOYL CHITOSAN; IN-VIVO; INDUCED PLURIPOTENT STEM CELLS; MICRORNA122; NANO STRUCTURED CHITOSAN; NANO-STRUCTURED;

CYTOLOGY;

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALBUMIN; ALPHA2 INTEGRIN; ALPHA6 INTEGRIN; AMPHOPHILE; BETA1 INTEGRIN; CHITOSAN; COPOLYMER; ENDOGLIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HERMES ANTIGEN; LACTATE DEHYDROGENASE; MICRORNA 122; NANOMATERIAL; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATE BUFFERED SALINE; POLYETHYLENEIMINE; POLYURETHAN; PREALBUMIN; PROTEIN; STAGE SPECIFIC EMBRYO ANTIGEN 3; STAGE SPECIFIC EMBRYO ANTIGEN 4; THY 1 ANTIGEN; TRA1 60 PROTEIN; TRA1 81 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX17; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; CARBOXYMETHYL-HEXANOYL CHITOSAN; MICRORNA; MIRN122 MICRORNA, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DYNAMIC LIGHT SCATTERING; EMBRYO; EMBRYOID BODY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FULMINANT HEPATIC FAILURE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GLYCOGEN SYNTHESIS; GRAFT RECIPIENT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIGHT SCATTERING; LIVER CELL; LIVER FUNCTION; MALE; MICROARRAY ANALYSIS; MOUSE; MTT ASSAY; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION; SURVIVAL; TOOTH PULP; UPREGULATION; UPTAKE ASSAY; WESTERN BLOTTING; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECTS; GENE TRANSFER; GENETICS; LIVER FAILURE; METABOLISM; NUDE MOUSE; PATHOLOGY; TRANSPLANTATION; XENOGRAFT;

ANIMALS; CELL DIFFERENTIATION; CHITOSAN; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; HEPATOCYTES; HETEROGRAFTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LIVER FAILURE; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; POLYURETHANES;

EID: 84920724975     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.11.018     Document Type: Article

References (33)

1. M.J. Tunon, M. Alvarez, J.M. Culebras, and J. Gonzalez-Gallego An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure World J Gastroenterol 15 2009 3086 3098
2. W.M. Lee Acute liver failure N Engl J Med 329 1993 1862 1872
3. A. Nussler, S. Konig, M. Ott, E. Sokal, B. Christ, and W. Thasler Present status and perspectives of cell-based therapies for liver diseases J Hepatol 45 2006 144 159
4. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, and K. Tomoda Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
5. M. Nakagawa, M. Koyanagi, K. Tanabe, K. Takahashi, T. Ichisaka, and T. Aoi Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nat Biotechnol 26 2008 101 106
6. Y.F. Chen, C.Y. Tseng, H.W. Wang, H.C. Kuo, V.W. Yang, and O.K. Lee Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol Hepatology 55 2012 1193 1203
7. S.T. Rashid, S. Corbineau, N. Hannan, S.J. Marciniak, E. Miranda, and G. Alexander Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells J Clin Invest 120 2010 3127 3136
8. B. Zhang, Q. Wang, and X. Pan MicroRNAs and their regulatory roles in animals and plants J Cell Physiol 210 2007 279 289
9. A.M. Lakner, H.L. Bonkovsky, and L.W. Schrum MicroRNAs: fad or future of liver disease World J Gastroenterol 17 2011 2536 2542
10. O. Cheung, P. Puri, C. Eicken, M.J. Contos, F. Mirshahi, and J.W. Maher Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression Hepatology 48 2008 1810 1820
11. R.R. Xu, C.W. Zhang, Y. Cao, and Q. Wang mir122 deficiency inhibits differentiation of zebrafish hepatoblast into hepatocyte Yi Chuan 35 2013 488 494
12. R. Doddapaneni, Y.K. Chawla, A. Das, J.K. Kalra, S. Ghosh, and A. Chakraborti Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells J Cell Biochem 114 2013 1575 1583
13. N. Davoodian, A.S. Lotfi, M. Soleimani, and S.J. Mowla MicroRNA-122 overexpression promotes hepatic differentiation of human adipose tissue-derived stem cells J Cell Biochem 115 2014 1582 1593
14. X.G. Deng, R.L. Qiu, Y.H. Wu, Z.X. Li, P. Xie, and J. Zhang Overexpression of miR-122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR-122/FoxA1/HNF4a-positive feedback loop Liver Int 34 2013 281 295
15. M. Larsson, W.C. Huang, M.H. Hsiao, Y.J. Wang, M. Nydén, and S.H. Chiou Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids Prog Polym Sci 38 2013 1307 1328
16. J.M. Yu, Y.J. Li, L.Y. Qiu, and Y. Jin Polymeric nanoparticles of cholesterol-modified glycol chitosan for doxorubicin delivery: preparation and in vitro and in vivo characterization J Pharm Pharmacol 61 2009 713 719
17. Y.H. Jin, H.Y. Hu, M.X. Qiao, J. Zhu, J.W. Qi, and C.J. Hu PH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation Colloids Surf, B 94 2012 184 191
18. Y.J. Wang, Y.C. Chien, C.H. Wu, and D.M. Liu Magnolol-loaded core-shell hydrogel nanoparticles: drug release, intracellular uptake, and controlled cytotoxicity for the inhibition of migration of vascular smooth muscle cells Mol Pharm 8 2011 2339 2349
19. Y.J. Wang, H.Y. Lin, C.H. Wu, and D.M. Liu Forming of demethoxycurcumin nanocrystallite-chitosan nanocarrier for controlled low dose cellular release for inhibition of the migration of vascular smooth muscle cells Mol Pharm 6 2012 2268 2279
20. S.C. Chapin, and P.S. Doyle Ultrasensitive multiplexed microRNA quantification on encoded gel microparticles using rolling circle amplification Anal Chem 83 2011 7179 7185
21. Y. Li, L. Fan, S. Liu, W. Liu, H. Zhang, and T. Zhou The promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a Biomaterials 34 2013 5048 5058
22. G.Y. Chiou, J.Y. Cherng, H.S. Hsu, M.L. Wang, C.M. Tsai, and K.H. Lu Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma J Controlled Release 159 2012 240 250
23. Y.P. Yang, Y. Chien, G.Y. Chiou, J.Y. Cherng, M.L. Wang, and W.L. Lo Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI Biomaterials 33 2012 1462 1476
24. Y. Chien, Y.W. Liao, D.M. Liu, H.L. Lin, S.J. Chen, and H.L. Chen Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel Biomaterials 33 2012 8003 8016
25. L. Lapasset, O. Milhavet, A. Prieur, E. Besnard, A. Babled, and N. Ait-Hamou Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state Genes Dev 25 2011 2248 2253
26. T. Lin, R. Ambasudhan, X. Yuan, W. Li, S. Hilcove, and R. Abujarour A chemical platform for improved induction of human iPSCs Nat Methods 6 2009 805 808
27. Z. Song, J. Cai, Y. Liu, D. Zhao, J. Yong, and S. Duo Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells Cell Res 19 2009 1233 1242
28. C.H. Peng, J.Y. Cherng, G.Y. Chiou, Y.C. Chen, C.H. Chien, and C.L. Kao Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium Biomaterials 32 2010 9077 9088
29. T.Y. Liu, S.Y. Chen, Y.L. Lin, and D.M. Liu Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation Langmuir 22 2006 9740 9745
30. R.D. Hughes, R.R. Mitry, and A. Dhawan Current status of hepatocyte transplantation Transplantation 93 2012 342 347
31. W. Chen, P.H. Tsai, Y. Hung, S.H. Chiou, and C.Y. Mou Nonviral cell labeling and differentiation agent for induced pluripotent stem cells based on mesoporous silica nanoparticles ACS Nano 7 2013 8423 8440
32. X. Ding, J. Ding, J. Ning, F. Yi, J. Chen, and D. Zhao Circulating microRNA-122 as a potential biomarker for liver injury Mol Med Rep 5 2012 1428 1432
33. C.J. Pirola, T.F. Gianotti, G.O. Castano, and S. Sookoian Circulating MicroRNA-122 signature in nonalcoholic fatty liver disease and cardiovascular disease: a new endocrine system in metabolic syndrome Hepatology 57 2013 2545 2547