Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 3, 2015, Pages 642-648

  Matos, Maria João ^a   Rodríguez Enríquez, Fernanda ^a   Vilar, Santiago ^a,b   Santana, Lourdes ^a   Uriarte, Eugenio ^a   Hripcsak, George ^b   Estrada, Martín ^c   Rodríguez Franco, María Isabel ^c   Viña, Dolores ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Department of Medicine   (United States)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

3 Arylcoumarins; ADME theoretical properties; Docking studies; Monoamine oxidase inhibitors; PAMPA assay; Perkin reaction

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B INHIBITOR; COUMARIN DERIVATIVE; ENZYME INHIBITOR; MOCLOBEMIDE; NITRO DERIVATIVE; SELEGILINE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); ISOPROTEIN; MONOAMINE OXIDASE INHIBITOR; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION STUDY; IC50; MOLECULAR DOCKING; NONHUMAN; PHYSICAL CHEMISTRY; THEORETICAL STUDY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COUMARINS; HUMANS; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SELEGILINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920723212     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.12.001     Document Type: Article

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