Molecular organization of axo-glial junctions

Current Opinion in Neurobiology

Volumn 13, Issue 5, 2003, Pages 552-559

  Bhat, Manzoor A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; ION CHANNEL;

CELL ADHESION; CELL INTERACTION; DROSOPHILA; GENETICS; GLIA CELL; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MYELINATED NERVE; NERVE FIBER; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; REVIEW; VERTEBRATE;

EID: 0242487890     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2003.09.004     Document Type: Review

References (41)

1. Peles E., Salzer J.L. Molecular domains of myelinated axons. Curr. Opin. Neurobiol. 10:2000;558-565.
2. Pedraza L., Huang J.K., Colman D.R. Organizing principles of the axoglial apparatus. Neuron. 30:2001;335-344 This study provides some novel insights into how axo-glial junctions might be involved into the organization of various domains in the myelinated fibers.
3. Scherer S.S., Arroyo E.J. Recent progress on the molecular organization of myelinated axons. J. Peripher. Nerv. Syst. 7:2002;1-12 This study reviews the various anatomical and molecular aspects of the axon-glial interactions, and diagrammatically illustrates the composition and location of various proteins in their respective domains.
4. Spiegel I., Peles E. Cellular junctions of myelinated nerves. Mol. Memb. Biol. 19:2002;95-101 This review provides a general description of various homotypic and heterotypic cell junction components in the myelinated fibers in view of the latest findings.
5. Girault J.A., Peles E. Development of nodes of Ranvier. Curr. Opin. Neurobiol. 12:2002;476-485 This review summarizes the latest data on the formation of various domains in the myelinated fibers by focusing on the biogenesis of the node of Ranvier.
6. Vabnick I., Shrager P. The clustering of axonal sodium channels during development of the peripheral nervous system. J. Neurosci. 16:1996;4914-4922.
7. Kaplan M.R., Meyer-Franke A., Lambert S., Bennett V., Duncan I.D., Levinson S.R., Barres B.A. Induction of sodium channel clustering by oligodendrocytes. Nature. 386:1997;724-728.
8. Rosenbluth J: Glial membranes and axoglial junctions. In Neuroglia. Edited by Kettenmann, Ransom BR. New York: Oxford University Press; 1995:613-633.
9. Baumgartner S., Littleton J.T., Broadie K., Bhat M.A., Harbecke R., Lengyel J.A., Chiquet-Ehrisman R., Prokop A., Bellen H.J. A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell. 87:1996;1059-1068.
10. Bellen H.J., Lu Y., Beckstead R., Bhat M.A. Neurexin IV, caspr and paranodin - novel members of the neurexin family: encounters of axons and glia. Trends Neurosci. 21:1998;444-449.
11. Coetzee T., Fujita N., Dupree J., Shi R., Blight A., Suzuki K., Suzuki K., Popko B. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell. 86:1996;209-219.
12. Dupree J.L., Girault J.A., Popko B. Axo-glial interactions regulate the localization of axonal paranodal proteins. J. Cell Biol. 147:1999;1145-1152.
13. Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J. Identification of a novel contactin associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J. 16:1997;978-988.
14. Menegoz M., Gaspar P., Le Bert M., Galvez T., Burgaya F., Palfrey C., Ezan P., Arnos F., Girault J.A. Paranodin, a glycoprotein of neuronal paranodal membranes. Neuron. 19:1997;319-331.
15. Einheber S., Zanazzi G., Ching W., Scherer S., Milner T.A., Peles E., Salzer J.L. The axonal membrane protein Caspr/neurexin IV is a component of the septate-like paranodal junctions that assemble during myelination. J. Cell Biol. 139:1997;1495-1506.
16. + channels to the juxtaparanodal region.
17. Boyle M.E., Berglund E.O., Murai K.K., Weber L., Peles E., Ranscht B. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron. 30:2001;385-397 This study demonstrates a functional association of contactin and Caspr/paranodin in vivo. In contactin mutant mice, Caspr/paranodin is absent from axons and paranodes and is retained in neuronal cell bodies, highlighting the importance of their interaction for proper targeting in vivo. The ultrastructural and functional phenotype of contactin mutant mice in central and peripheral neuronal fibers is similar to that of NCP1 knockout mice.
18. Charles P., Tait S., Faivre-Sarrailh C., Barbin G., Gunn-Moore F., Denisenko-Nehrbass N., Guennoc A.M., Girault J.A., Brophy P.J., Lubetzki C. Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction. Curr. Biol. 12:2002;217-220 Using cell biological and biochemical methods, this study shows that NF155 associates with the Caspr/paranodin and contactin complex. Furthermore, addition of a soluble form of NF155 protein to co-cultures of neurons and oligodendrocytes inhibited myelination, which suggests that NF155 may have some function in the process of myelination.
19. Honke K., Hirahara Y., Dupree J., Suzuki K., Popko B., Fukushima K., Fukushima J., Nagasawa T., Yoshida N., Wada Y., et al. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc. Natl. Acad. Sci. USA. 99:2002;4227-4232.
20. Ishibashi T., Dupree J.L., Ikenaka K., Hirahara Y., Honke K., Peles E., Popko B., Suzuki K., Nishino H., Baba H. A myelin galactolipid, sulfatide is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J. Neurosci. 22:2002;6507-6514.
21. Marcus J., Dupree J.L., Popko B. Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions. J. Cell Biol. 156:2002;567-577 In this study, the authors carried out a detailed morphological analyses of the role of galactolipids in the formation of paranodal junctions and their functional interaction with myelin-associated glycoprotein, which localizes to the paranodes. This study has provided new insights into the development of the ultrastructural features of paranodes and how paranodal junctions are modulated by the glial components.
22. Faivre-Sarrailh C., Gauthier F., Denisenko-Nehrbass N., Le Bivic A., Rougon G., Girault J.A. The GPI-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/caspr. J. Cell Biol. 149:2000;491-502.
23. Ohara R., Yamakawa H., Nakayama M., Ohara O. Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes. Brain Res. Mol. Brain Res. 85:2000;41-52.
24. Poliak S., Gollan L., Salomon D., Berglund E.O., Ohara R., Ranscht B., Peles E. Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. J. Neurosci. 21:2001;7568-7575.
25. Gollan L., Sabanay H., Poliak S., Berglund S.R., Ranscht B., Peles E. Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr. J. Cell Biol. 157:2002;1247-1256 The authors report that the extracellular region of Caspr/Paranodin is sufficient to direct it to the paranodal junction. However, retention of the Caspr/paranodin and contactin complex at this site requires its intracellular domain, which interacts with protein 4.1B.
26. Vabnick I., Trimmer J.S., Schwarz T.L., Levinson S.R., Risal D., Shrager P. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J. Neurosci. 19:1999;747-758.
27. Rasband M.N. Trimmer JS: Developmental clustering of ion channels at and near the node of Ranvier. Dev. Biol. 236:2001;5-16.
28. + channels. Neuron. 24:1999;1037-1047.
29. Rasband M.N., Park E.W., Zhen D., Arbuckle M.I., Poliak S., Peles E., Grant S.G., Trimmer J.S. Clustering of neuronal potassium channels is independent of their interaction with PSD-95. J. Cell Biol. 159:2002;663-672.
30. Traka M., Dupree J.L., Popko B., Karagogeos D. The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers. J. Neurosci. 22:2002;3016-3024 The authors describe the expression of TAG-1 in myelinating glial cells, and its localization to the juxtaparanodal region. The juxtaparanodal localization of TAG-1 and Caspr2 are suggestive of the existence of a complex similar to that of NCP1and contactin.
31. Rosenbluth J. A brief history of myelinated nerve fibers: one hundred and fifty years of controversy. J. Neurocytol. 28:1999;251-262.
32. Isom L.L. The role of sodium channels in cell adhesion. Front Biosci. 7:2002;12-23.
33. v1.6.
34. v1.6 at the CNS nodes. They suggest that these interactions also provide a lateral diffusion barrier to maintain a high concentration of components at the node, and the integrity of voltage-gated channel domains.
35. Berghs S., Aggujaro D., Dirkx R. Jr., Maksimova E., Stabach P., Hermel J.M., Zhang J.P., Philbrick W., Slepnev V., Ort T., Solimena M. Beta IV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system. J. Cell Biol. 151:2000;985-1002.
36. G and channel clustering.
37. Davis J.Q., Lambert S., Bennett V. Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. J. Cell Biol. 135:1996;1355-1367.
38. Koroll M., Rathjen F.G., Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J. Biol. Chem. 276:2001;10646-10654.
39. G clusters were seen during early development suggesting the possibility of a direct interaction between Schwann cells and axons during node organization.
40. Fannon A.M., Sherman D.L., Ilyina-Gragerova G., Brophy P.J., Friedrich V.L. Jr., Colman D.R. Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions. J. Cell Biol. 129:1995;189-202.
41. Gow A., Southwood C.M., Li J.S., Pariali M., Riordan G.P., Brodie S.E., Danias J., Bronstein J.M., Kachar B., Lazzarini R.A. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell. 99:1999;649-659.