The grasshopper: A novel model for assessing vertebrate brain uptake

Journal of Pharmacology and Experimental Therapeutics

Volumn 346, Issue 2, 2013, Pages 211-218

  Andersson, Olga ^a   Hansen, Steen Honoré ^b   Hellman, Karin ^a   Olsen, Line Rørbæk ^b   Andersson, Gunnar ^a   Badolo, Lassina ^c   Svenstrup, Niels ^c   Nielsen, Peter Aadal ^a  

^a EntomoPharm RandD   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; ATENOLOL; CAFFEINE; CARBAMAZEPINE; CETIRIZINE; CIMETIDINE; CITALOPRAM; CYCLOSPORIN A; DESIPRAMINE; DEXAMETHASONE; DIGOXIN; FLUOXETINE; HALOPERIDOL; LINCOMYCIN; LOPERAMIDE; MULTIDRUG RESISTANCE PROTEIN; NORFLOXACIN; PAROXETINE; PROPRANOLOL; QUINIDINE; RANITIDINE; RISPERIDONE; TRAZODONE; WARFARIN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CAELIFERA; CELL FUNCTION; CONTROLLED STUDY; DRUG UPTAKE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; CHROMATOGRAPHY, LIQUID; DOGS; DRUG DISCOVERY; GRASSHOPPERS; MADIN DARBY CANINE KIDNEY CELLS; MASS SPECTROMETRY; MODELS, ANIMAL; P-GLYCOPROTEIN; PERMEABILITY; VERAPAMIL;

EID: 84880444568     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.205476     Document Type: Article

References (28)

1. Abbott JN, Begley DJ, Preston JE, Romero NIA. Blood-Brain Barrier Consortium, 2012 Nov 9; King's College London, pp 6.1-6.5.
2. Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, and Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37:13-25.
3. Abbott NJ, Rönnbäck L, and Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41-53.
4. Abbott NJ, Dolman DEM, and Patabendige AK (2008) Assays to predict drug permeation across the blood-brain barrier, and distribution to brain. Curr Drug Metab 9:901-910.
5. Banerjee S and Bhat MA (2007) Neuron-glial interactions in blood-brain barrier formation. Annu Rev Neurosci 30:235-258.
6. Bundgaard M and Abbott NJ (2008) All vertebrates started out with a glial bloodbrain barrier 4-500 million years ago. Glia 56:699-708.
7. Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, Dehouck MP, and Fenart L (2007) Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 6:650-661.
8. Daneman R and Barres BA (2005) The blood-brain barrier: lessons from moody flies. Cell 123:9-12.
9. Dagenais C, Avdeef A, Tsinman O, Dudley A, and Beliveau R (2009) P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model. Eur J Pharm Sci 38:121-137.
10. DeSalvo MK, Mayer N, Mayer F, and Bainton RJ (2011) Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia 59:1322-1340.
11. Di L, Kerns EH, Bezar IF, Petusky SL, and Huang Y (2009) Comparison of bloodbrain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB. J Pharm Sci 98:1980-1991.
12. Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, and Cianfrogna J, et al. (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33: 165-174.
13. Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, and de Morais SM (2008) In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab Dispos 36: 268-275.
14. Freeman MR and Doherty J (2006) Glial cell biology in Drosophila and vertebrates. Trends Neurosci 29:82-90.
15. Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, Hurst RD, Lindmark T, Mabondzo A, Nilsson JE, and Raub TJ,, et al. (2005) In vitro models for the blood-brain barrier. Toxicol In Vitro 19:299-334.
16. Geldenhuys WJ, Allen DD, and Bloomquist JR (2012) Novel models for assessing blood-brain barrier drug permeation. Expert Opin Drug Metab Toxicol 8: 647-653.
17. Liu X, Chen C, and Smith BJ (2008) Progress in brain penetration evaluation in drug discovery and development. J Pharmacol Exp Ther 325:349-356.
18. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit- Singh CJ, Adkison KK, and Polli JW (2002) Passive permeability and Pglycoprotein- mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther 303:1029-1037.
19. Matsson P, Pedersen JM, Norinder U, Bergström CAS, and Artursson P (2009) Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs. Pharm Res 26:1816-1831.
20. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, and Bainton RJ (2009) Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci 29:3538-3550.
21. Mensch J, Oyarzabal J, Mackie C, and Augustijns P (2009) In vivo, in vitro and in silico methods for small molecule transfer across the BBB. J Pharm Sci 98: 4429-4468.
22. Molecular Operating Environment (MOE) 2012. Chemical Computing Group Inc., Montreal, QC, Canada.
23. Murakami H, Takanaga H, Matsuo H, Ohtani H, and Sawada Y (2000) Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique. Am J Physiol Heart Circ Physiol 279:H1022-H1028.
24. Nielsen PA, Andersson O, Hansen SH, Simonsen KB, and Andersson G (2011) Models for predicting blood-brain barrier permeation. Drug Discov Today 16: 472-475.
25. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, and Serabjit- Singh CS (2001) Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther 299:620-628.
26. Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, and Klämbt C (2008) Organization and function of the blood-brain barrier in Drosophila. J Neurosci 28:587-597.
27. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash NK, and Haefeli WE (2003) Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther 305:197-204.
28. Wu VM and Beitel GJ (2004) A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system. Curr Opin Cell Biol 16:493-499.