메뉴 건너뛰기




Volumn 5, Issue 4, 2003, Pages 611-620

The Claudin-like Megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN; CORACLE; GAP JUNCTION PROTEIN; MEGATRACHEA PROTEIN; MEMBRANE PROTEIN; NEUREXIN; UNCLASSIFIED DRUG;

EID: 0141920729     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(03)00275-2     Document Type: Article
Times cited : (177)

References (55)
  • 1
    • 0033711168 scopus 로고    scopus 로고
    • Genetic control of branching morphogenesis during Drosophila tracheal development
    • Affolter M. Shilo B.Z. Genetic control of branching morphogenesis during Drosophila tracheal development Curr. Opin. Cell Biol. 12 2000 731-735
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 731-735
    • Affolter, M.1    Shilo, B.Z.2
  • 2
    • 0038679606 scopus 로고    scopus 로고
    • Claudins in Caenorhabditis elegans: Their distribution and barrier function in the epithelium
    • Asano A. Asano K. Sasaki H. Furuse M. Tsukita S. Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium Curr. Biol. 13 2003 1042-1046
    • (2003) Curr. Biol. , vol.13 , pp. 1042-1046
    • Asano, A.1    Asano, K.2    Sasaki, H.3    Furuse, M.4    Tsukita, S.5
  • 4
    • 0033845748 scopus 로고    scopus 로고
    • Genetic control of epithelial tube size in the Drosophila tracheal system
    • Beitel G.J. Krasnow M.A. Genetic control of epithelial tube size in the Drosophila tracheal system Development 127 2000 3271-3282
    • (2000) Development , vol.127 , pp. 3271-3282
    • Beitel, G.J.1    Krasnow, M.A.2
  • 5
    • 0034617129 scopus 로고    scopus 로고
    • Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    • Bilder D. Li M. Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors Science 289 2000 113-116
    • (2000) Science , vol.289 , pp. 113-116
    • Bilder, D.1    Li, M.2    Perrimon, N.3
  • 6
    • 0037228253 scopus 로고    scopus 로고
    • Integrated activity of PDZ protein complexes regulates epithelial polarity
    • Bilder D. Schober M. Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity Nat. Cell Biol. 5 2003 53-58
    • (2003) Nat. Cell Biol. , vol.5 , pp. 53-58
    • Bilder, D.1    Schober, M.2    Perrimon, N.3
  • 7
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand A.H. Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401-415
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 9
    • 9144240042 scopus 로고    scopus 로고
    • Identification of the gene encoding brain cell membrane protein I (BCMPI), a putative four-transmembrane protein distantly related to the peripheral myelin protein 22/epithelial membrane proteins and the claudins
    • Christophe-Hobertus C. Szpirer C. Guyon R. Christophe D. Identification of the gene encoding brain cell membrane protein I (BCMPI), a putative four-transmembrane protein distantly related to the peripheral myelin protein 22/epithelial membrane proteins and the claudins BMC Genomics 2 2001 3
    • (2001) BMC Genomics , vol.2 , pp. 3
    • Christophe-Hobertus, C.1    Szpirer, C.2    Guyon, R.3    Christophe, D.4
  • 10
    • 0031040498 scopus 로고    scopus 로고
    • Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle
    • Clark I.E. Jan L.Y. Jan Y.N. Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle Development 124 1997 461-470
    • (1997) Development , vol.124 , pp. 461-470
    • Clark, I.E.1    Jan, L.Y.2    Jan, Y.N.3
  • 11
    • 0030758350 scopus 로고    scopus 로고
    • Segregation of two spectrin isoforms: Polarized membrane-binding sites direct polarized membrane skeleton assembly
    • Dubreuil R.R. Maddux P.B. Grushko T.A. MacVicar G.R. Segregation of two spectrin isoforms: polarized membrane-binding sites direct polarized membrane skeleton assembly Mol. Biol. Cell 8 1997 1933-1942
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1933-1942
    • Dubreuil, R.R.1    Maddux, P.B.2    Grushko, T.A.3    MacVicar, G.R.4
  • 12
    • 0028325048 scopus 로고
    • A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene
    • Fehon R.G. Dawson I.A. Artavanis-Tsakonas S. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene Development 120 1994 545-557
    • (1994) Development , vol.120 , pp. 545-557
    • Fehon, R.G.1    Dawson, I.A.2    Artavanis-Tsakonas, S.3
  • 13
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse M. Fujita K. Hiiragi T. Fujimoto K. Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin J. Cell Biol. 141 1998a 1539-1550
    • (1998) J. Cell Biol. , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 14
    • 0032547833 scopus 로고    scopus 로고
    • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    • Furuse M. Sasaki H. Fujimoto K. Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts J. Cell Biol. 143 1998b 391-401
    • (1998) J. Cell Biol. , vol.143 , pp. 391-401
    • Furuse, M.1    Sasaki, H.2    Fujimoto, K.3    Tsukita, S.4
  • 15
    • 0033571047 scopus 로고    scopus 로고
    • Manner of interaction of heterogeneous claudin species within and between tight junction strands
    • Furuse M. Sasaki H. Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands J. Cell Biol. 147 1999 891-903
    • (1999) J. Cell Biol. , vol.147 , pp. 891-903
    • Furuse, M.1    Sasaki, H.2    Tsukita, S.3
  • 16
    • 0037128938 scopus 로고    scopus 로고
    • Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice
    • Furuse M. Hata M. Furuse K. Yoshida Y. Haratake A. Sugitani Y. Noda T. Kubo A. Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice J. Cell Biol. 156 2002 1099-1111
    • (2002) J. Cell Biol. , vol.156 , pp. 1099-1111
    • Furuse, M.1    Hata, M.2    Furuse, K.3    Yoshida, Y.4    Haratake, A.5    Sugitani, Y.6    Noda, T.7    Kubo, A.8    Tsukita, S.9
  • 18
    • 0035102580 scopus 로고    scopus 로고
    • The roles of claudin superfamily proteins in paracellular transport
    • Heiskala M. Peterson P.A. Yang Y. The roles of claudin superfamily proteins in paracellular transport Traffic 2 2001 93-98
    • (2001) Traffic , vol.2 , pp. 93-98
    • Heiskala, M.1    Peterson, P.A.2    Yang, Y.3
  • 19
    • 0037268946 scopus 로고    scopus 로고
    • Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling
    • Hemphälä J. Uv A. Cantera R. Bray S. Samakovlis C. Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling Development 130 2003 249-258
    • (2003) Development , vol.130 , pp. 249-258
    • Hemphälä, J.1    Uv, A.2    Cantera, R.3    Bray, S.4    Samakovlis, C.5
  • 20
    • 0034089870 scopus 로고    scopus 로고
    • The genetics of the protein 4.1 family: Organizers of the membrane and cytoskeleton
    • Hoover K.B. Bryant P.J. The genetics of the protein 4.1 family: organizers of the membrane and cytoskeleton Curr. Opin. Cell Biol. 12 2000 229-234
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 229-234
    • Hoover, K.B.1    Bryant, P.J.2
  • 21
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    • Itoh M. Furuse M. Morita K. Kubota K. Saitou M. Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins J. Cell Biol. 147 1999 1351-1363
    • (1999) J. Cell Biol. , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3    Kubota, K.4    Saitou, M.5    Tsukita, S.6
  • 22
    • 0036208599 scopus 로고    scopus 로고
    • Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
    • Kiuchi-Saishin Y. Gotoh S. Furuse M. Takasuga A. Tano Y. Tsukita S. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments J. Am. Soc. Nephrol. 13 2002 875-886
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 875-886
    • Kiuchi-Saishin, Y.1    Gotoh, S.2    Furuse, M.3    Takasuga, A.4    Tano, Y.5    Tsukita, S.6
  • 23
    • 0037032804 scopus 로고    scopus 로고
    • Composition and formation of intercellular junctions in epithelial cells
    • Knust E. Bossinger O. Composition and formation of intercellular junctions in epithelial cells Science 298 2002 1955-1959
    • (2002) Science , vol.298 , pp. 1955-1959
    • Knust, E.1    Bossinger, O.2
  • 26
    • 0031740862 scopus 로고    scopus 로고
    • Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells
    • Lamb R.S. Ward R.E. Schweizer L. Fehon R.G. Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells Mol. Biol. Cell 9 1998 3505-3519
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3505-3519
    • Lamb, R.S.1    Ward, R.E.2    Schweizer, L.3    Fehon, R.G.4
  • 27
    • 0036339710 scopus 로고    scopus 로고
    • The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion
    • Lee S. Kolodziej P.A. The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion Development 129 2002 1509-1520
    • (2002) Development , vol.129 , pp. 1509-1520
    • Lee, S.1    Kolodziej, P.A.2
  • 28
    • 0030926546 scopus 로고    scopus 로고
    • Deciphering the function of neurexins at cellular junctions
    • Littleton J.T. Bhat M.A. Bellen H.J. Deciphering the function of neurexins at cellular junctions J. Cell Biol. 137 1997 793-796
    • (1997) J. Cell Biol. , vol.137 , pp. 793-796
    • Littleton, J.T.1    Bhat, M.A.2    Bellen, H.J.3
  • 29
    • 0037428084 scopus 로고    scopus 로고
    • Tube morphogenesis: Making and shaping biological tubes
    • Lubarsky B. Krasnow M.A. Tube morphogenesis: making and shaping biological tubes Cell 112 2003 19-28
    • (2003) Cell , vol.112 , pp. 19-28
    • Lubarsky, B.1    Krasnow, M.A.2
  • 30
    • 0033582334 scopus 로고    scopus 로고
    • Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
    • Morita K. Furuse M. Fujimoto K. Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands Proc. Natl. Acad. Sci. USA 96 1999 511-516
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 511-516
    • Morita, K.1    Furuse, M.2    Fujimoto, K.3    Tsukita, S.4
  • 31
    • 0037237122 scopus 로고    scopus 로고
    • Epithelia polarity in flies: More than just Crumbs
    • Müller H.A. Epithelia polarity in flies: more than just Crumbs Dev. Cell 4 2003 1-9
    • (2003) Dev. Cell , vol.4 , pp. 1-9
    • Müller, H.A.1
  • 32
    • 0034787457 scopus 로고    scopus 로고
    • claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing
    • Niimi T. Nagashima K. Ward J.M. Minoo P. Zimonjic D.B. Popescu N.C. Kimura S. claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing Mol. Cell. Biol. 21 2001 7380-7390
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7380-7390
    • Niimi, T.1    Nagashima, K.2    Ward, J.M.3    Minoo, P.4    Zimonjic, D.B.5    Popescu, N.C.6    Kimura, S.7
  • 33
    • 0023666143 scopus 로고
    • Characterization and cloning of Fasciclin III: A glycoprotein expressed on a subset of neurons and axon pathways in Drosophila
    • Patel N.H. Snow P.M. Goodman C.S. Characterization and cloning of Fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila Cell 48 1987 975-988
    • (1987) Cell , vol.48 , pp. 975-988
    • Patel, N.H.1    Snow, P.M.2    Goodman, C.S.3
  • 35
    • 0035141027 scopus 로고    scopus 로고
    • DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    • Petronczki M. Knoblich J.A. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila Nat. Cell Biol. 3 2001 43-49
    • (2001) Nat. Cell Biol. , vol.3 , pp. 43-49
    • Petronczki, M.1    Knoblich, J.A.2
  • 36
    • 0025094664 scopus 로고
    • Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless
    • Riggleman B. Schedl P. Wieschaus E. Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless Cell 63 1990 549-560
    • (1990) Cell , vol.63 , pp. 549-560
    • Riggleman, B.1    Schedl, P.2    Wieschaus, E.3
  • 37
    • 0024315423 scopus 로고
    • Morphogenesis of the polarized epithelial cell phenotype
    • Rodriguez-Boulan E. Nelson W.J. Morphogenesis of the polarized epithelial cell phenotype Science 245 1989 719-725
    • (1989) Science , vol.245 , pp. 719-725
    • Rodriguez-Boulan, E.1    Nelson, W.J.2
  • 38
    • 0026752739 scopus 로고
    • Structure, function, and regulation of cellular tight junctions
    • Schneeberger E.E. Lynch R.D. Structure, function, and regulation of cellular tight junctions Am. J. Physiol. 262 1992 L647-L661
    • (1992) Am. J. Physiol. , vol.262
    • Schneeberger, E.E.1    Lynch, R.D.2
  • 39
    • 0034916230 scopus 로고    scopus 로고
    • PDZ domains and the organization of supramolecular complexes
    • Sheng M. Sala C. PDZ domains and the organization of supramolecular complexes Annu. Rev. Neurosci. 24 2001 1-29
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1-29
    • Sheng, M.1    Sala, C.2
  • 41
    • 0038109935 scopus 로고    scopus 로고
    • The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans
    • Simske J.S. Köppen M. Sims P. Hodgkin J. Yonkof A. Hardin J. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans Nat. Cell Biol. 5 2003 619-625
    • (2003) Nat. Cell Biol. , vol.5 , pp. 619-625
    • Simske, J.S.1    Köppen, M.2    Sims, P.3    Hodgkin, J.4    Yonkof, A.5    Hardin, J.6
  • 42
    • 0033523773 scopus 로고    scopus 로고
    • Clostridium perfingens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
    • Sonoda N. Furuse M. Sasaki H. Yonemura S. Katahira J. Horiguchi Y. Tsukita S. Clostridium perfingens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier J. Cell Biol. 147 1999 195-204
    • (1999) J. Cell Biol. , vol.147 , pp. 195-204
    • Sonoda, N.1    Furuse, M.2    Sasaki, H.3    Yonemura, S.4    Katahira, J.5    Horiguchi, Y.6    Tsukita, S.7
  • 43
    • 0030578406 scopus 로고    scopus 로고
    • Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila
    • Tepass U. Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila Dev. Biol. 177 1996 217-225
    • (1996) Dev. Biol. , vol.177 , pp. 217-225
    • Tepass, U.1
  • 44
    • 0028176572 scopus 로고
    • The development of cellular junctions in the Drosophila embryo
    • Tepass U. Hartenstein V. The development of cellular junctions in the Drosophila embryo Dev. Biol. 161 1994 563-596
    • (1994) Dev. Biol. , vol.161 , pp. 563-596
    • Tepass, U.1    Hartenstein, V.2
  • 45
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass U. Theres C. Knust E. Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia Cell 61 1990 787-799
    • (1990) Cell , vol.61 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 46
    • 0035674837 scopus 로고    scopus 로고
    • Epithelial cell polarity and cell junctions in Drosophila
    • Tepass U. Tanentzapf G. Ward R. Fehon R. Epithelial cell polarity and cell junctions in Drosophila Annu. Rev. Genet. 35 2001 747-784
    • (2001) Annu. Rev. Genet. , vol.35 , pp. 747-784
    • Tepass, U.1    Tanentzapf, G.2    Ward, R.3    Fehon, R.4
  • 47
    • 0036773738 scopus 로고    scopus 로고
    • Claudin-based barrier in simple and stratified cellular sheets
    • Tsukita S. Furuse M. Claudin-based barrier in simple and stratified cellular sheets Curr. Opin. Cell Biol. 14 2002 531-536
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 531-536
    • Tsukita, S.1    Furuse, M.2
  • 49
    • 0032559823 scopus 로고    scopus 로고
    • A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity
    • Ward R.E. Lamb R.S. Fehon R.G. A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity J. Cell Biol. 140 1998 1463-1473
    • (1998) J. Cell Biol. , vol.140 , pp. 1463-1473
    • Ward, R.E.1    Lamb, R.S.2    Fehon, R.G.3
  • 50
    • 0034809326 scopus 로고    scopus 로고
    • The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation
    • Ward R.E. Schweizer L. Lamb R.S. Fehon R.G. The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation Genetics 159 2001 219-228
    • (2001) Genetics , vol.159 , pp. 219-228
    • Ward, R.E.1    Schweizer, L.2    Lamb, R.S.3    Fehon, R.G.4
  • 51
    • 0033518223 scopus 로고    scopus 로고
    • Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    • Wodarz A. Ramrath A. Kuchinke U. Knust E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts Nature 402 1999 544-547
    • (1999) Nature , vol.402 , pp. 544-547
    • Wodarz, A.1    Ramrath, A.2    Kuchinke, U.3    Knust, E.4
  • 52
    • 0033844077 scopus 로고    scopus 로고
    • Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila
    • Wolf C. Schuh R. Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila Genes Dev. 14 2000 2140-2145
    • (2000) Genes Dev. , vol.14 , pp. 2140-2145
    • Wolf, C.1    Schuh, R.2
  • 53
    • 0036304313 scopus 로고    scopus 로고
    • Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells
    • Wolf C. Gerlach N. Schuh R. Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells EMBO Rep. 3 2002 563-568
    • (2002) EMBO Rep. , vol.3 , pp. 563-568
    • Wolf, C.1    Gerlach, N.2    Schuh, R.3
  • 54
    • 0029819449 scopus 로고    scopus 로고
    • Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia
    • Woods D.F. Hough C. Peel D. Callaini G. Bryant P.J. Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia J. Cell Biol. 134 1996 1469-1482
    • (1996) J. Cell Biol. , vol.134 , pp. 1469-1482
    • Woods, D.F.1    Hough, C.2    Peel, D.3    Callaini, G.4    Bryant, P.J.5
  • 55
    • 0030991367 scopus 로고    scopus 로고
    • Localization of proteins to the apico-lateral junctions of Drosophila epithelia
    • Woods D.F. Wu J.-W. Bryant P.J. Localization of proteins to the apico-lateral junctions of Drosophila epithelia Dev. Genet. 20 1997 111-118
    • (1997) Dev. Genet. , vol.20 , pp. 111-118
    • Woods, D.F.1    Wu, J.-W.2    Bryant, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.