Metformin improves insulin signaling in obese rats via reduced IKK β action in a fiber-type specific manner

Journal of Obesity

Volumn 2010, Issue , 2010, Pages

  Bikman, Benjamin T ^a   Zheng, Donghai ^a   Kane, Daniel A ^a   Anderson, Ethan J ^a   Woodlief, Tracey L ^a,b   Price, Jesse W ^a   Dohm, G Lynis ^a,b   Neufer, P Darrell ^a,b   Cortright, Ronald N ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80052972887     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2010/970865     Document Type: Article

References (39)

1. Grundy S. M., Brewer H. B. Jr., Cleeman J. I., Smith S. C. Jr., Lenfant C., Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004 109 3 433 438 10.1161/01.CIR.0000111245. 75752.C6 2-s2.0-0842277242 (Pubitemid 38133916)
2. Perseghin G., Petersen K., Shulman G. I., Cellular mechanism of insulin resistance: potential links with inflammation. International Journal of Obesity 2003 27 supplement 3 S6 S11 10.1038/sj.ijo.0802491 2-s2.0-0346250165 (Pubitemid 38019180)
3. Arkan M. C., Hevener A. L., Greten F. R., IKK- β links inflammation to obesity-induced insulin resistance. Nature Medicine 2005 11 2 191 198 10.1038/nm1185 2-s2.0-20044387026 (Pubitemid 40321355)
4. Mokdad A. H., Marks J. S., Stroup D. F., Gerberding J. L., Actual causes of death in the United States, 2000. Journal of the American Medical Association 2004 291 10 1238 1245 10.1001/jama.291.10.1238 2-s2.0-1542347858 (Pubitemid 38541668)
5. Wellen K. E., Hotamisligil G. S., Inflammation, stress, and diabetes. Journal of Clinical Investigation 2005 115 5 1111 1119 10.1172/JCI200525102 2-s2.0-18244370762 (Pubitemid 40629025)
6. Kahn B. B., Flier J. S., Obesity and insulin resistance. Journal of Clinical Investigation 2000 106 4 473 481 2-s2.0-0033849777 (Pubitemid 30666380)
7. McGarry J. D., denis.mcgarry@utsouthwestern.edu Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002 51 1 7 18 2-s2.0-0027466641
8. Gray R. E., Tanner C. J., Pories W. J., MacDonald K. G., Houmard J. A., Effect of weight loss on muscle lipid content in morbidly obese subjects. American Journal of Physiology 2003 284 4 E726 E732 2-s2.0-0037376857 (Pubitemid 36323865)
9. Bikman B. T., Zheng D., Pories W. J., Mechanism for improved insulin sensitivity after gastric bypass surgery. Journal of Clinical Endocrinology & Metabolism 2008 93 12 4656 4663 10.1210/jc.2008-1030 2-s2.0-57349109343
10. Hotamisligil G. S., Inflammation and metabolic disorders. Nature 2006 444 7121 860 867 10.1038/nature05485 2-s2.0-33845866857 (Pubitemid 46024993)
11. Cai D., Yuan M., Frantz D. F., Local and systemic insulin resistance resulting from hepatic activation of IKK- β and NF- κ B. Nature Medicine 2005 11 2 183 190 10.1038/nm1166 2-s2.0-14644427890 (Pubitemid 40321354)
12. Ghanim H., Garg R., Aljada A., Suppression of nuclear factor- κ B and stimulation of inhibitor κ B by troglitazone: evidence for an antiinflammatory effect and a potential antiatherosclerotic effect in the obese. Journal of Clinical Endocrinology & Metabolism 2001 86 3 1306 1312 10.1210/jc.86.3.1306 2-s2.0-0035045084 (Pubitemid 32323021)
13. Yuan M., Konstantopoulos N., Lee J., Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKK β Science 2001 293 5535 1673 1677 10.1126/science.1061620 2-s2.0-0035979775 (Pubitemid 32807849)
14. Lessard S. J., Chen Z.-P., Watt M. J., Chronic rosiglitazone treatment restores AMPK α 2 activity in insulin-resistant rat skeletal muscle. American Journal of Physiology 2006 290 2 E251 E257 2-s2.0-17844400342 10.1152/ajpendo.00096.2005
15. Suwa M., Egashira T., Nakano H., Sasaki H., Kumagai S., Metformin increases the PGC-1 α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. Journal of Applied Physiology 2006 101 6 1685 1692 10.1152/japplphysiol.00255.2006 2-s2.0-33845411854 (Pubitemid 44904490)
16. Cacicedo J. M., Yagihashi N., Keaney J. F. Jr., Ruderman N. B., Ido Y., AMPK inhibits fatty acid-induced increases in NF- κ B transactivation in cultured human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 2004 324 4 1204 1209 10.1016/j.bbrc.2004.09.177 2-s2.0-14344257169 (Pubitemid 40292150)
17. Hattori Y., Suzuki K., Hattori S., Kasai K., Metformin inhibits cytokine-induced nuclear factor κ B activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension 2006 47 6 1183 1188 10.1161/01.HYP.0000221429.94591.72 2-s2.0-33744976813 (Pubitemid 44289177)
18. Jhun B. S., Jin Q., Oh Y. T., 5-aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF- α production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochemical and Biophysical Research Communications 2004 318 2 372 380 10.1016/j.bbrc.2004.04.035 2-s2.0-2142640818 (Pubitemid 38553790)
19. Giri S., Nath N., Smith B., Viollet B., Singh A. K., Singh I., 5-aminoimidazole-4-carboxamide-1- β -4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. Journal of Neuroscience 2004 24 2 479 487 10.1523/JNEUROSCI. 4288-03.2004 2-s2.0-1642499162 (Pubitemid 38112379)
20. Cleasby M. E., Dzamko N., Hegarty B. D., Cooney G. J., Kraegen E. W., Ye J.-M., Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. Diabetes 2004 53 12 3258 3266 10.2337/diabetes.53.12.3258 2-s2.0-9444272216 (Pubitemid 39564503)
21. Musi N., AMP-activated protein kinase and type 2 diabetes. Current Medicinal Chemistry 2006 13 5 583 589 10.2174/092986706776055724 2-s2.0-33645976877
22. Ropelle E. R., Pauli J. R., Prada P. O., Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. Journal of Physiology 2006 577 3 997 1007 10.1113/jphysiol.2006.120006 2-s2.0-33845296085 (Pubitemid 44873661)
23. Itani S. I., Ruderman N. B., Schmieder F., Boden G., Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I κ B- α Diabetes 2002 51 7 2005 2011 2-s2.0-0036300538 (Pubitemid 34729001)
24. Sinha S., Perdomo G., Brown N. F., O'Doherty R. M., Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor κ B. Journal of Biological Chemistry 2004 279 40 41294 41301 10.1074/jbc.M406514200 2-s2.0-4744344777 (Pubitemid 39313568)
25. Yin M.-J., Yamamoto Y., Gaynor R. B., The anti-inflammatory agents aspirin and salicylate inhibit the activity of I κ B kinase- β Nature 1998 396 6706 77 80 10.1038/23948 2-s2.0-0032487857 (Pubitemid 28520452)
26. Kim J. K., Kim Y.-J., Fillmore J. J., Prevention of fat-induced insulin resistance by salicylate. Journal of Clinical Investigation 2001 108 3 437 446 10.1172/JCI200111559 2-s2.0-0034903710 (Pubitemid 32730790)
27. Schmitz-Peiffer C., c.schmitz-peiffer@garvan.org.au Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Annals of the New York Academy of Sciences 2002 967 146 157 2-s2.0-0031750246 (Pubitemid 34721902)
28. Frangioudakis G., Burchfield J. G., Narasimhan S., Diverse roles for protein kinase C δ and protein kinase C ε in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C δ Diabetologia 2009 52 12 2616 2620 2-s2.0-70349742908 10.1007/s00125-009-1543-0
29. Ragheb R., Shanab G. M. L., Medhat A. M., Seoudi D. M., Adeli K., Fantus I. G., Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochemical and Biophysical Research Communications 2009 389 2 211 216 10.1016/j.bbrc.2009.08.106 2-s2.0-70349338611
30. Huang W., Bansode R., Mehta M., Mehta K. D., Loss of protein kinase C β function protects mice again diet-induced obesity and development of hepatic steatosis and insulin resistance. Hepatology 2009 49 5 1525 1536 10.1002/hep.22815 2-s2.0-66149093022
31. Fisher J. S., Gao J., Han D.-H., Holloszy J. O., Nolte L. A., Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. American Journal of Physiology 2002 282 1 E18 E23 2-s2.0-0036078863 (Pubitemid 34654101)
32. Merrill G. F., Kurth E. J., Hardie D. G., Winder W. W., AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. American Journal of Physiology 1997 273 6 E1107 E1112 2-s2.0-0024795323
33. Jeong H. W., Hsu K. C., Lee J.-W., Berberine suppresses proinflammatory responses through AMPK activation in macrophages. American Journal of Physiology 2009 296 4 E955 E964 10.1152/ajpendo.90599.2008 2-s2.0-65649108647
34. Steinberg G. R., Michell B. J., van Denderen B. J. W., Tumor necrosis factor α -induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism 2006 4 6 465 474 10.1016/j.cmet.2006. 11.005 2-s2.0-33751552452 (Pubitemid 44834113)
35. Ho R. C., Hirshman M. F., Li Y., Regulation of I κ B kinase and NF- κ B in contracting adult rat skeletal muscle. American Journal of Physiology 2005 289 4 C794 C801 2-s2.0-0032478822 10.1152/ajpcell.00632.2004 (Pubitemid 41361634)
36. Hawley S. A., Gadalla A. E., Olsen G. S., Hardie D. G., The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002 51 8 2420 2425 2-s2.0-0036324142 (Pubitemid 34827390)
37. Owen M. R., Doran E., Halestrap A. P., Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal 2000 348 3 607 614 10.1042/0264-6021: 3480607 2-s2.0-0034659785 (Pubitemid 30410251)
38. Bhatt B. A., Dube J. J., Dedousis N., Reider J. A., O'Doherty R. M., odohertyr@dom.pitt.edu Diet-induced obesity and acute hyperlipidemia reduce I κ B α levels in rat skeletal muscle in a fiber-type dependent manner. American Journal of Physiology 2006 290 1 R233 R240 2-s2.0-0035979775 10.1152/ajpregu.00097.2005
39. Iglesias M. A., Furler S. M., Cooney G. J., Kraegen E. W., Ye J.-M., AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo. Diabetes 2004 53 7 1649 1654 10.2337/diabetes.53.7.1649 2-s2.0-3042819292 (Pubitemid 38857020)