Apple polysaccharide reduces Nf-Kb mediated colitis-associated colon carcinogenesis

Nutrition and Cancer

Volumn 67, Issue 1, 2015, Pages 177-190

  Zhang, Dian ^a,b   Mi, Man ^a   Jiang, Fengliang ^b   Sun, Yang ^b   Li, Yuhua ^b   Yang, Libin ^a   Fan, Lei ^b   Li, Qian ^b   Meng, Jin ^b   Yue, Zhenggang ^b   Liu, Li ^c   Mei, Qibing ^b  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APPLE POLYSACCHARIDE EXTRACT; AZOXYMETHANE; BETA INTERFERON; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; PLANT EXTRACT; POLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APPLE; ARTICLE; CANCER MODEL; CANCER PREVENTION; CHEMOPROPHYLAXIS; COLITIS; COLON CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HT 29 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COLON; COLONIC NEOPLASMS; DIET SUPPLEMENTATION; DIET THERAPY; DISEASE MODEL; FRUIT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; INTESTINE MUCOSA; ISOLATION AND PURIFICATION; MALUS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TUMOR CELL LINE;

MALUS X DOMESTICA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; COLITIS; COLON; COLONIC NEOPLASMS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FRUIT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MALE; MALUS; MICE, INBRED ICR; NEOPLASM PROTEINS; NF-KAPPA B; PLANT EXTRACTS; POLYSACCHARIDES; SIGNAL TRANSDUCTION;

EID: 84920515449     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2015.965336     Document Type: Article

References (31)

1. Bansal P and Sonnenberg A: Risk factors of colorectal cancer in inflammatory bowel disease. The American Journal of Gastroenterology 91, 44, 1996.
2. Balog CI, Stavenhagen K, Fung WL, Koeleman CA, McDonnell LA, et al.: N-glycosylation of colorectal cancer tissues: a liquid chromatography and mass spectrometry-based investigation. Molecular & Cellular Proteomics 11, 571-585, 2012.
3. Ullman TA and Itzkowitz SH: Intestinal inflammation and cancer. Gastroenterology 140, 1807-1816, 2011.
4. Sekirov I, Russell SL, Antunes LCM, and Finlay BB: Gut microbiota in health and disease. Physiological Reviews 90, 859-904, 2010.
5. Chen K, Huang J, Gong W, Iribarren P, Dunlop NM, et al.: Toll-like receptors in inflammation, infection and cancer. International Immunopharmacology 7, 1271-1285, 2007.
6. Tsan MF: Toll-like receptors, inflammation and cancer. Seminars in Cancer Biology 16, 32-37, 2006.
7. Yew KH, Carpenter C, Duncan RS, and Harrison CJ: Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-Alpha expression. PLoS One 7, e44500, 2012.
8. Buchholz BM and Bauer AJ: Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis. Neurogastroenterology & Motility 22, 232-245, 2010.
9. Schottelius A and Dinter H: Cytokines, NF-kB, microenvironment, intestinal inflammation and cancer. Cancer Treatment and Research 130, 67-87, 2006.
10. Goel GA, Kandiel A, Achkar JP, and Lashner B: Molecular pathways underlying IBD-Associated colorectal neoplasia: therapeutic implications. The American Journal of Gastroenterology 106, 719-730, 2011.
11. Pan MH, Lai CS, Wu JC, and Ho CT: Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Molecular Nutrition & Food Research 55, 32-45, 2011.
12. Tak PP and Firestein GS: NF-kappaB: a key role in inflammatory diseases. Journal of Clinical Investigation 107, 7-12, 2001.
13. 'Annema N, Heyworth JS, McNaughton SA, Iacopetta B, and Fritschi L: Fruit and vegetable consumption and the risk of proximal colon, distal colon, and rectal cancers in a case-control study in Western Australia. Journal of the American Dietetic Association 111, 1479-1490, 2011.
14. Kyrø C, Skeie G, Loft S, Overvad K, Christensen J, et al.: Adherence to a healthy Nordic food index is associated with a lower incidence of colorectal cancer in women: the Diet, Cancer and Health cohort study. British Journal of Nutrition 109, 920-927, 2013.
15. McGhie TK, Hudault S, Lunken RC, and Christeller JT: Apple peels, from seven cultivars, have lipase-inhibitory activity and contain numerous ursenoic acids as identified by LC-ESI-QTOF-HRMS. Journal of Agricultural and Food Chemistry 60, 482-491, 2012.
16. Charde MS, Ahmed A, and Chakole R: Apple phytochemicals for human benefits. 1, 40-55, 2012.
17. Barth SW, Faehndrich C, Bub A, Watzl B, Will F, et al.: Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis. Journal of Agricultural and Food Chemistry 55, 1181-1187, 2007.
18. Liu L, Li YH, Niu YB, Sun Y, Guo ZJ, et al.: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/ NF-kB pathway in a mouse model of colitis-Associated colon cancer. Carcinogenesis 31, 1822-1832, 2010.
19. Li Y, Mei L, Niu Y, Sun Y, Huang H, et al.: Low molecular weight apple polysaccharides induced cell cycle arrest in colorectal tumor. Nutrition and Cancer 64, 439-463, 2012.
20. Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, et al.: Toll-like receptor-4 promotes the development of colitis-Associated colorectal tumors. Gastroenterology 133, 1869-1869, 2007.
21. Gerhauser C: Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Medica 74, 1608, 2008.
22. Satahoo SS, Brathwaite C, Davis JS, and Burnweit C: Obstructing apple core lesion of the rectum: a case report of inflammatory pseudotumor masquerading as colorectal carcinoma. Journal of Pediatric Surgery 48, 677-680, 2013.
23. Standiford LR, Standiford TJ, Newstead MJ, Zeng X, Ballinger MN, et al.: TLR4-dependent GM-CSF protects against lung injury in Gramnegative bacterial pneumonia. American Journal of Physiology: Lung Cellular and Molecular Physiology 302, L447-L454, 2012.
24. Triantafilou M and Triantafilou K: Lipopolysaccharide recognition: CD14, TLRs and the LPS-Activation cluster. Trends in Immunology 23, 301-304, 2002.
25. Zhang J, Kumar A, Wheater M, and Yu FSX: Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness. Immunology and Cell Biology 87, 141-148, 2008.
26. Kim SJ, Park HJ, Shin HJ, Shon DH, Kim DH, et al.: Suppression of TRIF-dependent signaling pathway of toll-like receptors by allyl isothiocyanate in RAW 264.7 macrophages. International Immunopharmacology 13, 403-407, 2012.
27. Maldonado ME, Bousserouel S, Gosse F, Lobstein A, and Raul F: Implication of NF-kB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. Biom -edica 30, 577-586, 2010.
28. Haidl ID, McAlpine SM, and Marshall JS: Enhancement of mast cell IL-6 production by combined toll-like and nucleotide-binding oligomerization domain-like receptor activation. International Archives of Allergy and Immunology 154, 227-235, 2011.
29. Vaiopoulos AG, Papachroni KK, and Papavassiliou AG: Colon carcinogenesis: Learning from NF-kB and AP-1. The International Journal of Biochemistry & Cell Biology 42, 1061-1065, 2010.
30. Kawai T and Akira S: Signaling to NF-[kappa] B by Toll-like receptors. Trends in Molecular Medicine 13, 460-469, 2007.
31. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, et al.: TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nature Immunology 4, 1144-1150, 2003.