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Volumn 194, Issue 2, 2015, Pages 795-802

Focal adhesion kinase-mediated activation of glycogen synthase kinase 3β regulates IL-33 receptor internalization and IL-33 signaling

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; FOCAL ADHESION KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; LONG FORM ST2 RECEPTOR; UNCLASSIFIED DRUG; FOCAL ADHESION KINASE 1; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; IL33 PROTEIN, MOUSE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 33; INTERLEUKIN DERIVATIVE; PROTEIN BINDING; PTK2 PROTEIN, MOUSE; ST2L PROTEIN, MOUSE;

EID: 84920438858     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401414     Document Type: Article
Times cited : (23)

References (51)
  • 1
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel alarmin?
    • Moussion, C., N. Ortega, and J. P. Girard. 2008. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel alarmin? PLoS One 3: e3331.
    • (2008) PLoS One , vol.3 , pp. e3331
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 2
    • 79955040263 scopus 로고    scopus 로고
    • The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    • Kouzaki, H., K. Iijima, T. Kobayashi, S. M. O'Grady, and H. Kita. 2011. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J. Immunol. 186: 4375-4387.
    • (2011) J. Immunol. , vol.186 , pp. 4375-4387
    • Kouzaki, H.1    Iijima, K.2    Kobayashi, T.3    O'Grady, S.M.4    Kita, H.5
  • 3
    • 67049158193 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    • Cayrol, C., and J. P. Girard. 2009. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc. Natl. Acad. Sci. USA 106: 9021-9026.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9021-9026
    • Cayrol, C.1    Girard, J.P.2
  • 5
    • 84862636380 scopus 로고    scopus 로고
    • F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation
    • Zhao, J., J. Wei, R. K. Mialki, D. F. Mallampalli, B. B. Chen, T. Coon, C. Zou, R. K. Mallampalli, and Y. Zhao. 2012. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat. Immunol. 13: 651-658.
    • (2012) Nat. Immunol. , vol.13 , pp. 651-658
    • Zhao, J.1    Wei, J.2    Mialki, R.K.3    Mallampalli, D.F.4    Chen, B.B.5    Coon, T.6    Zou, C.7    Mallampalli, R.K.8    Zhao, Y.9
  • 6
    • 67651053209 scopus 로고    scopus 로고
    • Interleukin-33 is biologically active independently of caspase-1 cleavage
    • Talabot-Ayer, D., C. Lamacchia, C. Gabay, and G. Palmer. 2009. Interleukin-33 is biologically active independently of caspase-1 cleavage. J. Biol. Chem. 284: 19420-19426.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19420-19426
    • Talabot-Ayer, D.1    Lamacchia, C.2    Gabay, C.3    Palmer, G.4
  • 8
    • 62349125566 scopus 로고    scopus 로고
    • Positive remodeling is associated with more plaque vulnerability and higher frequency of plaque prolapse accompanied with post-procedural cardiac enzyme elevation compared with intermediate/negative remodeling in patients with acute myocardial infarction
    • Hong, Y. J., M. H. Jeong, Y. H. Choi, J. S. Ko, M. G. Lee, W. Y. Kang, S. E. Lee, S. H. Kim, K. H. Park, D. S. Sim, et al. 2009. Positive remodeling is associated with more plaque vulnerability and higher frequency of plaque prolapse accompanied with post-procedural cardiac enzyme elevation compared with intermediate/negative remodeling in patients with acute myocardial infarction. J. Cardiol. 53: 278-287.
    • (2009) J. Cardiol. , vol.53 , pp. 278-287
    • Hong, Y.J.1    Jeong, M.H.2    Choi, Y.H.3    Ko, J.S.4    Lee, M.G.5    Kang, W.Y.6    Lee, S.E.7    Kim, S.H.8    Park, K.H.9    Sim, D.S.10
  • 9
    • 70449475108 scopus 로고    scopus 로고
    • Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
    • Choi, Y. S., H. J. Choi, J. K. Min, B. J. Pyun, Y. S. Maeng, H. Park, J. Kim, Y. M. Kim, and Y. G. Kwon. 2009. Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production. Blood 114: 3117-3126.
    • (2009) Blood , vol.114 , pp. 3117-3126
    • Choi, Y.S.1    Choi, H.J.2    Min, J.K.3    Pyun, B.J.4    Maeng, Y.S.5    Park, H.6    Kim, J.7    Kim, Y.M.8    Kwon, Y.G.9
  • 12
    • 67649207586 scopus 로고    scopus 로고
    • Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
    • Liu, X., M. Li, Y. Wu, Y. Zhou, L. Zeng, and T. Huang. 2009. Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. Biochem. Biophys. Res. Commun. 386: 181-185.
    • (2009) Biochem. Biophys. Res. Commun. , vol.386 , pp. 181-185
    • Liu, X.1    Li, M.2    Wu, Y.3    Zhou, Y.4    Zeng, L.5    Huang, T.6
  • 13
    • 79953777764 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice
    • Yin, H., X. Y. Li, B. H. Yuan, B. B. Zhang, S. L. Hu, H. B. Gu, X. B. Jin, and J. Y. Zhu. 2011. Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice. Clin. Exp. Immunol. 164: 248-255.
    • (2011) Clin. Exp. Immunol. , vol.164 , pp. 248-255
    • Yin, H.1    Li, X.Y.2    Yuan, B.H.3    Zhang, B.B.4    Hu, S.L.5    Gu, H.B.6    Jin, X.B.7    Zhu, J.Y.8
  • 16
    • 1942535018 scopus 로고    scopus 로고
    • T1/ST2-an IL-1 receptor-like modulator of immune responses
    • Trajkovic, V., M. J. Sweet, and D. Xu. 2004. T1/ST2-an IL-1 receptor-like modulator of immune responses. Cytokine Growth Factor Rev. 15: 87-95.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 87-95
    • Trajkovic, V.1    Sweet, M.J.2    Xu, D.3
  • 17
    • 0032499678 scopus 로고    scopus 로고
    • T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
    • Löhning, M., A. Stroehmann, A. J. Coyle, J. L. Grogan, S. Lin, J. C. Gutierrez-Ramos, D. Levinson, A. Radbruch, and T. Kamradt. 1998. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc. Natl. Acad. Sci. USA 95: 6930-6935.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6930-6935
    • Löhning, M.1    Stroehmann, A.2    Coyle, A.J.3    Grogan, J.L.4    Lin, S.5    Gutierrez-Ramos, J.C.6    Levinson, D.7    Radbruch, A.8    Kamradt, T.9
  • 19
    • 80755175891 scopus 로고    scopus 로고
    • Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells
    • Zhao, J., Q. Chen, H. Li, M. Myerburg, E. W. Spannhake, V. Natarajan, and Y. Zhao. 2012. Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells. Cell. Signal. 24: 77-85.
    • (2012) Cell. Signal. , vol.24 , pp. 77-85
    • Zhao, J.1    Chen, Q.2    Li, H.3    Myerburg, M.4    Spannhake, E.W.5    Natarajan, V.6    Zhao, Y.7
  • 20
    • 0036830441 scopus 로고    scopus 로고
    • Enhanced glycogen synthase kinase-3β activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism
    • Loberg, R. D., E. Vesely, and F. C. Brosius, III. 2002. Enhanced glycogen synthase kinase-3β activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J. Biol. Chem. 277: 41667-41673.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41667-41673
    • Loberg, R.D.1    Vesely, E.2    Brosius, F.C.3
  • 21
    • 0037160134 scopus 로고    scopus 로고
    • Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation
    • Song, L., P. De Sarno, and R. S. Jope. 2002. Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation. J. Biol. Chem. 277: 44701-44708.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44701-44708
    • Song, L.1    Sarno, P.D.2    Jope, R.S.3
  • 22
    • 80052724290 scopus 로고    scopus 로고
    • GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line
    • Dickey, A., S. Schleicher, K. Leahy, R. Hu, D. Hallahan, and D. K. Thotala. 2011. GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. J. Neurooncol. 104: 145-153.
    • (2011) J. Neurooncol. , vol.104 , pp. 145-153
    • Dickey, A.1    Schleicher, S.2    Leahy, K.3    Hu, R.4    Hallahan, D.5    Thotala, D.K.6
  • 23
    • 34447119530 scopus 로고    scopus 로고
    • Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: Functional effects in apoptosis
    • Meares, G. P., and R. S. Jope. 2007. Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis. J. Biol. Chem. 282: 16989-17001.
    • (2007) J. Biol. Chem. , vol.282 , pp. 16989-17001
    • Meares, G.P.1    Jope, R.S.2
  • 24
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost, C., M. Torres, J.R.Miller, E. Huang, D. Kimelman, and R. T. Moon. 1996. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10: 1443-1454.
    • (1996) Genes Dev , vol.10 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.R.3    Huang, E.4    Kimelman, D.5    Moon, R.T.6
  • 26
    • 0027475421 scopus 로고
    • Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
    • Hughes, K., E. Nikolakaki, S. E. Plyte, N. F. Totty, and J. R. Woodgett. 1993. Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 12: 803-808.
    • (1993) EMBO J , vol.12 , pp. 803-808
    • Hughes, K.1    Nikolakaki, E.2    Plyte, S.E.3    Totty, N.F.4    Woodgett, J.R.5
  • 27
    • 33745209918 scopus 로고    scopus 로고
    • Novel anti-inflammatory role for glycogen synthase kinase-3β in the inhibition of tumor necrosis factor-α- And interleukin-1β -induced inflammatory gene expression
    • Vines, A., S. Cahoon, I. Goldberg, U. Saxena, and S. Pillarisetti. 2006. Novel anti-inflammatory role for glycogen synthase kinase-3β in the inhibition of tumor necrosis factor-α- And interleukin-1β -induced inflammatory gene expression. J. Biol. Chem. 281: 16985-16990.
    • (2006) J. Biol. Chem. , vol.281 , pp. 16985-16990
    • Vines, A.1    Cahoon, S.2    Goldberg, I.3    Saxena, U.4    Pillarisetti, S.5
  • 28
    • 0348014544 scopus 로고    scopus 로고
    • Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor
    • Oksvold, M. P., C. B. Thien, J. Widerberg, A. Chantry, H. S. Huitfeldt, and W. Y. Langdon. 2003. Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor. Oncogene 22: 8509-8518.
    • (2003) Oncogene , vol.22 , pp. 8509-8518
    • Oksvold, M.P.1    Thien, C.B.2    Widerberg, J.3    Chantry, A.4    Huitfeldt, H.S.5    Langdon, W.Y.6
  • 29
    • 0033650093 scopus 로고    scopus 로고
    • Analysis of chemokine receptor endocytosis and recycling
    • Signoret, N., and M. Marsh. 2000. Analysis of chemokine receptor endocytosis and recycling. Methods Mol. Biol. 138: 197-207.
    • (2000) Methods Mol. Biol. , vol.138 , pp. 197-207
    • Signoret, N.1    Marsh, M.2
  • 30
    • 0036464697 scopus 로고    scopus 로고
    • Pathways for internalization and recycling of the chemokine receptor CCR5
    • Mueller, A., E. Kelly, and P. G. Strange. 2002. Pathways for internalization and recycling of the chemokine receptor CCR5. Blood 99: 785-791.
    • (2002) Blood , vol.99 , pp. 785-791
    • Mueller, A.1    Kelly, E.2    Strange, P.G.3
  • 31
    • 73149113991 scopus 로고    scopus 로고
    • Regulation of serotonin 1B receptor by glycogen synthase kinase-3
    • Chen, L., G. D. Salinas, and X. Li. 2009. Regulation of serotonin 1B receptor by glycogen synthase kinase-3. Mol. Pharmacol. 76: 1150-1161.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 1150-1161
    • Chen, L.1    Salinas, G.D.2    Li, X.3
  • 32
    • 78650226947 scopus 로고    scopus 로고
    • Interleukin-33: A novel mediator with a role in distinct disease pathologies
    • Kurowska-Stolarska, M., A. Hueber, B. Stolarski, and I. B. McInnes. 2011. Interleukin-33: A novel mediator with a role in distinct disease pathologies. J. Intern. Med. 269: 29-35.
    • (2011) J. Intern. Med. , vol.269 , pp. 29-35
    • Kurowska-Stolarska, M.1    Hueber, A.2    Stolarski, B.3    McInnes, I.B.4
  • 33
    • 33947635579 scopus 로고    scopus 로고
    • JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization
    • Martinez-Moczygemba, M., D. P. Huston, and J. T. Lei. 2007. JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. J. Leukoc. Biol. 81: 1137-1148.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1137-1148
    • Martinez-Moczygemba, M.1    Huston, D.P.2    Lei, J.T.3
  • 37
    • 84865599600 scopus 로고    scopus 로고
    • Endosomal crosstalk: Meeting points for signaling pathways
    • Pálfy, M., A. Reményi, and T. Korcsmáros. 2012. Endosomal crosstalk: meeting points for signaling pathways. Trends Cell Biol. 22: 447-456.
    • (2012) Trends Cell Biol , vol.22 , pp. 447-456
    • Pálfy, M.1    Reményi, A.2    Korcsmáros, T.3
  • 39
    • 0028913166 scopus 로고
    • Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β, and γ chains
    • Hémar, A., A. Subtil, M. Lieb, E. Morelon, R. Hellio, and A. Dautry-Varsat. 1995. Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor α, β, and γ chains. J. Cell Biol. 129: 55-64.
    • (1995) J. Cell Biol. , vol.129 , pp. 55-64
    • Hémar, A.1    Subtil, A.2    Lieb, M.3    Morelon, E.4    Hellio, R.5    Dautry-Varsat, A.6
  • 40
    • 77957817388 scopus 로고    scopus 로고
    • A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components
    • Gorbea, C., G. Pratt, V. Ustrell, R. Bell, S. Sahasrabudhe, R. E. Hughes, and M. Rechsteiner. 2010. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. 285: 31616-31633.
    • (2010) J. Biol. Chem. , vol.285 , pp. 31616-31633
    • Gorbea, C.1    Pratt, G.2    Ustrell, V.3    Bell, R.4    Sahasrabudhe, S.5    Hughes, R.E.6    Rechsteiner, M.7
  • 41
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D. A., D. R. Alessi, P. Cohen, M. Andjelkovich, and B. A. Hemmings. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 43
    • 0034718421 scopus 로고    scopus 로고
    • Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration
    • Bhat, R. V., J. Shanley, M. P. Correll, W. E. Fieles, R. A. Keith, C. W. Scott, and C. M. Lee. 2000. Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration. Proc. Natl. Acad. Sci. USA 97: 11074-11079.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11074-11079
    • Bhat, R.V.1    Shanley, J.2    Correll, M.P.3    Fieles, W.E.4    Keith, R.A.5    Scott, C.W.6    Lee, C.M.7
  • 45
    • 27444431517 scopus 로고    scopus 로고
    • Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration
    • Bianchi, M., S. De Lucchini, O. Marin, D. L. Turner, S. K. Hanks, and E. Villa-Moruzzi. 2005. Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem. J. 391: 359- 370.
    • (2005) Biochem. J. , vol.391 , pp. 359-370
    • Bianchi, M.1    De Lucchini, S.2    Marin, O.3    Turner, D.L.4    Hanks, S.K.5    Villa-Moruzzi, E.6
  • 46
    • 84897463092 scopus 로고    scopus 로고
    • FAK acts as a suppressor of RTKMAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells
    • Macagno, J. P., J. Diaz Vera, Y. Yu, I. MacPherson, E. Sandilands, R. Palmer, J. C. Norman, M. Frame, and M. Vidal. 2014. FAK acts as a suppressor of RTKMAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genet. 10: e1004262.
    • (2014) PLoS Genet , vol.10 , pp. e1004262
    • Macagno, J.P.1    Vera, J.D.2    Yu, Y.3    Macpherson, I.4    Sandilands, E.5    Palmer, R.6    Norman, J.C.7    Frame, M.8    Vidal, M.9
  • 47
    • 0035336425 scopus 로고    scopus 로고
    • A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
    • Sweet, M. J., B. P. Leung, D. Kang, M. Sogaard, K. Schulz, V. Trajkovic, C. C. Campbell, D. Xu, and F. Y. Liew. 2001. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J. Immunol. 166: 6633-6639.
    • (2001) J. Immunol. , vol.166 , pp. 6633-6639
    • Sweet, M.J.1    Leung, B.P.2    Kang, D.3    Sogaard, M.4    Schulz, K.5    Trajkovic, V.6    Campbell, C.C.7    Xu, D.8    Liew, F.Y.9
  • 48
    • 64549106883 scopus 로고    scopus 로고
    • ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis
    • Wieland, C. W., G. J. van der Windt, S. Florquin, A. N. McKenzie, and T. van der Poll. 2009. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 11: 524- 530.
    • (2009) Microbes Infect , vol.11 , pp. 524-530
    • Wieland, C.W.1    Van Der Windt, G.J.2    Florquin, S.3    McKenzie, A.N.4    Van Der Poll, T.5
  • 49
    • 34548825396 scopus 로고    scopus 로고
    • Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
    • Hayakawa, H., M. Hayakawa, A. Kume, and S. Tominaga. 2007. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem. 282: 26369-26380.
    • (2007) J. Biol. Chem. , vol.282 , pp. 26369-26380
    • Hayakawa, H.1    Hayakawa, M.2    Kume, A.3    Tominaga, S.4
  • 50
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • Mitra, S. K., and D. D. Schlaepfer. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18: 516-523.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2


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