T1/ST2 - An IL-1 receptor-like modulator of immune responses

Cytokine and Growth Factor Reviews

Volumn 15, Issue 2-3, 2004, Pages 87-95

  Trajkovic, Vladimir ^a   Sweet, Matthew J ^b   Xu, Damo ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cytokines; IL 1; Immune response; T1 ST2; Th2; TLR

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 4;

CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MEMBRANE; GENETIC STRAIN; HELPER CELL; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; REGULATORY MECHANISM; SHORT SURVEY; TH2 CELL;

ANIMALS; DOWN-REGULATION; HUMANS; INFLAMMATION; MACROPHAGES; MEMBRANE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 1942535018     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2004.02.004     Document Type: Short Survey

References (65)

1. Klemenz R., Hoffmann S., Werenskiold A.K. Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci USA. 86:1989;5708-5712.
2. Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor. FEBS Lett. 258:1989;301-304.
3. Tominaga S., Yokota T., Yanagisawa K., Tsukamoto T., Takagi T., Tetsuka T. Nucleotide sequence of a complementary DNA for human ST2. Biochim Biophys Acta. 1171:1992;215-218.
4. Bergers G., Reikerstorfer A., Braselmann S., Graninger P., Busslinger M. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 13:1994;1176-1188.
5. Tominaga S., Jenkins N.A., Gilbert D.J., Copeland N.G., Tetsuka T. Molecular cloning of the murine ST2 gene: characterization and chromosomal mapping. Biochim Biophys Acta. 1090:1991;1-8.
6. Dale M., Nicklin M.J. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics. 57:1999;177-179.
7. Kumar S., Minnich M.D., Young P.R. ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J Biol Chem. 270:1995;27905-27913.
8. Gayle M.A., Slack J.L., Bonnert T.P., Renshaw B.R., Sonoda G., Taguchi T.et al. Cloning of a putative ligand for the T1/ST2 receptor. J Biol Chem. 271:1996;5784-5789.
9. Gachter T., Werenskiold A.K., Klemenz R. Transcription of the interleukin-1 receptor-related T1 gene is initiated at different promoters in mast cells and fibroblasts. J Biol Chem. 271:1996;124-129.
10. Tago K., Noda T., Hayakawa M., Iwahana H., Yanagisawa K., Yashiro T.et al. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. Biochem Biophys Res Commun. 285:2001;1377-1383.
11. Iwahana H.K., Yanagisawa A., Ito-Kosaka K., Kuroiwa K., Tago H., Komatsu R.et al. Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. Eur J Biochem. 264:1999;397-406.
12. Mosmann T.R., Sad S. The expanding universe of T-cell subsets: TH1, Th2 and more. Immunol Today. 17:1996;1380.
13. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787.
14. Ho I., Hodge M.R., Rooney J.W., Glimcher L.H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell. 85:1996;973-983.
15. Zheng W., Flavell R. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:1997;587-596.
16. Del Prete G., De Carli M., Almerigogna F., Daniel C.K., D'Elios M.M., Zancuoghi G.et al. Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB J. 9:1995;81-86.
17. Sallusto F., Mackay C.R., Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 277:1997;2005-2007.
18. Bengtsson A., Johansson C., Linder M.T., Hallden G., van der Ploeg I., Scheynius A. Not only Th2 cells but also Th1 and Th0 cells express CD30 after activation. J Leukoc Biol. 58:1995;683-689.
19. Hamann D., Hilkens C.M., Grogan J.L., Lens S.M., Kapsenberg M.L., Yazdanbakhsh M.et al. CD30 expression does not discriminate between human Th1- and Th2-type T cells. J Immunol. 156:1996;1387-1391.
20. Yanagisawa K., Naito Y., Kuroiwa K., Arai T., Furukawa Y., Tomizuka H.et al. The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. J Biochem (Tokyo). 121:1997;95-103.
21. Xu D., Chan W.L., Leung B.P., Huang F., Wheeler R., Piedrafita D.et al. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med. 187:1998;787-794.
22. Lohning M., Stroehmann A., Coyle A.J., Grogan J.L., Lin S., Gutierrez-Ramos J.C.et al. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA. 95:1998;6930-6935.
23. Coyle A.J., Lloyd C., Tian J., Nguyen T., Erikkson C., Wang L.et al. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med. 190:1999;895-902.
24. Lambrecht B.N., De Veerman M., Coyle A.J., Gutierrez-Ramos J.C., Thielemans K., Pauwels R.A. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest. 106:2000;551-559.
25. Gajewska B.U., Swirski F.K., Alvarez D., Ritz S.A., Goncharova S., Cundall M.et al. Temporal-spatial analysis of the immune response in a murine model of ovalbumin-induced airways inflammation. Am J Respir Cell Mol Biol. 25:2001;326-334.
26. + T cells from schistosome egg-induced granulomas: analysis of Th cell cytokine coexpression ex vivo. J Immunol. 162:1999;3882-3889.
27. Townsend M.J., Fallon P.G., Matthews D.J., Jolin H.E., McKenzie A.N. T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med. 191:2000;1069-1076.
28. + Th2 cells in Leishmania major infection. Eur J Immunol. 32:2002;2450-2459.
29. Walzl G., Matthews S., Kendall S., Gutierrez-Ramos J.C., Coyle A.J., Openshaw P.J.et al. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med. 193:2001;785-792.
30. Chan W.L., Pejnovic N., Lee C.A., Al-Ali N.A. Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes. J Immunol. 167:2001;1238-1244.
31. Lecart S., Lecointe N., Subramaniam A., Alkan S., Ni D., Chen R.et al. Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol. 32:2002;2979-2987.
32. Salgame P., Abrams J.S., Clayberger H., Goldstein H., Convit J., Modlin R.L.et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 254:1991;279-282.
33. Croft M., Carter L., Swain S.L., Dutton R.W. Generation of polarized antigen-specific CD8 effector populations: reciprocal actions of interleukin IL-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 180:1994;1715-1728.
34. Peritt D., Robertson S., Gri G., Showe L., Aste-Amezaga M., Trinchieri G. Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol. 161:1998;5821-5824.
35. Kropf P., Herath S., Tewari R., Syed N., Klemenz R., Muller I. Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infect Immunol. 70:2002;5512-5520.
36. Kopf M., Le Gros M., Bachmann M., Lamers M.C., Bluethmann H., Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine response. Nature. 362:1993;245-248.
37. von der Weid T., Kopf M., Kohler G., Langhorne J. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur J Immunol. 24:1994;2285-2293.
38. Kropf P., Schopf L.R., Chung C.L., Xu D., Liew F.Y., Sypek J.P.et al. Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection. Eur J Immunol. 29:1999;3621-3628.
39. + T cells by IL-4 and IFN-γ J Immunol. 158:1997;2090-2098.
40. Carter R.W., Sweet M.J., Xu D., Klemenz R., Liew F.Y., Chan W.L. Regulation of ST2L expression on T helper (Th) type 2 cells. Eur J Immunol. 31:2001;2979-2985.
41. + T cells: induction of type 2 cytokine production by T1/ST2 cross-linking. J Immunol. 166:2001;3143-3150.
42. + T-cell responses: the alternative approaches. Annu Rev Immunol. 15:1997;297-322.
43. Murphy K.M., Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol. 2:2002;933-944.
44. Hoshino K., Kashiwamura S., Kuribayashi K., Kodama T., Tsujimura T., Nakanishi K.et al. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med. 190:1999;1541-1548.
45. Senn K.A., McCoy K.D., Maloy K.J., Stark G., Frohli E., Rulicke T.et al. T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. Eur J Immunol. 30:2000;1929-1938.
46. Brint E.K., Fitzgerald K.A., Smith P., Coyle A.J., Gutierrez-Ramos J.C., Fallon P.G.et al. Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2: A role for Jun N-terminal kinase in IL-4 induction. J Biol Chem. 277:2002;49205-49211.
47. Kropf P., Herath S., Klemenz R., Muller I. Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection. Infect Immunol. 71:2003;1961-1971.
48. Moritz D.R., Rodewald H.R., Gheyselinck J., Klemenz R. The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. J Immunol. 161:1998;4866-4874.
49. Kumar S., Tzimas M.N., Griswold D.E., Young P.R. Expression of ST2, an interleukin-1 receptor homologue, is induced by pro-inflammatory stimuli. Biochem Biophys Res Commun. 235:1997;474-478.
50. Saccani S., Polentarutti N., Penton-Rol G., Sims J.E., Mantovani A. Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo. Cytokine. 10:1998;773-780.
51. Oshikawa K., Yanagisawa K., Tominaga S., Sugiyama Y. ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation. Biochem Biophys Res Commun. 299:2002;18-24.
52. Kuroiwa K., Arai T., Okazaki H., Minota S., Tominaga S. Identification of human ST2 protein in the sera of patients with autoimmune diseases. Biochem Biophys Res Commun. 284:2001;1104-1108.
53. Oshikawa K., Kuroiwa K., Tago K., Iwahana H., Yanagisawa K., Ohno S.et al. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med. 164:2001;277-281.
54. Tajima S., Oshikawa K., Tominaga S., Sugiyama Y. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Chest. 124:2003;1206-1214.
55. Weinberg E.O., Shimpo M., De Keulenaer G.W., MacGillivray C., Tominaga S., Solomon S.D.et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 106:2002;2961-2966.
56. Oshikawa K., Yanagisawa K., Tominaga S., Sugiyama Y. Expression and function of the ST2 gene in a murine model of allergic airway inflammation. Clin Exp Allergy. 32:2002;1520-1526.
57. Standiford T.J., Strieter R.M., Lukacs N.W., Kunkel S.L. Neutralization of IL-10 increases lethality in endotoxemia: cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J Immunol. 155:1995;2222-2229.
58. Sweet M.J., Leung B.P., Kang D., Sogaard M., Schulz K., Trajkovic V.et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol. 166:2001;6633-6639.
59. Nomura F., Akashi S., Sakao Y., Sato S., Kawai T., Matsumoto M.et al. Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression. J Immunol. 164:2000;3476-3479.
60. Brint K, Xu D, Liu H, McKenzie AN, O'Neill LA, Liew FY. T1/ST2 is an inhibitor of IL-1R and TLR4 signalling and maintains endotoxin tolerance. Nat Immunol; 2004, in press.
61. O'Neill L.A. Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. Curr Top Microbiol Immunol. 270:2002;47-61.
62. Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol. 2:2001;947-950.
63. Muraille E., De Trez C., Brait M., De Baetselier P., Leo O., Carlier Y. Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J Immunol. 170:2003;4237-4241.
64. Thomas P.S. Tumour necrosis factor-α: the role of this multifunctional cytokine in asthma. Immunol Cell Biol. 79:2001;132-140.
65. Barnes P.J. Cytokine modulators as novel therapies for asthma. Annu Rev Pharmacol Toxicol. 42:2002;81-88.