-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61(2):69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, Issue.2
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
3
-
-
84858005605
-
Nuclear export of proteins and drug resistance in cancer
-
Turner J.G., Dawson J., Sullivan D.M. Nuclear export of proteins and drug resistance in cancer. Biochem Pharmacol 2012, 83(8):1021-1032.
-
(2012)
Biochem Pharmacol
, vol.83
, Issue.8
, pp. 1021-1032
-
-
Turner, J.G.1
Dawson, J.2
Sullivan, D.M.3
-
4
-
-
0030924190
-
CRM1 is an export receptor for leucine-rich nuclear export signals
-
Fornerod M., Ohno M., Yoshida M., Mattaj I.W. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 1997, 90(6):1051-1060.
-
(1997)
Cell
, vol.90
, Issue.6
, pp. 1051-1060
-
-
Fornerod, M.1
Ohno, M.2
Yoshida, M.3
Mattaj, I.W.4
-
5
-
-
0030831534
-
CRM1 is responsible for intracellular transport mediated by the nuclear export signal
-
Fukuda M., Asano S., Nakamura T., Adachi M., Yoshida M., Yanagida M., et al. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 1997, 390(6657):308-311.
-
(1997)
Nature
, vol.390
, Issue.6657
, pp. 308-311
-
-
Fukuda, M.1
Asano, S.2
Nakamura, T.3
Adachi, M.4
Yoshida, M.5
Yanagida, M.6
-
6
-
-
0030748907
-
Evidence for a role of CRM1 in signal-mediated nuclear protein export
-
Ossareh-Nazari B., Bachelerie F., Dargemont C. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 1997, 278(5335):141-144.
-
(1997)
Science
, vol.278
, Issue.5335
, pp. 141-144
-
-
Ossareh-Nazari, B.1
Bachelerie, F.2
Dargemont, C.3
-
7
-
-
0030985459
-
Exportin 1 (Crm1p) is an essential nuclear export factor
-
Stade K., Ford C.S., Guthrie C., Weis K. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 1997, 90(6):1041-1050.
-
(1997)
Cell
, vol.90
, Issue.6
, pp. 1041-1050
-
-
Stade, K.1
Ford, C.S.2
Guthrie, C.3
Weis, K.4
-
8
-
-
78649650714
-
Recognition of nuclear targeting signals by karyopherin-beta proteins
-
Xu D., Farmer A., Chook Y.M. Recognition of nuclear targeting signals by karyopherin-beta proteins. Curr Opin Struct Biol 2010, 20(6):782-790.
-
(2010)
Curr Opin Struct Biol
, vol.20
, Issue.6
, pp. 782-790
-
-
Xu, D.1
Farmer, A.2
Chook, Y.M.3
-
9
-
-
0033559256
-
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
-
Stommel J.M., Marchenko N.D., Jimenez G.S., Moll U.M., Hope T.J., Wahl G.M. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J 1999, 18(6):1660-1672.
-
(1999)
EMBO J
, vol.18
, Issue.6
, pp. 1660-1672
-
-
Stommel, J.M.1
Marchenko, N.D.2
Jimenez, G.S.3
Moll, U.M.4
Hope, T.J.5
Wahl, G.M.6
-
10
-
-
0842269247
-
The importance of p53 location: nuclear or cytoplasmic zip code?
-
O'Brate A., Giannakakou P. The importance of p53 location: nuclear or cytoplasmic zip code?. Drug Resist Updat 2003, 6(6):313-322.
-
(2003)
Drug Resist Updat
, vol.6
, Issue.6
, pp. 313-322
-
-
O'Brate, A.1
Giannakakou, P.2
-
11
-
-
0033953587
-
A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes
-
Huang T.T., Kudo N., Yoshida M., Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci U S A 2000, 97(3):1014-1019.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.3
, pp. 1014-1019
-
-
Huang, T.T.1
Kudo, N.2
Yoshida, M.3
Miyamoto, S.4
-
12
-
-
0036343736
-
CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin
-
Rodriguez J.A., Span S.W., Ferreira C.G., Kruyt F.A., Giaccone G. CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin. Exp Cell Res 2002, 275(1):44-53.
-
(2002)
Exp Cell Res
, vol.275
, Issue.1
, pp. 44-53
-
-
Rodriguez, J.A.1
Span, S.W.2
Ferreira, C.G.3
Kruyt, F.A.4
Giaccone, G.5
-
13
-
-
14844311208
-
Nuclear or cytoplasmic expression of survivin: what is the significance?
-
Li F., Yang J., Ramnath N., Javle M.M., Tan D. Nuclear or cytoplasmic expression of survivin: what is the significance?. Int J Cancer 2005, 114(4):509-512.
-
(2005)
Int J Cancer
, vol.114
, Issue.4
, pp. 509-512
-
-
Li, F.1
Yang, J.2
Ramnath, N.3
Javle, M.M.4
Tan, D.5
-
14
-
-
34447120194
-
Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential
-
Stauber R.H., Mann W., Knauer S.K. Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential. Cancer Res 2007, 67(13):5999-6002.
-
(2007)
Cancer Res
, vol.67
, Issue.13
, pp. 5999-6002
-
-
Stauber, R.H.1
Mann, W.2
Knauer, S.K.3
-
15
-
-
0037268889
-
Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs
-
Yashiroda Y., Yoshida M. Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs. Curr Med Chem 2003, 10(9):741-748.
-
(2003)
Curr Med Chem
, vol.10
, Issue.9
, pp. 741-748
-
-
Yashiroda, Y.1
Yoshida, M.2
-
16
-
-
61649105802
-
CRM1-mediated nuclear export of proteins and drug resistance in cancer
-
Turner J.G., Sullivan D.M. CRM1-mediated nuclear export of proteins and drug resistance in cancer. Curr Med Chem 2008, 15(26):2648-2655.
-
(2008)
Curr Med Chem
, vol.15
, Issue.26
, pp. 2648-2655
-
-
Turner, J.G.1
Sullivan, D.M.2
-
17
-
-
0033529866
-
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
-
Kudo N., Matsumori N., Taoka H., Fujiwara D., Schreiner E.P., Wolff B., et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A 1999, 96(16):9112-9117.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.16
, pp. 9112-9117
-
-
Kudo, N.1
Matsumori, N.2
Taoka, H.3
Fujiwara, D.4
Schreiner, E.P.5
Wolff, B.6
-
18
-
-
18544412268
-
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1
-
Koster M., Lykke-Andersen S., Elnakady Y.A., Gerth K., Washausen P., Höfle G., et al. Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Exp Cell Res 2003, 286(2):321-331.
-
(2003)
Exp Cell Res
, vol.286
, Issue.2
, pp. 321-331
-
-
Koster, M.1
Lykke-Andersen, S.2
Elnakady, Y.A.3
Gerth, K.4
Washausen, P.5
Höfle, G.6
-
19
-
-
58349104143
-
Identification of nuclear export inhibitors with potent anticancer activity in vivo
-
Mutka S.C., Yang W.Q., Dong S.D., Ward S.L., Craig D.A., Timmermans P.B., et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res 2009, 69(2):510-517.
-
(2009)
Cancer Res
, vol.69
, Issue.2
, pp. 510-517
-
-
Mutka, S.C.1
Yang, W.Q.2
Dong, S.D.3
Ward, S.L.4
Craig, D.A.5
Timmermans, P.B.6
-
20
-
-
0037152414
-
New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix
-
Murakami N., Ye Y., Kawanishi M., Aoki S., Kudo N., Yoshida M., et al. New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix. Bioorg Med Chem Lett 2002, 12(20):2807-2810.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, Issue.20
, pp. 2807-2810
-
-
Murakami, N.1
Ye, Y.2
Kawanishi, M.3
Aoki, S.4
Kudo, N.5
Yoshida, M.6
-
21
-
-
53749090455
-
Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action
-
Van Neck T., Pannecouque C., Vanstreels E., Stevens M., Dehaen W., Daelemans D. Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action. Bioorg Med Chem 2008, 16(21):9487-9497.
-
(2008)
Bioorg Med Chem
, vol.16
, Issue.21
, pp. 9487-9497
-
-
Van Neck, T.1
Pannecouque, C.2
Vanstreels, E.3
Stevens, M.4
Dehaen, W.5
Daelemans, D.6
-
22
-
-
80053619765
-
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity
-
Sakakibara K., Saito N., Sato T., Suzuki A., Hasegawa Y., Friedman J.M., et al. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood 2011, 118(14):3922-3931.
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3922-3931
-
-
Sakakibara, K.1
Saito, N.2
Sato, T.3
Suzuki, A.4
Hasegawa, Y.5
Friedman, J.M.6
-
24
-
-
84870502798
-
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
-
Lapalombella R., Sun Q., Williams K., Tangeman L., Jha S., Zhong Y., et al. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood 2012, 120(23):4621-4634.
-
(2012)
Blood
, vol.120
, Issue.23
, pp. 4621-4634
-
-
Lapalombella, R.1
Sun, Q.2
Williams, K.3
Tangeman, L.4
Jha, S.5
Zhong, Y.6
-
25
-
-
84865749132
-
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
-
Ranganathan P., Yu X., Na C., Santhanam R., Shacham S., Kauffman M., et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood 2012, 120(9):1765-1773.
-
(2012)
Blood
, vol.120
, Issue.9
, pp. 1765-1773
-
-
Ranganathan, P.1
Yu, X.2
Na, C.3
Santhanam, R.4
Shacham, S.5
Kauffman, M.6
-
26
-
-
84877601009
-
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth
-
Inoue H., Kauffman M., Shacham S., Landesman Y., Yang J., Evans C.P., et al. CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth. J Urol 2013, 189(6):2317-2326.
-
(2013)
J Urol
, vol.189
, Issue.6
, pp. 2317-2326
-
-
Inoue, H.1
Kauffman, M.2
Shacham, S.3
Landesman, Y.4
Yang, J.5
Evans, C.P.6
-
27
-
-
84881323214
-
Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice
-
Azmi A.S., Aboukameel A., Bao B., Sarkar F.H., Philip P.A., Kauffman M., et al. Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. Gastroenterology 2013, 144(2):447-456.
-
(2013)
Gastroenterology
, vol.144
, Issue.2
, pp. 447-456
-
-
Azmi, A.S.1
Aboukameel, A.2
Bao, B.3
Sarkar, F.H.4
Philip, P.A.5
Kauffman, M.6
-
28
-
-
84870887672
-
Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma
-
e64
-
Zhang K., Wang M., Tamayo A.T., Shacham S., Kauffman M., Lee J., et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol 2013, 41(1):67-78. e64.
-
(2013)
Exp Hematol
, vol.41
, Issue.1
, pp. 67-78
-
-
Zhang, K.1
Wang, M.2
Tamayo, A.T.3
Shacham, S.4
Kauffman, M.5
Lee, J.6
-
29
-
-
84873570648
-
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
-
Etchin J., Sun Q., Kentsis A., Farmer A., Zhang Z.C., Sanda T., et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia 2013, 27(1):66-74.
-
(2013)
Leukemia
, vol.27
, Issue.1
, pp. 66-74
-
-
Etchin, J.1
Sun, Q.2
Kentsis, A.3
Farmer, A.4
Zhang, Z.C.5
Sanda, T.6
-
30
-
-
84875052270
-
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
-
Etchin J., Sanda T., Mansour M.R., Kentsis A., Montero J., Le B.T., et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol 2013, 161(1):117-127.
-
(2013)
Br J Haematol
, vol.161
, Issue.1
, pp. 117-127
-
-
Etchin, J.1
Sanda, T.2
Mansour, M.R.3
Kentsis, A.4
Montero, J.5
Le, B.T.6
-
31
-
-
84891847971
-
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications
-
Tai Y.T., Landesman Y., Acharya C., Calle Y3, Zhong MY1, Cea M1 et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia 2014, 28(1):155-165.
-
(2014)
Leukemia
, vol.28
, Issue.1
, pp. 155-165
-
-
Tai, Y.T.1
Landesman, Y.2
Acharya, C.3
Calle, Y34
Zhong, M.Y.5
Cea, M.6
et, A.7
-
32
-
-
33847066706
-
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
-
Goldberg A.L. Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. Biochem Soc Trans 2007, 35(Pt 1):12-17.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 12-17
-
-
Goldberg, A.L.1
-
33
-
-
84890380827
-
Current treatment and future prospects for peripheral T-cell lymphoma
-
Eyre T.A., Collins G.P. Current treatment and future prospects for peripheral T-cell lymphoma. Drugs Today (Barc) 2013, 49(10):631-646.
-
(2013)
Drugs Today (Barc)
, vol.49
, Issue.10
, pp. 631-646
-
-
Eyre, T.A.1
Collins, G.P.2
-
34
-
-
84877782370
-
Treatment of peripheral T-cell lymphoma: are we data driven or driving the data?
-
Lunning M.A., Horwitz S. Treatment of peripheral T-cell lymphoma: are we data driven or driving the data?. Curr Treat Options Oncol 2013, 14(2):212-223.
-
(2013)
Curr Treat Options Oncol
, vol.14
, Issue.2
, pp. 212-223
-
-
Lunning, M.A.1
Horwitz, S.2
-
35
-
-
57149112608
-
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways
-
Dey A., Tergaonkar V., Lane D.P. Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways. Nat Rev Drug Discov 2008, 7(12):1031-1040.
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.12
, pp. 1031-1040
-
-
Dey, A.1
Tergaonkar, V.2
Lane, D.P.3
-
36
-
-
6344261577
-
Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms
-
Chakravarti A., Zhai G.G., Zhang M., Malhotra R., Latham D.E., Delaney M.A., et al. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene 2004, 23(45):7494-7506.
-
(2004)
Oncogene
, vol.23
, Issue.45
, pp. 7494-7506
-
-
Chakravarti, A.1
Zhai, G.G.2
Zhang, M.3
Malhotra, R.4
Latham, D.E.5
Delaney, M.A.6
-
37
-
-
4844227693
-
Survivin as a therapeutic target for radiation sensitization in lung cancer
-
Lu B., Mu Y., Cao C., Zeng F., Schneider S., Tan J., et al. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res 2004, 64(8):2840-2845.
-
(2004)
Cancer Res
, vol.64
, Issue.8
, pp. 2840-2845
-
-
Lu, B.1
Mu, Y.2
Cao, C.3
Zeng, F.4
Schneider, S.5
Tan, J.6
-
38
-
-
80052148548
-
Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia
-
Park E., Gang E.J., Hsieh Y.T., Schaefer P., Chae S., Klemm L., et al. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood 2011, 118(8):2191-2199.
-
(2011)
Blood
, vol.118
, Issue.8
, pp. 2191-2199
-
-
Park, E.1
Gang, E.J.2
Hsieh, Y.T.3
Schaefer, P.4
Chae, S.5
Klemm, L.6
-
39
-
-
33947311353
-
Survivin's dual role: an export's view
-
Knauer S.K., Mann W., Stauber R.H. Survivin's dual role: an export's view. Cell Cycle 2007, 6(5):518-521.
-
(2007)
Cell Cycle
, vol.6
, Issue.5
, pp. 518-521
-
-
Knauer, S.K.1
Mann, W.2
Stauber, R.H.3
-
40
-
-
33749529901
-
Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal
-
Stauber R.H., Rabenhorst U., Rekik A., Engels K., Bier C., Knauer S.K. Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal. Traffic 2006, 7(11):1461-1472.
-
(2006)
Traffic
, vol.7
, Issue.11
, pp. 1461-1472
-
-
Stauber, R.H.1
Rabenhorst, U.2
Rekik, A.3
Engels, K.4
Bier, C.5
Knauer, S.K.6
-
41
-
-
78649308461
-
Survivin withdrawal by nuclear export failure as a physiological switch to commit cells to apoptosis
-
Chan K.S., Wong C.H., Huang Y.F., Li H.Y. Survivin withdrawal by nuclear export failure as a physiological switch to commit cells to apoptosis. Cell Death Dis 2010, 1:e57.
-
(2010)
Cell Death Dis
, vol.1
, pp. e57
-
-
Chan, K.S.1
Wong, C.H.2
Huang, Y.F.3
Li, H.Y.4
|