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Volumn 56, Issue , 2015, Pages 45-55

Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity

Author keywords

Autoimmunity; CD4+ T lymphocytes; Cholesterol 25 hydroxylase (Ch25h); Experimental autoimmune encephalomyelitis; Oxysterols; Trafficking

Indexed keywords

7ALPHA,25 DIHYDROXYCHOLESTEROL; BIOLOGICAL MARKER; CHOLESTEROL; CHOLESTEROL 25 HYDROXYLASE; EPSTEIN BARR VIRUS INDUCED GENE 2; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 17; OXYGENASE; OXYSTEROL; PROTEIN; UNCLASSIFIED DRUG; ANTIGEN; CHOLESTEROL 25-HYDROXYLASE; CHOLESTEROL DERIVATIVE; CYTOKINE; GPR183 PROTEIN, MOUSE; STEROID MONOOXYGENASE;

EID: 84920284167     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2014.10.001     Document Type: Article
Times cited : (71)

References (36)
  • 1
    • 84885649688 scopus 로고    scopus 로고
    • Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event
    • Weinstock-Guttman B., Zivadinov R., Horakova D., Havrdova E., Qu J., Shyh G., et al. Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event. JNeurol Neurosurg Psychiatry 2013, 84:1186-1191.
    • (2013) JNeurol Neurosurg Psychiatry , vol.84 , pp. 1186-1191
    • Weinstock-Guttman, B.1    Zivadinov, R.2    Horakova, D.3    Havrdova, E.4    Qu, J.5    Shyh, G.6
  • 2
    • 77950209814 scopus 로고    scopus 로고
    • Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis
    • Marrie R.A., Rudick R., Horwitz R., Cutter G., Tyry T., Campagnolo D., et al. Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology 2010, 74:1041-1047.
    • (2010) Neurology , vol.74 , pp. 1041-1047
    • Marrie, R.A.1    Rudick, R.2    Horwitz, R.3    Cutter, G.4    Tyry, T.5    Campagnolo, D.6
  • 4
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef S., Stuve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002, 420:78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stuve, O.2    Patarroyo, J.C.3    Ruiz, P.J.4    Radosevich, J.L.5    Hur, E.M.6
  • 5
    • 2442561768 scopus 로고    scopus 로고
    • Oral simvastatin treatment in relapsing-remitting multiple sclerosis
    • Vollmer T., Key L., Durkalski V., Tyor W., Corboy J., Markovic-Plese S., et al. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 2004, 363:1607-1608.
    • (2004) Lancet , vol.363 , pp. 1607-1608
    • Vollmer, T.1    Key, L.2    Durkalski, V.3    Tyor, W.4    Corboy, J.5    Markovic-Plese, S.6
  • 6
    • 79960341237 scopus 로고    scopus 로고
    • Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial
    • Sorensen P.S., Lycke J., Eralinna J.P., Edland A., Wu X., Frederiksen J.L., et al. Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial. Lancet Neurol 2011, 10:691-701.
    • (2011) Lancet Neurol , vol.10 , pp. 691-701
    • Sorensen, P.S.1    Lycke, J.2    Eralinna, J.P.3    Edland, A.4    Wu, X.5    Frederiksen, J.L.6
  • 7
    • 84903318797 scopus 로고    scopus 로고
    • Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
    • Chataway J., Schuerer N., Alsanousi A., Chan D., MacManus D., Hunter K., et al. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet 2014, 383:2213-2221.
    • (2014) Lancet , vol.383 , pp. 2213-2221
    • Chataway, J.1    Schuerer, N.2    Alsanousi, A.3    Chan, D.4    MacManus, D.5    Hunter, K.6
  • 8
    • 84883181808 scopus 로고    scopus 로고
    • Sterols and oxysterols in immune cell function
    • Spann N.J., Glass C.K. Sterols and oxysterols in immune cell function. Nat Immunol 2013, 14:893-900.
    • (2013) Nat Immunol , vol.14 , pp. 893-900
    • Spann, N.J.1    Glass, C.K.2
  • 9
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 2003, 72:137-174.
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 10
    • 0037131563 scopus 로고    scopus 로고
    • Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
    • Leoni V., Masterman T., Diczfalusy U., De Luca G., Hillert J., Bjorkhem I. Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. Neurosci Lett 2002, 331:163-166.
    • (2002) Neurosci Lett , vol.331 , pp. 163-166
    • Leoni, V.1    Masterman, T.2    Diczfalusy, U.3    De Luca, G.4    Hillert, J.5    Bjorkhem, I.6
  • 11
    • 33645106219 scopus 로고    scopus 로고
    • Cholesterol-metabolizing cytochromes P450
    • Pikuleva I.A. Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos Biol Fate Chem 2006, 34:513-520.
    • (2006) Drug Metab Dispos Biol Fate Chem , vol.34 , pp. 513-520
    • Pikuleva, I.A.1
  • 12
    • 70349730033 scopus 로고    scopus 로고
    • 25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A production
    • Bauman D.R., Bitmansour A.D., McDonald J.G., Thompson B.M., Liang G., Russell D.W. 25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A 2009, 106:16764-16769.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16764-16769
    • Bauman, D.R.1    Bitmansour, A.D.2    McDonald, J.G.3    Thompson, B.M.4    Liang, G.5    Russell, D.W.6
  • 13
    • 84866518376 scopus 로고    scopus 로고
    • Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses
    • Yi T., Wang X., Kelly L.M., An J., Xu Y., Sailer A.W., et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity 2012, 37:535-548.
    • (2012) Immunity , vol.37 , pp. 535-548
    • Yi, T.1    Wang, X.2    Kelly, L.M.3    An, J.4    Xu, Y.5    Sailer, A.W.6
  • 14
    • 84872794099 scopus 로고    scopus 로고
    • The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response
    • Blanc M., Hsieh W.Y., Robertson K.A., Kropp K.A., Forster T., Shui G., et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 2013, 38:106-118.
    • (2013) Immunity , vol.38 , pp. 106-118
    • Blanc, M.1    Hsieh, W.Y.2    Robertson, K.A.3    Kropp, K.A.4    Forster, T.5    Shui, G.6
  • 15
    • 84872790828 scopus 로고    scopus 로고
    • Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
    • Liu S.Y., Aliyari R., Chikere K., Li G., Marsden M.D., Smith J.K., et al. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity 2013, 38:92-105.
    • (2013) Immunity , vol.38 , pp. 92-105
    • Liu, S.Y.1    Aliyari, R.2    Chikere, K.3    Li, G.4    Marsden, M.D.5    Smith, J.K.6
  • 17
    • 84876545322 scopus 로고    scopus 로고
    • The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells
    • Gatto D., Wood K., Caminschi I., Murphy-Durland D., Schofield P., Christ D., et al. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol 2013, 14:446-453.
    • (2013) Nat Immunol , vol.14 , pp. 446-453
    • Gatto, D.1    Wood, K.2    Caminschi, I.3    Murphy-Durland, D.4    Schofield, P.5    Christ, D.6
  • 18
    • 84879033554 scopus 로고    scopus 로고
    • EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture
    • Yi T., Cyster J.G. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. eLife 2013, 2:e00757.
    • (2013) eLife , vol.2 , pp. e00757
    • Yi, T.1    Cyster, J.G.2
  • 19
    • 84896522891 scopus 로고    scopus 로고
    • GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis
    • Ko H.J., Brady J.L., Ryg-Cornejo V., Hansen D.S., Vremec D., Shortman K., et al. GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis. JImmunol 2014, 192:2202-2209.
    • (2014) JImmunol , vol.192 , pp. 2202-2209
    • Ko, H.J.1    Brady, J.L.2    Ryg-Cornejo, V.3    Hansen, D.S.4    Vremec, D.5    Shortman, K.6
  • 20
    • 0027979005 scopus 로고
    • Minireview: autoimmune responses to myelin proteolipid protein
    • Sobel R.A., Greer J.M., Kuchroo V.K. Minireview: autoimmune responses to myelin proteolipid protein. Neurochem Res 1994, 19:915-921.
    • (1994) Neurochem Res , vol.19 , pp. 915-921
    • Sobel, R.A.1    Greer, J.M.2    Kuchroo, V.K.3
  • 22
    • 77954546617 scopus 로고    scopus 로고
    • Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. Journal of Alzheimer's disease
    • Laumet G., Chouraki V., Grenier-Boley B., Legry V., Heath S., Zelenika D., et al. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. Journal of Alzheimer's disease. JAD 2010, 20:1181-1188.
    • (2010) JAD , vol.20 , pp. 1181-1188
    • Laumet, G.1    Chouraki, V.2    Grenier-Boley, B.3    Legry, V.4    Heath, S.5    Zelenika, D.6
  • 23
    • 0033386960 scopus 로고    scopus 로고
    • Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides
    • Rao M.L., Lutjohann D., Ludwig M., Kolsch H. Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. Ann N. Y Acad Sci 1999, 893:379-381.
    • (1999) Ann N. Y Acad Sci , vol.893 , pp. 379-381
    • Rao, M.L.1    Lutjohann, D.2    Ludwig, M.3    Kolsch, H.4
  • 24
    • 79960908110 scopus 로고    scopus 로고
    • Oxysterols direct B-cell migration through EBI2
    • Liu C., Yang X.V., Wu J., Kuei C., Mani N.S., Zhang L., et al. Oxysterols direct B-cell migration through EBI2. Nature 2011, 475:519-523.
    • (2011) Nature , vol.475 , pp. 519-523
    • Liu, C.1    Yang, X.V.2    Wu, J.3    Kuei, C.4    Mani, N.S.5    Zhang, L.6
  • 25
    • 84898829627 scopus 로고    scopus 로고
    • Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages
    • Preuss I., Ludwig M.G., Baumgarten B., Bassilana F., Gessier F., Seuwen K., et al. Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages. Biochem Biophys Res Commun 2014, 446(3):663-668.
    • (2014) Biochem Biophys Res Commun , vol.446 , Issue.3 , pp. 663-668
    • Preuss, I.1    Ludwig, M.G.2    Baumgarten, B.3    Bassilana, F.4    Gessier, F.5    Seuwen, K.6
  • 26
    • 78649752711 scopus 로고    scopus 로고
    • Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
    • Park K., Scott A.L. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. JLeukoc Biol 2010, 88:1081-1087.
    • (2010) JLeukoc Biol , vol.88 , pp. 1081-1087
    • Park, K.1    Scott, A.L.2
  • 27
    • 84905923112 scopus 로고    scopus 로고
    • Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
    • Reboldi A., Dang E.V., McDonald J.G., Liang G., Russell D.W., Cyster J.G. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 2014, 345:679-684.
    • (2014) Science , vol.345 , pp. 679-684
    • Reboldi, A.1    Dang, E.V.2    McDonald, J.G.3    Liang, G.4    Russell, D.W.5    Cyster, J.G.6
  • 28
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: long secret life behind a barrier
    • Bjorkhem I., Meaney S. Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 2004, 24:806-815.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 806-815
    • Bjorkhem, I.1    Meaney, S.2
  • 29
    • 84898831894 scopus 로고    scopus 로고
    • Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease
    • Gosselet F., Saint-Pol J., Fenart L. Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. Biochem Biophys Res Commun 2014, 446(3):687-691.
    • (2014) Biochem Biophys Res Commun , vol.446 , Issue.3 , pp. 687-691
    • Gosselet, F.1    Saint-Pol, J.2    Fenart, L.3
  • 31
    • 84861742491 scopus 로고    scopus 로고
    • ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation
    • Gold E.S., Ramsey S.A., Sartain M.J., Selinummi J., Podolsky I., Rodriguez D.J., et al. ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. JExp Med 2012, 209:807-817.
    • (2012) JExp Med , vol.209 , pp. 807-817
    • Gold, E.S.1    Ramsey, S.A.2    Sartain, M.J.3    Selinummi, J.4    Podolsky, I.5    Rodriguez, D.J.6
  • 32
    • 0033535952 scopus 로고    scopus 로고
    • Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
    • Brocke S., Piercy C., Steinman L., Weissman I.L., Veromaa T. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci U S A 1999, 96:6896-6901.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6896-6901
    • Brocke, S.1    Piercy, C.2    Steinman, L.3    Weissman, I.L.4    Veromaa, T.5
  • 33
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 34
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. JImmunol 2006, 177:566-573.
    • (2006) JImmunol , vol.177 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6
  • 35
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T., Reddy J., Gao W., Bettelli E., Awasthi A., Petersen T.R., et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007, 13:423-431.
    • (2007) Nat Med , vol.13 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3    Bettelli, E.4    Awasthi, A.5    Petersen, T.R.6
  • 36
    • 84855475637 scopus 로고    scopus 로고
    • Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE
    • Rothhammer V., Heink S., Petermann F., Srivastava R., Claussen M.C., Hemmer B., et al. Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. JExp Med 2011, 208:2465-2476.
    • (2011) JExp Med , vol.208 , pp. 2465-2476
    • Rothhammer, V.1    Heink, S.2    Petermann, F.3    Srivastava, R.4    Claussen, M.C.5    Hemmer, B.6


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