Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides

Annals of the New York Academy of Sciences

Volumn 893, Issue , 1999, Pages 379-381

  Rao, Marie Luise ^a   Lütjohann, Dieter ^a   Ludwig, Michael ^a   Kölsch, Heike ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7 OXOCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; CHOLESTEROL; DNA FRAGMENT; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATIVE STRESS;

EID: 0033386960     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07860.x     Document Type: Conference Paper

References (6)

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2. 2. Lütjohann, D, O. Breuer, G. Ahlborg, I. Nennesmo, A. Sieden, U. Diczfalusy & I. Björkhem. 1996. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93: 9799-9804.
3. 3. Kölsch, H., D. Lütjohann, A. Tulke, I. Björkhem & M.L. Rao. 1999. The neurotoxic effect of 24-hydroxycholesterol on SY-SY5Y human neuroblastoma cells. Brain Res. 818: 171-175.
4. 4. Chang, J.Y., K.D. Phelan & J.A. Chavis. 1998. Neurotoxicity of 25-OH-cholesterol on sympathetic neurons. Brain Res. Bull. 45: 615-622.
5. 5. Papassotiropoulos, A., D. Lütjohann, S. Locatelli, M. Bagli, M.L. Rao, I. Björkhem, K. Von Bergmann & R. Heun. 1998. Oxidized products of brain cholesterol metabolism are potential markers of Alzheimer's disease. Soc. Neurosci. 24: 1270.
6. 6. Lütjohann, D., A. Papassotiropoulos, I. Björkhem, S. Locatelli, M. Bagli, R.D. Oehring, U. Schlegel, F. Jessen, M.L. Rao, K. Von Bergmann & R. Heun. 1999. Plasma 24S-hydroxy-cholesterol (cebrosterol) is increased in Alzheimer and vascular demented patients. J. Lipid Res. In press.