Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues

European Journal of Medicinal Chemistry

Volumn 67, Issue , 2013, Pages 152-157

  Yuan, Li ^a   Song, ChangWei ^a   Li, CaiHu ^a   Li, Ying ^a   Dong, Lin ^a   Yin, ShuFan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

17AAG; Allopurinol; Antitumour; Pyrazolo 3,4 d pyrimidines; XOD

Indexed keywords

2 [4 [(4 ACETAMIDOPHENYL)AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETIC ACID; 2 [4 [[4 (2 CHLOROACETAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D][3,4 D]PYRIMIDIN 1 YL]ACETIC ACID; 2 [4 [[4 (4 BROMOPHENYLSULFONAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETIC ACID; 2 [4 [[4 (4 NITROPHENYLSULFONAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETIC ACID; ANTINEOPLASTIC AGENT; CHLORINE; ETHYL 2 [4 [(4 ACETAMIDOPHENYL)AMINO] 1H PYRAZOLO[3,4 D] PYRIMIDIN 1 YL]ACETATE; ETHYL 2 [4 [(4 BENZAMIDOPHENYL)AMINO] 1H PYRAZOLO[3,4 D] PYRIMIDIN 1 YL]ACETATE; ETHYL 2 [4 [[4 (2 CHLOROACETAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETATE; ETHYL 2 [4 [[4 (4 NITROPHENYLSULFONAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETATE; ETHYL 2 [4 [[4 (PHENYLSULFONAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETATE; ETHYL 2[4 [[4 (4 BROMOPHENYLSULFONAMIDO)PHENYL]AMINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]ACETATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CARCINOMA; OPTIMAL DRUG DOSE;

17AAG; ALLOPURINOL; ANTITUMOUR; PYRAZOLO[3,4-D]PYRIMIDINES; XOD;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84882545840     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.019     Document Type: Article

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