Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 1-9

  Sun, Jian ^a   Lv, Xian Hai ^b   Qiu, Han Yue ^a   Wang, Yan Ting ^a   Du, Qian Ru ^a   Li, Dong Dong ^a   Yang, Yong Hua ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b ANHUI AGRICULTURAL UNIVERSITY   (China)

Author keywords

CDK2; Cell cycle profile; Cyclin dependent kinases; Molecular docking; Structure activity relationship

Indexed keywords

1 PHENYL 3 (P TOLYL) N (P TOLYLCARBAMOTHIOYL) 1H PYRAZOLE 4 CARBOXAMIDE; 1,3 DIPHENYL N (P TOLYLCARBAMOTHIOYL) 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 CHLOROPHENYL) 1 PHENYL N (P TOLYLCARBAMOTHIOYL) 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 CHLOROPHENYL) N ((4 METHOXYPHENYL)CARBAMOTHIOYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 CHLOROPHENYL)N ((4 FLUOROPHENYL)CARBAMOTHIOYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 FLUOROPHENYL) 1 PHENYL N (P TOLYLCARBAMOTHIOYL) 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 FLUOROPHENYL) N ((4 FLUOROPHENYL)CARBAMOTHIOYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 FLUOROPHENYL) N ((4 METHOXYPHENYL)CARBAMOTHIOYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 METHOXYPHENYL) 1 PHENYL N (P TOLYLCARBAMOTHIOYL) 1H PYRAZOLE 4 CARBOXAMIDE; 3 (4 METHOXYPHENYL) N ((4 METHOXYPHENYL) CARBAMOTHIOYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; AMIDE; CYCLIN DEPENDENT KINASE INHIBITOR; N ((4 CHLOROPHENYL)CARBAMOTHIOYL) 1 PHENYL 3 (P TOLYL) 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 CHLOROPHENYL)CARBAMOTHIOYL) 1,3 DIPHENYL 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 CHLOROPHENYL)CARBAMOTHIOYL) 3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 CHLOROPHENYL)CARBAMOTHIOYL) 3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 FLUOROPHENYL)CARBAMOTHIOYL) 1,3 DIPHENYL 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 FLUOROPHENYL)CARBAMOTHIOYL) 3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 METHOXYPHENYL)CARBAMOTHIOYL) 1 PHENYL 3 (P TOLYL) 1H PYRAZOLE 4 CARBOXAMIDE; N ((4 METHOXYPHENYL)CARBAMOTHIOYL) 1,3 DIPHENYL 1H PYRAZOLE 4 CARBOXAMIDE; PYRAZOLE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL PROLIFERATION; DRUG SYNTHESIS; EVALUATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; IC 50; MOLECULAR DOCKING;

CDK2; CELL CYCLE PROFILE; CYCLIN-DEPENDENT KINASES; MOLECULAR DOCKING; STRUCTURE-ACTIVITY RELATIONSHIP;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZOLES; THIOUREA;

EID: 84881161328     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.003     Document Type: Article

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