Catalytic generation of α-CF3 enolate: Direct catalytic asymmetric Mannich-type reaction of α-CF3 amide

Journal of the American Chemical Society

Volumn 136, Issue 52, 2014, Pages 17958-17961

  Yin, Liang ^a   Brewitz, Lennart ^a   Kumagai, Naoya ^a   Shibasaki, Masakatsu ^a,b  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CHEMICAL COMPOUNDS; STEREOCHEMISTRY;

CHIRAL BUILDING BLOCKS; COMMON STRATEGY; COOPERATIVE CATALYTIC SYSTEMS; ENANTIOSELECTIVE ADDITION; MANNICH-TYPE REACTIONS; MEDICINAL CHEMISTRY; METABOLIC DEGRADATION; PHARMACOKINETIC PROPERTIES;

OLEFINS;

AMIDE; CARBONYL DERIVATIVE; ENOLATE; NUCLEOPHILE; UNCLASSIFIED DRUG; ALKENE; FLUORINATED HYDROCARBON;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONFORMATION; DEGRADATION; MANNICH REACTION; MEDICINAL CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY; CHEMISTRY;

ALKENES; AMIDES; CATALYSIS; HYDROCARBONS, FLUORINATED; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

EID: 84920170716     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511458k     Document Type: Article

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