SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 54, Issue 1, 2015, Pages 144-148

A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences

(6) Ingham, Richard J a Battilocchio, Claudio a Fitzpatrick, Daniel E a Sliwinski, Eric a Hawkins, Joel M b Ley, Steven V a

a UNIVERSITY OF CAMBRIDGE (United Kingdom)

b PFIZER INC (United States)

Author keywords

Continuous processing; Flow reactors; Integrated systems; Synthetic methods

Indexed keywords

CHEMICAL REACTIONS;

CONTINUOUS PROCESSING; CONTINUOUS REACTIONS; CONTROL TECHNOLOGIES; DOWNSTREAM-PROCESSING; FLOW REACTORS; INTEGRATED SYSTEMS; MODULAR COMPONENTS; SYNTHETIC METHODS;

SYNTHESIS (CHEMICAL);

2-AMINOADAMANTANE; AMANTADINE; CARBOXYLIC ACID;

ANALOGS AND DERIVATIVES; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; SYNTHESIS;

AMANTADINE; CARBOXYLIC ACIDS; CHEMISTRY TECHNIQUES, SYNTHETIC; EQUIPMENT DESIGN;

EID: 84920168856 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201409356 Document Type: Article

Times cited : (138)

References (43)

1
- 84875539011
- I. R. Baxendale, J. Chem. Technol. Biotechnol. 2013, 88, 519-552;
- (2013) J. Chem. Technol. Biotechnol. , vol.88 , pp. 519-552
- Baxendale, I.R.¹

2
- 84856840761
- J. Wegner, S. Ceylan, A. Kirschning, Adv. Synth. Catal. 2012, 354, 17-57;
- (2012) Adv. Synth. Catal. , vol.354 , pp. 17-57
- Wegner, J.¹ Ceylan, S.² Kirschning, A.³

3
- 79961218749
- R. L. Hartman, J. P. McMullen, K. F. Jensen, Angew. Chem. Int. Ed. 2011, 50, 7502-7519;
- (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 7502-7519
- Hartman, R.L.¹ McMullen, J.P.² Jensen, K.F.³

4
- 80054031755
- R. L.Hartman, J. P.McMullen, K. F.Jensen, Angew. Chem. 2011, 123, 7642-7661.
- (2011) Angew. Chem. , vol.123 , pp. 7642-7661
- Hartman, R.L.¹ McMullen, J.P.² Jensen, K.F.³

5
- 84907965548
- T. A. Hamlin, G. M. L. Lazarus, C. B. Kelly, N. E. Leadbeater, Org. Process Res. Dev. 2014, 18, 1253-1258;
- (2014) Org. Process Res. Dev. , vol.18 , pp. 1253-1258
- Hamlin, T.A.¹ Lazarus, G.M.L.² Kelly, C.B.³ Leadbeater, N.E.⁴

6
- 84883557350
- J. Hartwig, S. Ceylan, L. Kupracz, L. Coutable, A. Kirschning, Angew. Chem. Int. Ed. 2013, 52, 9813-9817;
- (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 9813-9817
- Hartwig, J.¹ Ceylan, S.² Kupracz, L.³ Coutable, L.⁴ Kirschning, A.⁵

7
- 84888287738
- J.Hartwig, S.Ceylan, L.Kupracz, L.Coutable, A.Kirschning, Angew. Chem. 2013, 125, 9995-9999;
- (2013) Angew. Chem. , vol.125 , pp. 9995-9999
- Hartwig, J.¹ Ceylan, S.² Kupracz, L.³ Coutable, L.⁴ Kirschning, A.⁵

8
- 84884472774
- L. Dalla-Vechia, B. Reichart, T. N. Glasnov, L. S. M. Miranda, C. O. Kappe, R. deSouza, Org. Biomol. Chem. 2013, 11, 6806-6813;
- (2013) Org. Biomol. Chem. , vol.11 , pp. 6806-6813
- Dalla-Vechia, L.¹ Reichart, B.² Glasnov, T.N.³ Miranda, L.S.M.⁴ Kappe, C.O.⁵ DeSouza, R.⁶

9
- 70350348246
- A. R. Bogdan, S. L. Poe, D. C. Kubis, S. J. Broadwater, D. T. McQuade, Angew. Chem. Int. Ed. 2009, 48, 8547-8550;
- (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 8547-8550
- Bogdan, A.R.¹ Poe, S.L.² Kubis, D.C.³ Broadwater, S.J.⁴ McQuade, D.T.⁵

10
- 77950193844
- A. R.Bogdan, S. L.Poe, D. C.Kubis, S. J.Broadwater, D. T.McQuade,Angew. Chem. 2009, 121, 8699-8702;
- (2009) Angew. Chem. , vol.121 , pp. 8699-8702
- Bogdan, A.R.¹ Poe, S.L.² Kubis, D.C.³ Broadwater, S.J.⁴ McQuade, D.T.⁵

11
- 34547442446
- H. R. Sahoo, J. G. Kralj, K. F. Jensen, Angew. Chem. Int. Ed. 2007, 46, 5704-5708;
- (2007) Angew. Chem. Int. Ed. , vol.46 , pp. 5704-5708
- Sahoo, H.R.¹ Kralj, J.G.² Jensen, K.F.³

12
- 39749100673
- H. R.Sahoo, J. G.Kralj, K. F.Jensen,Angew. Chem. 2007, 119, 5806-5810.
- (2007) Angew. Chem. , vol.119 , pp. 5806-5810
- Sahoo, H.R.¹ Kralj, J.G.² Jensen, K.F.³

13
- 84896911106
- R. J. Ingham, C. Battilocchio, J. M. Hawkins, S. V. Ley, Beilstein J. Org. Chem. 2014, 10, 641-652.
- (2014) Beilstein J. Org. Chem. , vol.10 , pp. 641-652
- Ingham, R.J.¹ Battilocchio, C.² Hawkins, J.M.³ Ley, S.V.⁴

14
- 84887553366
- S. Mascia, P. L. Heider, H. Zhang, R. Lakerveld, B. Benyahia, P. I. Barton, R. D. Braatz, C. L. Cooney, J. M. B. Evans, T. F. Jamison, et al., Angew. Chem. Int. Ed. 2013, 52, 12359 - 12363;
- (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 12359-12363
- Mascia, S.¹ Heider, P.L.² Zhang, H.³ Lakerveld, R.⁴ Benyahia, B.⁵ Barton, P.I.⁶ Braatz, R.D.⁷ Cooney, C.L.⁸ Evans, J.M.B.⁹ Jamison, T.F.¹⁰

15
- 84901702639
- Angew. Chem. 2013, 125, 12585-12589;
- (2013) Angew. Chem. , vol.125 , pp. 12585-12589

16
- 84896953509
- P. L. Heider, S. C. Born, S. Basak, B. Benyahia, R. Lakerveld, H. Zhang, R. Hogan, L. Buchbinder, A.Wolfe, S. Mascia, et al., Org. Process Res. Dev. 2014, 18, 402-409;
- (2014) Org. Process Res. Dev. , vol.18 , pp. 402-409
- Heider, P.L.¹ Born, S.C.² Basak, S.³ Benyahia, B.⁴ Lakerveld, R.⁵ Zhang, H.⁶ Hogan, R.⁷ Buchbinder, L.⁸ Wolfe, A.⁹ Mascia, S.¹⁰

17
- 84920138563
- R. Lakerveld, B. Benyahia, P. L. Heider, H. Zhang, A.Wolfe, C. Testa, S. Ogden, D. R. Hersey, S. Mascia, J. Evans, et al., Org. Process Res. Dev. 2014, DOI: 10.1021/op500104d.
- (2014) Org. Process Res. Dev.
- Lakerveld, R.¹ Benyahia, B.² Heider, P.L.³ Zhang, H.⁴ Wolfe, A.⁵ Testa, C.⁶ Ogden, S.⁷ Hersey, D.R.⁸ Mascia, S.⁹ Evans, J.¹⁰

18
- 84888295275
- L. Kupracz A. Kirschning Adv. Synth. Catal. 2013 355 3375-3380
- (2013) Adv. Synth. Catal. , vol.355 , pp. 3375-3380
- Kupracz, L.¹ Kirschning, A.²

19
- 84857029523
- F. Lévesque, P. H. Seeberger, Angew. Chem. Int. Ed. 2012, 51, 1706-1709;
- (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 1706-1709
- Lévesque, F.¹ Seeberger, P.H.²

20
- 84870600958
- Angew. Chem. 2012, 124, 1738-1741;
- (2012) Angew. Chem. , vol.124 , pp. 1738-1741

21
- 78649582899
- T. N. Glasnov, C. O. Kappe, Adv. Synth. Catal. 2010, 352, 3089-3097.
- (2010) Adv. Synth. Catal. , vol.352 , pp. 3089-3097
- Glasnov, T.N.¹ Kappe, C.O.²

22
- 78651474657
- L. J. Martin, A. L. Marzinzik, S. V. Ley, I. R. Baxendale, Org. Lett. 2011, 13, 320-323;
- (2011) Org. Lett. , vol.13 , pp. 320-323
- Martin, L.J.¹ Marzinzik, A.L.² Ley, S.V.³ Baxendale, I.R.⁴

23
- 79952122285
- C. J. Smith, N. Nikbin, S. V. Ley, H. Lange, I. R. Baxendale, Org. Biomol. Chem. 2011, 9, 1938-1947;
- (2011) Org. Biomol. Chem. , vol.9 , pp. 1938-1947
- Smith, C.J.¹ Nikbin, N.² Ley, S.V.³ Lange, H.⁴ Baxendale, I.R.⁵

24
- 73949134234
- I. R. Baxendale, S. C. Schou, J. Sedelmeier, S. V. Ley, Chem. Eur. J. 2010, 16, 89-94;
- (2010) Chem. Eur. J. , vol.16 , pp. 89-94
- Baxendale, I.R.¹ Schou, S.C.² Sedelmeier, J.³ Ley, S.V.⁴

25
- 78249258386
- Z. Qian, I. R. Baxendale, S. V. Ley, Chem. Eur. J. 2010, 16, 12342-12348.
- (2010) Chem. Eur. J. , vol.16 , pp. 12342-12348
- Qian, Z.¹ Baxendale, I.R.² Ley, S.V.³

26
- 84878809904
- D. R. Snead, T. F. Jamison, Chem. Sci. 2013, 4, 2822-2827.
- (2013) Chem. Sci. , vol.4 , pp. 2822-2827
- Snead, D.R.¹ Jamison, T.F.²

27
- 84881394982
- settling tank
- A. Adamo, P. L. Heider, N. Weeranoppanant, K. F. Jensen, Ind. Eng. Chem. Res. 2013, 52, 10802-10808; settling tank:
- (2013) Ind. Eng. Chem. Res. , vol.52 , pp. 10802-10808
- Adamo, A.¹ Heider, P.L.² Weeranoppanant, N.³ Jensen, K.F.⁴

28
- 84865257966
- M. O'Brien, P. Koos, D. L. Browne, S. V. Ley, Org. Biomol. Chem. 2012, 10, 7031-7036;
- (2012) Org. Biomol. Chem. , vol.10 , pp. 7031-7036
- O'Brien, M.¹ Koos, P.² Browne, D.L.³ Ley, S.V.⁴

29
- 37249048438
- counter-current flow
- M. N. Kashid, Y. M. Harshe, D. W. Agar, Ind. Eng. Chem. Res. 2007, 46, 8420-8430; counter-current flow:
- (2007) Ind. Eng. Chem. Res. , vol.46 , pp. 8420-8430
- Kashid, M.N.¹ Harshe, Y.M.² Agar, D.W.³

30
- 33846665046
- A. Aota, M. Nonaka, A. Hibara, T. Kitamori, Angew. Chem. Int. Ed. 2007, 46, 878-880;
- (2007) Angew. Chem. Int. Ed. , vol.46 , pp. 878-880
- Aota, A.¹ Nonaka, M.² Hibara, A.³ Kitamori, T.⁴

31
- 34547451699
- A.Aota, M.Nonaka, A.Hibara, T.Kitamori, Angew. Chem. 2007, 119, 896-898.
- (2007) Angew. Chem. , vol.119 , pp. 896-898
- Aota, A.¹ Nonaka, M.² Hibara, A.³ Kitamori, T.⁴

32
- 84863708943
- A. G. O'Brien, Z. Horváth, F. Lévesque, J. W. Lee, A. Seidel-Morgenstern, P. H. Seeberger, Angew. Chem. Int. Ed. 2012, 51, 7028-7030;
- (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 7028-7030
- O'Brien, A.G.¹ Horváth, Z.² Lévesque, F.³ Lee, J.W.⁴ Seidel-Morgenstern, A.⁵ Seeberger, P.H.⁶

33
- 84885418426
- Angew. Chem. 2012, 124, 7134-7137.
- (2012) Angew. Chem. , vol.124 , pp. 7134-7137

34
- 84884181406
- B. J. Deadman, C. Battilocchio, E. Sliwinski, S. V. Ley, Green Chem. 2013, 15, 2050-2055.
- (2013) Green Chem. , vol.15 , pp. 2050-2055
- Deadman, B.J.¹ Battilocchio, C.² Sliwinski, E.³ Ley, S.V.⁴

35
- 84878550922
- C. Battilocchio, B. J. Deadman, N. Nikbin, M. O. Kitching, I. R. Baxendale, S. V. Ley, Chem. Eur. J. 2013, 19, 7917-7930.
- (2013) Chem. Eur. J. , vol.19 , pp. 7917-7930
- Battilocchio, C.¹ Deadman, B.J.² Nikbin, N.³ Kitching, M.O.⁴ Baxendale, I.R.⁵ Ley, S.V.⁶

36
- 79955604516
- a) H. Lange, C. F. Carter, M. D. Hopkin, A. Burke, J. G. Goode, I. R. Baxendale, S. V. Ley, Chem. Sci. 2011, 2, 765-769;
- (2011) Chem. Sci. , vol.2 , pp. 765-769
- Lange, H.¹ Carter, C.F.² Hopkin, M.D.³ Burke, A.⁴ Goode, J.G.⁵ Baxendale, I.R.⁶ Ley, S.V.⁷

37
- 84865258609
- J. S. Moore, K. F. Jensen, Org. Process Res. Dev. 2012, 16, 1409-1415.
- (2012) Org. Process Res. Dev. , vol.16 , pp. 1409-1415
- Moore, J.S.¹ Jensen, K.F.²

38
- 84862058551
- C. Battilocchio, I. R. Baxendale, M. Biava, M. O. Kitching, S. V. Ley, Org. Process Res. Dev. 2012, 16, 798-810.
- (2012) Org. Process Res. Dev. , vol.16 , pp. 798-810
- Battilocchio, C.¹ Baxendale, I.R.² Biava, M.³ Kitching, M.O.⁴ Ley, S.V.⁵

39
- 84878929444
- S. V. Ley, R. J. Ingham, M. O'Brien, D. L. Browne, Beilstein J. Org. Chem. 2013, 9, 1051-1072.
- (2013) Beilstein J. Org. Chem. , vol.9 , pp. 1051-1072
- Ley, S.V.¹ Ingham, R.J.² O'Brien, M.³ Browne, D.L.⁴

40
- 84858631218
- L. Audiger, K. Watts, S. C. Elmore, R. I. Robinson, T. Wirth, ChemSusChem 2012, 5, 257-260.
- (2012) Chemsuschem , vol.5 , pp. 257-260
- Audiger, L.¹ Watts, K.² Elmore, S.C.³ Robinson, R.I.⁴ Wirth, T.⁵

41
- 45249113717
- C. E. Schiaffo, P. H. Dussault, J. Org. Chem. 2008, 73, 4688-4690.
- (2008) J. Org. Chem. , vol.73 , pp. 4688-4690
- Schiaffo, C.E.¹ Dussault, P.H.²

42
- 10244222238
- A. R. Sorge, M. Turco, G. Pilone, G. Bagnasco, J. Propul. Power 2004, 20, 1069-1075.
- (2004) Power , vol.20 , pp. 1069-1075
- Sorge, A.R.¹ Turco, M.² Pilone, G.³ Bagnasco, G.⁴ Propul, J.⁵

43
- 84920181383
- 3D models of the apparatus used are available on the WWW under
- 3D models of the apparatus used are available on the WWW under http://www.leygroup.ch.cam.ac.uk/suppl/anie.2014.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.