Membrane-based, liquid-liquid separator with integrated pressure control

Industrial and Engineering Chemistry Research

Volumn 52, Issue 31, 2013, Pages 10802-10808

  Adamo, Andrea ^a   Heider, Patrick L ^a   Weeranoppanant, Nopphon ^a   Jensen, Klavs F ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUNTER-CURRENT EXTRACTIONS; DEVELOPMENT AND APPLICATIONS; DOWNSTREAM UNITS; INTEGRATED PRESSURE; MULTI-STAGE SEPARATION; OPERATING CONDITION; PHYSICAL EQUATIONS; SURFACE FORCES;

DESIGN; PRESSURE CONTROL; SEPARATION;

SEPARATORS;

EID: 84881394982     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie401180t     Document Type: Article

References (38)

1. Webb, D.; Jamison, T. F. Continuous Flow Multi-Step Organic Synthesis Chem. Sci. 2010, 1 (6) 675-680
2. Jensen, K. F. Microreaction Engineering-Is Small Better? Chem. Eng. Sci. 2001, 56 (2) 293-303
3. Wiles, C.; Watts, P. Recent Advances in Micro Reaction Technology Chem. Commun. 2011, 47 (23) 6512-6535
4. Hartman, R. L.; McMullen, J. P.; Jensen, K. F. Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis Angew. Chem., Int. Ed. 2011, 50 (33) 7502-7519
5. Pennemann, H.; Watts, P.; Haswell, S. J.; Hessel, V.; Löwe, H. Benchmarking of Microreactor Applications Org. Process Res. Dev. 2004, 8 (3) 422-439
6. Kockmann, N.; Gottsponer, M.; Zimmermann, B.; Roberge, D. M. Enabling Continuous-Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine-Chemical Production Chem.-Eur. J. 2008, 14 (25) 7470-7477
7. Wegner, J.; Ceylan, S.; Kirschning, A. Ten Key Issues in Modern Flow Chemistry Chem. Commun. 2011, 47 (16) 4583-4592
8. Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C. Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands Synthesis 2012, 2012 (04) 635-647
9. McMullen, J. P.; Jensen, K. F. Rapid Determination of Reaction Kinetics with an Automated Microfluidic System Org. Process Res. Dev. 2011, 15 (2) 398-407
10. Cervera-Padrell, A. E.; Nielsen, J. P.; Jønch Pedersen, M.; Müller Christensen, K.; Mortensen, A. R.; Skovby, T.; Dam-Johansen, K.; Kiil, S.; Gernaey, K. V. Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy Org. Process Res. Dev. 2012, 16 (5) 901-914
11. Kockmann, N.; Gottsponer, M.; Roberge, D. M. Scale-up Concept of Single-Channel Microreactors from Process Development to Industrial Production Chem. Eng. J. 2011, 167 (2-3) 718-726
12. Hessel, V.; Löb, P.; Löwe, H. Industrial Microreactor Process Development up to Production. In Microreactors in Organic Synthesis and Catalysis; Wiley-VCH Verlag GmbH & Co. KGaA: New York, 2008; pp 211-275.
13. Schuur, B.; Hallett, A. J.; Winkelman, J. G. M.; de Vries, J. G.; Heeres, H. J. Scalable Enantioseparation of Amino Acid Derivatives Using Continuous Liquid-Liquid Extraction in a Cascade of Centrifugal Contactor Separators Org. Process Res. Dev. 2009, 13 (5) 911-914
14. Smith, C. J.; Nikbin, N.; Ley, S. V.; Lange, H.; Baxendale, I. R. A Fully Automated, Multistep Flow Synthesis of 5-Amino-4-cyano-1,2,3-triazoles Org. Biomol. Chem. 2011, 9 (6) 1938-1947
15. Bogdan, A. R.; Poe, S. L.; Kubis, D. C.; Broadwater, S. J.; McQuade, D. T. The Continuous-Flow Synthesis of Ibuprofen Angew. Chem., Int. Ed. 2009, 48 (45) 8547-8550
16. Sahoo, H. R.; Kralj, J. G.; Jensen, K. F. Multistep Continuous-Flow Microchemical Synthesis Involving Multiple Reactions and Separations Angew. Chem., Int. Ed. 2007, 46 (30) 5704-5708
17. Varas, A. C.; Noël, T.; Wang, Q.; Hessel, V. Copper(I)-Catalyzed Azide-Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit ChemSusChem 2012, 5 (9) 1703-1707
18. Hartman, R. L.; Naber, J. R.; Buchwald, S. L.; Jensen, K. F. Multistep Microchemical Synthesis Enabled by Microfluidic Distillation Angew. Chem., Int. Ed. 2010, 49 (5) 899-903
19. Cervera-Padrell, A. E.; Morthensen, S. T.; Lewandowski, D. J.; Skovby, T.; Kiil, S.; Gernaey, K. V. Continuous Hydrolysis and Liquid-Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator Org. Process Res. Dev. 2012, 16 (5) 888-900
20. Tzschucke, C. C.; Markert, C.; Bannwarth, W.; Roller, S.; Hebel, A.; Haag, R. Modern Separation Techniques for the Efficient Workup in Organic Synthesis Angew. Chem., Int. Ed. 2002, 41 (21) 3964-4000
21. Kuhn, S.; Jensen, K. F. A pH-Sensitive Laser-Induced Fluorescence Technique To Monitor Mass Transfer in Multiphase Flows in Microfluidic Devices Ind. Eng. Chem. Res. 2012, 51 (26) 8999-9006
22. Burns, J. R.; Ramshaw, C. The Intensification of Rapid Reactions in Multiphase Systems Using Slug Flow in Capillaries Lab Chip 2001, 1 (1) 10-15
23. Günther, A.; Jensen, K. F. Multiphase Microfluidics: From Flow Characteristics to Chemical and Materials Synthesis Lab Chip 2006, 6 (12) 1487-1503
24. Aota, A.; Nonaka, M.; Hibara, A.; Kitamori, T. Countercurrent Laminar Microflow for Highly Efficient Solvent Extraction Angew. Chem., Int. Ed. 2007, 46 (6) 878-880
25. Aota, A.; Mawatari, K.; Kitamori, T. Parallel Multiphase Microflows: Fundamental Physics, Stabilization Methods and Applications Lab Chip 2009, 9 (17) 2470-2476
26. Aota, A.; Mawatari, K.; Takahashi, S.; Matsumoto, T.; Kanda, K.; Anraku, R.; Hibara, A.; Tokeshi, M.; Kitamori, T. Phase Separation of Gas-Liquid and Liquid-Liquid Microflows in Microchips Microchim. Acta 2009, 164 (3) 249-255
27. Hu, D. X.; O'Brien, M.; Ley, S. V. Continuous Multiple Liquid-Liquid Separation: Diazotization of Amino Acids in Flow Org. Lett. 2012, 14 (16) 4246-4249
28. O'Brien, M.; Koos, P.; Browne, D. L.; Ley, S. V. A Prototype Continuous-Flow Liquid-Liquid Extraction System Using Open-Source Technology Org. Biomol. Chem. 2012, 10 (35) 7031-7036
29. Castell, O. K.; Allender, C. J.; Barrow, D. A. Liquid-Liquid Phase Separation: Characterisation of a Novel Device Capable of Separating Particle Carrying Multiphase Flows Lab Chip 2009, 9 (3) 388-396
30. Kashid, M. N.; Harshe, Y. M.; Agar, D. W. Liquid-Liquid Slug Flow in a Capillary: An Alternative to Suspended Drop or Film Contactors Ind. Eng. Chem. Res. 2007, 46 (25) 8420-8430
31. Peroni, D.; van Egmond, W.; Kok, W. T.; Janssen, H.-G. Advancing Liquid/Liquid Extraction through a Novel Microfluidic Device: Theory, Instrumentation and Applications in Gas Chromatography J. Chromatogr. A 2012, 1226 (0) 77-86
32. Schuur, B.; Floure, J.; Hallett, A. J.; Winkelman, J. G. M.; deVries, J. G.; Heeres, H. J. Continuous Chiral Separation of Amino Acid Derivatives by Enantioselective Liquid-Liquid Extraction in Centrifugal Contactor Separators Org. Process Res. Dev. 2008, 12 (5) 950-955
33. Kralj, J. G.; Sahoo, H. R.; Jensen, K. F. Integrated Continuous Microfluidic Liquid-Liquid Extraction Lab Chip 2007, 7 (2) 256-263
34. Hartman, R. L.; Sahoo, H. R.; Yen, B. C.; Jensen, K. F. Distillation in Microchemical Systems Using Capillary Forces and Segmented Flow Lab Chip 2009, 9 (13) 1843-1849
35. Donahue, D. J.; Bartell, F. E. The Boundary Tension at Water-Organic Liquid Interfaces J. Phys. Chem. 1952, 56 (4) 480-484
36. Seader, J. D.; Henley, E. J. Separation Process Principles, 2 nd ed.; John Wiley & Sons, Inc.: New York, 2006.
37. Lam, K. F.; Cao, E.; Sorensen, E.; Gavriilidis, A. Development of Multistage Distillation in a Microfluidic Chip Lab Chip 2011, 11 (7) 1311-1317
38. Zhang, Y.; Kato, S.; Anazawa, T. Vacuum Membrane Distillation by Microchip with Temperature Gradient Lab Chip 2010, 10 (7) 899-908