Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test

Clinical Nutrition

Volumn 33, Issue 6, 2014, Pages 1122-1126

  Montelius, Caroline ^a   Szwiec, Katarzyna ^b   Kardas, Marek ^b,c   Lozinska, Liudmyla ^b   Erlanson Albertsson, Charlotte ^a   Pierzynowski, Stefan ^b,d   Rehfeld, Jens F ^e   Weström, Björn ^b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c Doctoral School of Medical University of Silesia   (Poland)

^d MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Appetite; Cholecystokinin; Ghrelin; High fat diet; OGTT; Thylakoids

Indexed keywords

CHOLECYSTOKININ; GHRELIN; GLUCOSE; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ARTICLE; CHOLECYSTOKININ BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC INDEX; HORMONE RELEASE; LIPID DIET; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; SWINE; THYLAKOID; ANIMAL; APPETITE; BLOOD; BODY WEIGHT; CHEMISTRY; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; INTESTINE ABSORPTION; METABOLISM; PIG;

ANIMALS; APPETITE; BLOOD GLUCOSE; BODY WEIGHT; CHOLECYSTOKININ; GHRELIN; GLUCOSE; GLUCOSE TOLERANCE TEST; GLYCEMIC INDEX; INTESTINAL ABSORPTION; SWINE; THYLAKOIDS;

EID: 84920161487     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.12.009     Document Type: Article

References (27)

1. Köhnke R., Svensson L., Piedra J.L.V., Pierzynowski S.G., Weström B., Erlanson-Albertsson C. Feeding appetite suppressing thylakoids to pigs alters pancreatic lipase/colipase secretion. Livest Sci 2010, 134:68-71.
2. Lindqvist A., la Cour de C.D., Stegmark A., Håkanson R., Erlanson-Albertsson C. Overeating of palatable food is associated with blunted leptin and ghrelin responses. Regul Pept 2005, 130:123-132.
3. Köhnke R., Lindbo A., Larsson T., Lindqvist A., Rayner M., Emek S.C., et al. Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans. Scand J Gastroenterol 2009, 44:712-719.
4. Erlanson-Albertsson C. How palatable food disrupts appetite regulation. Basic Clin Pharmacol Toxicol 2005, 97:61-73.
5. Stenblom E.-L., Montelius C., Ostbring K., Håkansson M., Nilsson S., Rehfeld J.F., et al. Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women. Appetite 2013, 68:118-123.
6. Geary N.N. Endocrine controls of eating: CCK, leptin, and ghrelin. Physiol Behav 2004, 81:719-733.
7. Rengman S., Fedkiv O., Botermans J., Svendsen J.R., Weström B., Pierzynowski S. An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. Clin Nutr 2009, 28:325-330.
8. Volger S., Wadden T.A., Sarwer D.B., Moore R.H., Chittams J., Diewald L.K., et al. Changes in eating, physical activity and related behaviors in a primary care-based weight loss intervention. Int J Obes 2013, 37:12-18.
9. Emek S.C., Szilagyi A., Akerlund H.-E., Albertsson P.-Å., Köhnke R., Holm A., et al. Alarge scale method for preparation of plant thylakoids for use in body weight regulation. Prep Biochem Biotechnol 2010, 40(1):13-27.
10. Köhnke R., Lindqvist A., Göransson N., Emek S.C., Albertsson P.-Å., Rehfeld J.F., et al. Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice. Phytother Res 2009, 23:1778-1783.
11. Albertsson P.-Å., Köhnke R., Emek S.C., Mei J., Rehfeld J.F., Akerlund H.-E., et al. Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase. Biochem J 2007, 401:727-733.
12. Montelius C., Osman N., Weström B., Ahrne S., Molin G., Albertsson P.-Å., Erlanson-Albertsson C. Feeding spinach thylakoids to rats modulates the gut microbiota, decreases food intake and affects the insulin response. JNutr Sci 2013, 2(e20):1-9.
13. Ball S.D., Keller K.R., Moyer-Mileur L.J., Ding Y.-W., Donaldson D., Jackson W.D. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. Pediatrics 2003, 111:488-494.
14. Montelius C., Gustafsson K., Weström B., Albertsson P.-Å., Emek S.C., Rayner M., et al. Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability. Brit J Nutr 2011, 106:836-844.
15. Emek S.C., Akerlund H.-E., Clausen M., Ohlsson L., Weström B., Erlanson-Albertsson C., et al. Pigments protect the light harvesting proteins of chloroplast thylakoid membranes against digestion by gastrointestinal proteases. Food Hydrocolloid 2011, 25:1618-1626.
16. Rehfeld J.F. Accurate measurement of cholecystokinin in plasma. Clin Chem 1998, 44(5):991-1001.
17. Houpt T.R. Controls of feeding in pigs. JAnim Sci 1984, 59:1345-1353.
18. Cuber J.C.J., Bernard C.C., Levenez F.F., Chayvialle J.A.J. Lipids, proteins and carbohydrates stimulate the secretion of intestinal cholecystokinin in the pig. Reprod Nutr Dev 1990, 30(2):267-275.
19. Reynolds R.C., Stockmann K.S., Atkinson F.S., Denyes G.S., Brand-Miller J.C. Effect of the glycemic index of carbohydrates on day-long (10h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin 2008, 63(7):872-878.
20. Wren A.M., Bloom S.R. Gut hormones and appetite control. Gastroenterol 2007, 132:2116-2130.
21. Callahan H.S., Cummings D.E., Pepe M.S., Breen P.A., Matthys C.C., Weigle D.S. Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. JClin Endocrinol Metab 2004, 89(3):1319-1324.
22. Monteleone P., Bencivenga R., Longobardi N., Serritella C., Maj M. Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women. JClin Endocrinol Metab 2003, 88(11):5510-5514.
23. Overduin J., Frayo R.S., Grill H.J., Kaplan J.M., Cummings D.E. Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology 2005, 146(2):845-850.
24. Tschöp M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature 2000, 407(6806):908-913.
25. Steinert R.E., Feinle-Bisset C., Geary N., Beglinger C. Digestive physiology of the pig symposium: secretion of gastrointestinal hormones and eating control. JAnim Sci 2013, 91:1963-1973.
26. Small C., Bloom S. Gut hormones and the control of appetite. Trends Endocrinol Metab 2004, 15(6):259-263.
27. WHO. Factsheet N 311: obesity and overweight [accessed 11.11.13], http://www.who.int/mediacentre/factsheets/fs311/en/index.html; 2013.