Feeding spinach thylakoids to rats modulates the gut microbiota, decreases food intake and affects the insulin response

Journal of Nutritional Science

Volumn 2, Issue , 2013, Pages 1-9

  Montelius, Caroline ^a   Osman, Nadia ^a   Weström, Björn ^b   Ahrné, Siv ^c   Molin, Göran ^a   Albertsson, Per Åke ^b   Erlanson Albertsson, Charlotte ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Colon; Lactobacilli; Obesity; Quantitative PCR; Small intestine

Indexed keywords

EID: 85022177601     PISSN: 20486790     EISSN: None     Source Type: Journal    
DOI: 10.1017/jns.2012.29     Document Type: Article

References (47)

1. Hill J, Wyatt H, Reed G, et al. (2003) Obesity and the environment: where do we go from here? Science 299, 853-855.
2. Ginsberg HN (2000) Insulin resistance and cardiovascular disease. J Clin Invest 106, 453-458.
3. van Hees AMJ, Saris WHM, Dallinga-Thie GM, et al. (2008) Fasting and postprandial remnant-like particle cholesterol concentrations in obese participants are associated with plasma triglycerides, insulin resistance, and body fat distribution. J Nutr 138, 2399-2405.
4. Kadooka Y, Sato M, Imaizumi K, et al. (2010) Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr 64, 636-643.
5. Andrade S & Borges N (2009) Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. J Dairy Res 76, 469-474.
6. Furtado M (2009) Probiotics, prebiotics, gut microbiota, and obesity. Bariatic Times 11, 27-30.
7. Bajzer M & Seeley RJ (2006) Physiology: obesity and gut flora. Nature 444, 1009-1010.
8. Ley RE, Bäckhed F, Turnbaugh P, et al. (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102, 11070-11075.
9. Bäckhed F, Ding H, Wang T, et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101, 15718-15723.
10. Taranto MP, Medici M, Perdigon G, et al. (2000) Effect of Lactobacillus reuteri on the prevention of hypercholesterolemia in mice. J Dairy Sci 83, 401-403.
11. Luoto R, Kalliomäki M, Laitinen K, et al. (2010) The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years. Int J Obes (Lond) 34, 1531-1537.
12. Köhnke R, Lindbo A, Larsson T, et al. (2009) Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans. Scand J Gastroenterol 44, 712-719.
13. Köhnke R, Lindqvist A, Göransson N, et al. (2009) Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice. Phytother Res 23, 1778-1783.
14. Emek SC, Szilagyi A, Akerlund H-E, et al. (2010) A large scale method for preparation of plant thylakoids for use in body weight regulation. Prep Biochem Biotechnol 40, 13-27.
15. Albertsson P-Å, Köhnke R, Emek SC, et al. (2007) Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase. Biochem J 401, 727-733.
16. Montelius C, Gustafsson K, Weström B, et al. (2011) Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability. Br J Nutr 106, 836-844.
17. Osman N, Adawi D, Molin G, et al. (2006) Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterol 6, 31.
18. Rada V & Petr J (2000) A new selective medium for the isolation of glucose non-fermenting bifidobacteria from hen caeca. J Microbiol Methods 43, 127-132.
19. Quednau M, Ahrné S, Petersson AC, et al. (1998) Identification of clinically important species of Enterococcus within 1 day with randomly amplified polymorphic DNA (RAPD). Curr Microbiol 36, 332-336.
20. Nordin N, Abdulamir A & Bakar F (2010) Methods for precise molecular detection of probiotic microflora: using adjusted molecular biology protocols, primer sets and PCR assays. J Biotechnol 9, 25-32.
21. Rinttilä TT, Kassinen AA, Malinen EE, et al. (2003) Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol 97, 1166-1177.
22. Bartosch S, Fite A, Macfarlane GT, et al. (2004) Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Appl Environ Microbiol 70, 3575-3581.
23. Okabe S, Okayama N, Savichtcheva O, et al. (2007) Quantification of host-specific Bacteroides-Prevotella 16S rRNA genetic markers for assessment of fecal pollution in freshwater. Appl Microbiol Biotechnol 74, 890-901.
24. Brosius J, Palmer ML, Kennedy PJ, et al. (1978) Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli. Proc Natl Acad Sci U S A 75, 4801-4805.
25. Magurran AE (2004) Measuring biological diversity. Afr J Aquat Sci 29, 285-286.
26. Servin AL & Coconnier M-H (2003) Adhesion of probiotic strains to the intestinal mucosa and interaction with pathogens. Best Pract Res Clin Gastroenterol 17, 741-754.
27. Johansson ML, Molin G, Jeppsson B, et al. (1993) Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora. Appl Environ Microbiol 59, 15-20.
28. Casas IA & Dobrogosz WJ (2000) Validation of the probiotic concept:Lactobacillus reuteri confers broad-spectrum protection against disease in humans and animals. Microb Ecol Health Dis 12, 247-285.
29. Cleusix V, Lacroix C, Vollenweider S, et al. (2008) Glycerol induces reuterin production and decreases Escherichia coli population in an in vitro model of colonic fermentation with immobilized human feces. FEMS Microbiol Ecol 63, 56-64.
30. Turner MS, Lo R & Giffard PM (2007) Inhibition of Staphylococcus aureus growth on tellurite-containing media by Lactobacillus reuteri is dependent on CyuC and thiol production. Appl Environ Microbiol 73, 1005-1009.
31. Gan BS, Kim J, Reid G, et al. (2002) Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats. J Infect Dis 185, 1369-1372.
32. Laughton JMJ, Devillard EE, Heinrichs DED, et al. (2006) Inhibition of expression of a staphylococcal superantigen-like protein by a soluble factor from Lactobacillus reuteri. Microbiology 152, 1155-1167.
33. Kalliomäki M, Collado MC, Salminen S, et al. (2008) Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 87, 534-538.
34. DiBaise JK, Zhang H, Crowell MD, et al. (2008) Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 83, 460-469.
35. Chang BJ, Park SU, Jang YS, et al. (2011) Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome. Eur J Clin Nutr 65, 1250-1255.
36. Mallappa RH, Rokana N, Duary RK, et al. (2012) Management of metabolic syndrome through probiotic and prebiotic interventions. Indian J Endocrinol Metab 16, 20-27.
37. An HM, Park SY, Lee DK, et al. (2011) Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats. Lipids Health Dis 10, 116.
38. Cani PD, Lecourt E, Dewulf EM, et al. (2009) Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am. J Clin Nutr 90, 1236-1243.
39. Cani PD, Neyrinck AM, Maton N, et al. (2005) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagonlike peptide-1. Obes Res 13, 1000-1007.
40. Reimer RA & Russell JC (2008) Glucose tolerance, lipids, and GLP-1 secretion in JCR:LA-cp rats fed a high protein fiber diet. Obesity 16, 40-46.
41. Köhnke R, Svensson L, Piedra JLV, et al. (2010) Feeding appetite suppressing thylakoids to pigs alters pancreatic lipase/colipase secretion. Livest Sci 134, 68-71.
42. de Kort S, Keszthelyi D & Masclee AAM (2011) Leaky gut and diabetes mellitus: what is the link? Obes Rev 12, 449-458.
43. Delzenne NM & Cani PD (2011) Interaction between obesity and the gut microbiota: relevance in nutrition. Annu Rev Nutr 31, 15-31.
44. Kondo S, Xiao J-Z, Satoh T, et al. (2010) Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem 74, 1656-1661.
45. Matsuzaki TT, Yamazaki RR, Hashimoto SS, et al. (1997) Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus (NIDDM) model using KK-Ay mice. Endocr J 44, 357-365.
46. Tabuchi M, Ozaki M, Tamura A, et al. (2003) Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 67, 1421-1424.
47. Yadav H, Jain S & Sinha PR (2008) Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats. J Dairy Res 75, 189-195.