Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 1, 2015, Pages 137-145

  Doddaballapur, Anuradha ^a   Michalik, Katharina M ^a   Manavski, Yosif ^a   Lucas, Tina ^a   Houtkooper, Riekelt H ^b   You, Xintian ^c   Chen, Wei ^c   Zeiher, Andreas M ^d,f   Potente, Michael ^e   Dimmeler, Stefanie ^a,f   Boon, Reinier A ^a  

^a GOETHE UNIVERSITY   (Germany)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Angiogenesis; endothelium; glycolysis; hemodynamics; human; metabolism; shear stress down regulated gene 1 protein

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; 6 PHOSPHOFRUCTOKINASE; FRUCTOSE 2,6 BIPHOSPHATASE 3; GLUCOSE; HEXOKINASE 2; KRUPPEL LIKE FACTOR 2; NITRIC OXIDE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; KLF2 PROTEIN, HUMAN; KLF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; PFKFB3 PROTEIN, HUMAN; PFKFB3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL AGING; CELL METABOLISM; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE REPRESSION; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; LAMINAR FLOW; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RNA SEQUENCE; SHEAR STRESS; UMBILICAL VEIN ENDOTHELIAL CELL; ANGIOGENESIS; ANIMAL; BIOMECHANICS; BLOOD FLOW; CELL CULTURE; DEFICIENCY; DOWN REGULATION; ENERGY METABOLISM; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEART MUSCLE; KNOCKOUT MOUSE; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; MITOCHONDRION; PHENOTYPE; RNA INTERFERENCE; TIME;

ANIMALS; BIOMECHANICAL PHENOMENA; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; ENERGY METABOLISM; GLUCOSE; GLYCOLYSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MECHANOTRANSDUCTION, CELLULAR; MICE, KNOCKOUT; MITOCHONDRIA; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; PHOSPHOFRUCTOKINASE-2; PROMOTER REGIONS, GENETIC; REGIONAL BLOOD FLOW; RNA INTERFERENCE; STRESS, MECHANICAL; TIME FACTORS; TRANSFECTION;

EID: 84920149932     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304277     Document Type: Article

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