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Volumn 6, Issue 1, 2015, Pages 17-33

Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

Author keywords

Biotransformation; Microbial biocatalysts; Natural products; Pharmaceutical products

Indexed keywords


EID: 84920134801     PISSN: 20901232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jare.2014.11.009     Document Type: Review
Times cited : (124)

References (57)
  • 1
    • 0025004467 scopus 로고
    • New antiinflammatory pseudopterosins from the marine octacoral Pseudopterogorgia elisabethae
    • Roussis V., Wu Z., Fenical W., Stobel S.A., Van Duyne D.G., Clardy J. New antiinflammatory pseudopterosins from the marine octacoral Pseudopterogorgia elisabethae. J Org Chem 1990, 55:4916-4922.
    • (1990) J Org Chem , vol.55 , pp. 4916-4922
    • Roussis, V.1    Wu, Z.2    Fenical, W.3    Stobel, S.A.4    Van Duyne, D.G.5    Clardy, J.6
  • 2
    • 0009538274 scopus 로고    scopus 로고
    • Gambling on marine biotechnology
    • Lilies G. Gambling on marine biotechnology. Bioscience 1996, 46:250-253.
    • (1996) Bioscience , vol.46 , pp. 250-253
    • Lilies, G.1
  • 3
    • 29744440873 scopus 로고    scopus 로고
    • Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC
    • Frydman A., Weisshaus O., Huhman D.V., Sumner L.W., Bar-Peled M., Lewinsohn E., et al. Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC. J Agric Food Chem 2005, 53(25):9708-9712.
    • (2005) J Agric Food Chem , vol.53 , Issue.25 , pp. 9708-9712
    • Frydman, A.1    Weisshaus, O.2    Huhman, D.V.3    Sumner, L.W.4    Bar-Peled, M.5    Lewinsohn, E.6
  • 4
    • 0001137949 scopus 로고
    • Advances in biotransformation processes
    • Lilly M.D. Advances in biotransformation processes. Chem Eng Sci 1994, 49(2):151-159.
    • (1994) Chem Eng Sci , vol.49 , Issue.2 , pp. 151-159
    • Lilly, M.D.1
  • 6
    • 0032765686 scopus 로고    scopus 로고
    • Biotransformations and bioconversions in New Zealand: past endeavours and future potential
    • Collins A.M., Kennedy M.J. Biotransformations and bioconversions in New Zealand: past endeavours and future potential. Austral Biotechnol 1999, 9(2):86-94.
    • (1999) Austral Biotechnol , vol.9 , Issue.2 , pp. 86-94
    • Collins, A.M.1    Kennedy, M.J.2
  • 7
    • 33745764380 scopus 로고    scopus 로고
    • Chemocatalysis and biocatalysis (biotransformation): some thoughts of a chemist and a biotechnologist
    • Leresche J.E., Meyer H.P. Chemocatalysis and biocatalysis (biotransformation): some thoughts of a chemist and a biotechnologist. Org Proc Res Dev 2006, 10:572-580.
    • (2006) Org Proc Res Dev , vol.10 , pp. 572-580
    • Leresche, J.E.1    Meyer, H.P.2
  • 8
    • 34147173595 scopus 로고    scopus 로고
    • Presence of ectoparasitic trichodinids (Ciliophora, Oligohymenophorea, Peritrichida) on the gills of cultured freshwater fish, Carassius auratus in Chongqing, China, with the description of a new species of the genus Trichodina
    • Tang F.H., Zhao Y.J., Tang A.K. Presence of ectoparasitic trichodinids (Ciliophora, Oligohymenophorea, Peritrichida) on the gills of cultured freshwater fish, Carassius auratus in Chongqing, China, with the description of a new species of the genus Trichodina. Acta Zootaxon Sin 2005, 30:35-40.
    • (2005) Acta Zootaxon Sin , vol.30 , pp. 35-40
    • Tang, F.H.1    Zhao, Y.J.2    Tang, A.K.3
  • 9
    • 33845788093 scopus 로고    scopus 로고
    • Production of aromas and fragrances through microbial oxidation of monoterpenes
    • Rozenbaum H.F., Patitucci M.L., Antunes O.A.C., Pereira N. Production of aromas and fragrances through microbial oxidation of monoterpenes. Brazil J Chem Eng 2006, 23(3):273-279.
    • (2006) Brazil J Chem Eng , vol.23 , Issue.3 , pp. 273-279
    • Rozenbaum, H.F.1    Patitucci, M.L.2    Antunes, O.A.C.3    Pereira, N.4
  • 10
    • 33745628075 scopus 로고    scopus 로고
    • Nematocysts of the Cubozoa
    • Gershwin L. Nematocysts of the Cubozoa. Zootaxa 2006, 1232:1-57.
    • (2006) Zootaxa , vol.1232 , pp. 1-57
    • Gershwin, L.1
  • 11
    • 0036324633 scopus 로고    scopus 로고
    • Extremely stable and versatile carboxylesterase from a hyperthermophilic
    • Hotta Y., Ezaki S., Atomi H., Imanaka T. Extremely stable and versatile carboxylesterase from a hyperthermophilic. Appl Environ Microbiol 2002, 68(8):3925-3931.
    • (2002) Appl Environ Microbiol , vol.68 , Issue.8 , pp. 3925-3931
    • Hotta, Y.1    Ezaki, S.2    Atomi, H.3    Imanaka, T.4
  • 12
    • 0027703508 scopus 로고
    • Prospects for the increased application of biocatalysts in organic transformations
    • Faber K., Franssen M.C.R. Prospects for the increased application of biocatalysts in organic transformations. Trends Biotechnol 1993, 11:461-470.
    • (1993) Trends Biotechnol , vol.11 , pp. 461-470
    • Faber, K.1    Franssen, M.C.R.2
  • 13
    • 0000466280 scopus 로고
    • Biotransformation reactor selection and operation
    • Harwood Academic, Chur, J.M.S. Cabral, D. Best, L. Boross, J. Tramper (Eds.)
    • Woodley J.M., Lilly M.D. Biotransformation reactor selection and operation. Applied biocatalysis 1994, Harwood Academic, Chur. J.M.S. Cabral, D. Best, L. Boross, J. Tramper (Eds.).
    • (1994) Applied biocatalysis
    • Woodley, J.M.1    Lilly, M.D.2
  • 14
    • 0030911891 scopus 로고    scopus 로고
    • Hydroxylation of 2 saturated acyclic monoterpenoids, tetrahydrogeraniol and tetrahydrolavandulol, by the plant-pathogenic fungus glomerella-cingulata
    • Nankai H., Miyazawa M., Kameoka H. Hydroxylation of 2 saturated acyclic monoterpenoids, tetrahydrogeraniol and tetrahydrolavandulol, by the plant-pathogenic fungus glomerella-cingulata. J Nat Prod 1997, 60(3):287-289.
    • (1997) J Nat Prod , vol.60 , Issue.3 , pp. 287-289
    • Nankai, H.1    Miyazawa, M.2    Kameoka, H.3
  • 16
    • 0036854722 scopus 로고    scopus 로고
    • Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata
    • El Sayed K.A., Yousaf M., Hamann M.T., Avery M.A., Kelly M., Wipf P. Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata. J Nat Prod 2002, 65(11):1547-1553.
    • (2002) J Nat Prod , vol.65 , Issue.11 , pp. 1547-1553
    • El Sayed, K.A.1    Yousaf, M.2    Hamann, M.T.3    Avery, M.A.4    Kelly, M.5    Wipf, P.6
  • 17
    • 0345161823 scopus 로고    scopus 로고
    • Microbial transformation of sesquiterpene lactones by the fungi Cunninghamella echinulata and Rhizopus oryzae
    • Barrero A.F., Oltra J.E., Raslan D.S., Saude D.A. Microbial transformation of sesquiterpene lactones by the fungi Cunninghamella echinulata and Rhizopus oryzae. J Nat Prod 1999, 62(5):726-729.
    • (1999) J Nat Prod , vol.62 , Issue.5 , pp. 726-729
    • Barrero, A.F.1    Oltra, J.E.2    Raslan, D.S.3    Saude, D.A.4
  • 18
    • 79951519148 scopus 로고    scopus 로고
    • Biotransformation of turmerones by Aspergillus niger
    • Fujiwara M., Marumoto S., Yagi N., Miyazawa M. Biotransformation of turmerones by Aspergillus niger. J Nat Prod 2011, 74(1):86-89.
    • (2011) J Nat Prod , vol.74 , Issue.1 , pp. 86-89
    • Fujiwara, M.1    Marumoto, S.2    Yagi, N.3    Miyazawa, M.4
  • 19
    • 33746208919 scopus 로고    scopus 로고
    • Microbiological transformation of two labdane diterpenes, the main constituents of Madia species, by two fungi
    • Haridy M.S.A., Ahmed A.A., Doe M. Microbiological transformation of two labdane diterpenes, the main constituents of Madia species, by two fungi. Phytochemistry 2006, 67(14):1455-1459.
    • (2006) Phytochemistry , vol.67 , Issue.14 , pp. 1455-1459
    • Haridy, M.S.A.1    Ahmed, A.A.2    Doe, M.3
  • 20
    • 70549097049 scopus 로고    scopus 로고
    • Microbial transformation of two 15a-hydroxy-ent-kaur-16-ene diterpenes by Mucor plumbeus
    • Fraga B.M., de Alfonso I., Gonzalez-Vallejo V., Guillermo R. Microbial transformation of two 15a-hydroxy-ent-kaur-16-ene diterpenes by Mucor plumbeus. Tetrahedron 2010, 66(1):227-234.
    • (2010) Tetrahedron , vol.66 , Issue.1 , pp. 227-234
    • Fraga, B.M.1    de Alfonso, I.2    Gonzalez-Vallejo, V.3    Guillermo, R.4
  • 21
    • 84862812509 scopus 로고    scopus 로고
    • Microbial transformation of the triterpene nigranoic acid in Trichoderma sp
    • Yang Y., Sun R., Song H., Xu Y., Yang P., Yang D., et al. Microbial transformation of the triterpene nigranoic acid in Trichoderma sp. Phytochem Lett 2012, 5(1):123-127.
    • (2012) Phytochem Lett , vol.5 , Issue.1 , pp. 123-127
    • Yang, Y.1    Sun, R.2    Song, H.3    Xu, Y.4    Yang, P.5    Yang, D.6
  • 22
    • 79956143969 scopus 로고    scopus 로고
    • New approaches to the structural modification of olean-type pentacyclic triterpenes via microbial oxidation and glycosylation
    • Zhu Y., Qian L., Zhang J., Liu J., Yu B. New approaches to the structural modification of olean-type pentacyclic triterpenes via microbial oxidation and glycosylation. Tetrahedron 2011, 67(23):4206-4211.
    • (2011) Tetrahedron , vol.67 , Issue.23 , pp. 4206-4211
    • Zhu, Y.1    Qian, L.2    Zhang, J.3    Liu, J.4    Yu, B.5
  • 23
    • 80055068381 scopus 로고    scopus 로고
    • Microbial transformations of diosgenin by the white-rot basidiomycete Coriolus versicolor
    • Wu G., Gao J., Shi X., Zhang Q., Wei S., Ding K. Microbial transformations of diosgenin by the white-rot basidiomycete Coriolus versicolor. J Nat Prod 2011, 74(10):2095-2101.
    • (2011) J Nat Prod , vol.74 , Issue.10 , pp. 2095-2101
    • Wu, G.1    Gao, J.2    Shi, X.3    Zhang, Q.4    Wei, S.5    Ding, K.6
  • 24
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin): an antimalarial drug from China
    • Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 25
    • 33144472887 scopus 로고    scopus 로고
    • A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273
    • Liu J.H., Chen Y.G., Yu B.Y., Chen Y.J. A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273. Bioorg Med Chem Lett 2006, 16:1909-1912.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1909-1912
    • Liu, J.H.1    Chen, Y.G.2    Yu, B.Y.3    Chen, Y.J.4
  • 26
    • 0037124438 scopus 로고    scopus 로고
    • Microbial transformation of artemisinin byCunninghamella echinulataandAspergillus niger
    • Zhan J., Guo H., Dai J., Zhang Y., Guo D. Microbial transformation of artemisinin byCunninghamella echinulataandAspergillus niger. Tetrahedron Lett 2002, 43:4519-4521.
    • (2002) Tetrahedron Lett , vol.43 , pp. 4519-4521
    • Zhan, J.1    Guo, H.2    Dai, J.3    Zhang, Y.4    Guo, D.5
  • 27
    • 0024518224 scopus 로고
    • Microbial metabolism studies of the antimalarial sesquiterpene artemisinin
    • Lee I.S., Elsohly H.N., Croom E.M., Hufford C.D. Microbial metabolism studies of the antimalarial sesquiterpene artemisinin. J Nat Prod 1989, 52:337-341.
    • (1989) J Nat Prod , vol.52 , pp. 337-341
    • Lee, I.S.1    Elsohly, H.N.2    Croom, E.M.3    Hufford, C.D.4
  • 28
    • 0032522115 scopus 로고    scopus 로고
    • Unified mechanistic framework for the Fe(II)-induced cleavage of qinghaosu and derivatives/analogues. The first spintrapping evidence for the previously postulated secondary C-4 radical
    • Wu W.M., Wu Y., Wu Y.L., Yao Z.J., Zhou C.M., Li Y., et al. Unified mechanistic framework for the Fe(II)-induced cleavage of qinghaosu and derivatives/analogues. The first spintrapping evidence for the previously postulated secondary C-4 radical. J Am Chem Soc 1998, 120:3316-3325.
    • (1998) J Am Chem Soc , vol.120 , pp. 3316-3325
    • Wu, W.M.1    Wu, Y.2    Wu, Y.L.3    Yao, Z.J.4    Zhou, C.M.5    Li, Y.6
  • 29
    • 33750161012 scopus 로고    scopus 로고
    • Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin
    • Tatineni R., Doddapaneni K.K., Dalavayi S., Kulkarni S.M., Mangamoori L.N. Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin. Process Biochem 2006, 41:2464-2467.
    • (2006) Process Biochem , vol.41 , pp. 2464-2467
    • Tatineni, R.1    Doddapaneni, K.K.2    Dalavayi, S.3    Kulkarni, S.M.4    Mangamoori, L.N.5
  • 32
    • 0036370799 scopus 로고    scopus 로고
    • Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    • Bae E.A., Han M.J., Choo M.K., Park S.Y., Kim D.H. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 2002, 25:58-63.
    • (2002) Biol Pharm Bull , vol.25 , pp. 58-63
    • Bae, E.A.1    Han, M.J.2    Choo, M.K.3    Park, S.Y.4    Kim, D.H.5
  • 33
    • 18044384071 scopus 로고    scopus 로고
    • The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity
    • Liu Y., Li W., Li P., Deng M.C., Yang S.L., Yang L. The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity. Biol Pharm Bull 2004, 27:1555-1560.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1555-1560
    • Liu, Y.1    Li, W.2    Li, P.3    Deng, M.C.4    Yang, S.L.5    Yang, L.6
  • 34
    • 0036633130 scopus 로고    scopus 로고
    • Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol
    • Hasegawa H., Suzuki R., Nagaoka T., Tezuka Y., Kadota S., Saiki I. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol Pharm Bull 2002, 25:861-866.
    • (2002) Biol Pharm Bull , vol.25 , pp. 861-866
    • Hasegawa, H.1    Suzuki, R.2    Nagaoka, T.3    Tezuka, Y.4    Kadota, S.5    Saiki, I.6
  • 35
    • 34548838251 scopus 로고    scopus 로고
    • Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products
    • Zhang J., Guo H., Tian T., Liu P., Li N., Zhou J., et al. Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products. Phytochemistry 2007, 68:2523-2530.
    • (2007) Phytochemistry , vol.68 , pp. 2523-2530
    • Zhang, J.1    Guo, H.2    Tian, T.3    Liu, P.4    Li, N.5    Zhou, J.6
  • 36
    • 20444438824 scopus 로고    scopus 로고
    • Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus
    • Tian Y., Guo H., Han J., Guo D. Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus. J Nat Prod 2005, 68:678-680.
    • (2005) J Nat Prod , vol.68 , pp. 678-680
    • Tian, Y.1    Guo, H.2    Han, J.3    Guo, D.4
  • 37
    • 65849165310 scopus 로고    scopus 로고
    • Fungal biotransformation of ginse-noside Rg3
    • Wu X., Wang Y., Zhao W., Zhang Y. Fungal biotransformation of ginse-noside Rg3. Acta Microbiol Sin 2008, 48:1181-1185.
    • (2008) Acta Microbiol Sin , vol.48 , pp. 1181-1185
    • Wu, X.1    Wang, Y.2    Zhao, W.3    Zhang, Y.4
  • 38
    • 31044431842 scopus 로고    scopus 로고
    • Enzymatic transformation of ginsenoside Rg 3 to Rh 2 using newly isolated Fusarium proliferatum ECU2042
    • Su J.H., Xu J.H., Lu W.Y., Lin G.Q. Enzymatic transformation of ginsenoside Rg 3 to Rh 2 using newly isolated Fusarium proliferatum ECU2042. J Mol Catal B Enzym 2006, 38:113-118.
    • (2006) J Mol Catal B Enzym , vol.38 , pp. 113-118
    • Su, J.H.1    Xu, J.H.2    Lu, W.Y.3    Lin, G.Q.4
  • 39
    • 68649092315 scopus 로고    scopus 로고
    • Fusarium proliferatum ECU2042 that converts ginsenoside Rg 3 into Rh 2
    • Su J.H., Xu J.H., Yu H.L., He Y.C., Lu W.Y., Lin G.Q. Fusarium proliferatum ECU2042 that converts ginsenoside Rg 3 into Rh 2. J Mol Catal B Enzym 2009, 57:278-283.
    • (2009) J Mol Catal B Enzym , vol.57 , pp. 278-283
    • Su, J.H.1    Xu, J.H.2    Yu, H.L.3    He, Y.C.4    Lu, W.Y.5    Lin, G.Q.6
  • 41
    • 1542548036 scopus 로고    scopus 로고
    • Purification and characterization of gypenoside-alpha-L-rhamnosidase hydrolyzing gypenoside-5 into ginsenoside Rd
    • Yu H., Liu H., Zhang C., Tan D., Lu M., Jin F. Purification and characterization of gypenoside-alpha-L-rhamnosidase hydrolyzing gypenoside-5 into ginsenoside Rd. Process Biochem 2004, 39:861-867.
    • (2004) Process Biochem , vol.39 , pp. 861-867
    • Yu, H.1    Liu, H.2    Zhang, C.3    Tan, D.4    Lu, M.5    Jin, F.6
  • 42
    • 64749104750 scopus 로고    scopus 로고
    • A novel ginsenoside Rb1-hydrolyzing b-D-glucosidase from Cladosporium fulvum
    • Zhao X., Gao L., Wang J., Bi H., Gao J., Du X., Zhou Y., Tai G. A novel ginsenoside Rb1-hydrolyzing b-D-glucosidase from Cladosporium fulvum. Process Biochem 2009, 44:612-618.
    • (2009) Process Biochem , vol.44 , pp. 612-618
    • Zhao, X.1    Gao, L.2    Wang, J.3    Bi, H.4    Gao, J.5    Du, X.6    Zhou, Y.7    Tai, G.8
  • 43
    • 33747330308 scopus 로고    scopus 로고
    • In vitro metabolism of ginsenosides by the ginseng root pathogen Pythium irregulare
    • Yousef L.F., Bernards M.A. In vitro metabolism of ginsenosides by the ginseng root pathogen Pythium irregulare. Phytochemistry 2006, 67:1740-1749.
    • (2006) Phytochemistry , vol.67 , pp. 1740-1749
    • Yousef, L.F.1    Bernards, M.A.2
  • 44
    • 37149031070 scopus 로고    scopus 로고
    • Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514
    • Cheng L.Q., Na J.R., Bang M.H., Kim M.K., Yang D.C. Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514. Phytochemistry 2008, 69:218-224.
    • (2008) Phytochemistry , vol.69 , pp. 218-224
    • Cheng, L.Q.1    Na, J.R.2    Bang, M.H.3    Kim, M.K.4    Yang, D.C.5
  • 46
    • 0036270712 scopus 로고    scopus 로고
    • Microbial transformation of alkaloids
    • Rathbone D.A., Bruce N.C. Microbial transformation of alkaloids. Curr Opin Microbiol 2002, 5:274-281.
    • (2002) Curr Opin Microbiol , vol.5 , pp. 274-281
    • Rathbone, D.A.1    Bruce, N.C.2
  • 47
    • 0032504605 scopus 로고    scopus 로고
    • A novel pathway for the metabolism of caffeine by a mixed culture consortium
    • Madyastha K.M., Sridhar G.R. A novel pathway for the metabolism of caffeine by a mixed culture consortium. Biochem Biophys Res 1998, 249:178-181.
    • (1998) Biochem Biophys Res , vol.249 , pp. 178-181
    • Madyastha, K.M.1    Sridhar, G.R.2
  • 48
    • 37049078582 scopus 로고
    • Mucor piriformis, an efficient N-dealkylating reagent for thebaine and its N-variants
    • Madyastha K.M., Reddy G.V.B. Mucor piriformis, an efficient N-dealkylating reagent for thebaine and its N-variants. J Chem Soc Perkin Trans 1994, 1:911-912.
    • (1994) J Chem Soc Perkin Trans , vol.1 , pp. 911-912
    • Madyastha, K.M.1    Reddy, G.V.B.2
  • 49
    • 33745198707 scopus 로고    scopus 로고
    • Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine
    • Li L., Liu R., Ye M., Hu X., Wang Q., Bi K., et al. Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine. Enzyme Microb Technol 2006, 39:561-567.
    • (2006) Enzyme Microb Technol , vol.39 , pp. 561-567
    • Li, L.1    Liu, R.2    Ye, M.3    Hu, X.4    Wang, Q.5    Bi, K.6
  • 52
    • 0042882373 scopus 로고    scopus 로고
    • The synthesis of buprenorphine intermediates by regioselective microbial N- and O-demethylation reactions using Cunninghamella echinulata
    • Abel A.M., Carnell A.J., Davis J.A., Paylor M. The synthesis of buprenorphine intermediates by regioselective microbial N- and O-demethylation reactions using Cunninghamella echinulata. Enzyme Microb Technol 2003, 33:743-748.
    • (2003) Enzyme Microb Technol , vol.33 , pp. 743-748
    • Abel, A.M.1    Carnell, A.J.2    Davis, J.A.3    Paylor, M.4
  • 54
    • 23644453260 scopus 로고    scopus 로고
    • New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus
    • Ye M., Han J., An D., Tu G., Guo G. New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus. Tetrahedron 2005, 61:8947-8955.
    • (2005) Tetrahedron , vol.61 , pp. 8947-8955
    • Ye, M.1    Han, J.2    An, D.3    Tu, G.4    Guo, G.5
  • 55
    • 0037735190 scopus 로고    scopus 로고
    • Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa
    • Zhan J., Liu W., Guo H., Zhang Y., Guo D. Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa. Enzyme Microb Technol 2003, 33:29-32.
    • (2003) Enzyme Microb Technol , vol.33 , pp. 29-32
    • Zhan, J.1    Liu, W.2    Guo, H.3    Zhang, Y.4    Guo, D.5
  • 56
    • 35148841963 scopus 로고    scopus 로고
    • Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR)
    • Zhang J., Sun Y., Liu J.H., Yu B.Y., Xu Q. Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR). Bioorg Med Chem Lett 2007, 17:6062-6065.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 6062-6065
    • Zhang, J.1    Sun, Y.2    Liu, J.H.3    Yu, B.Y.4    Xu, Q.5
  • 57
    • 34547195889 scopus 로고    scopus 로고
    • Biotransformation of cinobufagin by Cunninghamella elegans
    • Qiao L., Zhou Y.Z.H., Qi X.L., Lin L.H., Chen H.C.H., Pang L.Y., et al. Biotransformation of cinobufagin by Cunninghamella elegans. J Antibiot 2007, 60(4):261-264.
    • (2007) J Antibiot , vol.60 , Issue.4 , pp. 261-264
    • Qiao, L.1    Zhou, Y.Z.H.2    Qi, X.L.3    Lin, L.H.4    Chen, H.C.H.5    Pang, L.Y.6


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