The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 10, 2004, Pages 1555-1560

  Liu, Yong ^a,b   Li, Wei ^a,b   Li, Peng ^a   Deng, Mai Cun ^a   Yang, Sheng Li ^a   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

CYP3A; Ginseng drug interaction; Ginsenoside; Intestinal bacterial metabolite

Indexed keywords

20 PANAXATRIOL; 20 PROTOPANAXADIOL; 20 PROTOPANAXATRIOL; COMPOUND K; CYTOCHROME P450 3A; DRUG METABOLITE; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; LIVER ENZYME; TESTOSTERONE; UNCLASSIFIED DRUG; 6 BETA-HYDROXYTESTOSTERONE; 6BETA HYDROXYTESTOSTERONE; HERBACEOUS AGENT; N DEMETHYLASE; PROTOPANAXADIOL; PROTOPANAXATRIOL; SAPOGENIN; TESTOSTERONE DERIVATIVE; TRITERPENE; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; GINSENG; HYDROXYLATION; INHIBITION KINETICS; INTESTINE FLORA; LIVER MICROSOME; MALE; METABOLITE; NONHUMAN; PREDICTION; PRESCRIPTION; RAT; REACTION ANALYSIS; ANIMAL; BACTERIUM; DRUG ANTAGONISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; METABOLISM; MICROBIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BACTERIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; DRUGS, CHINESE HERBAL; GINSENOSIDES; HYDROXYLATION; HYDROXYTESTOSTERONES; INTESTINES; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; SAPOGENINS; TRITERPENES;

EID: 18044384071     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.1555     Document Type: Article

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