-
1
-
-
84859621752
-
The complex molecular biology of amyotrophic lateral sclerosis (ALS)
-
Redler RL, Dokholyan NV. The complex molecular biology of amyotrophic lateral sclerosis (ALS). Prog Mol Biol Transl Sci. 2012;107:215–62.
-
(2012)
Prog Mol Biol Transl Sci
, vol.107
, pp. 215-262
-
-
Redler, R.L.1
Dokholyan, N.V.2
-
2
-
-
0028802665
-
Amyotrophic lateral sclerosis
-
Eisen A. Amyotrophic lateral sclerosis. Intern Med. 1995;34:824–32.
-
(1995)
Intern Med
, vol.34
, pp. 824-832
-
-
Eisen, A.1
-
3
-
-
33847774429
-
Translational therapeutic strategies in amyotrophic lateral sclerosis
-
Ryu H, Ferrante RJ. Translational therapeutic strategies in amyotrophic lateral sclerosis. Mini Rev Med Chem. 2007;7:141–50.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 141-150
-
-
Ryu, H.1
Ferrante, R.J.2
-
4
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al.Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59–62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
-
5
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science. 1994;264:1772–5.
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
-
6
-
-
84155171976
-
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond
-
Da Cruz S, Cleveland DW. Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol. 2011;21:904–19.
-
(2011)
Curr Opin Neurobiol
, vol.21
, pp. 904-919
-
-
Da Cruz, S.1
Cleveland, D.W.2
-
7
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Vande Velde C, et al. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet. 2008;40:572–4.
-
(2008)
Nat Genet
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Vande Velde, C.6
-
8
-
-
59249085091
-
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
-
Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, et al. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol. 2009;117:137–49.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 137-149
-
-
Neumann, M.1
Kwong, L.K.2
Lee, E.B.3
Kremmer, E.4
Flatley, A.5
Xu, Y.6
-
9
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314:130–3.
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
-
10
-
-
78650680776
-
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1
-
Brady OA, Meng P, Zheng Y, Mao Y, Hu F. Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1. J Neurochem. 2011;116:248–59.
-
(2011)
J Neurochem
, vol.116
, pp. 248-259
-
-
Brady, O.A.1
Meng, P.2
Zheng, Y.3
Mao, Y.4
Hu, F.5
-
11
-
-
77953026500
-
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
-
Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, et al. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol. 2010;119:409–19.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 409-419
-
-
Kraemer, B.C.1
Schuck, T.2
Wheeler, J.M.3
Robinson, L.C.4
Trojanowski, J.Q.5
Lee, V.M.6
-
12
-
-
46749138739
-
Enrichment of C-terminal fragments in TAR DNAbinding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, et al. Enrichment of C-terminal fragments in TAR DNAbinding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am J Pathol. 2008;173:182–94.
-
(2008)
Am J Pathol
, vol.173
, pp. 182-194
-
-
Igaz, L.M.1
Kwong, L.K.2
Xu, Y.3
Truax, A.C.4
Uryu, K.5
Neumann, M.6
-
13
-
-
80051660738
-
Iron chelation and neuroprotection in neurodegenerative diseases
-
Li X, Jankovic J, Le W. Iron chelation and neuroprotection in neurodegenerative diseases. J Neural Transm. 2011;118:473–7.
-
(2011)
J Neural Transm
, vol.118
, pp. 473-477
-
-
Li, X.1
Jankovic, J.2
Le, W.3
-
14
-
-
84555179169
-
Dysregulation of iron metabolism in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis
-
Oshiro S, Morioka MS, Kikuchi M. Dysregulation of iron metabolism in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Adv Pharmacol Sci. 2011;2011:378278.
-
(2011)
Adv Pharmacol Sci
, vol.2011
, pp. 378278
-
-
Oshiro, S.1
Morioka, M.S.2
Kikuchi, M.3
-
16
-
-
77957904877
-
Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models
-
Yang EJ, Jiang JH, Lee SM, Yang SC, Hwang HS, Lee MS, et al. Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models. J Neuroinflammation. 2010;7:69.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 69
-
-
Yang, E.J.1
Jiang, J.H.2
Lee, S.M.3
Yang, S.C.4
Hwang, H.S.5
Lee, M.S.6
-
17
-
-
0030901162
-
Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
-
Schmued LC, Albertson C, Slikker W Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 1997;751:37–46.
-
(1997)
Brain Res
, vol.751
, pp. 37-46
-
-
Schmued, L.C.1
Albertson, C.2
Slikker, W.3
-
18
-
-
0034607595
-
Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain
-
Hopkins KJ, Wang G, Schmued LC. Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain. Brain Res. 2000;864:69–80.
-
(2000)
Brain Res
, vol.864
, pp. 69-80
-
-
Hopkins, K.J.1
Wang, G.2
Schmued, L.C.3
-
19
-
-
79959263450
-
Melittin restores proteasome function in an animal model of ALS
-
Yang EJ, Kim SH, Yang SC, Lee SM, Choi SM. Melittin restores proteasome function in an animal model of ALS. J Neuroinflammation. 2011;8:69.
-
(2011)
J Neuroinflammation
, vol.8
, pp. 69
-
-
Yang, E.J.1
Kim, S.H.2
Yang, S.C.3
Lee, S.M.4
Choi, S.M.5
-
20
-
-
77952105020
-
Decreased level of 5- methyltetrahydrofolate: A potential biomarker for pre-symptomatic amyotrophic lateral sclerosis
-
Zhang X, Chen S, Li L, Wang Q, Le W. Decreased level of 5- methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis. J Neurol Sci. 2010;293:102–5.
-
(2010)
J Neurol Sci
, vol.293
, pp. 102-105
-
-
Zhang, X.1
Chen, S.2
Li, L.3
Wang, Q.4
Le, W.5
-
21
-
-
84866667912
-
Therapeutic effects of DL-3-N-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis
-
Feng XH, Yuan W, Peng Y, Liu MS, Cui LY. Therapeutic effects of DL-3-N-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis. Chin Med J. 2012;125:1760–6.
-
(2012)
Chin Med J
, vol.125
, pp. 1760-1766
-
-
Feng, X.H.1
Yuan, W.2
Peng, Y.3
Liu, M.S.4
Cui, L.Y.5
-
22
-
-
0029017315
-
Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: A preliminary study
-
Kasarskis EJ, Tandon L, Lovell MA, Ehmann WD. Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study. J Neurol Sci. 1995;130:203–8.
-
(1995)
J Neurol Sci
, vol.130
, pp. 203-208
-
-
Kasarskis, E.J.1
Tandon, L.2
Lovell, M.A.3
Ehmann, W.D.4
-
24
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive taunegative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, et al. TDP-43 is a component of ubiquitin-positive taunegative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602–11.
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 602-611
-
-
Arai, T.1
Hasegawa, M.2
Akiyama, H.3
Ikeda, K.4
Nonaka, T.5
Mori, H.6
-
25
-
-
66149114101
-
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
-
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc Natl Acad Sci U S A. 2009;106:7607–12.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7607-7612
-
-
Zhang, Y.J.1
Xu, Y.F.2
Cook, C.3
Gendron, T.F.4
Roettges, P.5
Link, C.D.6
-
27
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci. 2008;11:251–3.
-
(2008)
Nat Neurosci
, vol.11
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
Gutmann, D.H.6
-
28
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci. 2007;10:615–22.
-
(2007)
Nat Neurosci
, vol.10
, pp. 615-622
-
-
Nagai, M.1
Re, D.B.2
Nagata, T.3
Chalazonitis, A.4
Jessell, T.M.5
Wichterle, H.6
-
29
-
-
34247473080
-
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci. 2007;10:608–14.
-
(2007)
Nat Neurosci
, vol.10
, pp. 608-614
-
-
Di Giorgio, F.P.1
Carrasco, M.A.2
Siao, M.C.3
Maniatis, T.4
Eggan, K.5
-
30
-
-
35548983991
-
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
-
Van Damme P, Bogaert E, Dewil M, Hersmus N, Kiraly D, Scheveneels W, et al. Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc Natl Acad Sci U S A. 2007;104:14825–30.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14825-14830
-
-
Van Damme, P.1
Bogaert, E.2
Dewil, M.3
Hersmus, N.4
Kiraly, D.5
Scheveneels, W.6
-
31
-
-
0029030610
-
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
-
Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol. 1995;38:73–84.
-
(1995)
Ann Neurol
, vol.38
, pp. 73-84
-
-
Rothstein, J.D.1
Van Kammen, M.2
Levey, A.I.3
Martin, L.J.4
Kuncl, R.W.5
-
32
-
-
80052936462
-
Pathological hallmarks of amyotrophic lateral sclerosis/ frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
-
Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, et al. Pathological hallmarks of amyotrophic lateral sclerosis/ frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011;134:2610–26.
-
(2011)
Brain
, vol.134
, pp. 2610-2626
-
-
Swarup, V.1
Phaneuf, D.2
Bareil, C.3
Robertson, J.4
Rouleau, G.A.5
Kriz, J.6
-
33
-
-
84872465426
-
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis
-
Esmaeili MA, Panahi M, Yadav S, Hennings L, Kiaei M. Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis. Int J Exp Pathol. 2013;94:56–64.
-
(2013)
Int J Exp Pathol
, vol.94
, pp. 56-64
-
-
Esmaeili, M.A.1
Panahi, M.2
Yadav, S.3
Hennings, L.4
Kiaei, M.5
-
34
-
-
81255177581
-
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
-
Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, et al. Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Mol Neurodegener. 2011;6:73.
-
(2011)
Mol Neurodegener
, vol.6
, pp. 73
-
-
Xu, Y.F.1
Zhang, Y.J.2
Lin, W.L.3
Cao, X.4
Stetler, C.5
Dickson, D.W.6
-
35
-
-
84880217322
-
Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
-
Tong J, Huang C, Bi F, Wu Q, Huang B, Liu X, et al. Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats. EMBO J. 2013;32:1917–26.
-
(2013)
EMBO J
, vol.32
, pp. 1917-1926
-
-
Tong, J.1
Huang, C.2
Bi, F.3
Wu, Q.4
Huang, B.5
Liu, X.6
-
36
-
-
84871734357
-
A role for calpain-dependent cleavage of TDP- 43 in amyotrophic lateral sclerosis pathology
-
Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, et al. A role for calpain-dependent cleavage of TDP- 43 in amyotrophic lateral sclerosis pathology. Nat Commun. 2012;3:1307.
-
(2012)
Nat Commun
, vol.3
, pp. 1307
-
-
Yamashita, T.1
Hideyama, T.2
Hachiga, K.3
Teramoto, S.4
Takano, J.5
Iwata, N.6
-
37
-
-
77957558614
-
Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis
-
Tradewell ML, Durham HD. Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis. Neuroreport. 2010;21:976–9.
-
(2010)
Neuroreport
, vol.21
, pp. 976-979
-
-
Tradewell, M.L.1
Durham, H.D.2
-
38
-
-
84860218803
-
Novel therapeutic approach for neurodegenerative pathologies: Multitarget ironchelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway
-
Weinreb O, Amit T, Mandel S, Youdim MB. Novel therapeutic approach for neurodegenerative pathologies: multitarget ironchelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway. Neurodegener Dis. 2012;10:112–5.
-
(2012)
Neurodegener Dis
, vol.10
, pp. 112-115
-
-
Weinreb, O.1
Amit, T.2
Mandel, S.3
Youdim, M.B.4
-
39
-
-
52049107811
-
New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs
-
Arduino D, Silva D, Cardoso SM, Chaves S, Oliveira CR, Santos MA. New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs. Front Biosci. 2008;13:6763–74.
-
(2008)
Front Biosci
, vol.13
, pp. 6763-6774
-
-
Arduino, D.1
Silva, D.2
Cardoso, S.M.3
Chaves, S.4
Oliveira, C.R.5
Santos, M.A.6
-
40
-
-
79958787596
-
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis
-
Wang Q, Zhang X, Chen S, Zhang X, Zhang S, Youdium M, et al. Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis. Neurodegener Dis. 2011;8:310–21.
-
(2011)
Neurodegener Dis
, vol.8
, pp. 310-321
-
-
Wang, Q.1
Zhang, X.2
Chen, S.3
Zhang, X.4
Zhang, S.5
Youdium, M.6
-
41
-
-
33745755199
-
Superoxide dismutase 1 modulates expression of transferrin receptor
-
Danzeisen R, Achsel T, Bederke U, Cozzolino M, Crosio C, Ferri A, et al. Superoxide dismutase 1 modulates expression of transferrin receptor. J Biol Inorg Chem. 2006;11:489–98.
-
(2006)
J Biol Inorg Chem
, vol.11
, pp. 489-498
-
-
Danzeisen, R.1
Achsel, T.2
Bederke, U.3
Cozzolino, M.4
Crosio, C.5
Ferri, A.6
-
42
-
-
84864917070
-
Iron toxicity in neurodegeneration
-
Núñez MT, Urrutia P, Mena N, Aguirre P, Tapia V, Salazar J. Iron toxicity in neurodegeneration. Biometals. 2012;25:761–76.
-
(2012)
Biometals
, vol.25
, pp. 761-776
-
-
Núñez, M.T.1
Urrutia, P.2
Mena, N.3
Aguirre, P.4
Tapia, V.5
Salazar, J.6
|