Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Yang, Eun Jin ^a   Jiang, Jing Hua ^a   Lee, Sang Min ^a   Yang, Sun Choel ^b   Hwang, Hye Suk ^a   Lee, Myeong Soo ^a   Choi, Sun Mi ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BEE VENOM; CASPASE 3; COPPER ZINC SUPEROXIDE DISMUTASE; GENE PRODUCT; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN IBA 1; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN STEM; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; ENZYME ACTIVITY; FACIAL NERVE NUCLEUS; GRAY MATTER; LUMBAR SPINAL CORD; MICROGLIA; MITOCHONDRIAL CRISTAE MORPHOLOGY; MITOCHONDRION; MITOCHONDRION STRUCTURE; MOTONEURON; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOUSE; MOUSE MUTANT; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ROTAROD TEST; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD VENTRAL HORN; SURVIVAL RATE; SURVIVAL TIME; SYMPTOM; TRANSGENIC MOUSE; WESTERN BLOTTING; WHITE MATTER; ANALYSIS OF VARIANCE; ANIMAL; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LONGEVITY; MALE; METABOLISM; NERVE CELL; NONPARAMETRIC TEST; PHYSIOLOGY;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; BEE VENOMS; BLOTTING, WESTERN; BRAIN STEM; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LONGEVITY; MALE; MICE; MICE, TRANSGENIC; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; ROTAROD PERFORMANCE TEST; SIGNAL TRANSDUCTION; SPINAL CORD; STATISTICS, NONPARAMETRIC;

EID: 77957904877     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-69     Document Type: Article

References (37)

1. Mulder DW. Clinical limits of amyotrophic lateral sclerosis. Adv Neurol 1982, 36:15-22.
2. Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2001, 2:806-819. 10.1038/35097565, 11715057.
3. Weishaupt JH, Bartels C, Polking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S, Bohn M, Huther G, Schneider A, Bach A, Siren AL, Hardeland R, Bahr M, Nave KA, Ehrenreich H. Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 2006, 41:313-323. 10.1111/j.1600-079X.2006.00377.x, 17014688.
4. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, Rahmani Z, Krizus A, McKenna-Yasek D, Cayabyab A, Gaston SM, Berger R, Tanzi RE, Halperin JJ, Herzfeldt B, Bergh RV, Hung W, Bird T, Deng G, Mulder DW, Smyth C, Laing NG, Soriano E, Pericak-Vance MA, Haines J, Rouleau GA, Gusella JS, Horvitz HR, Brown RH. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993, 362:59-62. 10.1038/362059a0, 8446170.
5. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 1994, 264:1772-1775. 10.1126/science.8209258, 8209258.
6. Brown RH, Brown RH, Robberecht W. Amyotrophic lateral sclerosis: pathogenesis. Semin Neurol 2001, 21:131-139. 10.1055/s-2001-15260, 11442322.
7. Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 2006, 7:710-723. 10.1038/nrn1971, 16924260.
8. McGeer PL, McGeer EG. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 2002, 26:459-470. 10.1002/mus.10191, 12362410.
9. Weydt P, Weydt P, Yuen EC, Ransom BR, Moller T. Increased cytotoxic potential of microglia from ALS-transgenic mice. Glia 2004, 48:179-182. 10.1002/glia.20062, 15378658.
10. Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 2004, 1:14. 10.1186/1742-2094-1-14, 509427, 15285801.
11. Schindler JF, Monahan JB, Smith WG. p38 pathway kinases as anti-inflammatory drug targets. J Dent Res 2007, 86:800-811. 10.1177/154405910708600902, 17720847.
12. Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 1989, 170:607-612. 10.1084/jem.170.2.607, 2189402, 2754393.
13. Fillit H, Ding WH, Buee L, Kalman J, Altstiel L, Lawlor B, Wolf-Klein G. Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett 1991, 129:318-320. 10.1016/0304-3940(91)90490-K, 1745413.
14. Hirsch EC, Hunot S, Damier P, Faucheux B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?. Ann Neurol 1998, 44:S115-S120.
15. Poloni M, Facchetti D, Mai R, Micheli A, Agnoletti L, Francolini G, Mora G, Camana C, Mazzini L, Bachetti T. Circulating levels of tumor necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci Lett 2000, 287:211-214. 10.1016/S0304-3940(00)01177-0, 10863032.
16. Wen W, Sanelli T, Ge W, Strong W, Strong MJ. Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor. Neurosci Res 2006, 55:87-95. 10.1016/j.neures.2006.02.004, 16529832.
17. Mir M, Asensio VJ, Tolosa L, Gou-Fabregas M, Soler RM, Llado J, Olmos G. Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants. Neuroscience 2009, 162:959-971. 10.1016/j.neuroscience.2009.05.049, 19477238.
18. Somerfield SD, Brandwein S. Bee venom and adjuvant arthritis. J Rheumatol 1988, 15:1878.
19. Wilms H, Zecca L, Rosenstiel P, Sievers J, Deuschl G, Lucius R. Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr Pharm Des 2007, 13:1925-1928. 10.2174/138161207780858429, 17584117.
20. Yin CS, Jeong HS, Park HJ, Baik Y, Yoon MH, Choi CB, Koh HG. A proposed transpositional acupoint system in a mouse and rat model. Res Vet Sci 2008, 842:159-165.
21. Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, Kingsman SM, Carmeliet P, Mazarakis ND. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004, 429:413-417. 10.1038/nature02544, 15164063.
22. Kirkinezos IG, Bacman SR, Hernandez D, Oca-Cossio J, Arias LJ, Perez-Pinzon MA, Bradley WG, Moraes CT. Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice. J Neurosci 2005, 25:164-172. 10.1523/JNEUROSCI.3829-04.2005, 15634778.
23. Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron 2002, 35:419-432. 10.1016/S0896-6273(02)00794-8, 12165466.
24. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 1997, 94:2007-2012. 10.1073/pnas.94.5.2007, 20033, 9050895.
25. Martin LJ, Price AC, Kaiser A, Shaikh AY, Liu Z. Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review). Int J Mol Med 2000, 5:3-13.
26. Troy CM, Stefanis L, Prochiantz A, Greene LA, Shelanski ML. The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc Natl Acad Sci USA 1996, 93:5635-5640. 10.1073/pnas.93.11.5635, 39300, 8643629.
27. Boillee S, Vande Velde C, Cleveland DW. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 2006, 52:39-59. 10.1016/j.neuron.2006.09.018, 17015226.
28. Moisse K, Strong MJ. Innate immunity in amyotrophic lateral sclerosis. Biochim Biophys Acta 2006, 1762:1083-1093.
29. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 2003, 10:45-65. 10.1038/sj.cdd.4401189, 12655295.
30. Ware CF. Network communications: lymphotoxins, LIGHT, and TNF. Annu Rev Immunol 2005, 23:787-819. 10.1146/annurev.immunol.23.021704.115719, 15771586.
31. Eissner G, Kolch W, Scheurich P. Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev 2004, 15:353-366. 10.1016/j.cytogfr.2004.03.011, 15450251.
32. Tansey MG, Wyss-Coray T. Cytokines in CNS inflammation and disease. Central Nervous System Diseases and Inflammation 2008, 59-106. California: Springer, Lane TE, Carson M, Bergmann C, Wyss-Coray T.
33. Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. Proliferation of astrocytes in vitro in response to cytokines: A primary role for tumor necrosis factor. J Immunol 1990, 144:129-135.
34. Castro HJ, Mendez-Lnocencio JI, Omidvar B, Omidvar J, Santilli J, Nielsen HS, Pavot AP, Richert JR, Bellanti JA. A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis. Allergy Asthma Proc 2005, 26:470-476.
35. Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, Kang SK, Mar W. Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Arch Pharm Res 2003, 26:383-388. 10.1007/BF02976695, 12785734.
36. Pasinelli P, Houseweart MK, Brown RH, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 2000, 97:13901-13906. 10.1073/pnas.240305897, 17673, 11095709.
37. Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007, 10:615-622. 10.1038/nn1876, 17435755.