Murder mysteries in type 1 diabetes

Nature Medicine

Volumn 9, Issue 2, 2003, Pages 161-162

  Kaufman, Daniel L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLIAL FIBRILLARY ACIDIC PROTEIN;

AUTOIMMUNITY; CELL DESTRUCTION; HUMAN; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; NERVOUS SYSTEM; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SCHWANN CELL; SHORT SURVEY; T LYMPHOCYTE;

ANIMALS; DIABETES MELLITUS, TYPE 1; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; SCHWANN CELLS;

EID: 0037327099     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0203-161     Document Type: Short Survey

References (15)

1. Tisch, R. & McDevitt, H. Insulin-dependent diabetes mellitus. Cell 85, 291-297 (1996).
2. Salomon, B. et al. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J. Exp. Med. 194, 677-684 (2001).
3. Winer, S. et al. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. J. Immunol. 166, 2831-2841 (2001).
4. Winer, S. et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive. Nat. Med. 9, 198-205 (2003).
5. Teitelman, G., Guz, Y., Ivkovic, S. & Ehrlich, M. Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells. J. Neurobiol. 34, 304-318 (1998).
6. Sunami, E. et al. Morphological characteristics of Schwann cells in the islets of Langerhans of the murine pancreas. Arch. Histol. Cytol. 64, 191-201 (2001).
7. Sreenan, S. et al. Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48, 989-996 (1999).
8. Mathis, D., Vence, L. & Benoist, C. β-Cell death during progression to diabetes. Nature 414, 792-798 (2001).
9. Tian, J., Gregori, S., Adorini, L. & Kaufman, D.L. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J. Immunol. 166, 7144-7150 (2001).
10. Haskins, K. & Wegmann, D. Diabetogenic T-cell clones. Diabetes 45, 1299-1305 (1996).
11. von Herrath, M.G. Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. Curr. Top. Microbiol. Immunol. 263, 145-175 (2002).
12. Larger, E., Becourt, C., Bach, J.F. & Boitard, C. Pancreatic islet β-cells drive T cell-immune responses in the nonobese diabetic mouse model. J. Exp. Med. 181, 1635-1642 (1995).
13. Kaufman, D.L. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-72 (1993).
14. French, M.B. et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 46, 34-39 (1997).
15. Saravia-Fernandez, F. et al. Localization of γ-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse. Endocrinology 137, 3497-3506 (1996).