Associations of methylarginines and homoarginine with diastolic dysfunction and cardiovascular risk factors in patients with preserved left ventricular ejection fraction

Journal of Cardiac Failure

Volumn 20, Issue 12, 2014, Pages 923-930

  Pilz, Stefan ^a,b   Edelmann, Frank ^c   Meinitzer, Andreas ^a   Gelbrich, Götz ^d   Döner, Ufuk ^c   Düngen, Hans Dirk ^e   Tomaschitz, Andreas ^a   Kienreich, Katharina ^a   Gaksch, Martin ^a   Duvinage, André ^c   Stahrenberg, Raoul ^c   Kunde, Jan ^f   Schmidt, Albrecht ^a   März, Winfried ^a,g,h   Wachter, Rolf ^c   Pieske, Burkert ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f THERMO FISHER SCIENTIFIC   (Germany)

^g SYNLAB ACADEMY   (Germany)

^h UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

cardiovascular risk; diastolic dysfunction; Homoarginine; methylarginines

Indexed keywords

6 N,N' DIMETHYLARGININE; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; HOMOARGININE; N(G),N(G) DIMETHYLARGININE; PROADRENOMEDULLIN; ARGININE; BIOLOGICAL MARKER; N,N'-DIMETHYLARGININE; NITRIC OXIDE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DISEASE SEVERITY; ECHOCARDIOGRAPHY; FEMALE; GLOMERULUS FILTRATION RATE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ANALOGS AND DERIVATIVES; BLOOD; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIASTOLIC HEART FAILURE; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; HEART STROKE VOLUME; METABOLISM; MULTICENTER STUDY; PHYSIOLOGY; REFERENCE VALUE; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARGININE; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HEART FAILURE, DIASTOLIC; HOMOARGININE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; NITRIC OXIDE; REFERENCE VALUES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; STROKE VOLUME;

EID: 84920057044     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2014.09.004     Document Type: Article

References (48)

1. D.M. Lloyd-Jones Cardiovascular risk prediction: basic concepts, current status, and future directions Circulation 121 2010 1768 1777
2. G.D. Lewis, A. Asnani, and R.E. Gerszten Application of metabolomics to cardiovascular biomarkers and pathway discovery J Am Coll Cardiol 52 2008 117 123
3. T.E. Owan, D.O. Hodge, R.M. Herges, S.J. Jacobsen, V.L. Roger, and M.M. Redfield Trends in prevalence and outcome of heart failure with preserved ejection fraction N Engl J Med 355 2006 251 259
4. D.S. Lee, P. Gona, R.S. Vasan, M.G. Larson, E.J. Benjamin, and T.J. Wang Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute Circulation 119 2009 3070 3077
5. G. Wu Amino acids: metabolism, functions, and nutrition Amino Acids 37 2009 1 17
6. M. Visser, W.J. Paulus, M.A. Vermeulen, M.C. Richir, M. Davids, and W. Wisselink The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature Eur J Heart Fail 12 2010 1274 1281
7. R.H. Böger, R. Maas, F. Schulze, and E. Schwedhelm Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-an update on patient populations with a wide range of cardiovascular risk Pharmacol Res 60 2009 481 487
8. R.H. Böger, L.M. Sullivan, E. Schwedhelm, T.J. Wang, R. Maas, and E.J. Benjamin Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community Circulation 119 2009 1592 1600
9. A. Meinitzer, J.T. Kielstein, S. Pilz, C. Drechsler, E. Ritz, and B.O. Boehm Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study Clin Chem 57 2011 112 121
10. M. Anderssohn, M. Rosenberg, E. Schwedhelm, C. Zugck, M. Lutz, and N. Lüneburg The L-arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathy J Card Fail 18 2012 904 911
11. C.P. Hsu, S.J. Lin, M.Y. Chung, and T.M. Lu Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure Atherosclerosis 225 2012 504 510
12. B. Siegerink, R. Maas, C.Y. Vossen, E. Schwedhelm, W. Koenig, and R. Böger Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study Clin Res Cardiol 102 2013 193 202
13. B.V. Djordjević, R. Pavlović, V. Ćosić, M. Deljanin-Ilić, T. Ristić, and N. Krstić High clinical accuracy of asymmetric dimethylarginine and symmetric dimethylarginine in patients with ischemic heart disease Amino Acids 43 2012 2293 2300
14. O. Tutarel, A. Denecke, S.M. Bode-Böger, J. Martens-Lobenhoffer, S. Lovric, and J. Bauersachs Asymmetrical dimethylarginine - more sensitive than NT-proBNP to diagnose heart failure in adults with congenital heart disease PLoS One 7 2012 e33795
15. A.A. Mangoni The emerging role of symmetric dimethylarginine in vascular disease Adv Clin Chem 48 2009 73 94
16. S.M. Bode-Böger, F. Scalera, J.T. Kielstein, J. Martens-Lobenhoffer, G. Breithardt, and M. Fobker Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease J Am Soc Nephrol 17 2006 1128 1134
17. A. Meinitzer, C. Drechsler, A. Tomaschitz, S. Pilz, V. Krane, and C. Wanner Homoarginine: a new cardiovascular risk marker in hemodialysis patients Lab Med 35 2011 153 159
18. P. Valtonen, T. Laitinen, T. Lyyra-Laitinen, O.T. Raitakari, M. Juonala, and J.S. Viikari Serum L-homoarginine is elevated during normal pregnancy and is related to flow-mediated vasodilatation Circ J 72 2008 1879 1884
19. W. März, A. Meinitzer, C. Drechsler, S. Pilz, V. Krane, and M.E. Kleber Homoarginine, cardiovascular risk, and mortality Circulation 122 2010 967 975
20. S. Pilz, A. Tomaschitz, A. Meinitzer, C. Drechsler, E. Ritz, and V. Krane Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography Stroke 42 2011 1132 1134
21. S. Pilz, A. Meinitzer, A. Tomaschitz, C. Drechsler, E. Ritz, and V. Krane Low homoarginine concentration is a novel risk factor for heart disease Heart 97 2011 1222 1227
22. C. Drechsler, A. Meinitzer, S. Pilz, V. Krane, A. Tomaschitz, and E. Ritz Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients Eur J Heart Fail 13 2011 852 859
23. D. Atzler, M. Rosenberg, M. Anderssohn, C.U. Choe, M. Lutz, and C. Zugck Homoarginine - an independent marker of mortality in heart failure Int J Cardiol 168 2013 4907 4909
24. C.U. Choe, D. Atzler, P.S. Wild, A.M. Carter, R.H. Böger, and F. Ojeda Homoarginine Levels are regulated by L-arginine:glycineamidinotransferase and affect stroke outcome: results from human and murine studies Circulation 128 2013 1451 1461
25. P. Ravani, R. Maas, F. Malberti, P. Pecchini, M. Mieth, and R. Quinn Homoarginine and mortality in pre-dialysis chronic kidney disease (C D) patients PLoS One 8 2013 e72694
26. W.L. Ryan, R.J. Johnson, and S. Dimari Homoarginine synthesis by rat kidney Arch Biochem Biophys 131 1969 521 526
27. M.E. Cullen, A.H. Yuen, L.E. Felkin, R.T. Smolenski, J.L. Hall, and S. Grindle Myocardial expression of the arginine:glycineamidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis Circulation 114 2006 16 20
28. W.H. Wilson Tang, W. Tong, K. Shrestha, Z. Wang, B.S. Levison, and B. Delfraino Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure Eur Heart J 29 2008 2506 2513
29. F. Edelmann, R. Stahrenberg, F. Polzin, A. Kockskämper, H.D. Düngen, and A. Duvinage Impaired physical quality of life in patients with diastolic dysfunction associates more strongly with neurohumoral activation than with echocardiographic parameters: quality of life in diastolic dysfunction Am Heart J 161 2011 797 804
30. R. Stahrenberg, F. Edelmann, M. Mende, A. Kockskämper, H.D. Düngen, and M. Scherer Association of glucose metabolism with diastolic function along the diabetic continuum Diabetologia 53 2010 1331 1340
31. R.M. Lang, M. Bierig, R.B. Devereux, F.A. Flachskampf, E. Foster, and P.A. Pellikka Recommendations for chamber quantification Eur J Echocardiogr 7 2006 79 108
32. T. Teerlink, R.J. Nijveldt, S. de Jong, and P.A. van Leeuwen Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography Anal Biochem 303 2002 131 137
33. A. Meinitzer, M. Puchinger, B.M. Winklhofer-Roob, E. Rock, J. Ribalta, and J.M. Roob Reference values for plasma concentrations of asymmetrical dimethylarginine (ADMA) and other arginine metabolites in men after validation of a chromatographic method Clin Chim Acta 384 2007 141 148
34. I.T. Klip, A.A. Voors, S.D. Anker, H.L. Hillege, J. Struck, and I. Squire Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction Heart 97 2011 892 898
35. A.S. Levey, J. Coresh, E. Balk, A.T. Kausz, A. Levin, and M.W. Steffes National Kidney Foundation. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification Ann Intern Med 139 2003 137 147
36. W. Lieb, R.A. Benndorf, E.J. Benjamin, L.M. Sullivan, R. Maas, and V. Xanthakis Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample Atherosclerosis 204 2009 282 287
37. A.L. Sverdlov, D.T. Ngo, A.K. Nightingale, S. Rajendran, K. Mishra, and T. Heresztyn The endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) predicts LV mass independent of afterload Nitric Oxide 25 2011 41 46
38. E. Schepers, D.V. Barreto, S. Liabeuf, G. Glorieux, S. Eloot, and F.C. Barreto Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease Clin J Am Soc Nephrol 6 2011 2374 2383
39. E. Schepers, G. Glorieux, A. Dhondt, L. Leybaert, and R. Vanholder Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes Nephrol Dial Transpl 24 2009 1429 1435
40. J.L. Hall, E.J. Birks, S. Grindle, M.E. Cullen, P.J. Barton, and J.E. Rider Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy Eur Heart J 28 2007 613 627
41. S.L. Rao A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass pea Food ChemToxicol 49 2011 620 622
42. J.T. Kielstein, S.R. Salpeter, S.M. Bode-Boeger, J.P. Cooke, and D. Fliser Symmetric dimethylarginine (SDMA) as endogenous marker of renal function-a meta-analysis Nephrol Dial Transpl 21 2006 2446 2451
43. O. Tutarel, A. Denecke, S.M. Bode-Böger, J. Martens-Lobenhoffer, B. Schieffer, and M. Westhoff-Bleck Symmetrical dimethylarginine outperforms CKD-EPI and MDRD-derived eGFR for the assessment of renal function in patients with adult congenital heart disease Kidney Blood Press Res 34 2011 41 45
44. E. Schwedhelm, and R.H. Böger The role of asymmetric and symmetric dimethylarginines in renal disease Nat Rev Nephrol 7 2011 275 285
45. C. Drechsler, B. Kollerits, A. Meinitzer, W. März, E. Ritz, and P. König Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study PLoS One 8 2013 e63560
46. M.M. Redfield, S.J. Jacobsen, J.C. Burnett Jr., D.W. Mahoney, K.R. Bailey, and R.J. Rodeheffer Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic JAMA 292 2003 194 202
47. A. Tomaschitz, A. Meinitzer, S. Pilz, J. Rus-Machan, B. Genser, and C. Drechsler Homoarginine, kidney function and cardiovascular mortality risk Nephrol Dial Transpl 29 2014 663 671
48. S. Pilz, T. Teerlink, P.G. Scheffer, A. Meinitzer, F. Rutters, and A. Tomaschitz Homoarginine and mortality in an older population: the Hoorn study Eur J Clin Invest 44 2014 200 208