Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: The KAROLA follow-up study

Clinical Research in Cardiology

Volumn 102, Issue 3, 2013, Pages 193-202

  Siegerink, Bob ^a,b   Maas, Renke ^c   Vossen, Carla Y ^b,d   Schwedhelm, Edzard ^e   Koenig, Wolfgang ^f   Böger, Rainer ^e   Rothenbacher, Dietrich ^a,f   Brenner, Hermann ^a   Breitling, Lutz P ^a,g  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f UNIVERSITY OF ULM   (Germany)

^g UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

ADMA; Cardiovascular disease; Mortality; Prospective cohort study; SDMA

Indexed keywords

6 N,N' DIMETHYLARGININE; N(G),N(G) DIMETHYLARGININE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; TANDEM MASS SPECTROMETRY;

EID: 84878545505     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-012-0515-4     Document Type: Article

References (34)

1. Boger RH, Zoccali C (2003) ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease. Atheroscler Suppl 4:23-28
2. Ogawa T, Kimoto M, Sasaoka K (1987) Occurrence of a new enzyme catalyzing the direct conversion of NG, NG-dimethyl-l-arginine to l-citrulline in rats. Biochem Biophys Res Commun 148:671-677
3. Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339:572-575
4. Boger RH (2007) The pharmacodynamics of l-arginine. J Nutr 137:1650S-1655S
5. Morris SM Jr (2007) Arginine metabolism: boundaries of our knowledge. J Nutr 137:1602S-1609S
6. Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 20(Suppl 12):S60-S62
7. Boger RH, Bode-Boger SM, Szuba A, Tsao PS, Chan JR, Tangphao O et al (1998) Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 98:1842-1847
8. Boger RH, Maas R, Schulze F, Schwedhelm E (2005) Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality. Clin Chem Lab Med 43:1124-1129
9. Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J et al (2006) ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Stroke 37:2024-2029
10. Maas R, Xanthakis V, Polak JF, Schwedhelm E, Sullivan LM, Benndorf R et al (2009) Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort. Stroke 40:2715-2719
11. Zoccali C, Benedetto FA, Maas R, Mallamaci F, Tripepi G, Malatino LS et al (2002) Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 13:490-496
12. Boger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ et al (2009) Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 119:1592-1600
13. Schnabel R, Blankenberg S, Lubos E, Lackner KJ, Rupprecht HJ, Espinola-Klein C et al (2005) Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study. Circ Res 97:e53-e59
14. Schulze F, Lenzen H, Hanefeld C, Bartling A, Osterziel KJ, Goudeva L et al (2006) Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. Am Heart J 152:493e1-493e8
15. Zoccali C, Bode-Boger S, Mallamaci F, Benedetto F, Tripepi G, Malatino L et al (2001) Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 358:2113-2117
16. Bode-Boger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M et al (2006) Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 17:1128-1134
17. Closs EI, Basha FZ, Habermeier A, Forstermann U (1997) Interference of l-arginine analogues with l-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide 1:65-73
18. Kielstein JT, Fliser D, Veldink H (2009) Asymmetric dimethylarginine and symmetric dimethylarginine: axis of evil or useful alliance? Semin Dial 22:346-350
19. Aucella F, Maas R, Vigilante M, Tripepi G, Schwedhelm E, Margaglione M et al (2009) Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study. Atherosclerosis 207:541-545
20. Schulze F, Carter AM, Schwedhelm E, Ajjan R, Maas R, von Holten RA et al (2010) Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke. Atherosclerosis 208:518-523
21. Wang Z, Tang WH, Cho L, Brennan DM, Hazen SL (2009) Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. Arterioscler Thromb Vasc Biol 29:1383-1391
22. Meinitzer A, Kielstein JT, Pilz S, Drechsler C, Ritz E, Boehm BO et al (2011) Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study. Clin Chem 57:112-121
23. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G et al (2010) Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121:948-954
24. Koenig W, Twardella D, Brenner H, Rothenbacher D (2006) Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress. Arterioscler Thromb Vasc Biol 26:1586-1593
25. Rothenbacher D, Koenig W, Brenner H (2006) Comparison of N-terminal pro-B-natriuretic peptide, C-reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease. Arch Intern Med 166:2455-2460
26. Schwedhelm E, Maas R, Tan-Andresen J, Schulze F, Riederer U, Boger RH (2007) High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci 851:211-219
27. Schwedhelm E, Tan-Andresen J, Maas R, Riederer U, Schulze F, Boger RH (2005) Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma. Clin Chem 51:1268-1271
28. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604-612
29. Desquilbet L, Mariotti F (2010) Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 29:1037-1057
30. Beauvieux MC, Le Moigne F, Lasseur C, Raffaitin C, Perlemoine C, Barthe N et al (2007) New predictive equations improve monitoring of kidney function in patients with diabetes. Diabetes Care 30:1988-1994
31. Soares AA, Eyff TF, Campani RB, Ritter L, Camargo JL, Silveiro SP (2009) Glomerular filtration rate measurement and prediction equations. Clin Chem Lab Med 47:1023-1032
32. Sun T, Zhou WB, Luo XP, Tang YL, Shi HM (2009) Oral l-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials. Clin Cardiol 32:649-652
33. Zhang QL, Brenner H, Koenig W, Rothenbacher D (2010) Prognostic value of chronic kidney disease in patients with coronary heart disease: role of estimating equations. Atherosclerosis 211:342-347
34. Jacobi J, Maas R, Cardounel AJ, Arend M, Pope AJ, Cordasic N et al (2010) Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol 176:2559-2570