The L-Arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathy

Journal of Cardiac Failure

Volumn 18, Issue 12, 2012, Pages 904-911

  Anderssohn, Maike ^a   Rosenberg, Mark ^b   Schwedhelm, Edzard ^a   Zugck, Christian ^c   Lutz, Matthias ^b   Lüneburg, Nicole ^a   Frey, Norbert ^b   Böger, Rainer H ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Asymmetric dimethylarginine; chronic heart failure; DCM; ICM

Indexed keywords

6 N,N' DIMETHYLARGININE; ARGININE; N(G),N(G) DIMETHYLARGININE;

ADULT; ARTICLE; CARDIOVASCULAR MORTALITY; CONGESTIVE CARDIOMYOPATHY; DISEASE ASSOCIATION; FEMALE; HEART FAILURE; HUMAN; ISCHEMIC CARDIOMYOPATHY; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TANDEM MASS SPECTROMETRY;

ARGININE; BIOLOGICAL MARKERS; CARDIOMYOPATHIES; CARDIOMYOPATHY, DILATED; CHROMATOGRAPHY, LIQUID; CREATININE; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL ISCHEMIA; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; SEVERITY OF ILLNESS INDEX; TANDEM MASS SPECTROMETRY;

EID: 84870530465     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2012.10.011     Document Type: Article

References (32)

1. B.M. Richartz, G.S. Werner, M. Ferrari, and H.R. Figulla Reversibility of coronary endothelial vasomotor dysfunction in idiopathic dilated cardiomyopathy: acute effects of vitamin C Am J Cardiol 88 2001 1001 1005
2. S.H. Kubo, T.S. Rector, A.J. Bank, R.E. Williams, and S.M. Heifetz Endothelium-dependent vasodilation is attenuated in patients with heart failure Circulation 84 1991 1589 1596
3. T.K. Krempl, R. Maas, K. Sydow, T. Meinertz, R.H. Böger, and J. Kähler Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events Eur Heart J 26 2005 1846 1851
4. R.H. Böger, H.G. Endres, E. Schwedhelm, H. Darius, D. Atzler, and N. Lüneburg Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease J Intern Med 269 2011 349 361
5. C. Dückelmann, F. Mittermayer, D.G. Haider, J. Altenberger, J. Eichinger, and M. Wolzt Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure Arterioscler Thromb Vasc Biol 27 2007 2037 2042
6. S. Haehling von, S.M. Bode-Böger, J. Martens-Lobenhoffer, M. Rauchhaus, J.C. Schefold, and S. Genth-Zotz Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol Clin Pharmacol Ther 88 2010 506 512
7. W.H. Wilson Tang, W. Tong, K. Shrestha, Z. Wang, B.S. Levison, and B. Delfraino Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure Eur Heart J 29 2008 2506 2513
8. F. Schulze, A.M. Carter, E. Schwedhelm, R. Ajjan, R. Maas, and R.A. von Holten Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke Atherosclerosis 208 2010 518 523
9. A. Meinitzer, J.T. Kielstein, S. Pilz, C. Drechsler, E. Ritz, and B.O. Boehm Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study Clin Chem 57 2011 112 121
10. V. Achan, M. Broadhead, M. Malaki, G. Whitley, J. Leiper, and R. MacAllister Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase Arterioscler Thromb Vasc Biol 23 2003 1455 1459
11. K. Numaguchi, K. Egashira, M. Takemoto, T. Kadokami, H. Shimokawa, and K. Sueishi Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats Hypertension 26 6 Pt 1 1995 957 962
12. H. Tomita, K. Egashira, Y. Ohara, M. Takemoto, M. Koyanagi, and M. Katoh Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats Hypertension 32 1998 273 279
13. S.M. Bode-Böger, R.H. Böger, S. Kienke, W. Junker, and J.C. Frölich Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits Biochem Biophys Res Commun 219 1996 598 603
14. R.H. Böger, L.M. Sullivan, E. Schwedhelm, T.J. Wang, R. Maas, and E.J. Benjamin Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community Circulation 119 2009 1592 1600
15. P.J. Cowburn, J.G. Cleland, A.J. Coats, and M. Komajda Risk stratification in chronic heart failure Eur Heart J 19 1998 696 710
16. M. Rosenberg, C. Zugck, M. Nelles, C. Juenger, D. Frank, and A. Remppis Osteopontin, a new prognostic biomarker in patients with chronic heart failure Circ Heart Fail 1 2008 43 49
17. Criteria Committee of the New York Heart Association Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis 96th Edition 1964 Little, Brown Boston, MA
18. E. Schwedhelm, R. Maas, J. Tan-Andresen, F. Schulze, U. Riederer, and R.H. Böger High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma J Chromatogr B Analyt Technol Biomed Life Sci 851 2007 211 219
19. A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro 3rd, H.I. Feldman, J.W. Kusek, P. Eggers, F. Van Lente, T. Greene, J. Coresh CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) A new equation to estimate glomerular filtration rate Ann Intern Med 150 2009 604 612
20. I. Seljeflot, B.B. Nilsson, A.S. Westheim, V. Bratseth, and H. Arnesen The L-arginine-asymmetric dimethylarginine ratio is strongly related to the severity of chronic heart failure. No effects of exercise training J Card Fail 17 2011 135 142
21. Y. Chen, Y. Li, P. Zhang, J.H. Traverse, M. Hou, and X. Xu Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts Am J Physiol Heart Circ Physiol 289 2005 H2212 H2219
22. Y.L. Tain, Y.H. Kao, C.S. Hsieh, C.C. Chen, J.M. Sheen, and I.C. Lin Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine Free Radic Biol Med 15 2010 1088 1098
23. E. Schepers, G. Glorieux, A. Dhondt, L. Leybaert, and R. Vanholder Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes Nephrol Dial Transplant 24 2009 1429 1435
24. Y. Nishijima, A. Sridhar, I. Bonilla, M. Velayutham, M. Khan, and R. Terentyeva Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart-failure-induced alterations in atrial electrophysiology Cardiovasc Res 91 2011 71 79
25. J.H. Kim, L.J. Bugaj, Y.J. Oh, T.J. Bivalacqua, S. Ryoo, and K.G. Soucy Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats J Appl Physiol 107 2009 1249 1257
26. E.I. Closs, F.Z. Basha, A. Habermeier, and U. Förstermann Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B Nitric Oxide 1 1997 65 73
27. M.M. Parnell, D.P. Holst, and D.M. Kaye Augmentation of endothelial function following exercise training is associated with increased L-arginine transport in human heart failure Clin Sci (Lond) 109 2005 523 530
28. R.H. Böger, S.M. Bode-Böger, W. Thiele, A. Creutzig, K. Alexander, and J.C. Frölich Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease Vasc Med 8 2003 77 81
29. S.M. Bode-Böger, J. Muke, A. Surdacki, G. Brabant, R.H. Böger, and J.C. Frölich Oral L-arginine improves endothelial function in healthy individuals older than 70 years J Am Coll Cardiol 32 1998 1336 1344
30. R. Hambrecht, L. Hilbrich, S. Erbs, S. Gielen, E. Fiehn, and N. Schoene Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation J Am Coll Cardiol 35 2000 706 713
31. C. Heymes, M. Vanderheyden, J.G. Bronzwaer, A.M. Shah, and W.J. Paulus Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy Circulation 99 1999 3009 3016
32. S.P. Jones, and R. Bolli The ubiquitous role of nitric oxide in cardioprotection J Mol Cell Cardiol 40 2006 16 23