Bortezomib induces AMPK-dependent autophagosome formation uncoupled from apoptosis in drug resistant cells

Oncotarget

Volumn 5, Issue 23, 2014, Pages 12358-12370

  Jaganathan, Sajjeev ^a   Malek, Ehsan ^a   Vallabhapurapu, Subrahmanya ^a   Vallabhapurapu, Sivakumar ^a   Driscoll, James J ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Autophagy; Drug resistance; Myeloma; Proteasome

Indexed keywords

AUTOPHAGY PROTEIN 5; BORTEZOMIB; CALPAIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ANTINEOPLASTIC AGENT; ATG5 PROTEIN, HUMAN; BORONIC ACID DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; PYRAZINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOENERGY; CANCER CELL DESTRUCTION; CANCER RESISTANCE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; MYELOMA CELL; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PROTEIN CLEAVAGE; DRUG RESISTANCE; GENE INACTIVATION; GENETIC TRANSFECTION; HUMAN; METABOLISM; MULTIPLE MYELOMA; PHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; BORONIC ACIDS; BORTEZOMIB; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GENE KNOCKOUT TECHNIQUES; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MULTIPLE MYELOMA; PYRAZINES; TRANSFECTION;

EID: 84920031400     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2590     Document Type: Article

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